KEGG   Rattus norvegicus (rat): 170911Help
Entry
170911            CDS       T01003                                 

Gene name
Pik3ca
Definition
(RefSeq) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00562  Inositol phosphate metabolism
rno01100  Metabolic pathways
rno01521  EGFR tyrosine kinase inhibitor resistance
rno01522  Endocrine resistance
rno01524  Platinum drug resistance
rno04012  ErbB signaling pathway
rno04014  Ras signaling pathway
rno04015  Rap1 signaling pathway
rno04024  cAMP signaling pathway
rno04062  Chemokine signaling pathway
rno04066  HIF-1 signaling pathway
rno04068  FoxO signaling pathway
rno04070  Phosphatidylinositol signaling system
rno04071  Sphingolipid signaling pathway
rno04072  Phospholipase D signaling pathway
rno04140  Autophagy - animal
rno04150  mTOR signaling pathway
rno04151  PI3K-Akt signaling pathway
rno04152  AMPK signaling pathway
rno04210  Apoptosis
rno04211  Longevity regulating pathway
rno04213  Longevity regulating pathway - multiple species
rno04218  Cellular senescence
rno04360  Axon guidance
rno04370  VEGF signaling pathway
rno04380  Osteoclast differentiation
rno04510  Focal adhesion
rno04550  Signaling pathways regulating pluripotency of stem cells
rno04611  Platelet activation
rno04620  Toll-like receptor signaling pathway
rno04625  C-type lectin receptor signaling pathway
rno04630  Jak-STAT signaling pathway
rno04650  Natural killer cell mediated cytotoxicity
rno04660  T cell receptor signaling pathway
rno04662  B cell receptor signaling pathway
rno04664  Fc epsilon RI signaling pathway
rno04666  Fc gamma R-mediated phagocytosis
rno04668  TNF signaling pathway
rno04670  Leukocyte transendothelial migration
rno04722  Neurotrophin signaling pathway
rno04725  Cholinergic synapse
rno04750  Inflammatory mediator regulation of TRP channels
rno04810  Regulation of actin cytoskeleton
rno04910  Insulin signaling pathway
rno04914  Progesterone-mediated oocyte maturation
rno04915  Estrogen signaling pathway
rno04917  Prolactin signaling pathway
rno04919  Thyroid hormone signaling pathway
rno04923  Regulation of lipolysis in adipocytes
rno04926  Relaxin signaling pathway
rno04930  Type II diabetes mellitus
rno04931  Insulin resistance
rno04932  Non-alcoholic fatty liver disease (NAFLD)
rno04933  AGE-RAGE signaling pathway in diabetic complications
rno04960  Aldosterone-regulated sodium reabsorption
rno04973  Carbohydrate digestion and absorption
rno05100  Bacterial invasion of epithelial cells
rno05142  Chagas disease (American trypanosomiasis)
rno05146  Amoebiasis
rno05160  Hepatitis C
rno05161  Hepatitis B
rno05162  Measles
rno05163  Human cytomegalovirus infection
rno05164  Influenza A
rno05165  Human papillomavirus infection
rno05166  Human T-cell leukemia virus 1 infection
rno05167  Kaposi sarcoma-associated herpesvirus infection
rno05168  Herpes simplex virus 1 infection
rno05169  Epstein-Barr virus infection
rno05170  Human immunodeficiency virus 1 infection
rno05200  Pathways in cancer
rno05203  Viral carcinogenesis
rno05205  Proteoglycans in cancer
rno05210  Colorectal cancer
rno05211  Renal cell carcinoma
rno05212  Pancreatic cancer
rno05213  Endometrial cancer
rno05214  Glioma
rno05215  Prostate cancer
rno05218  Melanoma
rno05220  Chronic myeloid leukemia
rno05221  Acute myeloid leukemia
rno05222  Small cell lung cancer
rno05223  Non-small cell lung cancer
rno05224  Breast cancer
