KEGG   REACTION: R06470
Entry
R06470                      Reaction                               
Definition
6,8a-Seco-6,8a-deoxy-5-oxoavermectin ''1b'' aglycone + NADPH + Oxygen <=> 5-Oxoavermectin ''1b'' aglycone + NADP+ + H2O
Equation
C11961 + C00005 + C00007 <=> C11962 + C00006 + C00001
Comment
cytochrome P450 hydroxylase,AveE
Reaction class
RC00001  C00005_C00006
RC01527  C11961_C11962
Enzyme
1.14.-.-
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.-  Acting on paired donors, with incorporation or reduction of molecular oxygen
    1.14.-.-
     R06470  6,8a-Seco-6,8a-deoxy-5-oxoavermectin ''1b'' aglycone + NADPH + Oxygen <=> 5-Oxoavermectin ''1b'' aglycone + NADP+ + H2O
Orthology
K14372  cytochrome P450 hydroxylase [EC:1.14.-.-]

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG RCLASS (2)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (18)   

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