KEGG   Rattus norvegicus (rat): 24470
Entry
24470             CDS       T01003                                 
Symbol
Hsd3b5
Name
(RefSeq) NADPH-dependent 3-keto-steroid reductase Hsd3b5
  KO
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00140  Steroid hormone biosynthesis
rno01100  Metabolic pathways
rno04913  Ovarian steroidogenesis
rno04925  Aldosterone synthesis and secretion
rno04927  Cortisol synthesis and secretion
rno04934  Cushing syndrome
Module
rno_M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
rno_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
rno_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
rno_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    24470 (Hsd3b5)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    24470 (Hsd3b5)
   04925 Aldosterone synthesis and secretion
    24470 (Hsd3b5)
   04927 Cortisol synthesis and secretion
    24470 (Hsd3b5)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    24470 (Hsd3b5)
Enzymes [BR:rno01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     24470 (Hsd3b5)
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     24470 (Hsd3b5)
SSDB
Motif
Pfam: 3Beta_HSD Epimerase NAD_binding_4 GDP_Man_Dehyd NAD_binding_10 NmrA Polysacc_synt_2 KR RmlD_sub_bind Ldh_1_N Sacchrp_dh_NADP DapB_N
Other DBs
NCBI-GeneID: 24470
NCBI-ProteinID: NP_036716
RGD: 2838
Ensembl: ENSRNOG00000019417
UniProt: P27364 A6K3D9 A0A0G2JSR3
Position
2:complement(188697669..188717141)
AA seq 373 aa
MPGWSCLVTGAGGFLGQRIVQMLVQEKELQEVRVLYRTFSPKHKEELSKLQTKAKVTVLR
GDIVDAQFLRRACQGMSVIIHTAAALDIAGFLPRQTILDVNVKGTQLLLDACVEASVPAF
IYSSSTGVAGPNSYKETILNDREEEHRESTWSNPYPYSKRMAEKAVLAANGSILKNGGTL
HTCALRLPFIYGEESQIISTMVNTALKNNSIIKRHATFSIANPVYVGNAAWAHILAARGL
RDPEKSQSIQGQFYYISDDTPHQSYDDLNYTLSKEWGFCLDSSWSLPLPLLYWLAFLLET
VSFLLRPFYNYRPPFNRFMVTILNSVFTISYKKAQRDLGYEPLVSWEEAKQKTSEWIGTL
VEQHRETLDTKSQ
NT seq 1122 nt   +upstreamnt  +downstreamnt
atgcctgggtggagctgcctggtgacaggagcaggaggatttctgggccagaggattgtc
caaatgttggtgcaagagaaagagctgcaggaggtcagagtcctgtataggaccttcagt
ccaaaacacaaagaggaactgtccaagctgcagacaaaagccaaggtgacggtactgagg
ggagacattgtggatgcccagttcctgaggagagcgtgccagggcatgtccgtcatcatc
cacaccgctgctgcccttgatatcgcaggcttcctgcccaggcagaccatcctagatgtc
aatgtgaaaggtactcagctcctgttggatgcttgtgtggaagccagcgtaccagccttc
atctacagcagctcaacaggtgtggctggaccaaactcctacaaggagaccatcctgaac
gaccgtgaggaagagcatcgtgaaagcacatggtcaaatccatacccatacagcaaaagg
atggccgagaaggcagtgctggcagccaatgggagcatcctgaaaaatggtggcactttg
catacgtgtgccttaagactcccattcatctatggggaagaaagccaaatcatttcaacc
atggtaaatacagcactcaagaacaacagcataattaaaagacatgccacattctccata
gccaacccagtgtatgtgggtaatgcagcctgggcacacattctggctgccaggggcctt
cgagaccccgagaagtcacaaagcatccaaggacagttctactacatctcagatgacacc
cctcaccaaagctatgatgatttaaattataccctgagcaaagaatggggcttctgcctt
gattccagttggagccttcctctgcccctgctctactggcttgccttcctgctggaaact
gtgagcttcctgctgcgtccattttacaactataggccaccctttaaccgcttcatggtc
acgatcttaaatagcgtgtttaccatttcctacaaaaaagctcagagagatctgggctat
gagccacttgtcagctgggaggaagccaagcaaaaaacctcagagtggatcgggacacta
gtggagcaacacagggagacactggacacaaagtctcaatga

  All links  
Gene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (6)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (6)   
   RefSeq(nuc) (2)   
   GenBank (2)   
   EMBL (2)   
Protein domain (12)   
   Pfam (12)   
All databases (29)   

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