rno05225  Hepatocellular carcinoma
rno05226  Gastric cancer
rno05230  Central carbon metabolism in cancer
rno05231  Choline metabolism in cancer
rno05418  Fluid shear stress and atherosclerosis
Module
rno_M00676  PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    170911 (Pik3ca)
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    170911 (Pik3ca)
   04015 Rap1 signaling pathway
    170911 (Pik3ca)
   04012 ErbB signaling pathway
    170911 (Pik3ca)
   04370 VEGF signaling pathway
    170911 (Pik3ca)
   04630 Jak-STAT signaling pathway
    170911 (Pik3ca)
   04668 TNF signaling pathway
    170911 (Pik3ca)
   04066 HIF-1 signaling pathway
    170911 (Pik3ca)
   04068 FoxO signaling pathway
    170911 (Pik3ca)
   04070 Phosphatidylinositol signaling system
    170911 (Pik3ca)
   04072 Phospholipase D signaling pathway
    170911 (Pik3ca)
   04071 Sphingolipid signaling pathway
    170911 (Pik3ca)
   04024 cAMP signaling pathway
    170911 (Pik3ca)
   04151 PI3K-Akt signaling pathway
    170911 (Pik3ca)
   04152 AMPK signaling pathway
    170911 (Pik3ca)
   04150 mTOR signaling pathway
    170911 (Pik3ca)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    170911 (Pik3ca)
  09143 Cell growth and death
   04210 Apoptosis
    170911 (Pik3ca)
   04218 Cellular senescence
    170911 (Pik3ca)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    170911 (Pik3ca)
   04550 Signaling pathways regulating pluripotency of stem cells
    170911 (Pik3ca)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    170911 (Pik3ca)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    170911 (Pik3ca)
   04620 Toll-like receptor signaling pathway
    170911 (Pik3ca)
   04625 C-type lectin receptor signaling pathway
    170911 (Pik3ca)
   04650 Natural killer cell mediated cytotoxicity
    170911 (Pik3ca)
   04660 T cell receptor signaling pathway
    170911 (Pik3ca)
   04662 B cell receptor signaling pathway
    170911 (Pik3ca)
   04664 Fc epsilon RI signaling pathway
    170911 (Pik3ca)
   04666 Fc gamma R-mediated phagocytosis
    170911 (Pik3ca)
   04670 Leukocyte transendothelial migration
    170911 (Pik3ca)
   04062 Chemokine signaling pathway
    170911 (Pik3ca)
  09152 Endocrine system
   04910 Insulin signaling pathway
    170911 (Pik3ca)
   04923 Regulation of lipolysis in adipocytes
    170911 (Pik3ca)
   04915 Estrogen signaling pathway
    170911 (Pik3ca)
   04914 Progesterone-mediated oocyte maturation
    170911 (Pik3ca)
   04917 Prolactin signaling pathway
    170911 (Pik3ca)
   04926 Relaxin signaling pathway
    170911 (Pik3ca)
   04919 Thyroid hormone signaling pathway
    170911 (Pik3ca)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    170911 (Pik3ca)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    170911 (Pik3ca)
  09156 Nervous system
   04725 Cholinergic synapse
    170911 (Pik3ca)
   04722 Neurotrophin signaling pathway
    170911 (Pik3ca)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    170911 (Pik3ca)
  09158 Development
   04360 Axon guidance
    170911 (Pik3ca)
   04380 Osteoclast differentiation
    170911 (Pik3ca)
  09149 Aging
   04211 Longevity regulating pathway
    170911 (Pik3ca)
   04213 Longevity regulating pathway - multiple species
    170911 (Pik3ca)
 09160 Human Diseases
  09161 Cancers: Overview
   05200 Pathways in cancer
    170911 (Pik3ca)
   05230 Central carbon metabolism in cancer
