KEGG   Rattus norvegicus (rat): 170921
Entry
170921            CDS       T01003                                 

Gene name
Itga2
Definition
(RefSeq) integrin alpha-2
  KO
K06481  integrin alpha 2
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04145  Phagosome
rno04151  PI3K-Akt signaling pathway
rno04510  Focal adhesion
rno04512  ECM-receptor interaction
rno04611  Platelet activation
rno04640  Hematopoietic cell lineage
rno04810  Regulation of actin cytoskeleton
rno05165  Human papillomavirus infection
rno05200  Pathways in cancer
rno05205  Proteoglycans in cancer
rno05222  Small cell lung cancer
rno05410  Hypertrophic cardiomyopathy
rno05412  Arrhythmogenic right ventricular cardiomyopathy
rno05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    170921 (Itga2)
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    170921 (Itga2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    170921 (Itga2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    170921 (Itga2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    170921 (Itga2)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    170921 (Itga2)
   04611 Platelet activation
    170921 (Itga2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    170921 (Itga2)
   05205 Proteoglycans in cancer
    170921 (Itga2)
  09162 Cancer: specific types
   05222 Small cell lung cancer
    170921 (Itga2)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    170921 (Itga2)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    170921 (Itga2)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    170921 (Itga2)
   05414 Dilated cardiomyopathy
    170921 (Itga2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:rno04147]
    170921 (Itga2)
   04515 Cell adhesion molecules [BR:rno04515]
    170921 (Itga2)
   04090 CD molecules [BR:rno04090]
    170921 (Itga2)
Exosome [BR:rno04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   170921 (Itga2)
  Exosomal proteins of bladder cancer cells
   170921 (Itga2)
Cell adhesion molecules [BR:rno04515]
 Integrins
  Integrin alpha subunits
   170921 (Itga2)
CD molecules [BR:rno04090]
 Proteins
  170921 (Itga2)
SSDB
Motif
Pfam: Integrin_alpha2 VWA FG-GAP VWA_2 FG-GAP_2 FG-GAP_3 Integrin_alpha DUF11 HisK_sensor
Other DBs
NCBI-GeneID: 170921
NCBI-ProteinID: XP_345157
RGD: 621632
Ensembl: ENSRNOG00000058111
UniProt: A0A0G2K470
Position
2
AA seq 1178 aa
MGPGQAGGALLLQLLLLTQGLLSCLAYNVGLPGAKIFSGSSSEQFGYSVQQLTTPQGNWL
LVGSPWSGFPDNRMGDVYKCPVDLPTATCEKLNLQNSASISNVTEIKTNMSLGLTLTRNP
GTGGFLTCGPLWAHQCGNQYYATGICSDVSPDFQSLTSFSPAVQACPSLVDVVVVCDESN
SIYPWEAVKNFLEKFVQGLDIGPKKTQVALIQYANDPRVVFNLTTYKNKEDMVQATSETR
QYGGDLTNTFKAIQFARDIAYLPESGGRPGATKVMVVVTDGESHDGSKLQTVIQQCNDDE
ILRFGIAVLGYLNRNALDTKNLIKEIKAIASTPTERYFFNVADEAALLEKAGTLGEHIFS
