KEGG   REACTION: R06459Help
Entry
R06459                      Reaction                               

Name
(2S)-methylmalonyl-CoA:malonyl-CoA malonyltransferase (narbonolide forming)
Definition
6 (S)-Methylmalonyl-CoA + Malonyl-CoA + 5 NADPH + 5 H+ <=> Narbonolide + 7 CoA + 7 CO2 + 5 NADP+ + 2 H2O
Equation
6 C00683 + C00083 + 5 C00005 + 5 C00080 <=> C11997 + 7 C00010 + 7 C00011 + 5 C00006 + 2 C00001
Comment
type I polyketide synthase, PikA1-4
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C00083  C00010_C00683
RC02828  C00683_C11997
RC02829  C00683_C11997
RC02830  C00683_C11997
RC02910  C00683_C11997
RC02911  C00083_C11997
RC02915  C00683_C11997
RC03330  C00683_C11997
Enzyme
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01130  Biosynthesis of antibiotics
Module
M00776  Pikromycin/methymycin biosynthesis, methylmalonyl-CoA + malonyl-CoA => narbonolide/10-deoxymethynolide => pikromycin/methymycin
Orthology
K16000  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16001  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16002  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16003  narbonolide synthase [EC:2.3.1.240]
Other DBs
RHEA: 42847

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