KEGG   REACTION: R12404
Entry
R12404                      Reaction                               
Name
4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol:NADP+ 3-oxidoreductase (decarboxylating)
Definition
4alpha-Carboxy-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ <=> Zymosterone + NADPH + H+ + CO2
Equation
Reaction class
RC03536  C22112_C22136
Enzyme
Pathway
rn00100  Steroid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00101  Cholesterol biosynthesis, FPP => cholesterol
M00102  Ergocalciferol biosynthesis, FPP => ergosterol/ergocalciferol
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.170
     R12404  4alpha-Carboxy-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ <=> Zymosterone + NADPH + H+ + CO2
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.1.1.170
   R12406  3beta-Hydroxysteroid-4alpha-carboxylate <=> 3-Oxosteroid
    R12404  4alpha-Carboxy-5alpha-cholesta-8,24-dien-3beta-ol <=> Zymosterone
Orthology
K07748  sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating) [EC:1.1.1.170]

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