KEGG   Rattus norvegicus (rat): 114207
Entry
114207            CDS       T01003                                 

Gene name
Ryr1
Definition
(RefSeq) ryanodine receptor 1 isoform X1
  KO
K04961  ryanodine receptor 1
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04020  Calcium signaling pathway
rno04371  Apelin signaling pathway
rno04713  Circadian entrainment
rno04730  Long-term depression
rno04921  Oxytocin signaling pathway
rno05017  Spinocerebellar ataxia
rno05020  Prion disease
rno05022  Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    114207 (Ryr1)
   04020 Calcium signaling pathway
    114207 (Ryr1)
 09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    114207 (Ryr1)
  09156 Nervous system
   04730 Long-term depression
    114207 (Ryr1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    114207 (Ryr1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05017 Spinocerebellar ataxia
    114207 (Ryr1)
   05020 Prion disease
    114207 (Ryr1)
   05022 Pathways of neurodegeneration - multiple diseases
    114207 (Ryr1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:rno01009]
    114207 (Ryr1)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:rno04147]
    114207 (Ryr1)
   04040 Ion channels [BR:rno04040]
    114207 (Ryr1)
Protein phosphatases and associated proteins [BR:rno01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     114207 (Ryr1)
Exosome [BR:rno04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   114207 (Ryr1)
Ion channels [BR:rno04040]
 Voltage-gated cation channels
  Ryanodine receptor
   114207 (Ryr1)
SSDB
Motif
Pfam: RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 Serglycin DNA_pol_phi
Other DBs
NCBI-GeneID: 114207
NCBI-ProteinID: XP_038956779
RGD: 1586637
Ensembl: ENSRNOG00000020557
Position
1
AA seq 5035 aa
MGDGGGEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVP
PDLAICCFILEQSLSVRALQEMLANTVEAGVESSQGGGHRTLLYGHAILLRHAHSRMYLS
CLTTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDLILVSVSSERY
LHLSTASGELQVDASFMQTLWNMNPICSCCEEGFVTGGHVLRLFHGHMDECLTISPSDSD
DQRRLVYYEGGPVCTHARSLWRLEPLRISWSGSHLRWGQPLRIRHVTTGRYLALTEDQGL
VVVDASKAHTKATSFCFRISKEKLDVAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTY
AAPDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIYSTAGLYNQFIKGLD
SFSGKPRGSGPPAGSALPIEGVILSLQDLIGYFEPPSEELQHEEKQTKLRSLRNRQSLFQ
EEGMLSLVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNRTNCAL
FSTNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKV
LDVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAEGSTQY
GKWYFEVMVDEVAPFLTAQATHLRVGWALSEGYSPYPGGGEGWGGNGVGDDLYSYGFDGL
HLWTGHVARPVTSPGQHLLGPEDVVSCCLDLSVPSISFRINGCPVQGVFESFNLDGLFFP
VVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLQPIKEYRREGPRGPHL
VGPSRCLSHLDFVPCPVDTIQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDD
NKRLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTY
MMNNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVAQGWSYSAVQDIPARRNP
RLVPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVDSQSRGDRARIFRAEK
SYAVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADDLAYVFNGHRGQRWHLGSEPF
GRPWQSGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLPVCSLGPGQV
GHLNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKSLPQFEPVPLEHPHYEVAR
MDGTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPLASPGLQPPA
EDEARAAEPDTDYENLRRSAGGWGEAEAGKDGTAKEGTPGGAAQPGVEAQPARAENEKDA
TTEKNKKRGFLFKAKKVAMMTQPPSTPALPRLPRDVVPADNRDDPEIILNTTTYYYSVRV
FAGQEPSCVWVGWVTPDYHQHDMSFDLSKVRAVTVTMGDEQGNVHSSLKCSNCYMVWGGD
FVSPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQ
NVVQFELGKQKNIMPLSAAMFLSERKNPAPQCPPRLEVQMLMPVSWSRMPNHFLHVDTRR
AGERLGWAVQCQEPLMMMALHIPEENRCMDILELSERLDLQRFHSHTLSLYRSVCALGNN
RVAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLT
EETRAITLFPPGRSAEDGPRRHGLPGVGVTTSLRPPHHFSPPCFVVALPAAGAAEAPARL
SPAIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGVFSDED
VKQILKMIEPEVFTEEEEVEEEEEEEEEDEEEKEEDEEEEAHEKEDEEKEEAEEAAEEEK
EELEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQSNQRGRYGL
LMKAFTMSAAETARRTREFRSPPQEQINMLLQFKNGADEEDCPLPEEIREDLVNFHQDLL
AHCGIQLEGEEEEPEEESTLGSRLMSLLEKVRLVKKKEEKPEEEPAAEEHKPQSLQELVS
HTVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISLSSVEDTMSLLECL
GQIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGE
SKEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVAAAS
VIDNNELALALQEQDLEKVVSYLAGCGLQSCPMLLAKGYPDIGWNPCGGERYLDFLRFAV
FVNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLAAIEEAIRISEDPARDGPGVRR
DRRREHFGEEPPEENRVHLGHAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRS
LVPLDDLVGIISLPLQIPTLGKDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDFLL
HVLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIMV
DSMLHTVYRLSRGRSLTKAQRDVIEDCLMALCRYIRPSMLQHLLRRLVFDVPILNEFAKM
PLKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYDQELYRIA
MPCLCAIAGALPPDYVDASYSSKTEKKATVDAEGNFDPRPVETLNVIIPEKLDSFINKFA
EYAHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIAW
EWTVEKAREGEEEKTEKKKTRKISQTAQTYDPREGYNPQPPDLSVVTLSRELQAMAEQLA
ENYHNTWGRKKKQELEAKGGGSHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTR
GLKDMELDTSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFA
KILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFGT
DAPAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQAR
TQVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTTR
NPYVEKLRPALGECLARLAAAMPVAFLEPELNEYNACSVYTTKSPRERAILGLPNSVEEM
CPDIPVLERLMAEIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAPPPALPAG
APPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRARPELLRSHFI
PTIGRLRKRAGKVVAEEEQLRLEAKAEAEEGELLVRDEFSVLCRDLYALYPLLIRYVDNN
RAHWLTEPNPNSEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTADNKSKMA
KAGDVQSGGSDQERTKKKRRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQDLIVLAKAR
YALKDTDEEVREFLQNNLNLQGKVEGSPSLRWQMALYRGVPGREEDADDPEKIVRRVQEV
SAVLYHLDQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYKA
SWILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDED
YLYMAYADIMAKSCHLEEGGENVEEGGEEEEVEVSFEEKEMEKQRLLYQQSRLHNRGAAE
MVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKDKKEVGFFQSIQALMQ
TCSVLDLNAFERQNKAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNN
DFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSV
AKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELL
DLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAF
QDYVTDPRGLISKKDFQKAMDSQKQFTGPEIQFLLSCSEADENEMINCEEFANRFQEPAR
DIGFNVAVLLTNLSEHVPHDPRLRNFLELAESILDYFRPYLGRIEIMGASRRIERIYFEI
SETNRAQWEMPQVKESKRQFIFDVVNEGGESEKMELFVSFCEDTIFEMQIAAQISEPEGE
PEEDDDEGAEEAEEGAAGPDGSGSAAAAGVWTWLATAAGRTLRGLSYRSLRRRVRRLRRL
TAREAATAVAVLLWAMVARAGGAGAGAAAGVLRLLWGSLFGGGLVDSAKKVTVTELLAGM
PDPTGDEVHGQQPSGAGSDAEGEGQGEGEGDAAEGVGDEEVAADQAGTGGADRTVAVADG
SPFRPEGAGGLGDMGDTTPVEPPTPEGSPILKRKLGVDGEEEEPQPEPEPEPEPEPEKAD
TENGEKEVPEPPPEPPKKAPPPPPPKKEEAGGAGLEEFWGELEVQRVKFLNYLSRNFYTL
RFLALFLAFAINFILLFYKVSDSPPGEDDIEGSGAGDMSGAGSGDGSGWGSRASEEVEGD
EDENMVYYFLEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLE
FDGLYITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIFGRERIAELLG
MDLASLEITAHNERKPDPPPGLLTWIMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLG
HYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKF
YNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFF
FVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEE
HNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG
NT seq 15108 nt   +upstreamnt  +downstreamnt
atgggtgatggaggaggtgaaggcgaggacgaggtccagtttttgcggacggacgacgaa
gtggtcctgcagtgcagcgccaccgtgctcaaggagcagctcaagttgtgtctggccgct
gagggtttcggtaatcgcctctgcttcctcgaacccaccagcaacgcgcagaatgtaccc
cctgatctggccatctgctgctttatcctggagcagtctctgtcagttcgagccctgcag
gagatgctggccaatactgtggaggccggtgtagagtcatcccagggcgggggacacagg
acactcttgtatggccatgccatcctgctccggcacgcacacagccgtatgtacctgagt
tgcctcaccacctcccgatccatgactgacaagttggcctttgatgtgggattacaggaa
gacgccacaggggaggcctgttggtggacgatgcacccagcctcgaagcagaggtctgaa
ggagagaaggttcgagttggggatgacctcatccttgtgagtgtctcctctgagcgatac
ctgcacctgtcaaccgcaagtggggaactccaggtggatgcctccttcatgcagactctg
tggaatatgaaccctatctgctcctgctgtgaagaaggctttgtgactggaggacatgtc
ctccgcctctttcatggacatatggatgaatgtctgaccatttccccttctgacagtgat
gaccaacgcagacttgtctactacgagggagggcctgtgtgcacccatgcccgctccctg
tggaggctggagccactgagaatcagctggagtggaagccatctccgctggggccagcca
ctaagaatcaggcatgtgaccacagggaggtaccttgcgctcactgaggaccaaggcctt
gtggtggttgatgccagcaaggcccacaccaaggccacttccttttgcttccgcatctcc
aaggagaagctggatgtggcccccaagagagatgtggagggcatggggccccctgagatc
aagtatggagagtcactctgctttgtgcagcatgtggcctcaggtctgtggctcacctat