IEGTVQGGDNFQMEMAQVGFSADYSPQNDILMLGAVGAFDWSGTVVQETSYEHLIFPKQA
FDQVLQDRNHSSFLGYSVAAISTENGVHFVAGAPRANYTGQIVLYSVNKHGNVTVIQSHR
GDQIGSYFGSVLCSVDVDKDTITDVLLVGAPMYMNDLKKEEGKVYLFTITKGVLNQHQFL
EGPEGTGNARFGSAIAALSDINMDGFNDVIVGSPVENENSGAVYIYNGHQGTIRTKYSQK
ILGSDGAFKSHLQFFGRSLDGYGDLNGDSITDVSIGALGQVVQLWSQSVADVATEASFTP
DKIILLNKEAKITLKLCFRAKFRPPGQNHQVAILFNMTLDADQYSSRVTSRGIFRENSER
FLQKTMVVSEVENCSEYHISIQKPSDVVNPLDLRVDISLEKPGTSPALEAYSETVKVFSI
PFYKECGSDGICISDLILDVRQLPALRNQPFIVSNQNKRLTFSVTLKNRGESAYNTAVLA
EFSENLFFASFSMPVDGTEVTCQIGSSQKSVTCDVGYPALKSEQQVTFTINFDFNLQNLQ
NQAAINFQAFSESQETNKADNSVSLIVPLLYDAELHLTRSTNINFYEISSDENAPSVINS
VEDIGPEFIFSLKITAGSAPVSMASVTIHIPLHTKEKNPLLYLTGIQTDKAGDISCRAEI
NPLNLPHTASPVSFKSENFRHMKELDCKTTSCSNVSCWLKDLHMKAEYFINVTTRVWNRT
FAASTFQTVQLTAAAEIDTHNPQLFVIEENAVTIPLMIMKPTEKAEVPTGVIIGSIIAGI
LLLLAMVAGLWKLGFFKRQYKKMGQNPDETDETTELNS
NT seq 3537 nt   +upstreamnt  +downstreamnt
atgggaccgggacaggcagggggcgcgcttctgctgcagctgctactgctcactcaaggt
cttttgagttgtctggcatataatgttggcctcccaggagcgaaaatattttctgggtct
tcaagtgaacagtttggctattcggtgcagcagcttacgaccccacaaggcaactggcta
ctggttggttcgccatggagtggcttccctgacaaccgaatgggagacgtgtacaagtgc
cctgttgacttacccactgccacctgtgaaaagctgaatctgcaaaattcagcaagcatc
tcaaatgttaccgagataaagaccaacatgagcctgggtttgaccctcaccaggaatccg
gggaccggcggctttctaacctgcggtcctctgtgggcacatcagtgtggaaatcagtat
tatgcaactggaatttgttctgatgtcagtccagactttcagtcgttgacaagcttctca
cctgcagttcaagcttgcccttccctcgtagatgtcgtagttgtctgtgatgaatcaaac
agtatttatccctgggaagcagtaaagaattttttggaaaagtttgtgcaaggcctggat
ataggacctaaaaagacacaggtggcgttaattcaatatgccaacgacccaagagttgtc
tttaacttgaccacttacaaaaacaaagaagatatggttcaggccacatccgagacgcgc
cagtatggtggggacctcacaaacaccttcaaggctatccaatttgcaagagacattgct
tatttaccggagtctggcgggcgcccaggtgctacaaaagtcatggtagttgtgactgat
ggggaatcccatgatgggtcgaagctgcaaactgtgatccagcaatgcaatgatgacgag
atactgaggtttggcatagcggttcttggatatttaaacagaaatgctcttgatactaaa
aatctaatcaaagaaattaaagcaatcgctagcactccaacggagaggtactttttcaat
gtggccgatgaggcggctcttctggagaaagctggcactctaggggagcacatattcagc
attgaaggcactgttcaaggaggagacaacttccagatggaaatggcacaagttggattc
agtgcagattactctcctcaaaatgatatcctgatgctaggtgcagtgggagcttttgac
tggagtggaactgttgtccaggagacatcttacgagcacttgatctttcctaaacaagcc
tttgaccaggttctgcaggatagaaatcacagttcatttttaggttactctgtggctgca
atttctactgaaaatggtgtccactttgttgctggtgctcctcgagcaaattatactggc
cagatagtgctgtacagtgttaacaagcatggcaatgtgaccgtgattcagtctcacaga
ggggaccagattggctcctattttggcagtgtgctgtgttcggtggatgtggataaagat
accattacagatgtgctcttggtaggtgctcccatgtacatgaacgacctcaagaaagaa
gaagggaaagtctacctgttcacaatcacaaagggcgtcctgaaccagcaccagtttctt
gaaggacctgaaggcactggaaatgctcggtttggttcagcaattgcagccctttcagac
atcaacatggatggctttaatgatgtgattgttggttcgcctgtagagaatgagaactct
ggagctgtgtacatctacaatggccaccagggtaccattcgcaccaagtactcccagaaa
atccttggatccgacggagcctttaagagccatctccagttctttggaaggtccctggat
ggctatggagatttaaatggggactccatcactgatgtatccattggtgctttggggcaa
