KEGG   REACTION: R06473Help
Entry
R06473                      Reaction                               

Definition
5-Oxoavermectin ''1a'' aglycone + NADPH + H+ <=> Avermectin B1a aglycone + NADP+
Equation
Comment
C-5 ketoreductase,AveF
Reaction class
RC00001  C00005_C00006
RC01528  C11978_C11979
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Orthology
K14373  C-5 ketoreductase

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