KEGG   REACTION: R10052
Entry
R10052                      Reaction                               

Name
(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase
Definition
(2R,3S)-3-Isopropylmalate + NAD+ <=> 4-Methyl-2-oxopentanoate + CO2 + NADH + H+
Equation
Comment
two-step reaction (see R04426+R01652)
Reaction class
RC00001  C00003_C00004
RC03036  C00233_C04411
Enzyme
Pathway
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
Orthology
K00052  3-isopropylmalate dehydrogenase [EC:1.1.1.85]
K21360  3-isopropylmalate/methylthioalkylmalate dehydrogenase [EC:1.1.1.85 1.1.1.-]
Other DBs
RHEA: 32274

KEGG   REACTION: R04426
Entry
R04426                      Reaction                               

Name
(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase
Definition
(2R,3S)-3-Isopropylmalate + NAD+ <=> (2S)-2-Isopropyl-3-oxosuccinate + NADH + H+
Equation
Comment
subsequently R01652
Reaction class
RC00001  C00003_C00004
RC00084  C04236_C04411
Enzyme
Pathway
rn00290  Valine, leucine and isoleucine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01210  2-Oxocarboxylic acid metabolism
Module
M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Orthology
K00052  3-isopropylmalate dehydrogenase [EC:1.1.1.85]
K21360  3-isopropylmalate/methylthioalkylmalate dehydrogenase [EC:1.1.1.85 1.1.1.-]
Other DBs
RHEA: 10895

KEGG   REACTION: R01652
Entry
R01652                      Reaction                               

Definition
4-Methyl-2-oxopentanoate + CO2 <=> (2S)-2-Isopropyl-3-oxosuccinate
Equation
Comment
spontaneous (following EC 1.1.1.85 or R04426 reaction)
Reaction class
RC00577  C00233_C04236
Enzyme
Pathway
rn00290  Valine, leucine and isoleucine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01210  2-Oxocarboxylic acid metabolism
Module
M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Other DBs
RHEA: 25081

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