KEGG   REACTION: R07253Help
Entry
R07253                      Reaction                               

Name
acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl-reducing, thioester-hydrolysing and cyclizing)
Definition
Acetyl-CoA + 3 Malonyl-CoA + NADPH + H+ <=> 6-Methylsalicylate + 4 CoA + 3 CO2 + NADP+ + H2O
Equation
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C00024  C00010_C00083
Enzyme
Pathway
rn01059  Biosynthesis of enediyne antibiotics
rn01130  Biosynthesis of antibiotics
Module
M00829  3,6-Dimethylsalicylyl-CoA biosynthesis, malonyl-CoA => 6-methylsalicylate => 3,6-dimethylsalicylyl-CoA
Orthology
K15320  6-methylsalicylic acid synthase [EC:2.3.1.165]
Other DBs
RHEA: 12243

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