KEGG   REACTION: R05522Help
Entry
R05522                      Reaction                               

Name
erythromycin-D,NADPH:oxygen oxidoreductase (12-hydroxylating)
Definition
Erythromycin D + NADPH + H+ + Oxygen <=> Erythromycin C + NADP+ + H2O
Equation
Comment
1200-1900-fold preference for erythromycin D over the alternative substrate erythromycin B
Reaction class
RC00001  C00005_C00006
RC01892  C06616_C06633
Enzyme
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00774  Erythromycin biosynthesis, propanoyl-CoA + methylmalonyl-CoA => deoxyerythronolide B => erythromycin A/B
Orthology
K14370  erythromycin 12 hydroxylase [EC:1.14.13.154]
Other DBs
RHEA: 32634

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