gcggccccagaccccaaggccctgaggcttggggtactcaagaagaaggccatgctgcac
caggaaggccacatggatgatgcgctatcactgacgcgatgccagcaggaggagtcccag
gctgcccggatgatatacagcactgcgggcctgtacaaccagttcataaagggtctcgat
agcttcagcgggaagccacggggttcggggccaccggctgggtcagcactgcccatcgag
ggcgtcatcctgagcctacaagacctcatcggctatttcgagccgccttcggaggagctg
cagcacgaggagaagcagaccaagctccgcagcctgcgcaaccgacaaagcctcttccag
gaggaggggatgctctccctggtcctgaattgcattgatcgcctcaatgtctacaccacc
gcagcccattttgctgaatttgcaggggaggaggcagctgaatcctggaaagagattgtg
aacctgctctatgaacttctagcttctctgatccgtggcaatcgcaccaactgtgccctc
ttttccacaaacttggattggctggtcagcaaactggatcgtctggaggcctcatctggc
atcctggaggtgttgtactgtgttctgattgagagtcctgaggtgctaaacatcatccag
gagaaccacatcaagtctatcatctccctcttagacaagcatgggaggaatcacaaggtc
ctggatgtgctatgctcactctgtgtgtgcaatggtgtagctgtgcgctccaaccaggat
ctcattactgagaacttgctcccgggccgtgaacttctgctgcagacaaaccttatcaac
tacgtcaccagcatccgtcccaacatctttgtgggccgagcagagggctccacgcagtat
ggcaagtggtacttcgaggtgatggtggacgaggtggctccgtttctgacagctcaggcc
acccacctgcgggtgggctgggccctcagcgagggctacagtccctaccctggaggtggc
gagggctggggcggcaacggggtcggcgatgacctctattcttacggctttgatgggctg
cacctctggacagggcatgtggcacgcccagtgacttctcccggacaacacctcttgggc
ccggaggatgtggtcagctgctgcctggacctcagcgtaccatccatctcctttcgtatc
aatggctgccccgtgcagggtgtctttgaatccttcaacctcgatgggctctttttcccc
gtcgtgagcttctccgctggtatcaaagtgcgcttcctccttggcgggcgccacggtgaa
tttaagttcctgcccccacctggctatgccccatgccatgaagctgtgcttcctcgggag
cggctccatctccaaccaatcaaagagtatcgcagggaagggcctcgggggccccacctg
gtgggccccagtcgctgcctctcacatctggactttgtgccctgccctgtggacaccatc
cagatcgtcttgcccccccacctggagcgaattcgggagaagctggcagagaacattcat
gaactctgggcactgactcgcattgagcagggatggacctatggtccggttcgggatgac
aacaagaggctgcacccatgtcttgtggattttcacagcttgccagagcctgagcggaat
tacaacttgcagatgtcaggggagacactcaagactctgctggccctgggctgccatgtc
ggcatggcagatgagaaggcagaggacaacctgaagaagacgaagctccctaagacgtat
atgatgaacaacggatataagccggctcctctggacctgagccacgtgaggctgacgcct
gcgcagacgactctggtggaccggctggcagagaacgggcacaatgtatgggcgagagac
cgggtggcacagggctggagctatagcgctgtgcaggacatccctgcacgcagaaaccct
cgcctcgtgccctaccgcctgcttgacgaggccaccaagcgcagcaaccgggacagcctc
tgccaggctgtgcgcacactcttgggctatggctacaacatcgagccacctgaccaggag
cccagtcaggtggacagccagtctcgaggcgaccgggcccgcatcttccgggcggagaag
tcctatgcagtccagagcggccgctggtacttcgagtttgaagcagtcaccacaggagag
atgcgagtggggtgggcaagacctgagctgagacctgacgtggagctgggggctgatgat
ctggcctatgtcttcaatgggcaccgaggccagcgctggcacttgggcagtgagccattc
ggacgtccctggcagtcgggtgatgtcgttggctgcatgattgatctcacggagaacacc
atcatcttcaccctcaatggcgaggtcctcatgtctgactcgggctcggaaacagccttc
cgagaaattgagattggggacggcttcctgccagtctgcagcttgggacctggtcaggtg
ggccacctgaacctgggccaggatgtgagctccctgaggttttttgccatctgtggcctc
caggaaggctttgagccgttcgccatcaacatgcaacgcccagtgaccacctggtttagc
aagagccttcctcagtttgagcctgtgcccctcgaacacccccactatgaggtggcccgc
atggatggcactgtggatacacctccctgcctgcgcttgactcaccgtacctggggctca
cagaacagtctggtggagatgctgtttctccggctaagccttccggtccagttccaccag
cacttccgctgcaccgcaggggccacacccctcgcatcccctggcctgcagccgcctgcg
gaagatgaggcccgggcagcagaaccggatacggactatgagaacctgcgccgctctgct
ggaggctggggagaggctgaggcgggcaaggatggaactgccaaggaggggacacccgga
ggcgctgcccagccaggggtagaggctcagcctgcaagggcggagaatgagaaagacgcc
accacggagaagaacaagaagagagggttcttattcaaggccaagaaggttgccatgatg
acccaaccaccttccaccccggctcttccccgactccctcgagatgtagtacctgctgac
aaccgtgacgaccctgagatcatcctcaacaccaccacgtactattactctgtgagggtc
ttcgcgggtcaggagcccagctgcgtgtgggtgggctgggtcactcctgactaccatcaa
catgacatgagcttcgacctcagcaaggtccgggcggtgacagtgaccatgggggatgaa
caaggcaatgtccacagcagcctcaagtgtagcaactgttacatggtgtggggcggggat
ttcgtgagtccgggacagcaaggccgcatcagccacacggacctagtcattggatgcctg
gtggatctggccaccggcttgatgacctttacagccaatggcaaagaaagcaacaccttc
ttccaggtggagcccaacacaaagctgtttcctgccgtctttgtcctgcccacccaccag
aacgtggtccagtttgagttggggaagcaaaagaacatcatgccgctgtcagccgccatg
ttcctcagcgagcgcaagaatccagccccgcagtgcccaccaaggctggaggtgcagatg
ctgatgcctgtctcctggagccgaatgcccaaccacttcctacatgtggacacgcggcgt
gctggcgagcggctgggctgggctgtgcagtgccaggagccgctgatgatgatggcgcta
cacatcccggaggagaacaggtgcatggacatcctggagctgtctgagcggctggatcta
cagcgcttccactcgcacacgctctcgctctaccgctccgtgtgcgccctgggcaacaac
cgcgtggctcatgccctgtgcagccacgtggaccaggcacagctgctgcatgctctggaa
gacgcgcacttgccgggtcctctgcgtgcaggctactatgacctcctcatcagcatccac
ctcgaaagcgcctgccgcagccgtcgctccatgctctctgagtacattgtgccgctcaca
gaggagacccgagccatcacgcttttcccacccggtcgtagcgcggaagatggcccccgc
cgccatggcctgcctggcgttggggtcacaacctccctgagacctccacaccacttctca
cccccgtgttttgtggtcgccctgccagctgctggggccgcagaagctccggctcgcctc
agccctgccatccctctggaggctctgcgagacaaggcgctgagaatgttgggggaagcc
gtgcgtgacggaggacagcatgctcgcgacccagtagggggctctgtggagttccagttt
gtgccggtgctcaagcttgtgtctaccctcctggtgatgggtgtctttagcgacgaggat
gtgaagcagatcctgaagatgatagagcctgaagtcttcaccgaggaagaagaggtggag
gaggaggaagaggaggaagaggaagatgaggaggagaaagaggaggacgaggaggaagag
gcacacgagaaggaagatgaggaaaaagaagaggcagaggaggccgcagaggaggagaag
gaagagctggaggaggggctgctgcagatgaagttgcctgagtctgtgaaattacagatg
tgccacctcctggagtatttctgtgaccaagagctgcagcaccgggtggagtccttggca
gcctttgcggagcgatatgtggacaagctgcagagcaatcagcggggtcgctacggcctc
ctcatgaaagccttcaccatgagcgcggccgagactgcaaggcgcacgcgggagttccgc
tctccgccccaagagcagatcaacatgctattgcaattcaaaaatggtgccgatgaggaa
gattgtcctctccctgaagagatccgagaggatttagttaactttcaccaagacctgttg
gcacattgtggaatccagctggagggagaggaggaggagccagaggaagagagcactctg
ggcagccgcctcatgagcctgttggagaaggtgcggctggtgaagaagaaagaggagaag
cctgaggaggagccggcagctgaggagcacaagcctcagtccttgcaggagctggtgtcg
cacacagtggtgcgctgggcccaggaggacttcgttcagagcccagagctggtccgagcc
atgttcagcctcctgcaccggcagtacgatggactcggcgagctgctgcgtgccctgcct
cgggcctacacgatctctctgtcctcagtggaggacaccatgagcctgctggagtgtctg
ggccagatacgctcactgcttattgtgcagatgggtccccaggaggagaacctcatgatc
cagagcattgggaacatcatgaataacaaagtcttctaccagcacccaaacctgatgaga
gcgctcggtatgcacgaaactgtcatggaggtcatggtgaatgtcctcgggggcggcgag
tcaaaggagatccgcttccccaagatggtgacaagctgctgccgtttcctctgctacttc
tgccggatcagccggcagaaccagcgctctatgtttgaccacctgagctacctgctggag
aacagtggcattggcctggggatgcagggctccacgcccctggatgtagcagctgcttct
gtcattgacaacaatgagctggccttggcattacaggagcaagacctggaaaaggttgtg
tcatacttggcagggtgtggcttacaaagctgccccatgctcctggccaaaggctatcct
gacatcggatggaatccctgtgggggcgagcgctacctggacttcctgcgctttgccgtc
tttgtcaacggtgagagcgtggaagagaacgctaatgtggtagtgcggctgttgatccga
aagcccgagtgctttggacctgccctgcggggtgagggtggctcagggctgctggctgcc
atcgaagaagccatccgcatctccgaggaccctgcacgggatgggccgggtgtccgcagg
gaccggcgacgtgagcactttggtgaggaaccccctgaagagaaccgggtacatctagga
cacgccatcatgtccttctatgctgctttgattgacctgctgggacgctgtgctcctgag
atgcatctgattcaagccggtaagggtgaggccctgaggatccgtgctatccttcggtcc
ctcgtgcctttggatgaccttgtgggcatcatcagcctcccactgcagatccccaccctg
ggcaaagatggcgcactggttcagccaaagatgtctgcatccttcgtgcctgaccacaag
gcatccatggtgcttttcctggaccgagtgtatggcattgagaaccaggacttcttgctg
catgtgctggatgtggggttccttcctgacatgagggcagctgcctcactggacacggct
actttcagcaccacggagatggcgctggcacttaaccgctacttgtgcctggctgtgctg
ccgctcatcaccaagtgcgcgccactctttgcgggcaccgagcaccgcgccatcatggtg
gactccatgctgcacacagtataccgactgtcgcggggccgctcgctcaccaaagcacag
cgcgacgtcattgaggactgcctcatggcgctgtgcaggtatatccgcccgtccatgctg
cagcacctgcttcgacgcctggtgttcgatgtgcccatcctcaatgagtttgccaagatg
cctctcaagctccttaccaaccactacgagcgttgctggaagtactactgccttcccaca
ggctgggccaacttcggggtcacctctgaggaagagctgcacctcacacgcaagctcttc
tggggcatctttgattctctggcgcataagaaatacgaccaggagctttaccgaatagcc
atgccgtgtctctgtgccattgcgggggcactgccccccgactatgtggatgcctcatac
tcctccaagacggagaaaaaagccacagtggatgcggaaggcaactttgatccccggcct
gtggagaccctcaatgtcatcatcccagagaagctggactccttcattaacaagttcgca
gaatatgcccatgagaagtgggcctttgacaagattcagaacaactggtcctatggcgag
aacattgatgaagaactgaagacccaccccatgctgagaccctacaagaccttctcagag
aaggacaaagagatttaccgctggcccatcaaggagtccttgaaggccatgattgcctgg
gaatggacggtcgagaaggccagggaaggtgaggaggaaaagaccgaaaagaaaaaaaca
agaaagatatcccaaacggcccagacatatgaccctcgagaaggctacaatccccagcca
ccagacctcagtgtggttacgttgtcccgggagctgcaggccatggctgaacaattggca
gagaattatcacaacacttgggggcgaaagaagaagcaagagctggaggctaaagggggt
gggtcccatcctctgctggtcccctacgacacgcttacggccaaggagaaggcgcgggac
cgggagaaggcccaggagttgctgaagtttctgcagatgaatggctatgctgtcaccagg
ggtcttaaggacatggaactggacacatcttccattgagaaacgatttgcctttggcttc
ctgcagcagctgctgcgctggatggacatctcccaggagtttatcgcccacttggaggct
gtggtcagcagtggacgggtagagaaatccccacatgaacaggagattaaattctttgct
aagattctgctgcctttaatcaaccaatacttcaccaaccactgtctctacttcctatcc
acaccggccaaagtgctgggcagtggtggccatgcctccaacaaggagaaggaaatgatc
accagcctcttctgtaaacttgctgctcttgtccgccaccgagtctccctctttgggacg
gatgccccagctgtggtcaactgtcttcatatattggcacgttccctggatgccaggacg
gtgatgaaatcgggccctgagatcgtaaaggcgggtctgcgctccttcttcgagagtgcc
tcggaggacattgagaagatggtggagaacctgcggctaggcaaggtgtcccaggcacgc
acgcaggtgaagggtgtgggccagaacctcacctacaccacagtggctctgctgcctgtc
