KEGG   REACTION: R10880Help
Entry
R10880                      Reaction                               

Definition
5 ATP + 3 L-4-Hydroxyphenylglycine + L-Arginine + L-Serine + H2O <=> 5 AMP + 5 Diphosphate + Nocardicin G + L-4-Hydroxyphenylglycyl-L-arginine
Equation
Comment
nocardicin nonribosomal peptide synthetase
(1) 3 L-pHPG + L-Arg + L-Ser + 5 ATP <=> Pro-nocardicin G + 5 AMP + 5 Diphosphate
(2) Pro-nocardicin G + H2O <=> Nocardicin G + L-pHPG-L-Arg
Reaction class
RC00064  C00062_C20910
RC00141  C12323_C20910
RC03296  C12323_C17355
RC03297  C12323_C17355
RC03298  C00065_C17355
Pathway
rn00261  Monobactam biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01130  Biosynthesis of antibiotics
Module
M00736  Nocardicin A biosynthesis, L-pHPG + arginine + serine => nocardicin A
Orthology
K05375  MbtH protein
K19102  nocardicin nonribosomal peptide synthetase NocA
K19103  nocardicin nonribosomal peptide synthetase NocB
Reference
1  [PMID:25624104]
  Authors
Gaudelli NM, Long DH, Townsend CA.
  Title
beta-Lactam formation by a non-ribosomal peptide synthetase during antibiotic biosynthesis.
  Journal
Nature (2015)
DOI:10.1038/nature14100
Reference
2  [PMID:24531841]
  Authors
Gaudelli NM, Townsend CA.
  Title
Epimerization and substrate gating by a TE domain in beta-lactam antibiotic biosynthesis.
  Journal
Nat Chem Biol 10:251-8 (2014)
DOI:10.1038/nchembio.1456

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