    170911 (Pik3ca)
   05231 Choline metabolism in cancer
    170911 (Pik3ca)
   05205 Proteoglycans in cancer
    170911 (Pik3ca)
   05203 Viral carcinogenesis
    170911 (Pik3ca)
  09162 Cancers: Specific types
   05210 Colorectal cancer
    170911 (Pik3ca)
   05212 Pancreatic cancer
    170911 (Pik3ca)
   05225 Hepatocellular carcinoma
    170911 (Pik3ca)
   05226 Gastric cancer
    170911 (Pik3ca)
   05214 Glioma
    170911 (Pik3ca)
   05221 Acute myeloid leukemia
    170911 (Pik3ca)
   05220 Chronic myeloid leukemia
    170911 (Pik3ca)
   05218 Melanoma
    170911 (Pik3ca)
   05211 Renal cell carcinoma
    170911 (Pik3ca)
   05215 Prostate cancer
    170911 (Pik3ca)
   05213 Endometrial cancer
    170911 (Pik3ca)
   05224 Breast cancer
    170911 (Pik3ca)
   05222 Small cell lung cancer
    170911 (Pik3ca)
   05223 Non-small cell lung cancer
    170911 (Pik3ca)
  09166 Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    170911 (Pik3ca)
  09167 Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    170911 (Pik3ca)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    170911 (Pik3ca)
   04931 Insulin resistance
    170911 (Pik3ca)
   04933 AGE-RAGE signaling pathway in diabetic complications
    170911 (Pik3ca)
  09171 Infectious diseases: Bacterial
   05100 Bacterial invasion of epithelial cells
    170911 (Pik3ca)
  09172 Infectious diseases: Viral
   05166 Human T-cell leukemia virus 1 infection
    170911 (Pik3ca)
   05170 Human immunodeficiency virus 1 infection
    170911 (Pik3ca)
   05162 Measles
    170911 (Pik3ca)
   05164 Influenza A
    170911 (Pik3ca)
   05161 Hepatitis B
    170911 (Pik3ca)
   05160 Hepatitis C
    170911 (Pik3ca)
   05168 Herpes simplex virus 1 infection
    170911 (Pik3ca)
   05163 Human cytomegalovirus infection
    170911 (Pik3ca)
   05167 Kaposi sarcoma-associated herpesvirus infection
    170911 (Pik3ca)
   05169 Epstein-Barr virus infection
    170911 (Pik3ca)
   05165 Human papillomavirus infection
    170911 (Pik3ca)
  09174 Infectious diseases: Parasitic
   05146 Amoebiasis
    170911 (Pik3ca)
   05142 Chagas disease (American trypanosomiasis)
    170911 (Pik3ca)
  09176 Drug resistance: Antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    170911 (Pik3ca)
   01524 Platinum drug resistance
    170911 (Pik3ca)
   01522 Endocrine resistance
    170911 (Pik3ca)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:rno04131]
    170911 (Pik3ca)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     170911 (Pik3ca)
Membrane trafficking [BR:rno04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    170911 (Pik3ca)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_rbd PI3K_C2 PI3K_p85B DUF2321 DUF4135 ASC
Motif
Other DBs
NCBI-GeneID: 170911
NCBI-ProteinID: NP_596890
RGD: 620916
Ensembl: ENSRNOG00000056371
UniProt: A0A0G2K344
Position
2q24
AA seq 1068 aa AA seqDB search
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLVTIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFV
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPID
SFTMPSYSRRISTATPYMNGETATKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHTGLSNRLARDNELRENDKEQLRALCTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRSFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRQPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQEYTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFTKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt NT seq  +upstreamnt  +downstreamnt
