KEGG   REACTION: R06704Help
Entry
R06704                      Reaction                               

Name
tetracenomycin-A2,NADPH:oxygen oxidoreductase (tetracenomycin-C-forming)
Definition
Tetracenomycin A2 + 2 Oxygen + H2O + 2 NADPH + 2 H+ <=> Tetracenomycin C + 2 NADP+ + 2 H2O
Equation
C12371 + 2 C00007 + C00001 + 2 C00005 + 2 C00080 <=> C06801 + 2 C00006 + 2 C00001
Reaction class
RC00001  C00005_C00006
RC02681  C06801_C12371
Enzyme
Pathway
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00783  Tetracenomycin C/8-demethyltetracenomycin C biosynthesis, tetracenomycin F2 => tetracenomycin C/8-demethyltetracenomycin C
Orthology
K15972  tetracenomycin A2 monooxygenase-dioxygenase [EC:1.14.13.200]
Reference
1  [PMID:11009387]
  Authors
Rafanan ER Jr, Hutchinson CR, Shen B.
  Title
Triple hydroxylation of tetracenomycin A2 to tetracenomycin C involving two molecules of O(2) and one molecule of H(2)O.
  Journal
Org Lett 2:3225-7 (2000)
DOI:10.1021/ol0002267
Other DBs
RHEA: 42827

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