KEGG   REACTION: R11125Help
Entry
R11125                      Reaction                               

Name
malonyl-CoA:acetyl-CoA malonyltransferase (2-hydroxy-5-methyl-1-naphthoic acid forming)
Definition
Acetyl-CoA + 5 Malonyl-CoA + 2 NADPH + 2 H+ <=> 2-Hydroxy-5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 3 H2O + 2 NADP+
Equation
C00024 + 5 C00083 + 2 C00005 + 2 C00080 <=> C20856 + 6 C00010 + 5 C00011 + 3 C00001 + 2 C00006
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C00024  C00010_C00083
Enzyme
Pathway
rn01059  Biosynthesis of enediyne antibiotics
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00830  Neocarzinostatin naphthoate moiety biosynthesis, malonyl-CoA => 2-hydroxy-5-methyl-1-naphthoate => 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA
Orthology
K20422  neocarzinostatin naphthoate synthase [EC:2.3.1.237]
Other DBs
RHEA: 42843

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