KEGG   REACTION: R10052
Entry
R10052                      Reaction                               
Name
(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase
Definition
(2R,3S)-3-Isopropylmalate + NAD+ <=> 4-Methyl-2-oxopentanoate + CO2 + NADH + H+
Equation
Comment
two-step reaction (see R04426+R01652)
Reaction class
RC00001  C00003_C00004
RC03036  C00233_C04411
Enzyme
Pathway
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.85
     R10052  (2R,3S)-3-Isopropylmalate + NAD+ <=> 4-Methyl-2-oxopentanoate + CO2 + NADH + H+
Orthology
K00052  3-isopropylmalate dehydrogenase [EC:1.1.1.85]
K21360  3-isopropylmalate/methylthioalkylmalate dehydrogenase [EC:1.1.1.85 1.1.1.-]
Other DBs
RHEA: 32274

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