KEGG   REACTION: R10633
Entry
R10633                      Reaction                               
Definition
NAD+ + Histone N6-acetyl-L-lysine + H2O <=> Nicotinamide + Histone-L-lysine + O-Acetyl-ADP-ribose + H+
Equation
C00003 + C01997 + C00001 <=> C00153 + C02415 + C20658 + C00080
Reaction class
RC00033  C00003_C00153
RC00096  C01997_C02415
Enzyme
2.3.1.286
Pathway
rn00760  Nicotinate and nicotinamide metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.286
     R10633  NAD+ + Histone N6-acetyl-L-lysine + H2O <=> Nicotinamide + Histone-L-lysine + O-Acetyl-ADP-ribose + H+
IUBMB reaction hierarchy [BR:br08202]
 2. Transferase reactions
  2.3.1.286
   R10634  Protein N6-acetyl-L-lysine <=> Protein lysine
    R10633  Histone N6-acetyl-L-lysine <=> Histone-L-lysine
Orthology
K11121  NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]
K11411  NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
K11412  NAD-dependent protein deacetylase sirtuin 2 [EC:2.3.1.286]
K11413  NAD-dependent protein deacetylase sirtuin 3 [EC:2.3.1.286]
K11414  NAD-dependent protein deacetylase/lipoamidase sirtuin 4 [EC:2.3.1.286 2.3.1.313]
K11415  NAD-dependent protein deacetylase sirtuin 5 [EC:2.3.1.286]
K11416  NAD-dependent protein deacetylase sirtuin 6 [EC:2.3.1.286]
K11417  NAD-dependent protein deacetylase sirtuin 7 [EC:2.3.1.286]
K12410  NAD-dependent protein deacetylase/lipoamidase [EC:2.3.1.286 2.3.1.313]

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