gtggttcaactctggtcacaaagcgttgcagatgtggccacagaagcttcgttcactcca
gacaaaatcatattgctcaacaaggaagctaagataaccctcaaactctgcttcagagca
aagtttagacctcctgggcaaaaccaccaagtggccatcctgtttaacatgacacttgat
gctgaccaatattcatccagagtaacctccagggggatatttagagaaaatagtgagcga
ttcttgcagaagactatggttgtaagtgaagtggagaactgttctgagtaccacattagt
atacagaagccctctgatgttgtcaaccctttggatctgcgagtggacatcagtttggaa
aagccaggcactagccctgcccttgaagcctattcagaaactgtgaaagtcttcagtatc
cctttctataaagagtgtggcagcgatggaatttgcatctctgacctgatcctggatgtc
cgacagctgccagcccttagaaatcagccctttattgtcagtaaccaaaacaagaggtta
acattttcagtcacactgaaaaacagaggggaaagcgcgtacaacactgccgtcctggct
gagttttctgagaacttgttttttgcctctttctccatgccggtcgatggaacagaagta
acatgccagattggttcatcacagaaatctgttacctgtgacgtgggataccctgcctta
aagagtgagcagcaggtgacttttaccattaacttcgacttcaatcttcagaacctccag
aatcaggcggccatcaatttccaagccttcagtgagagccaagaaacaaacaaagcagac
aattcggtcagcctcatagttcctctcctgtatgacgctgaacttcacttaaccagatcc
accaacataaacttttatgaaatctcttcggatgagaatgctccttctgtcataaacagt
gttgaagatattggtcctgaattcatcttctctctcaagataacagcgggaagtgctcca
gtgagcatggcatcagtaaccatccacattcctctgcacaccaaggaaaagaacccactc
ctgtatctgaccgggatacaaacagacaaggctggcgacatcagctgcagagcagaaatt
aatccactaaacttaccacacacggcctcacccgtatctttcaagagtgaaaacttccgg
catatgaaagaattggactgcaaaaccacttcctgcagtaacgtctcctgctggctgaaa
gaccttcacatgaaagcggagtactttatcaatgtgactaccagggtttggaacaggacc
tttgctgcatcaactttccagactgtgcagctgacagcagcagccgagatcgatacgcat
aaccctcagctcttcgtgattgaagaaaatgctgtcacgattcccctcatgataatgaaa
cccaccgagaaagcagaagtgcccacaggagttatcataggaagcataattgctggaatc
cttttgctgttggctatggttgcaggcttgtggaagctcggcttcttcaaaagacaatat
aaaaaaatgggccaaaatccagatgagacggacgagaccacagaactcaacagctaa

KEGG   Rattus norvegicus (rat): 24511
Entry
24511             CDS       T01003                                 

Gene name
Itgb1
Definition
(RefSeq) integrin beta-1 precursor
  KO
K05719  integrin beta 1
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04015  Rap1 signaling pathway
rno04145  Phagosome
rno04151  PI3K-Akt signaling pathway
rno04360  Axon guidance
rno04510  Focal adhesion
rno04512  ECM-receptor interaction
rno04514  Cell adhesion molecules
rno04530  Tight junction
rno04611  Platelet activation
rno04670  Leukocyte transendothelial migration
rno04810  Regulation of actin cytoskeleton
rno05100  Bacterial invasion of epithelial cells
rno05133  Pertussis
rno05135  Yersinia infection
rno05140  Leishmaniasis
rno05145  Toxoplasmosis
rno05165  Human papillomavirus infection
rno05200  Pathways in cancer
rno05205  Proteoglycans in cancer
rno05222  Small cell lung cancer
rno05410  Hypertrophic cardiomyopathy
rno05412  Arrhythmogenic right ventricular cardiomyopathy
rno05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    24511 (Itgb1)
   04151 PI3K-Akt signaling pathway
    24511 (Itgb1)
