KEGG   REACTION: R06480
Entry
R06480                      Reaction                               

Definition
2-Methylbutanoyl-CoA + 5 Methylmalonyl-CoA + 7 Malonyl-CoA + 9 NADPH + 9 H+ <=> 6,8a-Seco-6,8a-deoxy-5-oxoavermectin ''2a'' aglycone + 12 CO2 + 13 CoA + 5 H2O + 9 NADP+
Equation
C01033 + 5 C02557 + 7 C00083 + 9 C00005 + 9 C00080 <=> C11969 + 12 C00011 + 13 C00010 + 5 C00001 + 9 C00006
Comment
type I polyketide synthase, AveA1-4
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C00083  C00010_C01033  C00010_C02557
RC02913  C01033_C11969
RC02914  C02557_C11969
RC02915  C02557_C11969
RC02920  C02557_C11969
RC02921  C02557_C11969
RC02922  C02557_C11969
RC02923  C00083_C11969
RC02924  C00083_C11969
RC02925  C00083_C11969
RC02926  C00083_C11969
RC02927  C00083_C11969
RC02928  C00083_C11969
RC02929  C00083_C11969
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
Orthology
K14371  avermectin polyketide synthase AveA1
K24567  avermectin polyketide synthase AveA2
K24568  avermectin polyketide synthase AveA3
K24569  avermectin polyketide synthase AveA4

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (10)   
   KEGG COMPOUND (10)   
Chemical reaction (15)   
   KEGG RCLASS (15)   
Gene (5)   
   KEGG ORTHOLOGY (4)   
   KEGG GENES (1)   
All databases (33)   

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