KEGG   REACTION: R12049
Entry
R12049                      Reaction                               
Definition
Anthraniloyl-CoA + 2 Malonyl-CoA <=> 2-Methylquinolin-4-ol + 3 CO2 + 3 CoA
Equation
C02247 + 2 C00083 <=> C21873 + 3 C00011 + 3 C00010
Enzyme
2.3.1.-
Pathway
rn00998  Biosynthesis of various antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00848  Aurachin biosynthesis, anthranilate => aurachin A
Orthology
K02078  acyl carrier protein
K14245  PKS ketosynthase (KS/KS alpha) [EC:2.3.1.-]
K14246  PKS chain-length factor (CLF/KS beta) [EC:2.3.1.-]
K22798  anthranilate-CoA-ACP transferase [EC:6.2.1.-]
Reference
1  [PMID:17335090]
  Authors
Sandmann A, Dickschat J, Jenke-Kodama H, Kunze B, Dittmann E, Muller R
  Title
A Type II polyketide synthase from the gram-negative Bacterium Stigmatella aurantiaca is involved in Aurachin alkaloid biosynthesis.
  Journal
Angew Chem Int Ed Engl 46:2712-6 (2007)
DOI:10.1002/anie.200603513

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