KEGG   Rattus norvegicus (rat): 24312Help
Entry
24312             CDS       T01003                                 

Gene name
Dhfr, Dhfr1
Definition
(RefSeq) dihydrofolate reductase
  KO
K00287  dihydrofolate reductase [EC:1.5.1.3]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00670  One carbon pool by folate
rno00790  Folate biosynthesis
rno01100  Metabolic pathways
rno01523  Antifolate resistance
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    24312 (Dhfr)
   00670 One carbon pool by folate
    24312 (Dhfr)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    24312 (Dhfr)
Enzymes [BR:rno01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     24312 (Dhfr)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: DHFR_1
Motif
Other DBs
NCBI-GeneID: 24312
NCBI-ProteinID: NP_569084
RGD: 2500
Ensembl: ENSRNOG00000013521
Vega: OTTRNOG00000000125
UniProt: Q920D2 B0BMV8
Position
2q12
AA seq 187 aa AA seqDB search
MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKF
EVYEKKD
NT seq 564 nt NT seq  +upstreamnt  +downstreamnt
atggttcgtccgctgaactgcatcgtcgccgtgtcccaaaatatgggcattggcaagaac
ggagacttaccctggcctctgctcaggaatgagttcaagtacttccagagaatgaccaca
acctcttcagtagaaggtaaacagaatctggtgattatgggtaggaaaacctggttctcc
attcctgagaagaatcgacctttaaaggacagaattaatatagttctcagtagagaactc
aaggaaccaccacaaggagctcattttcttgccaaaagtctggatgatgccttaaaactt
attgaacaaccagagctagcaagtaaagtggacatggtctgggtagtcggaggcagctct
gtctaccaggaagccatgaatcagccaggccacctcagactctttgtgacaaggatcatg
caggagtttgaaagtgacacattcttcccagaaattgatttggagaaatataaacttctc
ccagaatacccaggcgtcctctctgagatccaggaggaaaaaggcatcaagtacaagttt
gaagtctatgaaaagaaagactaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (4)   
   KEGG MODULE (2)   
Chemical substance (10)   
   KEGG COMPOUND (10)   
Chemical reaction (8)   
   KEGG ENZYME (1)   
   KEGG REACTION (7)   
Genome (1)   
   KEGG GENOME (1)   
Gene (7)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (5)   
   RefSeq(nuc) (1)   
   GenBank (2)   
   EMBL (2)   
Protein domain (1)   
   Pfam (1)   
All databases (44)   

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