atgcctccacgaccatcttcgggtgaactgtggggcatccacttgatgcccccacgaatc
ctagtggaatgtttactcccaaatggaatgatagtgactttagaatgcctccgtgaggcc
acactagtcaccatcaagcatgaactgttcaaagaggccaggaaataccctctccatcag
cttctgcaagatgaatcatcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaatttttcgatgaaacaagacggctttgtgaccttcggctttttcaaccctttttaaaa
gtaattgagccagtaggcaaccgtgaagaaaagatcctcaaccgagaaattggttttgtt
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtccaagacttccga
aggaacattctgaatgtttgcaaagaagccgtggacctgcgggatctcaactcgcctcat
agcagagcaatgtatgtctaccctccaaatgtcgagtcttccccagaactgccaaagcac
atctacaacaagttagataaaggacaaatcatagtggtgatttgggtgatagtctctcca
aacaacgacaagcagaagtacactctgaagatcaaccatgactgcgtgccagagcaagtc
attgctgaggccatcaggaagaagacccggagcatgttgctgtcctcggagcagctgaaa
ctctgtgtcttagaataccagggcaagtacattctcaaagtgtgtggctgtgatgagtac
ttcctagagaagtaccctctgagtcagtacaagtacataagaagctgtataatgctgggg
aggatgcccaacttgatgctgatggccaaggagagcctgtactctcagctgccgatcgat
agcttcacaatgccatcctactccaggcgcatttccacagcgacaccctatatgaacggg
gagactgctacgaaatccctctgggttataaatagcgcgctcagaataaaaattctgtgt
gcaacctatgtaaatgtaaatattcgagacattgataagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgacaatgtgaatactcaaagagtcccttgttccaat
cctaggtggaatgaatggctgaattatgatatatacattcctgatcttcctcgtgctgcc
cgcctttgcctttcaatctgctctgttaaaggccgaaagggtgctaaggaggagcactgt
ccgttggcctggggaaacataaacttgtttgattatacagacaccctagtgtccgggaaa
atggctttgaatctctggcctgtaccacatgggttggaagatctgctgaaccctattggt
gttactgggtcaaatccaaataaagaaactccatgcttagagttggagtttgattggttc
agcagtgtggtgaagtttccagatatgtctgtgatcgaagagcatgccaattggtctgtg
tcccgagaagccggattcagttactctcatacaggactgagtaacagactagccagagac
aatgagttaagagaaaatgacaaggaacagctccgagcactttgtacccgggacccactg
tctgaaatcactgaacaagagaaagacttcctatggagccacagacactactgtgtaact
attcctgaaatcctacccaaattgcttctgtctgtcaagtggaattccagagatgaagtg
gcccagatgtactgcttagtaaaagattggcctccaatcaaaccagagcaagccatggag
ctcctggactgtaactacccagaccccatggttcggagctttgctgtccggtgcttggaa
aaatacttaacagatgacaaactttctcagtacctcatccagcttgtacaggtcttaaaa
tatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcactgacaaat
caaaggattggccattttttcttttggcatttaaaatctgagatgcacaataagactgtc
agtcagaggttcggcctgctgttggagtcctactgccgtgcctgtgggatgtatctgaag
cacctgaacagacaggtagaggccatggagaagctcatcaatctaactgacatcctcaag
caggagaagaaggatgagacacagaaggtacagatgaagttcttggttgaacagatgaga
cagccagatttcatggatgctttgcagggttttctgtcccctctaaatcctgctcatcaa
ctaggaaacctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagctactgtttcagaacaatgagatcatc
tttaaaaatggcgatgacttacggcaagacatgttaacccttcagatcatccgaatcatg
gagaacatctggcaaaaccaaggccttgaccttcgcatgctaccttatggctgtctatcc
attggggactgtgtgggtctcatcgaggtggtgagaaactctcacaccatcatgcagatt
cagtgcaaaggaggcctgaaaggggcactgcagttcaacagccacacgctgcatcagtgg
ctcaaggacaagaacaagggcgagatatatgacgcagccattgacctgttcactcggtcc
tgcgctgggtactgcgtggcaacctttatcttgggaattggagaccggcacaacagcaac
atcatggtgaaagatgacggacagctgtttcatatagattttgggcactttttggatcac
aagaagaaaaaatttggctataaacgggaacgtgtgccgtttgttttgacgcaggatttc
ttaatagtgattagtaaaggagcacaagagtacacaaagaccagagagtttgagaggttt
caggagatgtgttacaaggcgtacctagcaattcggcagcatgccaatctcttcatcaac
cttttctccatgatgcttggctccggaatgccagaactgcagtctttcgatgatattgca
tatattcgaaagactctagccttagacaaaactgagcaagaggctctggagtatttcaca
aagcaaatgaatgacgcacatcatggtggctggacaacaaaaatggactggatcttccac
accatcaagcagcatgcattgaactga

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