KEGG   Rattus norvegicus (rat): 24479
Entry
24479             CDS       T01003                                 

Gene name
Idh1
Definition
(RefSeq) isocitrate dehydrogenase [NADP] cytoplasmic
  KO
K00031  isocitrate dehydrogenase [EC:1.1.1.42]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00020  Citrate cycle (TCA cycle)
rno00480  Glutathione metabolism
rno01100  Metabolic pathways
rno01200  Carbon metabolism
rno01210  2-Oxocarboxylic acid metabolism
rno01230  Biosynthesis of amino acids
rno04146  Peroxisome
rno05230  Central carbon metabolism in cancer
Module
rno_M00009  Citrate cycle (TCA cycle, Krebs cycle)
rno_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    24479 (Idh1)
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    24479 (Idh1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    24479 (Idh1)
 09160 Human Diseases
  09161 Cancer: overview
   05230 Central carbon metabolism in cancer
    24479 (Idh1)
Enzymes [BR:rno01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.42  isocitrate dehydrogenase (NADP+)
     24479 (Idh1)
SSDB
Motif
Pfam: Iso_dh
Other DBs
NCBI-GeneID: 24479
NCBI-ProteinID: NP_113698
RGD: 2862
Ensembl: ENSRNOG00000015020
UniProt: P41562
Position
9
AA seq 414 aa
MSRKIHGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDA
AEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
VTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGSQKVTYLVHDFEEGGGVAM
GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSKFE
AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFANALE
EVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLAQAKL
NT seq 1245 nt   +upstreamnt  +downstreamnt
atgtccagaaaaatccatggcggttctgtggtggaaatgcaaggagatgaaatgacacgg
atcatctgggaattgattaaagaaaagctcattcttccctacgtggaactggatctgcat
agctatgacttaggcatagagaatcgggatgccaccaatgaccaggtcaccaaggatgct
gcggaggctataaagaaatacaacgtcggcgtcaagtgtgctaccatcacccccgatgag
aagagggttgaggagttcaagttgaaacaaatgtggaaatcacccaacggtaccatccgg
aacattctgggcggcactgtcttcagagaagctattatctgcaaaaatatcccccggcta
gtgacaggctgggtaaaacccatcatcattggccgacacgcctatggggaccaatacaga
gcaacagatttcgttgttcctgggcctggaaaagtagagataacctacacaccaaaagat
gggtcgcagaaagtgacatacctggtgcatgactttgaagaaggtggtggtgttgccatg
ggtatgtacaaccaggataagtcaattgaagattttgcacacagttccttccaaatggct
ctgtcgaagggctggcctttgtatctaagcaccaagaacactattctgaagaagtatgat
ggacgcttcaaagacatcttccaggagatctatgacaagcaatacaagtccaagtttgaa
gctcagaagatctggtatgaacacaggctcatagatgacatggtggcccaggctatgaaa
tcagaaggaggcttcatctgggcctgtaagaactatgatggtgatgtgcagtcagactca
gtagcccaaggttatggctcccttggcatgatgaccagtgtgctgatttgtccagatggt
aagacggtagaagcagaggctgcccatggcactgtcacacgtcactaccgcatgtaccag
aaaggacaggagacgtccaccaatcccattgcttccatttttgcctggtcccgagggtta
gcccacagagcaaagcttgacaacaatactgagctcagcttctttgcaaatgctttggaa
gaagtctgcattgagaccattgaggctggctttatgactaaggacttggctgcttgcatt
aaaggcttacccaatgtacagcgttctgactacttgaatacatttgagtttatggacaaa
cttggagaaaacttgaaggccaaactagctcaggccaaactttaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (12)   
   KEGG PATHWAY (8)   
   KEGG MODULE (4)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (13)   
   RefSeq(nuc) (3)   
   GenBank (5)   
   EMBL (5)   
Protein domain (1)   
   Pfam (1)   
All databases (51)   

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KEGG   Rattus norvegicus (rat): 361596
Entry
361596            CDS       T01003                                 