ctcaccaccctcttccagcacatcgcccagcaccagttcggagatgatgtcatcctggat
gacgttcaagtttcttgctaccgaacactatgcagtatctactctctgggaaccaccagg
aacccctacgtggaaaagctgcggccagccctgggggaatgcctggcccgcctggccgca
gccatgccagtggcattcctggagcctgagctgaatgaatacaacgcctgctctgtctac
accaccaagtctcctcgagagcgggccatcctggggcttcccaacagtgtggaagagatg
tgtccagacatcccggtgctagaacggcttatggcagagatcggggggctggccgagtcc
ggggcgcgctacaccgagatgccgcacgtcatcgagatcacactgcctatgctgtgcagc
tacctgccccgctggtgggagcgagggcctgaggcgcccccaccagccctgcctgcagga
gccccaccaccctgtacagccgtcacctccgatcacctcaattccctactggggaacatc
cttcgaatcatcgtcaataacctgggcatcgatgaggcctcgtggatgaagcggttggct
gtgtttgcccagcccatcgtgagccgtgccaggccagagctcctacgctcccacttcatc
cctactatcgggcgactgcgtaagcgggcagggaaggtggtggctgaggaggagcagctg
cgcctggaggccaaggcagaggctgaggagggtgagctcctggtccgggatgagttctcc
gtgctctgccgtgacctgtatgccctctacccactgctcatccgctacgtagacaacaac
agggcacactggctgacagagcccaatcccaactcggaggagctgttcaggatggtggga
gaaatcttcatctactggtccaagtcccacaactttaagcgtgaagaacagaacttcgtg
gtccagaacgagattaacaacatgtcctttttgaccgctgacaataagagcaaaatggcc
aaggcaggagacgtacagtcaggtggctcggaccaggaacgcaccaagaagaaacgccgg
ggggaccgctactcggtgcagacatccttgatcgtggccacgctcaagaagatgttaccg
ataggactaaacatgtgtgctcccactgaccaggacctcattgtgctggccaaggcccgc
tatgcgctgaaagatacagatgaggaggttcgtgaattccttcaaaacaaccttaacctt
cagggaaaggtggaaggctcaccatctcttcgctggcaaatggcactgtaccgcggcgtt
ccaggccgcgaggaagatgccgatgatcctgagaaaatcgtgcgcagagtccaggaagtg
tccgctgtgctctatcacctagaccagacggagcatccttacaagtccaagaaggcggtg
tggcataaacttttgtccaagcaacgccggagggcagtggtggcctgtttccgcatgacg
cccctatacaacttacccacgcaccgagcatgcaacatgttcttggagagctacaaagcc
tcctggatcctgactgaggaccacagtttcgaggaccgcatgatagatgacctatcaaaa
gctggggagcaggaggaagaggaggaagaagtggaggagaagaagccagaccccctacac
cagttggtcctacacttcagccggacagctctgactgaaaagagcaaactggatgaggac
tacctgtacatggcttacgctgacatcatggcaaagagctgccacctggaggagggcggg
gaaaatgtcgaagaaggaggtgaagaagaggaagtggaggtgtcctttgaggagaaggag
atggagaagcagaggctcctgtaccagcagtcgaggctgcacaaccggggtgccgccgag
atggtactgcagatgatcagtgcttgcaaaggagagacgggtgccatggtgtcttccacc
ctgaagctgggcatctccatcctcaacggagggaacgctgaagtgcagcagaaaatgctg
gattacctgaaggacaagaaggaagtgggcttcttccagagtatccaggcgctaatgcaa
acgtgcagcgtcctggacctcaatgcctttgagaggcagaacaaggcggaggggctgggc
atggtgaatgaagacgggactgtcatcaatcgccagaacggagagaaagtcatggcagat
gatgagttcacacaggacctgttccgcttcctgcagctgctctgcgagggccataacaac
gatttccaaaactacctacggacacagactgggaacaccaccaccatcaatatcatcatc
tgcacagtggactacctcctgcggctgcaggaatccatcagtgacttctactggtactac
tcgggcaaggatgtcattgaggagcagggaaagagaaacttctccaaagccatgtcggta
gcgaaacaagtgttcaacagcctcactgagtacatccagggaccctgcaccggaaaccag
cagagtctagcgcacagtcgcctctgggatgctgtggtgggcttcctgcacgtgttcgca
cacatgatgatgaagctggctcaggactctagccagatagagctgctgaaggagctgctg
gacctgcaaaaggacatggtggtgatgttgctgtcccttctggaaggaaatgtggtgaac
ggcatgatcgcacggcagatggtggacatgctcgtggagtcttcgtccaatgtggagatg
atcctcaagttcttcgacatgtttctgaagctcaaggacatcgtgggctctgaggccttc
caggactacgtcaccgatccccgtggcctcatctccaagaaggacttccagaaggccatg
gacagccagaagcagttcactggcccagagatccagttcctgctttcgtgttcagaagca
gatgagaatgagatgatcaattgtgaagagtttgcgaaccgcttccaggaaccagcgcgg
gacattggcttcaacgtggcagtgctgctcaccaacctgtcagagcatgtgccccacgac
ccgcgcctgcgcaacttcctggagttggctgagagcatcctggattacttccggccttac
ctgggccgcatcgaaatcatgggcgcatcgcgtcgcatagaacggatctacttcgaaatc
tcagaaaccaaccgtgcccagtgggagatgccccaggtgaaggagtctaagcgccagttc
atcttcgacgtggtgaacgagggcggcgagtccgagaagatggagctgttcgtgagcttc
tgcgaggacacgatcttcgagatgcagatcgctgctcagatctctgagccggagggcgag
ccggaggaggacgatgatgagggcgctgaggaggctgaggagggcgcagcgggtcccgac
gggtcgggctctgcagcggccgcaggggtgtggacgtggctggcgacggcggcgggccga
acgctgcggggtctgagctaccggagcctgcggcgacgtgtgcggaggctgcggcggctg
acggcgcgggaggctgccacggccgtggccgtgttgctctgggcgatggtggcccgcgcg
gggggcgcgggcgcgggcgcggcggccggggtactgcggctgctctggggctcgctgttc
ggtggtgggctggtagacagcgccaagaaggtgactgtgaccgagctcttggcaggcatg
ccggaccccactggcgacgaggtgcacggtcagcagcctagcggcgctggcagcgatgcg
gagggcgagggccagggtgagggcgaaggggatgcggctgaaggcgtcggagatgaagag
gtggcagcggaccaggctggcacgggaggtgctgaccggacggtggccgtagccgatggg
agccccttcaggccagaaggagccggtggtctcggggatatgggtgacacgacaccagtg
gagcccccaacgccagagggctcgcccatcctcaagaggaagctgggggtggacggagaa
gaagaggagccgcagccagagccagagccggagccagagcctgaaccggaaaaagctgat
accgagaatggagagaaggaagtccctgagccgcctccggagccccccaagaaggcacct
cctccaccccctccaaagaaggaggaagctggaggtgcaggcctggaagaattctggggt
gaactggaagtgcagagggtgaaattcttgaactacttgtcgaggaacttctacacgctg
cgattcctggccctcttcctggcatttgccatcaactttatcttattgttttataaggtt
tcagactctccgccaggggaggatgacatagaaggttccggagctggggacatgtcaggg
gcagggtctggtgatggctctggctggggctccagagccagcgaggaggtagagggtgat
gaagatgagaacatggtgtactacttcctggaggagagcaccggctacatggaacctgcc
ctgaggtgcttgagcctgctgcataccctggtggcctttctctgcatcattggctacaac
tgtctcaaggtgccccttgtgatctttaagagggagaaggagctggcccggaagctggag
ttcgatggtctctacattacagagcagccagaggatgatgatgtgaagggacagtgggat
cgcctggtgctcaacacaccgtctttccccagcaactactgggacaagtttgtcaagcgg
aaggttctggacaaacacggggacatcttcgggcgggagcggattgcagagctgctgggc
atggatctggcctctctggagatcacagcccacaatgagcgcaaacctgaccctccacca
ggcctgctgacatggatcatgtccatcgatgtcaaataccagatctggaagtttggagtc
atcttcacagacaactctttcctgtatctgggctggtacatggtgatgtccctcctgggc
cactacaataacttcttcttcgctgcccacctcttggatatcgccatgggagtcaagacg
ctgcgcaccatcctttcatccgtcactcacaacggaaagcagctggtgatgacagtaggg
ctcctggctgtagtggtctacttgtatacggtggtggccttcaacttcttccgcaagttc
tacaacaagagcgaagatgaggacgagcctgacatgaagtgtgacgacatgatgacgtgc
tacctgttccacatgtatgtgggcgtccgggccggtggtggcatcggggacgagatcgag
gacccggctggtgatgaatatgaactgtaccgggtcgtcttcgacatcacctttttcttc
ttcgtcattgtcatcctactggctatcatccagggtctgattattgatgctttcggggag
ctccgagaccaacaagagcaagtgaaggaagacatggagaccaagtgcttcatctgtggg
ataggcagtgactacttcgacacgaccccacatgggtttgagacccacactctggaagag
cacaacctagccaattacatgtttttcctgatgtatttgataaataaggatgagacagag
cacaccggtcaggagtcatatgtctggaagatgtaccaggagaggtgctgggacttcttc
cctgctggagactgtttccgaaagcagtatgaggaccagcttggctga

KEGG   Rattus norvegicus (rat): 170546
Entry
170546            CDS       T01003                                 

Gene name
Ryr3
Definition
(RefSeq) LOW QUALITY PROTEIN: ryanodine receptor 3
  KO
K04963  ryanodine receptor 3
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04020  Calcium signaling pathway
rno04371  Apelin signaling pathway
rno04713  Circadian entrainment
rno04921  Oxytocin signaling pathway
rno04970  Salivary secretion
rno05010  Alzheimer disease
rno05012  Parkinson disease
rno05020  Prion disease
rno05022  Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    170546 (Ryr3)
   04020 Calcium signaling pathway
    170546 (Ryr3)
 09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    170546 (Ryr3)
  09154 Digestive system
   04970 Salivary secretion
    170546 (Ryr3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    170546 (Ryr3)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    170546 (Ryr3)
   05012 Parkinson disease
    170546 (Ryr3)
   05020 Prion disease
    170546 (Ryr3)
   05022 Pathways of neurodegeneration - multiple diseases
    170546 (Ryr3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:rno04040]
    170546 (Ryr3)
Ion channels [BR:rno04040]
 Voltage-gated cation channels
  Ryanodine receptor
   170546 (Ryr3)
SSDB
Motif
Pfam: RYDR_ITPR RyR RR_TM4-6 Ins145_P3_rec MIR SPRY RIH_assoc Ion_trans EF-hand_1 EF-hand_6 EF-hand_7 EF-hand_5 EF-hand_8
Other DBs
NCBI-GeneID: 170546
NCBI-ProteinID: XP_038962734
RGD: 68952
Ensembl: ENSRNOG00000006645
Position
3
AA seq 4868 aa
MAESGEGGEDEIQFLRTEDEVVLQCIANIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYIP
PDLCVCNFVLEQSLSVRALQEMLANTVENGGEGAAQGGSHRTLLYGHAILLRHSFSGMYL
TCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER
YLHLSISNGSIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD
QNDSQHRRVFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQALRLRHLTTGHYLALTED
QGLLLQDRGKADTKSTAFSFRASKEIKEKLDSSHKRDMEGMGVPEIKYGDSVCFVQHVAS
GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQQEESQAARIIRNTTALFSQ
FVSGNNRTAAPVALPIEEVLQTLQDLIAYFQPPEEDMQHEDKQNKLRSLKNRQNLFKEEG
MLALVLNCIDRLNIYNSVAHFAGIIREENGMAWKEILNLLYKLLAALIRGNRNNCAQFSN
NLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEGHIKSIISLLDKHGRNHKVLDV
LCSLCLCNGVAVRXNQNLICDNLLPEGNLLLQTRLINDVTSIRPNIFLGVAEGSPRYKKW
LLSLIIDQVEPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW
SGRIPRAVASINQHLLKSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVMS
FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDADGVRDLLGT
TQFLSQASFIPCPIDTSQVVLPLHLEKIRDRLAENIHELWGMNKIELGWTFGKVRDDNKR
QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKNYMMS
NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV
PYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPTVEKVSIDKIRFFRGVERS
YAVKSGKWYFEFEVVTGGDMRVGWARPGARPDIELGADDQAFVFEGKQGQRWHQGSGYFG
RTWLPGDVVGVHLNLDDASMVFTLYGELLITTXGSELAFADYEIENGFVPICSLGLSQIG
RMNLGTDASTFKFYTMCGLQEGFEPFAVNMNRDVAVWFSKRLPTFVNVPKDHPHIEVVRI
DGXMDSPPCLKVTHKTFGTQNSNANMIYCRLSMPVECHXSFSHSPCLDSEAFQKRKQMQE
ILSHTTTQCYYAIRIFAGQDPSCVWVXWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVH
ESVKRSNCYMVWGGDIVASSQRSSRSNVDLEIGCLLDLAMGMLSFSANGKELGTCYQVEP
NTKVFPAVFXQPTSTSLFQFELXKLKNAMPLSAAIFKSEEKNPIPQCPPRLDVQTIQPVL
WSRMPSSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMQFHY
HTLRLYSAVCALGNSRVASALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLANAK
ERKLMMKNEYIIPITSSTRNIRLYPDESKRHGLPGVGLRTCLKPGFRFSTPCFVVTNEDH
QKQSPEIPLQILKTKALSMLTEAVHCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFD
DDDVRQILLLIDPSVFGEHSGETEEGVEKEVTHVEEKAVEAGEKASKEAPVKGLLQTRLP
ESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTA
RKTREFRSPPQEQINMLLNFHLGENCPCPEEIREELYDFHEDLLVHCGVPLEEEEEEEED
TSWTGKLCALVYKIKGQPKPEKEPPTEEEEPYPTTLKELVSQTMIRWAQENQIQDAELVR
MMFNLLRRQYDSIGELLQALRKTYTISQASVNDTINLLAALGQIRSLLSVRMGREEELLM
INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQIAFPKMVASCCRFLCYF
CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLE
KVVTYLAGCGLQSCPMLLAKGYPDIGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKL
LIRRPECFGPALRGEGGNGLLAAMQGAIKISESPALDLPSQGYKTEVTQDDEEEEEIVHM
GNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPS
LNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLDT
VSLSTTEAALALNRYLCSAVLPLLTRCAPLFSGTEHCTSLIDSTLQTIYRLSKGRSLTKA
QRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLSEYCKMPLKLLTNHYEQCWKYYCLP
SGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDTR
ITATLEKQVSVDADGNFDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSHSGWKYG
ISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQREN
EKLRCVSQSNQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGGG
SHPLLVPYDTLTAKEKLRDREKAQDLFKFLQVNGILVSRGVKDMELDASSMEKRFAYKFL
RKILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHRLYFLSS
PLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRTV
MKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPIL
TSIFEHIAQHQFGVDLLLSDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAA
IPVAFLEPSLNRYNPLSVFNTKTPRERSILGMPDKVEDMCPDVPQLEGLMKEINGLAESG
ARYTEMPHVIEVILPMLCNYLSYWWERGPENLPPSIGPCCTKVTSEHLSLILGNILKIIN
NNLGIDEASWMKRIAVYAQPIISKARPDLLRSHFIPTLEKLKKKAVKIVQEEEQLKTDGK
GDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDTDSDQLFRMVAEVFIL
WCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRGDLYS
IQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSCRDTDEEVKEHLRNNLHLQEKSD
DPAVKWQLNLYKDVLRNEEPSNPEKTVERVQRISAALFHLEQVEQPLRSKKAVWHKLLSK
QRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEAYSFEEKLVQDLAKSPRVEDE
EEEETEKQPDPLHQIILHFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEEEEDKE
KTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNA
GVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRER
GEKVLQNDEFTQDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNIIISTVDYLLRLQESI
SDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVV
GFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVE
SSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISRKEFQKAMEGLKQYTQSEIDF
LLSCTEADENDMFNYVDFVERFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESV
LNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEK
MELFVNFCEDTIFEMQLASQISESDSTDRPEEEEEEDEDSYSVEIEGEEEDKSFESASAF
AMACASAKRNVTKFLKKATLKNLRKQYRNVKKMSAKELVRVLSSFFWMLVVGLFQLLFSI
LGGIFHILWNTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDVMEIDRAEVTEPGITT
ELVHFVKGEAGDTDVMSDLFGIHSKKEGGSKQGPEVGLGDLSEITGKDEPPTLESTVRKK
RKAQAAEMKAVHEAEGRTESEKADMEDREKEDKIKEEGQAEYLWADTTVKKTRRRGQKAE
KPVAFMANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEEET
EDVANLWNSFNEDDEEEAMVFFVLQESTGYMAPTLRALAIVHTVISLVCVVGYYCLKVPL
VVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKY
GDLYGAERIAELLGLDKNALDFSPVEEAKAEAASLVSWLSSIDMKYHIWKLGVVFTDNSF
LYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVY
LYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPY
EMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFD
TTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFR
KQYEDQLG
NT seq 14607 nt   +upstreamnt  +downstreamnt
atggctgaatcgggagaaggaggcgaggatgagatccagttcctgcggactgaggatgag
gttgtactccagtgcatcgcaaacattcacaaggagcagcggaagttctgcctggcagct
gagggacttgggaatcgcctgtgcttcttggaacctacctcagaagcaaagtacattcct
ccagatctctgtgtctgcaatttcgtgctggaacagtccttatctgtcagagcactgcaa
gaaatgcttgccaacaccgttgaaaatggtggagaaggggcagcacaaggcggtagccac
aggaccctgctctacgggcatgcaattctcctgcggcactccttcagtggaatgtatcta
acgtgcttgaccacgtcaagatcccagacggataaacttgcctttgatgtaggtctgcgg
gaacatgccacaggagaagcctgttggtggaccatacatcctgcttcgaaacaaaggtct
gaaggagagaaagtacgaattggtgatgaccttatccttgtcagtgtgtcctccgaaaga
tatctccatctctcaatctcaaatggtagcatccaagtggatgcctcctttatgcaaaca
ctctggaatgtacatcctacatgttcaggaagtagcatcgaagaaggatacctactcggt
ggccacgtagttcgacttttccacggtcatgatgaatgtttgacgataccatctacggat
cagaatgactctcagcacaggagggtgttctatgaagctggaggagctgggaccagagcc
aggtctctatggagagtggaaccccttcggataagctggagtggcagtaacatcaggtgg
ggccaggctctccgactccggcatctcaccacaggccactacctggccttgaccgaagac
caaggccttcttcttcaagaccgtggaaaagccgacaccaagtccacagccttctccttc
cgagcatcaaaggaaatcaaggagaaactagattccagtcacaaaagagatatggaaggc
atgggagttccagaaatcaagtatggggattctgtctgctttgttcagcatgtagccagt
ggcctctgggtcacctacaaagcacaagatgccaagacttcccgcctgggacctctgaaa
aggaaggtcatactccatcaggaaggccacatggatgatggattaacactgcagcgatgc
cagcaggaagagtcccaggctgctcgcatcatccggaacaccacagccttattcagccag
tttgtcagtggaaacaatcgcacagctgcccctgtggccttgccaatagaagaggtccta
cagaccctacaagacttgatagcctacttccaaccaccagaggaggacatgcaacatgaa
gacaaacagaataagctccgctctctaaaaaacagacagaatcttttcaaggaagagggg
atgctggcccttgtattgaactgcatcgatcgattaaacatctacaacagtgtagcacac
tttgcagggatcatcagggaagagaacggcatggcctggaaagagattctgaacctgcta
tacaaattactagctgctctcattcgtggaaacagaaacaactgtgctcaattctccaat
aaccttgattggttaattagtaagttggacagattagaatcttcctcaggtatcttggag
gtcttgcactgcatcttgattgaaagcccagaagccttaaacctaatagcagagggccac
atcaagtccatcatctccctactggataagcacgggcggaatcacaaggttcttgatgtc
ctgtgctccctctgtctctgcaatggggttgcagtaagangcaaccagaatctgatctgt
gacaacctactacccgaaggaaacctgcttctgcagacacggctaattaatgatgtcacc
agtatccgaccaaacatcttcctgggagttgctgaaggttcccccaggtacaagaagtgg
ttattgagtttaattatcgaccaagtggagcctttcctaacagcagagcccactcatctg
cgggtgggctgggcctcctcttcaggctatgccccataccctggaggtggagaaggatgg
ggaggcaacggtgttggtgatgacctgtactcctatggctttgatgggcttcatctctgg
tcaggccggatacccagagctgtggcctccatcaaccagcatctgctgaagtcagatgat
gtggtgagctgctgccttgaccttggagtacccagcatttctttccgaatcaatggacaa
cctgtgcagggaatgtttgagaatttcaacacagatggactctttttccccgtgatgagt
ttttcggctggtgtcaaagtacgcttcctgatgggtggtcggcatggggaatttaagttc
ctgcctccttctggctatgccccttgctatgaagccttacttccgaaggagaagatgaga
ttggagcctgtcaaagaatataagcgtgatgctgatggtgttagagatctgttgggtacc
actcagtttctctcccaagcctctttcatcccatgtcccatagataccagtcaggttgtt
ttgccacttcacctagagaagatcagagacagactggccgagaatatccatgagctttgg
ggaatgaataaaatagaactcggctggacttttggcaaagtgcgggatgacaacaaaaga
caacatccctgccttgtggagttttcaaagctccctgaaactgagaagaattataacctg
cagatgtcaactgaaaccttgaaaaccttgctggctctgggctgccacattgctcatgtt
aacccagctgcagaagaggatctaaagaaagtgaaactgcccaaaaactatatgatgtcc
aatggctataagccagcccctttggatttatctgatgtgaagctattaccacctcaagaa
attttagtagataagcttgcagaaaatgcacacaatgtttgggcaaaggacagaataaaa
caaggatggacctacggcattcaacaggatttgaagaataaaagaaatccccgcctggtg
ccatatgcgttactagatgagcgaaccaagaaatcaaacagggacagcctacgggaagct
gtacggacatttgttggttatggatataacattgaaccatcagaccaagaactagctgac
cctactgtcgagaaggtcagcatagacaagatccgatttttccggggggtagagcggtca
tatgcagtaaaatctggaaagtggtactttgaattcgaagtagtaacaggaggagacatg
cgcgttggctgggccaggccaggcgctcgtcctgacattgagctcggagctgacgaccaa
gccttcgtgtttgaaggcaagcagggtcagcgttggcaccaaggcagtgggtattttgga
cgaacttggctgccaggagatgtggtcggggtgcatttaaacctggacgacgcctctatg
gtcttcacactgtatggggagctgctcatcaccacataaggctctgaacttgccttcgca
gactatgagatcgagaacggttttgtgcccatttgctctctggggctgtcccagattggc
cgcatgaatcttgggacagatgccagtaccttcaagttttataccatgtgtggactccag
gagggctttgagccttttgcggtaaatatgaaccgagatgttgctgtgtggtttagcaag
cgcctcccaacatttgtgaatgtgcccaaggatcatccccacatagaggttgtgagaatt
gatggcnacatggacagtcctccatgcctcaaggtgacccacaagaccttcggcacacag
aacagcaatgccaacatgatctactgccgcctgagcatgcccgttgaatgccatncttca
ttcagccacagtccctgcctagacagtgaagccttccaaaaaaggaaacagatgcaagaa
atactctctcacacaacaacacaatgctactatgctatccgcatttttgctgggcaggac
ccatcatgtgtctgggttngatgggtgactccagactaccatttatacagtgaaaagttt
gacctgaataaaaactgcaccgtgactgtcaccctgggagatgaaaggggccgggttcat
