KEGG   REACTION: R06481
Entry
R06481                      Reaction                               
Definition
2-Methylbutanoyl-CoA + 5 Methylmalonyl-CoA + 7 Malonyl-CoA + 9 NADPH + 9 H+ <=> 6,8a-Seco-6,8a-deoxy-5-oxoavermectin ''1a'' aglycone + 12 CO2 + 13 CoA + 6 H2O + 9 NADP+
Equation
C01033 + 5 C02557 + 7 C00083 + 9 C00005 + 9 C00080 <=> C11977 + 12 C00011 + 13 C00010 + 6 C00001 + 9 C00006
Comment
type I polyketide synthase, AveA1-4
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C00083  C00010_C01033  C00010_C02557
RC02913  C01033_C11977
RC02915  C02557_C11977
RC02920  C02557_C11977
RC02921  C02557_C11977
RC02922  C02557_C11977
RC02924  C00083_C11977
RC02925  C00083_C11977
RC02926  C00083_C11977
RC02927  C00083_C11977
RC02928  C00083_C11977
RC02929  C00083_C11977
RC02930  C00083_C11977
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Orthology
K14371  avermectin polyketide synthase AveA1
K24567  avermectin polyketide synthase AveA2
K24568  avermectin polyketide synthase AveA3
K24569  avermectin polyketide synthase AveA4

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