KEGG   REACTION: R05829
Entry
R05829                      Reaction                               
Name
(19E)-geissoschizine:[oxidized NADPH---hemoprotein reductase] oxidoreductase (polyneuridine aldehyde forming)
Definition
(19E)-Geissoschizine + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Polyneuridine aldehyde + [Oxidized NADPH---hemoprotein reductase] + 2 H2O
Equation
C02151 + C03024 + C00007 <=> C11632 + C03161 + 2 C00001
Reaction class
RC01905  C02151_C11632
Enzyme
1.14.19.81
Pathway
rn00901  Indole alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00979  Ajmaline biosynthesis, geissoschizine => ajmaline
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.19  With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
    1.14.19.81
     R05829  (19E)-Geissoschizine + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Polyneuridine aldehyde + [Oxidized NADPH---hemoprotein reductase] + 2 H2O
Orthology
K27776  polyneuridine aldehyde synthase [EC:1.14.19.81]
Reference
1  [PMID:29942076]
  Authors
Dang TT, Franke J, Carqueijeiro IST, Langley C, Courdavault V, O'Connor SE
  Title
Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modes.
  Journal
Nat Chem Biol 14:760-763 (2018)
DOI:10.1038/s41589-018-0078-4

  All links  
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