KEGG   Rattus norvegicus (rat): 24312Help
Entry
24312             CDS       T01003                                 

Gene name
Dhfr, Dhfr1
Definition
(RefSeq) dihydrofolate reductase
  KO
K00287  dihydrofolate reductase [EC:1.5.1.3]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00670  One carbon pool by folate
rno00790  Folate biosynthesis
rno01100  Metabolic pathways
rno01523  Antifolate resistance
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    24312 (Dhfr)
   00670 One carbon pool by folate
    24312 (Dhfr)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    24312 (Dhfr)
Enzymes [BR:rno01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     24312 (Dhfr)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: DHFR_1
Motif
Other DBs
NCBI-GeneID: 24312
NCBI-ProteinID: NP_569084
RGD: 2500
Ensembl: ENSRNOG00000013521
Vega: OTTRNOG00000000125
UniProt: Q920D2 B0BMV8
Position
2q12
AA seq 187 aa AA seqDB search
MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKF
EVYEKKD
NT seq 564 nt NT seq  +upstreamnt  +downstreamnt
atggttcgtccgctgaactgcatcgtcgccgtgtcccaaaatatgggcattggcaagaac
ggagacttaccctggcctctgctcaggaatgagttcaagtacttccagagaatgaccaca
acctcttcagtagaaggtaaacagaatctggtgattatgggtaggaaaacctggttctcc
attcctgagaagaatcgacctttaaaggacagaattaatatagttctcagtagagaactc
aaggaaccaccacaaggagctcattttcttgccaaaagtctggatgatgccttaaaactt
attgaacaaccagagctagcaagtaaagtggacatggtctgggtagtcggaggcagctct
gtctaccaggaagccatgaatcagccaggccacctcagactctttgtgacaaggatcatg
caggagtttgaaagtgacacattcttcccagaaattgatttggagaaatataaacttctc
ccagaatacccaggcgtcctctctgagatccaggaggaaaaaggcatcaagtacaagttt
gaagtctatgaaaagaaagactaa

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