KEGG   REACTION: R04639
Entry
R04639                      Reaction                               
Name
2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate hydrolase
Definition
7,8-Dihydroneopterin 3'-triphosphate + H2O <=> 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
Equation
C04895 + C00001 <=> C06148
Comment
the last step of four-step reaction (see R00424, R00428+R05046+R05048+R04639)
possibly spontaneous
following after R05048
Reaction class
RC01188  C04895_C06148
Enzyme
3.5.4.16
Pathway
rn00790  Folate biosynthesis
rn01100  Metabolic pathways
Module
M00126  Tetrahydrofolate biosynthesis, GTP => THF
M00841  Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF
M00842  Tetrahydrobiopterin biosynthesis, GTP => BH4
M00843  L-threo-Tetrahydrobiopterin biosynthesis, GTP => L-threo-BH4
Brite
Enzymatic reactions [BR:br08201]
 3. Hydrolase reactions
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.16
     R04639  7,8-Dihydroneopterin 3'-triphosphate + H2O <=> 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
Orthology
K01495  GTP cyclohydrolase IA [EC:3.5.4.16]
K09007  GTP cyclohydrolase IB [EC:3.5.4.16]
K22391  GTP cyclohydrolase I [EC:3.5.4.16]

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (8)   
   KEGG PATHWAY (4)   
   KEGG MODULE (4)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG RCLASS (1)   
Gene (11836)   
   KEGG ORTHOLOGY (3)   
   KEGG GENES (11833)   
All databases (11850)   

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