KEGG   REACTION: R05467Help
Entry
R05467                      Reaction                               

Name
L-N2-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming)
Definition
L-N2-(2-Carboxyethyl)arginine + ATP <=> Deoxyguanidinoproclavaminic acid + AMP + Diphosphate
Equation
Comment
beta-lactam synthase
Reaction class
RC01389  C06655_C06656
Enzyme
Pathway
rn00331  Clavulanic acid biosynthesis
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00674  Clavaminate biosynthesis, arginine + glyceraldehyde-3P => clavaminate
Orthology
K12674  (carboxyethyl)arginine beta-lactam-synthase [EC:6.3.3.4]
Reference
1  [PMID:9614345]
  Authors
McGowan SJ, Bycroft BW, Salmond GP.
  Title
Bacterial production of carbapenems and clavams: evolution of beta-lactam antibiotic pathways.
  Journal
Trends Microbiol 6:203-8 (1998)
DOI:10.1016/S0966-842X(98)01251-7
Other DBs
RHEA: 23623

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