KEGG   REACTION: R07600
Entry
R07600                      Reaction                               
Definition
2-Methyl-1-hydroxypropyl-ThPP + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + Thiamin diphosphate
Equation
C15976 + C15972 <=> C15977 + C00068
Comment
Oxo-acid dehydrogenase complexes (see R01701), following after R07599
Reaction class
RC00027  C00068_C15976
RC00627  C15972_C15977
RC02953  C15976_C15977
Enzyme
1.2.4.4
Pathway
rn00280  Valine, leucine and isoleucine degradation
rn00785  Lipoic acid metabolism
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.4
     R07600  2-Methyl-1-hydroxypropyl-ThPP + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + Thiamin diphosphate
Orthology
K00166  2-oxoisovalerate dehydrogenase E1 component subunit alpha [EC:1.2.4.4]
K00167  2-oxoisovalerate dehydrogenase E1 component subunit beta [EC:1.2.4.4]
K11381  2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4]

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG RCLASS (3)   
Gene (11364)   
   KEGG ORTHOLOGY (3)   
   KEGG GENES (11361)   
All databases (11377)   

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