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    24511 (Itgb1)
   04514 Cell adhesion molecules
    24511 (Itgb1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    24511 (Itgb1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    24511 (Itgb1)
   04530 Tight junction
    24511 (Itgb1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    24511 (Itgb1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    24511 (Itgb1)
   04670 Leukocyte transendothelial migration
    24511 (Itgb1)
  09158 Development and regeneration
   04360 Axon guidance
    24511 (Itgb1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    24511 (Itgb1)
   05205 Proteoglycans in cancer
    24511 (Itgb1)
  09162 Cancer: specific types
   05222 Small cell lung cancer
    24511 (Itgb1)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    24511 (Itgb1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    24511 (Itgb1)
   05133 Pertussis
    24511 (Itgb1)
   05100 Bacterial invasion of epithelial cells
    24511 (Itgb1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    24511 (Itgb1)
   05140 Leishmaniasis
    24511 (Itgb1)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    24511 (Itgb1)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    24511 (Itgb1)
   05414 Dilated cardiomyopathy
    24511 (Itgb1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:rno04131]
    24511 (Itgb1)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:rno04147]
    24511 (Itgb1)
   04515 Cell adhesion molecules [BR:rno04515]
    24511 (Itgb1)
   04090 CD molecules [BR:rno04090]
    24511 (Itgb1)
Membrane trafficking [BR:rno04131]
 Endocytosis
  Phagocytosis
   Integrins (complement receptors)
    24511 (Itgb1)
Exosome [BR:rno04147]
 Exosomal proteins
  Proteins found in most exosomes
   24511 (Itgb1)
Cell adhesion molecules [BR:rno04515]
 Integrins
  Integrin beta subunits
   24511 (Itgb1)
CD molecules [BR:rno04090]
 Proteins
  24511 (Itgb1)
SSDB
Motif
Pfam: Integrin_beta Integrin_b_cyt Integrin_B_tail I-EGF_1 PSI_integrin EGF_2
Other DBs
NCBI-GeneID: 24511
NCBI-ProteinID: NP_058718
RGD: 2927
Ensembl: ENSRNOG00000010966
UniProt: P49134 A0A0G2JSK5
Position
19
AA seq 798 aa
MNLQLVFWIGLISLICSVFGQTDKNRCLKANAKSCGECIQAGPNCGWCTNTTFLQEGMPT
SARCDDLEALKKKGCQPSDIENPRGSQTIKKNKNVTNRSKGMAEKLRPEDITQIQPQQLL
LKLRSGEPQKFTLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDF
RIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNVLSLTDRGEFFNELVGQQR
ISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQ
CHLENNVYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTL
SGNSSNVIQLIIDAYNSLSSEVILENSKLPDGVTINYKSYCKNGVNGTGENGRKCSNISI
GDEVQFEISITANKCPNKESETIKIKPLGFTEEVEVVLQFICKCNCQSHGIPASPKCHEG
NGTFECGACRCNEGRVGRHCECSTDEVNSEDMDAYCRKENSSEICSNNGECVCGQCVCRK
