KEGG   Rattus norvegicus (rat): 192647
Entry
192647            CDS       T01003                                 

Gene name
Mfn1
Definition
(RefSeq) mitofusin-1
  KO
K21356  mitofusin 1 [EC:3.6.5.-]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04137  Mitophagy - animal
rno04621  NOD-like receptor signaling pathway
rno05012  Parkinson disease
rno05022  Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:rno00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    192647 (Mfn1)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    192647 (Mfn1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    192647 (Mfn1)
   05022 Pathways of neurodegeneration - multiple diseases
    192647 (Mfn1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis [BR:rno03029]
    192647 (Mfn1)
Enzymes [BR:rno01000]
 3. Hydrolases
  3.6  Acting on acid anhydrides
   3.6.5  Acting on GTP to facilitate cellular and subcellular movement
    3.6.5.-  
     192647 (Mfn1)
Mitochondrial biogenesis [BR:rno03029]
 Mitochondrial quality control factors
  Mitochondrial dynamics
   Fission and Fusion factors
    192647 (Mfn1)
SSDB
Motif
Pfam: Fzo_mitofusin Dynamin_N MMR_HSR1 FadA
Other DBs
NCBI-GeneID: 192647
NCBI-ProteinID: NP_620432
RGD: 621460
Ensembl: ENSRNOG00000011057
UniProt: Q8R4Z9
Position
2
AA seq 741 aa
MAETVSPLKHFVLAKKAITAIFGQLLEFVTEGSHFVEATYRNPELDRIATEDDLVEIQGY
RNKLAVIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHTTNCFLSVEGTDG
DKAYLMTEGSDEKKSVKTVNQLAHALHMDKDLKAGCLVHVFWPKAKCALLRDDLVLVDSP
GTDVTTELDIWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWD
ASASEPEYMEDVRRQHMERCLHFLVEELKVVSPLEARNRIFFVSAKEVLNSRMNKAQGMP
EGGGALAEGFQARLQEFQNFEQTFEECISQSAVKTKFEQHTIRAKQILDTVKNILDSVNV
AAAEKRVYSMEEREDQIDRLDFIRNQMNLLTMDVKKKIKEVTEEVANKVSCAMTDEICRL
SVLVDEFCSEFHPTPSVLKVYKSELNKHIEDGMGRNLADRCTSEVNASILQSQQEIIENL
KPLLPAGIQNKLHTLIPCKKFDLSYDLNCHKLCSDFQEDIVFRFSLGWSSLVHRFLGSTN
AQRVLLGLSEPIFQVPRSLASTPTAPSNPAAPDNAAQEELMITLITGLASLTSRTSMGII
VVGGVIWKTVGWKLISVTLSMYGALYLYERLTWTTRAKERAFKQQFVNYATEKLQMIVKF
TSANCSHQVQQEMATTFARLCQQVDVTQKHLEEEIARLSKEIDQLEKIQNNSKLLRNKAV
QLERELENFSKQFLHPSSGES
NT seq 2226 nt   +upstreamnt  +downstreamnt
atggcagaaacggtatctccactgaagcacttcgtgctggcaaagaaggccatcactgcg
atcttcggccagttactggagtttgttactgagggctcacattttgttgaagcaacatac
aggaacccggaacttgatcggatagcaaccgaggatgatctggtggagatacagggctac
agaaacaagctcgctgtcattggggaggtgctgtctcggaggcatatgaaagtggcattt
tttggcaggacaagtagtggcaagagctctgtcatcaacgcaatgctgtgggataaagtc
ctccccagcgggattggtcacacaaccaactgcttcctgagtgtggagggaactgatgga
gataaagcctaccttatgaccgaagggtcagatgagaagaaaagcgtgaagactgttaat
cagctggcccatgccctccatatggataaagacttgaaagctggttgtcttgtgcacgta
ttttggcccaaagcaaaatgtgccctcttgagagatgacctggttttagtagacagccca
ggtacagatgtcaccacagagctggacatctggattgataagttctgccttgatgctgat
gtttttgttttggtggcaaactcggaatcaacgctgatgaacacggagaaacattttttc
cataaggtgaatgagcggctctccaagccaaacatttttatcctgaataatcgttgggat
gcttctgcttcagagccagaatatatggaggatgtgcgcagacagcacatggaaagatgt
cttcacttcttggtagaagagctcaaggttgtgagtcctttagaagctcggaatcggatc
ttttttgtttcagccaaggaagttctcaactccagaatgaataaagcccaggggatgcca
gaaggtggaggggcacttgcagaaggatttcaggcaagattacaggagtttcaaaatttt
gaacaaacttttgaggagtgtatctcgcagtcagcagtgaaaacaaagtttgaacagcac
actatcagagctaaacagatactagacactgtgaaaaacatactggactcagtaaacgtg
gcagcagcagagaagagggtttattcaatggaagagagggaagaccaaatcgacagactg
gactttattcgaaaccagatgaaccttttaacaatggatgttaagaagaagatcaaggag
gtcacggaggaggtggcaaacaaggtttcttgtgcaatgacagatgagatttgtcgcctg
tctgttttggttgatgagttttgttctgagtttcatcctacccccagtgtgctgaaagtg
tataagagtgaattaaataagcacatagaagatggcatgggaagaaatttggctgatcgg
tgcaccagtgaagtcaatgcctccattcttcaatctcagcaagaaatcattgaaaatttg
aagccactacttccagctggtatacagaataaacttcatacattaatcccttgcaaaaag
tttgatctcagctatgatctcaattgccacaagctgtgttcggattttcaagaagacatt
gtgtttcggttttccctgggctggtcttcccttgtacatcgattcctgggttctacgaat
gcacagagggtgctgcttgggctgtcagagcctatctttcaggtccctagatctttagct
tcaactcctactgctccttctaacccagcagcaccagataatgcagcccaggaagagctc
atgatcacactgatcacaggattggcatccctcacgtctagaacctccatgggcatcata
gttgttgggggcgtgatttggaaaacagtgggctggaaactcatctctgtcaccttaagt
atgtatggagctttgtacctttatgaaagactgacttggactactcgtgcgaaagagaga
gcgtttaagcagcagtttgtaaactatgcaactgaaaaactgcagatgattgtgaagttc
acaagtgcaaactgcagccaccaagtccagcaagaaatggccaccacttttgctcgactg
tgccaacaagttgatgttactcagaaacatctggaagaagaaattgctagattatccaaa
gagattgaccaactggagaaaatacaaaacaattcaaagctcttaagaaataaagctgtt
caacttgaacgtgagctggaaaatttttcgaagcagtttctccacccgagcagtggagaa
tcctaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (13)   
   RefSeq(nuc) (5)   
   GenBank (4)   
   EMBL (4)   
Protein domain (4)   
   Pfam (4)   
All databases (38)   