gaaagtgtgaaacgtagcaactgctatatggtctggggtggggacattgtagccagttcc
cagagatcaagccggagcaatgtggacctggagattggctgccttctagatctggcaatg
ggcatgttgtccttctctgcgaatgggaaggaacttggcacctgctaccaggtggagcct
aacaccaaagtattcccagcagtcttcnctcagcctaccagcacctccttgtttcagttt
gaacttngaaaactgaagaatgcaatgcctctgtcagcagccatatttaagagtgaagag
aagaaccccatcccacagtgcccacctaggctggatgtccaaaccatccagcctgtgctc
tggagccgcatgcccagcagcttcctcaaagtggagaccgagcgagtgagcgagcgccac
ggctgggtggtgcagtgcctagaacccctgcaaatgatggcactccacatccctgaggag
aacaggtgtgtggacatcctcgagctctgtgagcaggaggacctgatgcagttccattac
cacacactgagactttacagcgctgtgtgcgctctgggaaatagccgagttgcttctgcc
ctgtgcagccatgtggacctctcacagctcttctatgccattgacaacaagtacctgcct
ggcctcctccgatctggtttctatgacctgcttattagcatccacctggccaatgctaag
gagaggaagctgatgatgaagaatgagtacatcatccctatcaccagcagtaccaggaat
atccgcctatacccagatgagtccaagaggcatggtttgcctggggtgggcctgaggaca
tgcctcaagccaggcttcaggttctctaccccttgctttgtggtgactaatgaggaccat
cagaaacagagccctgagattcccttgcagattctcaagacaaaggccctgagcatgctg
accgaggcggtacattgtagtggggcccacatcagagaccctgttgggggttctgtggag
ttccagtttgtgcctgtgctgaaactcattgggaccttgttagtcatgggagtttttgac
gacgatgatgttcgccagattctcctcctgatagatccctctgtgtttggggagcacagt
ggtgagacagaagagggagtggagaaagaagtgacccacgtagaggaaaaggcggtggag
gctggagaaaaggctagcaaggaggctccagtcaaaggcttgctgcagacccgattacct
gagtctgtcaagctgcagatgtgcgaactcctcagctacctctgtgactgtgaactacag
caccgagtagaggctattgtggcatttggtgacatttacgtgtccaagctgcaggcaaat
cagaagttccgctacaatgagctcatgcaggccctgaatatgtctgcagccctaactgcc
cggaagacaagagagttccgctcaccaccccaggagcagatcaacatgctcctcaacttt
cacctgggagagaactgcccctgcccagaggagatccgagaggagctgtacgacttccat
gaggaccttctggttcactgtggggtccccttggaggaagaggaggaagaggaggaggac
acttcatggacaggaaaactgtgtgctctggtgtataaaatcaaggggcaacccaagcct
gagaaggagccaccaacagaggaagaggaaccgtaccctacaacactgaaggaactagtc
tcacagacaatgatccgttgggcccaggagaaccaaatccaggatgcagagctggtgagg
atgatgttcaacctcctccggagacagtatgacagcatcggggagttgctacaggctctg
cggaagacctacaccatcagccaggcctctgtgaacgacaccatcaacctgctggctgcc
ctgggccagattcggtccctgcttagtgtcaggatggggagagaagaggagctcctcatg
atcaacgggctaggggacataatgaacaacaaggtgttttaccagcatcccaaccttatg
agagtcctcggcatgcatgagacagtgatggaagtgatggtgaatgtgttgggtacagaa
aagtcacagattgccttcccaaagatggttgctagctgctgccgcttcctttgctatttc
tgtcgaattagccggcaaaatcagaaggccatgtttgagcatctgagttacctgctggag
aacagtagtgtgggcctagcatccccatcaatgagggggtccaccccactggatgtggca
gcctcctctgtgatggacaataacgaattagcactgggcttagaagaaccggatcttgag
aaggttgtaacctacttggcaggttgtggtcttcagagctgccccatgcttctggccaaa
ggataccctgacatcggttggaaccccattgaaggagagcgttacctgtccttcctgagg
tttgccgtcttcgtgaacagtgaaagtgtggaggaaaatgccagtgttgtggtcaagttg
ctcatcagacgtcccgagtgctttggtccagctctgaggggtgaaggagggaacggactg
ctggcagctatgcagggtgccattaagatctcagagagccctgccctcgaccttccttcc
cagggttacaagacggaagtcacacaggacgatgaagaggaggaagagattgtgcacatg
ggcaatgcaattatgtcattttattcagcgcttatcgatctattaggccgatgtgctcct
gaaatgcatctcatccaaacaggcaaaggggaagccatccggatccggtccatcctgcgc
tccctggtccccacagaagacctggttggaatcatcagcattcccctgaagctgccctcc
ctaaacaaagatgggtccgtcagcgagccagacatggcggccaacttctgtcctgaccac
aaagcacccatggtgctgttcttggaccgtgtttatggcattaaagatcaaacttttctg
ctccacttgctggaagttgggtttttacccgatttacgagcttctgcatctctagataca
gtgtccctcagcaccacagaggccgcgctggcactgaataggtatttatgttcggctgtg
ctcccgctccttactagatgcgcccctctcttttctgggacagagcactgtacttctctg
atcgactctacactgcagacaatatacagactttccaaaggacggtccctcaccaaggca
cagagggacaccatagaagaatgtttgctagccatttgcaatcacttgagaccttccatg
ttacagcaactcctgcggcgtctggtctttgacgtgccacagctcagcgagtactgcaaa
atgccactcaagctcctgacaaatcactatgagcagtgctggaagtattactgcctgcct
tcgggatgggggagctatgggctagcagtggaggaggagctgcacctcacggagaagctc
ttctgggggatttttgactccctctcgcacaagaaatacgacccggaccttttccgaatg
gccctgccttgtctcagtgctattgctggagccttgccaccggactatttagatactaga
atcacggccacactggagaagcaggtctcagtggatgcagatggaaactttgaccccaaa
cctatcaacaccatgaatttttccttgcctgaaaaattggaatacattgtcaccaagtac
gctgagcattctcatgataaatgggcttgcgacaagagtcacagtggatggaaatatggg
atttctctggatgaaaatgtgaagacccacccactaatacggcctttcaagaccttaaca
gagaaggagaaggaaatttatcgctggcctgccagagagtccctgaaaaccatgctggct
gtgggctggacagtggaaaggaccaaagaaggagaagctttggttcaacaaagagagaat
gagaagcttcgatgtgtgtcccagtccaatcagggcaacagctacagccctgcccctctg
gatctctcaaatgttgtgctgtccagggagcttcagggaatggtggaggtggtggctgaa
aactatcacaatatctgggccaagaagaagaagctggagctggaaagcaaaggtggtggc
agtcaccctcttttggtaccatatgacaccttgactgccaaggaaaagctcagggatcga
gaaaaggcacaggacctgttcaaattcctccaggtgaatggcattctagtttctagaggc
gtgaaggacatggagctggatgcctcctccatggaaaagagatttgcctacaagtttttg
aggaagatcctgaagtacgttgactctgctcaagagtttattgcccacttggaagccatt
gtcagcagtgggaaaacggaaaagtctccccatgaccaggagatcaaattctttgccaaa
gttctcctcccactggttgaccagtacttcaccaaccaccgcctttatttcctgtcatct
cctttgaagccgcttagcagcagtgggtatgcttcccataaagagaaagaaatggtggcc
agcctattctgcaagctggccgctcttgtgagacacaggatttccctctttgggagtgat
tcaactacaatggtgagctgtcttcatatcttagctcagacacttgacacaaggacagtg
atgaagtcaggctcagagctggtgaaagccgggctgcgagcgttctttgaaaatgctgcg
gaagaccttgagaagacctcagaaaacctgaagctggggaagtttacccattccagaacg
cagatcaaaggtgtttctcagaatattaactacaccacagtggctctgcttcccatcctg
acatccatctttgagcacatcgctcagcatcagtttggggtggatctactcttgagtgac
gtgcagatttcatgctaccacattctgtgcagcctctattcccttgggactgggaaaaat
atctatgttgaaaggcaacgtcctgctcttggagaatgtctggcttccctagcagctgct
atccctgtggcatttctggaacccagccttaaccgctataatcccctctcagtcttcaac
accaaaacacccagggagcggtctattctggggatgccagacaaggtggaggacatgtgt
cctgacgtcccgcagctggaaggcctgatgaaggaaatcaatggcttggccgagtcaggt
gcccggtataccgagatgccccatgtcattgaagtgatcttgcccatgctctgcaactac
ctgtcctactggtgggagcggggacctgagaacctgcccccaagcataggaccctgctgc
accaaggtcacatctgaacacctcagcctcatcctgggcaacatactgaaaatcatcaac
aacaacctgggcattgatgaggcctcctggatgaagcgtatcgcagtgtatgcccagcca
atcatcagcaaagccaggcctgacctgcttcgaagccacttcatccccaccctggagaag
ctgaagaagaaggcggtgaagattgtgcaggaggaggagcagctgaagactgatggcaag
ggggatacccaggaggctgagctcctcatcctagacgagtttgctgtcctctgcagggac
ctgtatgccttctaccccatgctgatccgctatgtggacaacaacagatctaactggctc
aaaagcccggatactgattctgaccagctcttccgaatggtggccgaggtcttcattctg
tggtgtaaatctcacaacttcaagagggaagagcaaaatttcgtgattcaaaatgaaatt
aataacttggcatttttaactggagacagcaaaagcaagatgtcaaaagccatgcaagta
aagtctggaggacaggaccaggaacggaagaagacaaagaggcgaggagacttgtattcc
atccagacgtccctcatcgtggctgcactcaagaaaatgctgcccattggtctgaacatg
tgtactccaggcgaccaggagctcatctcgcttgcgaaatcacgatacagctgtagagac
actgatgaagaagtcaaggaacatcttcggaataacctgcacctgcaggagaagtctgat
gaccccgctgtgaaatggcaactgaacctctacaaagacgttctgaggaatgaagagcct
tctaatccagaaaagacggtggagcgggtgcagaggatttcagcggctctgttccacctg
gagcaggtggaacagcctttgaggtccaaaaaggctgtgtggcataaattgttgtcaaag
caacggaaacgggcagtggtggcctgtttcaggatggctccactctacaatctgcccagg
caccgctctattaacctcttcctccatggctatcagagattttggatagaaacagaggcg
tattcctttgaagagaaactagtacaggatttggctaaatctcccagggttgaagatgag
gaagaagaggagaccgaaaagcaacctgacccccttcaccagatcattctacattttagc
cgcaatgcgctcactgagaggagcaaattggaagatgacccactgtacacttcctattcc
agcatgatggccaagagctgtcagagtggtgaggatgaagaagaagaggaagacaaggaa
aaaacattcgaagagaaggagatggagaagcaaaagacactatatcagcaagcacgacta
cacgagcgtggtgctgcagagatggtccttcagatgataagtgccagcaaaggtgagatg
agccccatggtggttgagaccctgaagctggggattgccattctgaacggaggcaatgct
ggtgtgcaacagaaaatgctagattacttaaaggagaaaaaagatgctggattctttcaa
agcctttctggtcttatgcagtcttgcagtgtccttgatttgaatgcatttgagaggcag
aataaagctgaaggcctggggatggttacagaagaaggcaccctcattgtccgtgagcgt
ggtgaaaaggtactccagaatgatgaattcacacaagatctctttagatttctacagttg
ctttgtgaaggacataacagtgactttcagaacttcctgagaactcagatgggcaacacc
actactgtgaacatcattattagcaccgtggactaccttctgcgtctgcaggagtcaatc
agcgatttctattggtactattcaggaaaggacatcattgatgaatctggacagcacaat
ttctctaaagctctggcagtcaccaagcaaatctttaattctcttacagagtacatccag
ggcccttgcatcgggaaccagcagagcctggctcacagtaggctgtgggatgcagtggtt
ggattcctccatgtatttgctaacatgcagatgaagctctctcaggattccagtcagatc
gagctgctgaaggaactcttggatctccttcaggacatggtggtgatgcttctgtccctc
ctggaaggaaatgtggtaaatgggactattggaaagcagatggttgacacgctggtagaa
tcgtctactaatgtagagatgatcttgaaattctttgacatgttcttgaaacttaaagac
ttaaccagctcagacaccttcaaagaatatgacccagatggtaaagggatcatctcccga
aaagaattccagaaggccatggaaggtctaaagcaatatacacagtcagagattgatttt
cttctttcgtgtacagaggctgatgagaatgacatgtttaattatgtggattttgtagag
aggttccacgagccagccaaggacatagggttcaatgtggcggtgttattgacaaatctc
tctgagcatatgccaaatgattctcgtctcaagtgtctcttggacccagcagaaagtgtg
ctaaattactttgaaccatacctgggtcgaatcgagatcatgggtggggccaagaagatt
gagcgtgtttattttgagatcagtgaatccagtcgaactcagtgggaaaagcctcaagtg
aaggaatctaagcgacagttcatctttgatgttgtcaatgaaggcggggagcaagagaag
atggaactgtttgtgaacttctgtgaagatacaatattcgagatgcaattagcatctcag
atctcagaatctgactcaactgacaggccagaagaggaagaggaagaggatgaagattcc
tattcggtagaaattgagggggaggaagaagataaatcttttgagtctgcctctgcattt
gccatggcctgtgcctcagcaaagagaaatgtcaccaagtttctgaagaaggcaaccttg
