KEGG   REACTION: R08770
Entry
R08770                      Reaction                               

Definition
4-Hydroxy-3-polyprenylbenzoate + Oxygen <=> 3,4-Dihydroxy-5-polyprenylbenzoate + H2O
Equation
Comment
general reaction (see R06865, n=5-9)
Reaction class
RC00046  C05848_C17554
Enzyme
1.14.13.-
Pathway
rn00130  Ubiquinone and other terpenoid-quinone biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01240  Biosynthesis of cofactors
Module
M00128  Ubiquinone biosynthesis, eukaryotes, 4-hydroxybenzoate + polyprenyl-PP => ubiquinol
Orthology
K06126  ubiquinone biosynthesis monooxygenase Coq6 [EC:1.14.13.-]
Reference
1  [PMID:21944752]
  Authors
Ozeir M, Muhlenhoff U, Webert H, Lill R, Fontecave M, Pierrel F.
  Title
Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue Coq6 deficiency.
  Journal
Chem Biol 18:1134-42 (2011)
DOI:10.1016/j.chembiol.2011.07.008
Reference
2  [PMID:26808124]
  Authors
Ismail A, Leroux V, Smadja M, Gonzalez L, Lombard M, Pierrel F, Mellot-Draznieks C, Fontecave M.
  Title
Coenzyme Q Biosynthesis: Evidence for a Substrate Access Channel in the FAD-Dependent Monooxygenase Coq6.
  Journal
PLoS Comput Biol 12:e1004690 (2016)
DOI:10.1371/journal.pcbi.1004690

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