KEGG   REACTION: R10793
Entry
R10793                      Reaction                               

Name
dihydromonacolin L acid,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (3-hydroxylating)
Definition
Dihydromonacolin L acid + Oxygen + [Reduced NADPH---hemoprotein reductase] <=> Monacolin L acid + [Oxidized NADPH---hemoprotein reductase] + 2 H2O
Equation
Comment
two-step reaction (see R10791+R10792)
Reaction class
RC03282  C20851_C20853
Enzyme
Other DBs
RHEA: 42371

KEGG   REACTION: R10791
Entry
R10791                      Reaction                               

Name
dihydromonacolin L acid,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (3-hydroxylating)
Definition
Dihydromonacolin L acid + Oxygen + [Reduced NADPH---hemoprotein reductase] <=> 3alpha-Hydroxy-3,5-dihydromonacolin L acid + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
Comment
the first step of two-step reaction (see R10793, R10791+R10792)
Reaction class
RC03280  C20851_C20852
Enzyme
Pathway
rn00999  Biosynthesis of various secondary metabolites - part 1
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00893  Lovastatin biosynthesis, malonyl-CoA => lovastatin acid
Orthology
K20980  dihydromonacolin L/monacolin L hydroxylase [EC:1.14.14.124 1.14.14.125]
Other DBs
RHEA: 12207

KEGG   REACTION: R10792
Entry
R10792                      Reaction                               

Name
3alpha-hydroxy-3,5-dihydromonacolin L acid hydro-lyase
Definition
3alpha-Hydroxy-3,5-dihydromonacolin L acid <=> Monacolin L acid + H2O
Equation
Comment
spontaneous
the second step of two-step reaction (see R10793, R10791+R10792)
Reaction class
RC03281  C20852_C20853
Enzyme
Pathway
rn00999  Biosynthesis of various secondary metabolites - part 1
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00893  Lovastatin biosynthesis, malonyl-CoA => lovastatin acid
Orthology
K20980  dihydromonacolin L/monacolin L hydroxylase [EC:1.14.14.124 1.14.14.125]
Other DBs
RHEA: 24335

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