aagaacctcaggaaacagtacaggaatgtgaaaaagatgagcgcaaaggagctggtcagg
gtgctctcctccttcttctggatgctggttgtgggcctctttcagttgctcttctctatc
ttgggaggaatctttcacatactctggaacacagtatttggagggggccttgtagaaggg
gcaaagaacatcagagtgactaagatcctaggtgacatgcccgaccccacccagtttggg
atccatgatgatgtaatggagattgacagggcggaagtgactgagccaggtatcaccacc
gagctggtccactttgtaaagggtgaggccggagacacagacgtcatgtcagacctcttt
ggaatccactcaaagaaagaaggtggttcaaagcaagggcctgaagtgggattaggtgac
ctctctgaaattaccggcaaagacgaacccccgacattagagagtactgtacggaagaaa
aggaaagcacaggcagcagagatgaaggcagtgcatgaagctgaaggaagaactgaatct
gagaaggccgacatggaagacagagaaaaggaagacaaaatcaaggaggagggacaagca
gagtacctgtgggcagacacaacagtaaagaagacgcgacggcgtggtcagaaggccgag
aagccagtagccttcatggccaacttcttcaaagggctggagatttatcagaccaagtta
ctgcactacctggccaggaatttctacaacctgaggttcctcgctctatttgtagccttc
gctatcaacttcatcctgcttttctataaggtcacggaagagcctttagaggaagaaaca
gaggatgttgcaaacctgtggaactcattcaatgaggatgatgaggaagaagcgatggtg
ttctttgttcttcaggagagcactgggtatatggcaccaacactgcgtgccctggccatt
gtccacactgtcatctctctggtctgtgtggtgggctattactgcctgaaggtacctttg
gtggtattcaaaagggagaaggaaattgccaggaagctggagtttgatggtctgtatatc
actgagcagccatctgaggatgacatcaaagggcagtgggatcgcttggtgatcaacacg
ccatcttttcctaataactactgggacaagtttgtgaagagaaaggtgatcaacaagtat
ggagatctctatggagcagagcgcatcgctgaactcctgggtttggacaaaaatgccctg
gactttagcccagtagaagaggccaaagcagaggcggcgtctctggtgtcatggctaagt
tccatcgacatgaagtaccatatttggaagctaggggtggttttcactgacaactccttt
ctctaccttgcctggtacacaaccatgtctgtcctgggccactacaacaacttcttcttt
gctgctcatctgttggatattgccatgggctttaagaccttgaggacgatcctgtcatct
gtgactcacaatggcaaacagctggttctgactgttggcctcctggctgtagttgtttac
ctctatactgtggtggctttcaacttcttccgcaagttctacaacaaaagcgaagatgat
gatgagccggatatgaagtgtgatgacatgatgacgtgctacctcttccacatgtatgtg
ggcgtaagagcaggtggcggcattggtgacgaaattgaagatcccgctggtgacccttat
gaaatgtatcgcatcgtctttgatattaccttcttcttctttgtcattgtcatcttgctg
gccatcattcaaggtcttattattgatgcttttggagagctgagggaccagcaggaacaa
gtacgggaagacatggagactaaatgcttcatctgtggcattggcaatgactactttgac
acgacccctcatggttttgaaacgcatacattgcaagagcacaacttagccaattatcta
ttcttccttatgtatttgattaacaaggatgaaacagaacacacgggtcaggaatcctat
gtgtggaagatgtaccaggaaaggtgttgggacttcttcccagctggagactgcttccgt
aagcaatatgaagatcagctcgggtaa

KEGG   Rattus norvegicus (rat): 689560
Entry
689560            CDS       T01003                                 

Gene name
Ryr2
Definition
(RefSeq) ryanodine receptor 2 isoform 1
  KO
K04962  ryanodine receptor 2
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04020  Calcium signaling pathway
rno04024  cAMP signaling pathway
rno04260  Cardiac muscle contraction
rno04261  Adrenergic signaling in cardiomyocytes
rno04371  Apelin signaling pathway
rno04713  Circadian entrainment
rno04911  Insulin secretion
rno04921  Oxytocin signaling pathway
rno04972  Pancreatic secretion
rno05020  Prion disease
rno05022  Pathways of neurodegeneration - multiple diseases
rno05410  Hypertrophic cardiomyopathy
rno05412  Arrhythmogenic right ventricular cardiomyopathy
rno05414  Dilated cardiomyopathy
rno05415  Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    689560 (Ryr2)
   04020 Calcium signaling pathway
    689560 (Ryr2)
   04024 cAMP signaling pathway
    689560 (Ryr2)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    689560 (Ryr2)
   04921 Oxytocin signaling pathway
    689560 (Ryr2)
  09153 Circulatory system
   04260 Cardiac muscle contraction
    689560 (Ryr2)
   04261 Adrenergic signaling in cardiomyocytes
    689560 (Ryr2)
  09154 Digestive system
   04972 Pancreatic secretion
    689560 (Ryr2)
  09159 Environmental adaptation
   04713 Circadian entrainment
    689560 (Ryr2)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05020 Prion disease
    689560 (Ryr2)
   05022 Pathways of neurodegeneration - multiple diseases
    689560 (Ryr2)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    689560 (Ryr2)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    689560 (Ryr2)
   05414 Dilated cardiomyopathy
    689560 (Ryr2)
   05415 Diabetic cardiomyopathy
    689560 (Ryr2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:rno04040]
    689560 (Ryr2)
   04990 Domain-containing proteins not elsewhere classified [BR:rno04990]
    689560 (Ryr2)
Ion channels [BR:rno04040]
 Voltage-gated cation channels
  Ryanodine receptor
   689560 (Ryr2)
Domain-containing proteins not elsewhere classified [BR:rno04990]
 EF-hand domain-containing proteins
  Other EF-hand domain-containing proteins
   689560 (Ryr2)
SSDB
Motif
Pfam: RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8
Other DBs
NCBI-GeneID: 689560
NCBI-ProteinID: NP_114467
RGD: 620314
Ensembl: ENSRNOG00000017060
UniProt: B0LPN4
Position
17
AA seq 4953 aa
MADAGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAGGFGNRLCFLESTSNSKNVPP
DLSICTFVLEQSLSVRALQEMLANTVEKSEGKFMMKTAQGGGHRTLLYGHAILLRHSYSG
MYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVS
SERYLHLSYGNSSWRVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTV
PSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLS
LMEDKNLLLMDKEKADVKSTAFAFRSSKEKLDAGVRKEVDGMGTSEIKYGDSICYIQHVD
TGLRLTYQAVDVKSARMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIRSTVFLFN
RFIRGLDALSKRAKLPTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQN
LFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAALIRGNRKN
CAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRN
HKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEGS
AQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGF
DGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGL
FFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAACYEAVLPKEKLKVEHSREYKQERTYT
RDLLGPTVSLTQAAFTPVPVDTSQIVLPPHLERIRERLAENIHELWVMNKIELGWQYGPV
RDDNKRQHPCLVEFCKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEKVKKMKLP
KNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNR
RNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYHLEAPDQDHASRAEVCSGTGERFRI
FRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDLELGSDERAFAFDGFKAQRWHQ
GNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSL
GVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQVPSNHEH
IEVTRIDGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFSKSVAGGIPGAGF
YGPKNDLEDFDVDSDFEVLMKTAHGHLVPDRMDKDKETPKPEFNNHKDYAQEKPSRLKQR
FLLRRTKPDYSTSHSARLTEDVLADDRDDYEYLMQTSTYYYSVRIFPGQEPANVWVGWIT
SDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGRNNSNGLE
IGCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPL
SAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQCLDPLQ
FMSLHIPEENRSVDILELTEQEELLQFHYHTLRLYSAVCALGNHRVAHALCSHVDEPQLL
YAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEFIVPMTEETKSITLFPDENKKH
GLPGIGLSTSLRPRMCFSSPSFVSISNECYQYSPEFPLDILKAKTIQMLTEAVKEGSLHA
RDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILRLIEPSVFKEAATPEEEGGAPEK
EISIDDSKLEVKEEAKAGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVAF
SDDFVAKLQDNQRFRYNEVMQALNMSAALTARKEFRSPPQEQINMLLNFKDDKSECPCPE
EIRDQLLDFHEDLMTHCGIELDEDGSLDGSNDLTIRGRLLSLVEKVTYLKKKQAEKPVAS
DSRKSSSLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTYTING
VSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHET
VMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLA
SPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQMLVSKGYPDIGW
NPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEA
IKIAEDPSRDGPSPTSGSSKTLDAEEEEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIH
AGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGKVVEPDMSAGFCPDHKAAMVL
FLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTR
CAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRPSMMQHLLR
RLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWSNFGAASEEELHLSRKLFWGIFD
ALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGNSNPQPVDTSN
ITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKIQPLMKPYKLLSEKEKEI
YRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSIDAAHGYSPRAIDMSN
VTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAKEKAKDREKAQ
DIFKFLQISGYAVSRGFKDLDLDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGGSRSK
GEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCTGGHASNKEKEMVTSLFCK
LGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLDSVKSALRAFLDNAAEDLEK
TMENLKQGQFTHTRSQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGEDLILEDVQVSC
YRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPIAFLETHLDKHNVYSIYNTRSSR
ERAALSLPANVEDVCPNIPSLEKLMTEIIELAESGTRYTQMPHMMGVVLPMLCSYMSRWW
EHGPENHPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIINKV
KPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAELLILDEFTTLARNLYAFY
PLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFVVQNEINNMSF
LITDTKSKMSKAAISDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPGDQELIA
LAKNRFSLKDTEEEVRDVIRSNIHLQGKLEDPAIRWQMALYKDLPNRAEDTSDPERTVER
ILDIANVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQ
GYEKSWIETEEHYFEDKLIEDLAKPGSELPEEDEAMKRVDPLHQLILLFSRTALTEKCKL
EEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEVTGSQRSKEKEMEKQKLLYQQARLHDR
GAAEMVLQTFSASKGETGPMVAATLKLGIATLNGGNSTVQQKMLDYLKEKKDVGFFQSLA
GLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLFRFLQLLCEGHNSDF
QNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDIIGEQGQRNFSKAIQVAK
QVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDL
QKDMVVMLLSMLEGNVVNGTIGKQMVDMLAESSNNVEMILKFFDMFLKLKDLTSSDTFKE
YDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDI
GFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISE
SSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESGLNER
SANKEESEKERPEEQAPRMGFFSLLTVQSALFALRYNVLTLVRMLSLKSLKKQMKRMKKM
TAKDMVSAFFSSYWSVFVTLLHFVASVCRGFFRIVSSLLLGGSLVEGAKKIKVAELLANM
PDPTQDEVRGDEEEGERKPLESALPSEDLTDLKELTEESDLLSDIFGLDLKREGGQYKLI
PHNPNAGLSDLMTNPIPVPEVQEKFQEQKVKEEKEGKEETKSEPEKAEGEDGEKEEKAKD
DKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINF
ILLFYKVSTSSVVEGKELPTRTSSDAAKVTTSLDSGPHRIIAVHYVLEESSGYMEPTLRI
LAILHTIISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLV
INTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSGAREKKKPKKDSSL
SAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLR
TILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYM
FHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELR
DQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHT
GQESYVWKMHQERCWEFFPAGDCFRKQYEDQLN
NT seq 14862 nt   +upstreamnt  +downstreamnt
atggctgatgcgggcgaaggcgaggacgagatccagttcctgagaactgatgatgaggtg
gttctacagtgcaccgcaaccatccacaaagagcagcagaagctgtgcttggctgcagga
ggatttggcaacagactttgctttttggagtctacttccaattctaagaatgtccccccg
gacctgtccatctgcacctttgtgctggagcagtccctgtcagtacgggccctgcaggag
atgctagccaacacagtggaaaagtcagaagggaagttcatgatgaagactgctcaaggt
ggaggccaccggacactcctctatggacacgccatactactacgccattcctacagtggt
atgtatctctgctgtctctccacctcccggtcttccaccgacaaactggcctttgatgtt
ggccttcaagaggataccacaggggaggcttgctggtggaccatacatcctgcctctaag
cagagatcagaaggagaaaaggtgcgggttggagacgacctcatattggtcagcgtgtcc
tcagaaaggtacttgcacttgtcatacggcaacagcagctggcgtgtagacgcagccttc
cagcagaccctctggagcgtggcccctatcagctcaggaagtgaagcagcccaagggtat
ctcattggtggtgatgttctccggctgctacatggacacatggatgaatgtctcactgtt
ccttcaggagaacatggtgaagaacagcggagaacagtccattatgaaggtggtgctgta
tcagttcatgcccgctccctctggagactagagaccctaagagtcgcgtggagtggaagt
cacataagatggggccagccattccgactgcggcacgtcacgacaggaaaatacttaagc
ctcatggaagacaagaaccttctactcatggacaaagaaaaagctgatgtaaaatcaacg
gcgtttgccttccggtcttccaaggaaaaattggatgcaggtgtaaggaaagaagtcgat
ggcatgggaacctcagaaatcaagtatggagactccatttgctatatacaacatgtggac
acgggcctgcggctaacctaccaggccgtggatgtcaaatcagcacgaatgggatccata
cagcgtaaggctatcatgcaccacgaaggccacatggatgacggcttgaacttatccaga
tcgcagcacgaggagtcccgcactgcccgtgtcatccggagcacagtgtttctcttcaat
aggttcataaggggcctggatgctctcagcaagagagcgaagctgcccactgttgacttg
cccatcgagtctgtgagcctgagtttgcaggacctcatcggctacttccaccccccagac
gagcacctggagcacgaggacaagcagaacaggctgcgagccctgaagaaccggcagaat
ctcttccaggaagagggaatgatcaacctggttctggagtgcatcgaccgcctccatgtc
tacagcagtgcagcccactttgcagacgttgcaggacgagaagcgggggagtcttggaaa
tccatcctgaattctctgtatgagttgctggcggctctaattagaggaaatcgtaaaaac
tgtgctcaattttctggctccctcgactggctgatcagcagactggagagactggaagcg
tcctctggtatcctggaggtcctccactgtgtgttagtggagagcccggaagctctgaat
atcatcaaagaaggacacatcaagtccattatttcccttttagacaagcatgggagaaac
cacaaggtcctggatgtgctgtgttctctctgtgtgtgccatggagttgccgtccgttct
aatcagcatctcatctgtgataacctcctgccgggacgagacctcttactgcagacccgg
cttgtgaatcatgtcagcagcatgaggcctaatattttcctgggtgtcagcgaaggatca
gcacagtataagaagtggtactacgagctcatggtggaccacacggaaccctttgtgacc
gcagaagccactcacctgcgagtgggctgggcttccactgaagggtattccccgtaccca
ggtgggggtgaagagtggggtggcaatggcgttggtgatgacctcttctcctatgggttt
gatggccttcacctctggtcaggttgtatagctcgaacagtgagctcccccaaccagcac
ctgctgagaactgatgatgtcataagttgctgtttagatctaagtgccccgagcatctcg
tttcgcattaatggacaacctgtgcaagggatgtttgagaacttcaatatcgatggcctg
ttctttccggttgtcagtttctctgcaggaataaaggttcgctttttgcttggggggaga
cacggagaattcaaatttctccctccaccgggctatgcagcttgctatgaagctgttttg
cccaaagagaaattgaaggtggaacacagccgagaatataagcaagagaggacgtacaca
cgagacctgctggggcctacagtgtccctgacccaagctgccttcacacctgttcctgtg
gacaccagccagattgtgttgcctcctcacctggaaaggataagagaaagactggcagaa
aatatccacgagctctgggttatgaataaaattgagcttggctggcagtatggtccggtt
agagatgacaacaagagacagcacccatgtctggtggagttctgcaagcttccggaacag
gaacgcaactacaatttgcagatgtctctggaaaccctcaagactttgctggcattagga
tgtcatgtgggtatagcggatgaacatgctgaagagaaggtgaagaaaatgaagctgccc
aagaattaccagctgaccagtggatacaagcctgcccccatggatctgagctttataaaa
cttaccccgtctcaggaagcaatggtggacaagttggctgaaaatgctcacaacgtgtgg
gcccgggaccgaatccggcagggctggacttacggcatccagcaggatgtgaagaacagg
agaaaccctcgtctggttccctacactcttctggatgacagaaccaagaagtccaacaaa
gacagtctccgagaggcagtgcgaacactgctgggctacggctaccacctggaagctcct
gatcaggaccacgcctcaagagccgaggtgtgcagcggtactggggagaggttccgcatc
ttcagggcagagaagacctatgcagtaaaggctgggcgctggtactttgaatttgaggcc
gtcactgctggagacatgagggtgggatggagcaggccaggctgccaaccggatctagaa
ctgggttctgatgaacgtgccttcgcttttgacggctttaaggcccagcggtggcaccag
ggcaatgaacactacgggcgttcttggcaagcaggtgatgtcgtgggctgcatggttgat
atgaatgaacacaccatgatgttcactctgaacggtgagatcctgctggatgactcaggc
tccgagctggctttcaaggactttgatgttggtgacggattcatccctgtgtgtagcctc
ggggtggcacaagtaggcaggatgaactttggaaaggacgtcagcactttgaaatacttt
accatctgtggcttacaagagggctacgagccatttgcagttaacacaaatagggacatc
accatgtggctgagcaagcggcttcctcagttcctccaggtcccctcaaaccacgaacac
atcgaggtgaccagaatagatggtaccatagacagttctccatgtctgaaggtcactcag
aagtcctttggttctcagaacagcaacacagacatcatgttttaccgcctgagtatgccc
attgagtgtgctgaggtcttctcaaagtccgtggctggagggatccctggcgccggcttc
tatgggcccaagaatgatttggaggactttgatgtggattctgactttgaggttctgatg
aagacagctcatggtcatcttgtgcccgaccgcatggacaaggacaaagagacccccaag
ccagaattcaataaccacaaagattatgctcaggaaaagccctcacgcctaaagcaaaga
ttcttacttagaaggaccaagccagattacagcacaagccattctgcaagactcactgaa
gacgtccttgctgatgaccgggatgactatgaatatctgatgcagacatctacatactat
tattcagtgaggatctttcctggacaagaaccagctaacgtctgggtgggctggattaca
tctgacttccaccagtatgacacaggcttcgatttggacagagtgcgcacagtgacagtc
accctaggagatgaaaaagggaaagtgcacgagagcatcaaacgcagcaactgctatatg
gtgtgtgcgggagagagcatgagccccgggcaaggccgaaacaacagcaatggcttggag
atcggctgtgtggtggacgctgccagtgggctgctcacattcatagccaacggcaaggag
ctaagcacttactatcaggtggagccaagcacgaagttatttcctgcggttttcgcgcaa
gctacaagtcccaatgttttccagtttgagttgggcagaataaagaatgtgatgcctctc
tcagcgggattgtttaagagtgagcacaaaaaccccgtgccccagtgtcctccacgtctg
cacgtgcagttcctgtcacatgtcctgtggagccggatgcccaaccagttcctcaaggtg
gacgtctctcgaatcagtgaacgccaaggctggctggtgcagtgtctggatcctctgcag
ttcatgtccctccacatccccgaggagaacagatctgttgatatcttagagctgaccgag
caggaggagttgttgcagtttcactaccacaccctccgcctctactctgcagtctgtgcc
cttgggaatcaccgggtggcgcatgcactgtgcagccacgtggacgaacctcagctgctc
tatgccattgagaacaagtacatgcctggcttgctgcgagccgggtactatgacctgctg
attgacatccacctcagctcctacgccaccgccaggctcatgatgaacaatgagttcatc
gtcccgatgacagaggagacaaagagcatcaccctcttccctgatgagaacaagaaacat
ggcctcccgggcataggcctcagcacctctctccgccctcggatgtgcttttcctcccct
agtttcgtgagcattagcaacgaatgctatcagtatagtcccgagttcccactggacatc
ctcaaggccaagaccatccagatgctcacagaagcggtgaaggagggcagcctccacgcg
cgggatcccgtgggcgggaccaccgagttcctctttgtgcctctcatcaagctcttctac
accctgctcatcatgggcatctttcacaatgaggatttgaaacacatcctgcggttgatt
gagcctagtgtgtttaaggaagctgccactccagaggaggaaggaggtgccccagagaag
gagattagtatagacgactctaaactggaagtcaaagaggaagccaaagcaggcaaaagg
cctaaggaaggcttactccagatgaaactcccggagcctgttaaactacagatgtgcctc
ttgcttcagtacctctgtgactgccaggttcggcaccggatagaagccattgtagccttt
tcagatgactttgtagccaaactccaagacaatcagcggttcaggtataatgaagtcatg
caagccttaaacatgtctgctgcactcactgccaggaaggagttccggtcaccaccacag
gagcagatcaatatgcttcttaattttaaggatgataaaagtgaatgcccctgccctgaa
gaaatccgagaccaactcctagatttccatgaggacctgatgactcactgtggaattgaa
ctggatgaagatggatctctagacggaagcaatgacttaacaatcagaggacgtctgctg
tccctggtagaaaaggtgacctacctgaagaaaaagcaagctgaaaaaccagtcgcaagt
gactccagaaagtcctccagcctccagcaactcatttctgagactatggtgcggtgggct
caagagtctgtcatcgaggaccctgagctggtgagggctatgtttgtgctgctgcaccgg
cagtatgatggcattgggggtctcgttcgagcactgccaaagacctacactatcaacggc
gtctctgtggaggacaccatcaatctgcttgcatcacttggtcagatccgatccctgctg
agtgtgaggatgggcaaagaagaagagaagctgatgatccgaggattaggggatattatg
aataacaaggtgttttatcagcatcccaatctcatgagggcccttgggatgcacgaaaca
gtgatggaagtcatggtgaacgtccttggaggtggggagtccaaggaaatcaccttcccc
aagatggtggccaactgctgccgttttctctgttacttctgtcgtataagtaggcagaat
