KEGG   REACTION: R06482
Entry
R06482                      Reaction                               
Definition
2-Methylpropanoyl-CoA + 5 Methylmalonyl-CoA + 7 Malonyl-CoA + 9 NADPH + 9 H+ <=> 6,8a-Seco-6,8a-deoxy-5-oxoavermectin ''2b'' aglycone + 12 CO2 + 13 CoA + 5 H2O + 9 NADP+
Equation
C00630 + 5 C02557 + 7 C00083 + 9 C00005 + 9 C00080 <=> C11953 + 12 C00011 + 13 C00010 + 5 C00001 + 9 C00006
Comment
type I polyketide synthase, AveA1-4
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C00083  C00010_C00630  C00010_C02557
RC02913  C00630_C11953
RC02914  C02557_C11953
RC02915  C02557_C11953
RC02920  C02557_C11953
RC02921  C02557_C11953
RC02922  C02557_C11953
RC02923  C00083_C11953
RC02924  C00083_C11953
RC02925  C00083_C11953
RC02926  C00083_C11953
RC02927  C00083_C11953
RC02928  C00083_C11953
RC02929  C00083_C11953
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
Orthology
K14371  avermectin polyketide synthase AveA1
K24567  avermectin polyketide synthase AveA2
K24568  avermectin polyketide synthase AveA3
K24569  avermectin polyketide synthase AveA4

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