REACTION: R08215
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Entry
R08215 Reaction
Name
(-)-threo-iso(homo)3-citrate:NAD+ oxidoreductase (decarboxylating)
Definition
(-)-threo-Iso(homo)3-citrate + NAD+ <=> 2-Oxosuberate + CO2 + NADH + H+
Equation
C16600
+
C00003
<=>
C16589
+
C00011
+
C00004
+
C00080
Reaction class
RC00001
C00003_C00004
RC00114
C16589_C16600
Enzyme
1.1.1.-
Pathway
rn00680
Methane metabolism
rn01100
Metabolic pathways
rn01120
Microbial metabolism in diverse environments
rn01210
2-Oxocarboxylic acid metabolism
rn01240
Biosynthesis of cofactors
Module
M00608
2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Brite
Enzymatic reactions [BR:
br08201
]
1. Oxidoreductase reactions
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.-
R08215 (-)-threo-Iso(homo)3-citrate + NAD+ <=> 2-Oxosuberate + CO2 + NADH + H+
BRITE hierarchy
Orthology
K10978
methanogen homoisocitrate dehydrogenase [EC:
1.1.1.87
1.1.1.-]
Reference
1 [PMID:
10940051
]
Authors
Howell DM, Graupner M, Xu H, White RH
Title
Identification of enzymes homologous to isocitrate dehydrogenase that are involved in coenzyme B and leucine biosynthesis in methanoarchaea.
Journal
J Bacteriol 182:5013-6 (2000)
DOI:
10.1128/JB.182.17.5013-5016.2000
Other DBs
RHEA:
68411
All links
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