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KEGG   Rattus norvegicus (rat): 64476
Entry
64476             CDS       T01003                                 

Gene name
Mfn2
Definition
(RefSeq) mitofusin-2
  KO
K06030  mitofusin 2 [EC:3.6.5.-]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04137  Mitophagy - animal
rno04621  NOD-like receptor signaling pathway
rno05012  Parkinson disease
rno05022  Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:rno00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    64476 (Mfn2)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    64476 (Mfn2)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    64476 (Mfn2)
   05022 Pathways of neurodegeneration - multiple diseases
    64476 (Mfn2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:rno04131]
    64476 (Mfn2)
   03029 Mitochondrial biogenesis [BR:rno03029]
    64476 (Mfn2)
Enzymes [BR:rno01000]
 3. Hydrolases
  3.6  Acting on acid anhydrides
   3.6.5  Acting on GTP to facilitate cellular and subcellular movement
    3.6.5.-  
     64476 (Mfn2)
Membrane trafficking [BR:rno04131]
 Autophagy
  Mitophagy
   PINK1-Parkin associated proteins
    64476 (Mfn2)
  Other autophagy associated proteins
   ER-mitochondria tethering complex
    64476 (Mfn2)
Mitochondrial biogenesis [BR:rno03029]
 Mitochondrial quality control factors
  Mitochondrial dynamics
   Fission and Fusion factors
    64476 (Mfn2)
SSDB
Motif
Pfam: Fzo_mitofusin Dynamin_N MMR_HSR1 Synaptobrevin
Other DBs
NCBI-GeneID: 64476
NCBI-ProteinID: NP_570964
RGD: 628843
Ensembl: ENSRNOG00000046424
UniProt: Q6IRL2
Position
5
AA seq 757 aa
MSLLFSRCNSIVTVKKDKRHMAEVNASPLKHFVTAKKKINGIFEQLGAYIQESAGFLEDT
HRNTELDPVTTEEQVLDVKGYLSKVRGISEVLARRHMKVAFFGRTSNGKSTVINAMLWDK
VLPSGIGHTTNCFLRVGGTDGHEAFLLTEGSEEKKSVKTVNQLAHALHQDEQLHAGSLVS
VMWPNSKCPLLKDDLVLMDSPGIDVTTELDSWIDKFCLDADVFVLVANSESTLMQTEKQF
FHKVSERLSRPNIFILNNRWDASASEPEYMEEVRRQHMERCTSFLVDELGVVDRAQAGDR
IFFVSAKEVLSARVQKAQGMPEGGGALAEGFQVRMFEFQNFERRFEECISQSAVKTKFEQ
HTVRAKQIAEAVRLIMDSLHIAAQEQRVYCLEMREERQDRLRFIDKQLELLAQDYKLRIK
QMTEEVERQVSTAMAEEIRRLSVLVDEYQMDFHPSPVVLKVYKNELHRHIEEGLGRNMSD
RCSTAIASSLQTMQQDMIDGLKPLLPVSVRNQIDMLVPRQCFSLSYDLNCDKLCADFQED
IEFHFSLGWTMLVNRFLGPKNSRRALLGYNDQVQRPLPLTPANPSMPPLPQGSLTQEELM
VSMVTGLASLTSRTSMGILVVGGVVWKAVGWRLIALSFGLYGLLYVYERLTWTTRAKERA
FKRQFVEYASEKLQLIISYTGSNCSHQVQQELSGTFAHLCQQVDITRDNLEQEIAAMNKK
VEALDSLQSKAKLLRNKAGWLDSELNMFIHQYLQPSR
NT seq 2274 nt   +upstreamnt  +downstreamnt
atgtccctgctcttttctcgatgcaactccatcgtcaccgtcaagaaggataagcgacac
atggctgaggtgaatgcttcccctctcaagcactttgtcactgccaagaaaaagatcaat