RENTNEIYSGKFCECDNFNCDRSNGLICGGNGVCRCRVCECYPNYTGSACDCSLDTVPCV
ATNGQICNGRGICECGACKCTDPKFQGPTCETCQTCLGVCAEHKECVQCRAFNKGEKKDT
CAQECSHFNLTKVESREKLPQPVQVDPVTHCKEKDIDDCWFYFTYSVNSNGEAHVHVVET
PDCPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTGEN
PIYKSAVTTVVNPKYEGK
NT seq 2397 nt   +upstreamnt  +downstreamnt
atgaatttgcaactggttttctggattggattgatcagcttgatttgttctgtatttggc
caaacagataaaaatagatgtttaaaagcaaatgccaaatcttgtggagaatgtatacaa
gcagggccaaattgtgggtggtgtacaaatacgacatttttacaagaaggaatgcctact
tctgcacgatgtgatgatttagaagctttgaaaaagaagggttgccaaccaagtgacata
gagaatcccagaggctcccaaactataaagaagaataaaaacgtcaccaatcgcagcaaa
gggatggcagagaagctccggccagaagacattactcagatccaaccacaacagctgctt
ctaaagttgcgatcaggagaaccacagaagtttacattaaaattcaagagggctgaagac
taccctattgatctgtactaccttatggatctctcctactctatgaaagatgatctggag
aatgtgaagagtcttgggacggatctgatgaatgaaatgaggaggattacttcagacttc
cgcattggctttggctcatttgtggagaaaactgtgatgccatacattagtacaacacca
gcaaagctaagaaatccttgtacgagtgaacaaaactgtaccagcccatttagctacaaa
aacgtgcttagtcttactgacagaggagagtttttcaatgaacttgttggtcagcagcgc
atatctggaaacttggactctccagaaggtggctttgatgcaatcatgcaggttgcagtt
tgtgggtcgctgattggctggaggaatgtaacacgactgctggtgttttccacggatgct
gggtttcactttgctggagatgggaaacttggtggtattgttttacccaatgatggccag
tgtcacctggaaaataatgtgtatacaatgagccattactatgattatccttcaattgct
caccttgttcagaaactaagtgaaaataatattcagacgatttttgcagtcactgaagag
ttccagcctgtttacaaggaattgaagaatttgattcctaagtcagcagtgggcacactg
tctggaaactctagtaatgtgatacagctgattatcgatgcctacaattccctttcttca
gaagtcattctggaaaacagcaaattgccagatggagtaacaataaattacaagtcctac
tgcaagaatggagtgaatgggacaggagaaaatggacgaaagtgctctaacatttccatt
ggagatgaggttcaatttgaaattagcataactgctaataaatgtccaaacaaggagtct
gaaacaattaaaattaaacctctgggcttcacagaagaagtagaggtggtccttcagttc
atctgtaagtgtaattgtcaaagccatggcatcccagcaagtcccaagtgccatgaggga
aatgggacatttgagtgtggagcctgcaggtgcaatgagggtcgtgttgggagacactgt
gaatgtagcacagatgaagtgaacagtgaagacatggatgcttactgcagaaaagagaac
agctcagagatctgcagtaacaatggagagtgtgtctgtggacagtgtgtgtgcaggaag
agagagaatacaaatgaaatttactccggcaaattctgcgagtgtgataacttcaactgc
gataggtccaacggcttaatctgtggaggaaatggtgtgtgcaggtgtcgtgtctgtgaa
tgctatcccaactacactggcagtgcatgtgactgttccttggacactgttccatgcgta
gcgacaaatggtcagatctgcaatggccggggcatctgtgaatgtggtgcttgtaagtgc
acagatcccaagttccaagggccaacctgtgagacctgtcagacctgccttggtgtctgt
gcagagcataaagaatgtgttcagtgcagagccttcaataaaggagaaaaaaaagacacg
tgtgcacaggagtgctcccatttcaacctcactaaagtggaaagcagggagaagttgccc
cagcctgtgcaggtggaccctgtgacccactgcaaggagaaggacattgatgactgctgg
ttctatttcacctactcagtgaacagcaacggtgaagctcacgtgcatgttgtggagact
ccagactgtcctactggtcccgacatcatcccaattgtagcaggcgtggttgccggaatt
gttcttattggccttgccttgctgctgatttggaaacttttaatgataattcatgacaga
agggaatttgctaaatttgaaaaggagaaaatgaatgccaagtgggacacgggtgaaaat
cctatttacaagagtgccgtgacaactgtggtcaatccgaagtatgagggaaaatga

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