cagaaagccatgtttgatcatctcagttatttactggaaaacagcagtgttggtcttgcc
tcaccagccatgagaggttcaactccattagacgtggccgcagcgtcagtgatggataac
aatgagcttgcccttgctctacgagagccggatctggagaaggtggttcgctatctggcc
ggctgtggtctgcagagctgccagatgctggtgtctaagggttacccagacattgggtgg
aatccagttgaaggagaacgatatcttgactttctcagatttgccgtcttctgtaatggg
gagagtgtggaagagaatgcaaatgttgtggtgaggttgctcatccggagaccggagtgc
tttggccctgccttgagaggagaaggtggtaatggtctccttgcagccatggaagaagcc
ataaaaatagctgaggatccttctagagatggcccctctccaaccagtggatccagcaaa
acccttgatgcggaagaggaggaagacgacaccatccacatggggaacgcaatcatgacc
ttctacgcagctttgattgacctgcttggtcgctgtgctcctgaaatgcatttgattcat
gctggaaagggagaagccatccgaatcaggtctattttgcgatccctgattccattggga
gacttggtgggtgtaatcagcattgcatttcagatgccaacaatagccaaagatgggaag
gtggtggagcctgacatgtccgcggggttttgcccagatcacaaggcagccatggttttg
ttccttgacagggtctatggaattgaggtgcaagatttcctcctccatctccttgaggtt
ggctttctgccagatcttcgcgctgctgcctctctagacacggctgcactaagtgctaca
gacatggccttggccctcaatcggtacctctgcacagctgtcctgcctttgttaacgaga
tgtgctcccctgtttgctggaacagagcaccatgcttccctcattgactctctgctacac
actgtatatagactctctaagggatgttccctcaccaaagctcagcgggactccatagaa
gtgtgcctgctctctatatgtggccaactgcgaccttctatgatgcagcacctactccga
aggctggtgtttgatgtcccactgctgaacgagcacgcaaagatgcctctaaagctgctg
accaatcattatgaaagatgctggaaatattactgcctacctggagggtggagcaacttt
ggtgctgcctcggaagaagaacttcatttatcaagaaaattattttggggcatttttgat
gctttgtctcaaaagaaatacgaacaagaacttttcaaactggccctgccttgcctgagt
gcagttgcgggagctttacctccagactacatggagtcaaactatgtcagtatgatggaa
aaacagtcatccatggactctgaagggaactctaacccacaacctgttgatacctcaaac
attacaattcccgagaagctggaatacttcattaacaagtatgcggagcattcccatgat
aaatggtctatggacaagttggcgaatggatggatttatggggaaatatattcagactct
tctaagatccagccactaatgaagccatataaactcttatctgaaaaggaaaaagaaatt
tatcgttggccaatcaaggagtctttaaaaacgatgctggcttggggttggagaattgag
aggacacgggagggagacagtatggccctttataaccggactcggcgcatttctcagact
agccaggtgtctatagatgctgcacatgggtatagcccccgtgctatcgacatgagtaac
gttaccctctcgagagacctgcatgctatggcggagatgatggctgaaaactaccacaac
atatgggccaagaaaaagaaaatggagctggaatccaaaggaggaggaaaccaccccctg
ctagtgccctacgacacactgacagccaaggagaaagccaaggacagagaaaaggcccag
gacatcttcaagttcctacagatcagtggttatgctgtatccagagggttcaaggacctg
gatctggacacaccttccattgagaagcgatttgcctacagtttcctgcagcagctgatc
cgatatgtggacgaggcccatcagtacatcctggagtttgacggtggcagcagaagcaaa
ggagagcatttcccgtacgagcaagagatcaagttcttcgccaaagttgttcttccttta
attgatcagtatttcaaaaaccatcgcctgtacttcttgtctgctgcaagcaggcctctt
tgcaccggaggacatgcgtccaacaaggagaaggagatggttacaagcctgttctgcaaa
cttggagttcttgtcaggcataggatttcactgtttgggaatgatgctacctcaattgtg
aactgtcttcatattttgggtcagactttggatgcaaggactgtgatgaagacgggtctg
gacagcgtgaaaagtgctctcagggcctttctggacaatgcggcggaggatctggaaaag
acgatggaaaaccttaagcagggccagtttactcacaccaggagccagcccaagggcgtg
actcagatcatcaactataccaccgtggcgctcctgcccatgctctcttccctgtttgag
cacattggccagcatcagtttggagaagatctgatattggaggatgtgcaggtgtcttgt
tacagaattctgaccagcttgtatgccttgggaaccagcaagagcatctatgtggaaagg
caacgttctgcactcggagaatgcctagctgcctttgctggtgccttccctatcgccttt
ctagaaacccacctggacaaacataatgtttactccatctacaacaccaggtcttcacga
gaaagagcagctctcagtttacccgcaaatgtggaggatgtctgcccaaatataccatcc
ctggagaagctcatgactgagatcatagagctggcagagtcaggaacccgttacactcag
atgccacacatgatgggggtggtactgcccatgttatgcagctacatgtcaaggtggtgg
gagcacggtcctgagaaccatccagagagggctgagatgtgctgcacagcgctcaactca
gagcacatgaacacactgctgggcaacattctcaagatcatctacaacaacctggggatt
gatgaaggggcctggatgaagcgcttagctgtattttcacagccaatcatcaacaaggtg
aaacctcagctcttaaaaactcatttcttacccttaatggagaaactaaagaaaaaggct
gccatggtagtgtctgaggaagaccacctaaaagccgaagccagaggggacatgtccgaa
gcggagctgctcattctagatgagtttaccacattggccaggaatctctatgccttctac
ccactcttgatccgatttgtggactataacagggcaaagtggctgaaggaacccaaccca
gaagcagaggagctatttcgaatggtagctgaagtcttcatttactggtccaaatcccat
aatttcaaaagagaggaacagaactttgtggtgcagaatgaaatcaacaacatgtccttc
ctcatcaccgacacaaagtctaagatgtccaaggcagccatttctgatcaagagaggaag
aaaatgaagcggaaaggagaccggtattctatgcagacatctttgattgtggcagctctg
aagcgattgcttcccattggactgaacatctgtgcccctggggaccaagagctcattgct
ctggccaaaaaccgatttagcttgaaagacactgaggaggaagtacgtgatgtaatccgc
agtaatatacacttgcaaggcaagctggaagaccctgcaatcaggtggcagatggctcta
tacaaagacttgccaaacagggcagaagacacctcagacccagagaggacagtggagcgt
atcctggatatagcgaatgtgctttttcaccttgaacaggtggagcaccctcagagatca
aagaaagccgtgtggcacaaactgctctctaagcagagaaaaagagctgttgttgcctgt
ttccggatggcccctttgtacaatctgccaaggcatcgggctgtcaatctctttcttcag
ggatatgaaaagtcttggattgaaacagaagagcattactttgaggataaattgatcgaa
gatttagcgaaaccggggtctgaactcccagaagaagatgaagccatgaaaagagttgat
cctctgcatcagcttattcttctgttcagccgcacagccttaacagagaaatgcaaactg
gaggaagattttctgtacatggcgtatgcagacattatggcaaagagttgtcacgatgaa
gaagacgatgatggtgaagaagaagtgaagagctttgaagtcacaggatcccaacgcagc
aaggaaaaggaaatggaaaagcagaagcttctgtaccagcaagccagactgcatgaccgc
ggggctgccgagatggttctccagaccttcagtgccagcaaaggtgaaactggaccaatg
gtggctgccactttgaagctgggtattgctactttaaatggtgggaactccacggtgcag
cagaagatgctggattacctgaaggagaaaaaagatgtaggcttcttccagagcctggca
ggcctcatgcagtcttgcagtgtcctggacctgaatgcctttgagaggcaaaacaaagca
gaaggacttgggatggtgactgaggaaggatcaggagagaaggtacttcaggatgatgag
ttcacctgtgacctcttccgattcctgcagctgctctgtgaaggacacaactcagatttt
cagaattacctgagaacccagactggcaacaacaccacagttaatatcatcatctctact
gtggactacctccttcgagtgcaggagtccattagtgatttctattggtactactctggc
aaggacatcataggtgagcagggccagcgtaacttttccaaagccatccaagtggcgaag
caggtgttcaacacactcacggagtacatccagggtccttgtaccggaaaccagcagagt
ttggcacacagcaggctctgggatgctgttgtgggcttccttcatgtatttgcacacatg
cagatgaagctgtctcaggattccagccagattgagctcttaaaagaactgatggatctc
caaaaggacatggtggtcatgctgctgtctatgctagagggtaatgtggtaaacggaaca
ataggcaagcagatggtggacatgcttgcggagtcatccaacaacgtggagatgatcctc
aagttctttgacatgtttctgaagttaaaggacttgacatcctctgacacatttaaagag
tatgaccctgatggcaaaggcgtcatttccaagagagacttccacaaagccatggagagc
cacaaacactacacccagtcagagactgagtttctgttgtcctgtgcagagacagatgag
aacgagacgctggattatgaagagtttgtcaaaaggttccacgagcctgccaaggacatc
ggcttcaacgtcgccgttctgctgaccaacctctcagagcacatgcccaatgacacgagg
ctgcagaccttcttggagctggcagagagtgtcctcaactacttccaacctttcctgggt
cgcatcgagatcatgggcagcgccaagcgcatcgagagggtctactttgagatcagcgaa
tccagccgaacccagtgggagaagccccaggtcaaggagtccaagaggcagttcatattc
gatgtggtcaatgagggcggggaaaaggagaagatggagctctttgtgaacttctgtgag
gacaccatctttgagatgcagctggcagctcagatctcagagtccggcctgaatgagagg
tcggcaaataaagaggagagtgaaaaggagaggccagaggagcaggccccacggatgggc
ttcttctccctgctcaccgtccagtcagccctgtttgcactcaggtacaatgtcctaacc
cttgtgaggatgctcagcctgaagagcctgaagaagcagatgaagagaatgaagaagatg
acagcgaaggacatggtctcagccttcttctcgtcctactggagtgtgtttgtcaccctc
ctacacttcgtggccagcgtctgtaggggcttcttccgcattgtctccagcctactgctg
gggggcagcctggtggaaggtgctaagaaaatcaaagtggcggagcttcttgccaacatg
ccagaccctactcaggatgaggtgcgaggagatgaagaggagggagagaggaagccatta
gagtcagccctgccctctgaagacctaacggacttgaaggaactgacggaggaaagtgac
cttctttcagacatatttggcttggatctgaagagagaaggagggcagtacaaactaatt
cctcacaacccaaatgctggtctcagtgacctcatgacgaaccccatccctgtccctgag
gtacaagaaaagtttcaggagcagaaggtaaaagaagaaaaggaaggaaaggaagaaacc
aagtctgaaccggagaaggctgagggagaggatggagaaaaagaagaaaaagccaaagat
gataagggtaaacagaagttgaggcagcttcatacacatcgatatggggagcctgaggtc
cccgagtcagcattctggaagaaaatcatagcctaccaacagaagctgctgaactatttt
gctcgcaacttttacaacatgagaatgctggccctgtttgtcgccttcgccatcaatttc
atcctgctcttctacaaggtctccacttcttctgtggttgaaggaaaggagctgcctacc
cgaacttccagcgatgccgctaaagtgaccaccagcctggacagcggcccccacagaatc
attgcggttcactacgtcctggaggagagtagcggctacatggaacccaccttgcgcatc
ctagccatcctccacaccatcatctccttcttctgcatcatcggatactactgcctgaaa
gtccccttggttatttttaagcgagagaaggaagtggcacggaagttggagtttgatggg
ctttacattacggagcagccatcggaagacgatatcaaaggccagtgggacagactggtg
atcaacacacagtcatttcccaataactactgggataaatttgttaaaagaaaggtaatg
gataaatatggagagttttatgggagagacagaatcagcgagttactgggcatggataag
gctgcactggatttcagcggtgcaagagagaagaagaagcccaagaaggacagttccttg
tctgctgtattgaactctattgacgtgaagtaccagatgtggaaacttggagtcgtgttc
acagacaattccttcctctacctagcctggtatatgaccatgtctgttcttggacactac
aacaactttttttttgctgcccacctccttgacatcgcgatgggcttcaagaccttgaga
actatcctgtcctcagttacccataatggcaaacagctcgtgttaactgttggcttgttg
gctgtcgttgtatacctgtacactgttgtggcgttcaatttcttccgaaaattctacaat
aaaagcgaggatggtgacacgccggacatgaagtgtgacgacatgctgacgtgttacatg
ttccacatgtatgtgggcgtccgtgctggagggggcatcggtgatgaaattgaagaccca
gcaggagatgagtacgagatctaccgaatcatctttgatatcacattcttcttctttgtg
attgtcatccttttggctatcatacaaggtttgatcattgatgcttttggagaactcaga
gaccaacaagagcaagtcaaggaagacatggagaccaagtgcttcatctgtgggataggc
aacgactactttgatacagtgccgcatggctttgaaacccatactctacaggagcacaac
ctggccaactacctgttttttctgatgtacctcataaacaaggatgaaacagaacacacg
ggacaggaatcttatgtctggaagatgcaccaagagaggtgttgggaatttttcccagca
ggagactgtttccggaaacagtatgaggaccagttaaattaa

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