ggcatctttgagcagctgggggcctacatccaagagagtgccggcttccttgaagacacc
cacaggaatacagaactggacccagttactacagaagagcaggtcctggatgtcaaaggg
tacctgtccaaggtcaggggaatcagcgaggtgctggccaggcggcacatgaaggtggct
ttttttggccggacgagcaatgggaagagcaccgtgatcaatgccatgctttgggacaaa
gttctgccatctgggattggccacaccaccaattgcttcctgcgggttgggggcacggat
ggccacgaggccttcctcctcacggagggctcagaagagaagaagagtgtcaagaccgtg
aaccagctagcccatgccctccatcaggatgagcagctgcatgcaggcagcctggtgagt
gtgatgtggcccaactccaagtgtccacttctgaaggatgacctcgtgctgatggacagc
cctgggatcgatgtcaccacggagctggacagctggattgataagttttgcctggatgct
gatgtgtttgtactggtggccaactcagagtccacgctgatgcagacggagaagcagttc
ttccacaaagtgagtgagcgtctctcccggcccaacatcttcatcctgaacaaccgctgg
gatgcgtctgcctcggagcctgagtacatggaggaggtgcggcggcagcacatggaacgc
tgcaccagctttctggtggatgagctaggcgtggtggatcgagctcaggccggggaccgg
atcttctttgtgtctgccaaggaggtgctcagtgccagggtccagaaagcccagggcatg
ccagaaggaggtggcgctcttgcagaaggttttcaagtgaggatgtttgagtttcagaat
ttcgagaggcgatttgaggagtgcatttcccagtctgcagtaaagaccaaatttgagcag
cacacagtccgggccaagcagattgcagaggccgtccgtctcatcatggattccctgcac
attgcggctcaggagcagcgggtttattgtcttgaaatgcgggaagagcggcaagaccgg
ctgagattcattgacaagcagctggagctcctggctcaagactataagctacggattaag
cagatgacagaggaagtggaaaggcaggtgtccacagccatggctgaagagatcaggcgc
ctctctgtgctggttgacgagtaccagatggactttcacccatccccagttgtcctcaag
gtttataagaatgaactgcaccgccatatagaggaaggcctgggacgaaacatgtctgac
cgctgctccacagccattgccagttcactgcagactatgcagcaagacatgatagacggc
ttgaagccccttcttcctgtgtctgtgcggaatcagatagacatgctggtccctcgacag
tgtttctccctcagctatgacctgaactgtgacaagctgtgcgctgactttcaggaggac
atcgaattccatttctcccttggatggactatgctagtgaataggttcctgggccctaag
aatagccggcgggccttgctgggctacaatgatcaggttcagcgtcctctccctctgaca
cctgccaaccccagcatgccacccttgccacagggctccctcacccaggaggagctcatg
gtctccatggttactggcctggcctctctgacttccaggacctctatgggcattctcgtg
gtcggaggagtggtgtggaaggcagtgggctggagactcatcgccctctcctttggactg
tatggcctcctgtacgtgtatgagcggctgacctggaccaccagagccaaggagagggcc
ttcaagcgccagtttgtggagtatgccagtgagaagctgcagctcattatcagttatacc
ggctctaactgcagccaccaagttcagcaagaattgtctgggacatttgctcatctgtgc
cagcaagttgacatcacccgggataatctggagcaggaaattgctgccatgaacaagaaa
gttgaggctctggattcacttcagagcaaagccaaattgctcaggaataaagctggctgg
ttggacagcgaactcaacatgttcatacaccagtacctgcagcccagcagatag

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (4)   
   KEGG PATHWAY (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (5)   
   UniProt (1)   
   RefSeq(pep) (4)   
DNA sequence (10)   
   RefSeq(nuc) (4)   
   GenBank (3)   
   EMBL (3)   
Protein domain (4)   
   Pfam (4)   
All databases (34)   

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