Gene name
Idh2
Definition
(RefSeq) isocitrate dehydrogenase [NADP], mitochondrial precursor
  KO
K00031  isocitrate dehydrogenase [EC:1.1.1.42]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00020  Citrate cycle (TCA cycle)
rno00480  Glutathione metabolism
rno01100  Metabolic pathways
rno01200  Carbon metabolism
rno01210  2-Oxocarboxylic acid metabolism
rno01230  Biosynthesis of amino acids
rno04146  Peroxisome
rno05230  Central carbon metabolism in cancer
Module
rno_M00009  Citrate cycle (TCA cycle, Krebs cycle)
rno_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    361596 (Idh2)
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    361596 (Idh2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    361596 (Idh2)
 09160 Human Diseases
  09161 Cancer: overview
   05230 Central carbon metabolism in cancer
    361596 (Idh2)
Enzymes [BR:rno01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.42  isocitrate dehydrogenase (NADP+)
     361596 (Idh2)
SSDB
Motif
Pfam: Iso_dh
Other DBs
NCBI-GeneID: 361596
NCBI-ProteinID: NP_001014183
RGD: 1597139
Ensembl: ENSRNOG00000013949
UniProt: P56574
Position
1
AA seq 452 aa
MAGYLRAVSSLCRASGSTRTWAPAALNVPSWPEQPRRHYAEKRIKVEKPVVEMDGDEMTR
IIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSALATQKYSVAVKCATITPDE
ARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYK
ATDFVVDRAGMFKLVFTPKDGSGAKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYSI
QKKWPLYLSTKNTIMKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS
SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK
GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVQTVESGAMTKDLAGCIH
GLSNVKLNEHFLNTTDFLDTIKSNLDRALGKQ
NT seq 1359 nt   +upstreamnt  +downstreamnt
atggccggctatctgcgggccgtgagctcgctctgcagagcctcgggctcaacacggacc
tgggcaccggctgcactgaatgtccccagctggccggagcagccgcggcgccactatgct
gagaagagaatcaaggtggagaagccggtggtggagatggatggcgatgagatgacccgg
atcatctggcagttcatcaaggagaagctcatcctgcctcacgtggatgtccagctcaag
tattttgaccttgggcttccaaaccgtgaccagaccaatgaccaggtcaccatcgactct
gcgctggccactcagaagtacagtgtggctgttaagtgtgctacaatcacccccgatgag
gcccgtgtggaagagttcaagctgaagaaaatgtggaagagccctaacggaactatccgt
aacatccttgggggaacggtcttcagagagccaattatctgcaaaaatatcccccgcctt
gtccctggctggaccaagcccatcaccattggcagacacgcccatggcgaccagtacaag
gccacagattttgtggtagatcgagctggcatgttcaagttggtcttcaccccaaaggat
ggcagtggtgccaaggagtgggaggtgtataacttccctgccggaggcgttggtatgggg
atgtacaacaccgacgagtccatttcgggcttcgcgcacagctgcttccagtactctatc
cagaagaaatggccgctctacttgagcaccaagaacaccattatgaaggcctatgacggg
cgtttcaaggacatcttccaggagatctttgacaagcactataagactgactttgacaag
aataagatctggtacgagcatcggctcattgacgacatggtggctcaggtgctcaagtct
tccggtggctttgtgtgggcctgcaagaactatgacggagatgtacagtctgacatcctg
gctcaaggatttggctcccttggcctgatgacatctgtgctggtctgccctgacgggaag
accattgaagctgaggctgctcacgggacagtcacccgccactaccgagaacaccagaag
ggccggcccaccagtaccaaccctattgccagcatctttgcctggacacggggtctggag
catcgagggaagctggatgggaaccaggacctcatcaggtttgcacagactctggagaag
gtgtgcgtgcagactgtggagagcggagctatgaccaaggacctggctggctgcatccat
ggcctcagcaatgtgaagctgaatgagcacttcctgaacaccacagacttcctggacacc
attaagagcaacctggacagagctctgggcaagcagtag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (12)   
   KEGG PATHWAY (8)   
   KEGG MODULE (4)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (3)   
   RefSeq(nuc) (1)   
   GenBank (1)   
   EMBL (1)   
Protein domain (1)   
   Pfam (1)   
All databases (39)   

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