KEGG   REACTION: R09190Help
Entry
R09190                      Reaction                               

Name
6-methylpretetramide,NADPH:oxygen oxidoreductase (4,12a-hydroxylating)
Definition
6-Methylpretetramide + 2 NADPH + 2 H+ + 2 Oxygen <=> 4-Keto-anhydrotetracycline + 2 NADP+ + 2 H2O
Equation
C06629 + 2 C00005 + 2 C00080 + 2 C00007 <=> C06627 + 2 C00006 + 2 C00001
Comment
two-step reaction (see R05463+R05462)
bifunctional enzyme, OxyL
Reaction class
RC00001  C00005_C00006
RC02460  C06627_C06629
Enzyme
Pathway
rn00253  Tetracycline biosynthesis
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00780  Tetracycline/oxytetracycline biosynthesis, pretetramide => tetracycline/oxytetracycline
M00823  Chlortetracycline biosynthesis, pretetramide => chlortetracycline
Orthology
K14252  6-methylpretetramide 4-monooxygenase / 4-hydroxy-6-methylpretetramide 12a-monooxygenase [EC:1.14.13.232 1.14.13.233]

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