KEGG   REACTION: R06778Help
Entry
R06778                      Reaction                               

Definition
5-[[(4,7-Dihydroxy-2-oxo-2H-1-benzopyran-3-yl)amino]carbonyl]-4-methyl-1H-pyrrole-3-carboxylate + 3-Amino-4,7-dihydroxycoumarin + ATP + 2 S-Adenosyl-L-methionine <=> Coumermic acid + AMP + Diphosphate + 2 S-Adenosyl-L-homocysteine
Equation
Comment
multi-step reaction
ligase, CouL
methyltransferase, CouO
Reaction class
RC00003  C00019_C00021
RC03149  C12479_C20637
RC03150  C12468_C12479
Pathway
rn00401  Novobiocin biosynthesis
rn01130  Biosynthesis of antibiotics
Orthology
K12705  8-demethylnovobiocic acid C8-methyltransferase [EC:2.1.1.284]
K12709  8-demethylnovobiocic acid synthase [EC:6.3.1.15]

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