KEGG   Rattus norvegicus (rat): 24514
Entry
24514             CDS       T01003                                 

Gene name
Jak2
Definition
(RefSeq) tyrosine-protein kinase JAK2
  KO
K04447  Janus kinase 2 [EC:2.7.10.2]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno01521  EGFR tyrosine kinase inhibitor resistance
rno04062  Chemokine signaling pathway
rno04151  PI3K-Akt signaling pathway
rno04217  Necroptosis
rno04550  Signaling pathways regulating pluripotency of stem cells
rno04630  JAK-STAT signaling pathway
rno04658  Th1 and Th2 cell differentiation
rno04659  Th17 cell differentiation
rno04725  Cholinergic synapse
rno04917  Prolactin signaling pathway
rno04920  Adipocytokine signaling pathway
rno04933  AGE-RAGE signaling pathway in diabetic complications
rno04935  Growth hormone synthesis, secretion and action
rno05140  Leishmaniasis
rno05145  Toxoplasmosis
rno05152  Tuberculosis
rno05161  Hepatitis B
rno05164  Influenza A
rno05167  Kaposi sarcoma-associated herpesvirus infection
rno05168  Herpes simplex virus 1 infection
rno05200  Pathways in cancer
rno05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
rno05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    24514 (Jak2)
   04151 PI3K-Akt signaling pathway
    24514 (Jak2)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    24514 (Jak2)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    24514 (Jak2)
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    24514 (Jak2)
   04659 Th17 cell differentiation
    24514 (Jak2)
   04062 Chemokine signaling pathway
    24514 (Jak2)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    24514 (Jak2)
   04917 Prolactin signaling pathway
    24514 (Jak2)
   04935 Growth hormone synthesis, secretion and action
    24514 (Jak2)
  09156 Nervous system
   04725 Cholinergic synapse
    24514 (Jak2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    24514 (Jak2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    24514 (Jak2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    24514 (Jak2)
   05164 Influenza A
    24514 (Jak2)
   05168 Herpes simplex virus 1 infection
    24514 (Jak2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    24514 (Jak2)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    24514 (Jak2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    24514 (Jak2)
   05140 Leishmaniasis
    24514 (Jak2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    24514 (Jak2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    24514 (Jak2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    24514 (Jak2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:rno01001]
    24514 (Jak2)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     24514 (Jak2)
Protein kinases [BR:rno01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   24514 (Jak2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 Jak1_Phl SH2 ABC1 Kinase-like RIO1 APH
Other DBs
NCBI-GeneID: 24514
NCBI-ProteinID: NP_113702
RGD: 2939
Ensembl: ENSRNOG00000059968
UniProt: Q62689
Position
1
AA seq 1132 aa
MGMACLTMTEMEGTSTSPAHQNGDIPGNANSVKQTEPVLQVYLYHSLGQAEGDYLKFPNG
EYVAEEICVAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNILYRIRFYF
PHWYCSGSNRTYRYGVSRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKEKDQTPLAVYNSISYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIQQF
SQCKATARNLKLKYLINLETLQSAFYTEQFEVKESARGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPDIIDVSIKQANQECSTESRVVTVHKQDGKVLEIELSSLK
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIHSNCHGPISMDFAISKLKKAGNQT
GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENGEYNLSGTKRNFSSLKDLLNC
YQMETVRSDSIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVQLSPTLQRHNNVNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLGVAKQLAWA
MHFLEEKSLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLTLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDKHQLPAPKWTEL
ANLINTCMDYEPDFRPAFRAVIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD
PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE
ILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQI
CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW
YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIE
LLKNNGRLPRPEGCPDEIYVIMTECWNNNVNQRPSFRDLSLRVDQIRDSMAA
NT seq 3399 nt   +upstreamnt  +downstreamnt
atgggaatggcttgccttacaatgacagaaatggagggaacctccacatctcctgcacat
cagaatggtgatattcctggaaatgctaactctgtgaagcagacagagccagtccttcaa
gtgtacctgtaccattctcttgggcaagctgaaggagactatctgaagtttccaaatgga
gagtatgttgccgaagaaatttgtgtggctgcttctaaagcatgtggtattacgcctgtg
tatcataatatgtttgctttaatgagtgaaacagaaaggatctggtatccacccaatcat
gtcttccacatagatgagtcaaccaggcataatatactctacagaataaggttttacttt
cctcattggtactgcagtggcagcaacagaacctataggtacggagtatctcgtggggct
gaagctcctctccttgacgactttgtcatgtcttacctttttgctcagtggcggcatgat
tttgttcatgggtggataaaagtacctgtgactcacgaaactcaggaagaatgtcttggc
atggcagtgttagacatgatgagaatagctaaggagaaggaccagactcccctggctgtc
tataactccatcagctacaagacgttcttaccgaagtgcgtgcgagcgaagatccaggac
tatcacattttaactcggaagcggataaggtacagattccgcaggttcattcagcagttc
agtcagtgcaaagccactgccaggaacctaaaacttaagtatctcataaacctggagacc
ctgcagtctgccttctacacagaacagtttgaagtaaaagaatctgcaagaggtccttca
ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga
gggaaacataaggaaagtgagacactgacagaacaggatttacagttgtattgtgatttt
cctgatattattgatgtcagtattaagcaagcaaatcaggaatgctcaactgaaagtaga
gttgtgaccgtccacaagcaggacgggaaggtcttggaaatagaacttagctcattaaaa
gaagccttgtcatttgtgtcgttaattgacgggtattacagactaactgcggatgcacac
cattacctctgtaaagaggtggctcctccagccgtgcttgaaaacatacacagcaactgt
cacggcccaatttcaatggattttgccatcagcaaactaaagaaggcaggaaaccagact
ggactgtatgtacttcgatgtagccctaaggacttcaacaaatacttcctgacctttgcc
gttgagcgagaaaatgttattgaatataaacactgtttgattacaaagaatgagaatgga
gagtacaacctcagtgggactaagaggaacttcagtagtcttaaggaccttttgaattgc
taccagatggaaactgtgcgctcagacagtatcatcttccagttcaccaaatgctgtcct
ccaaagccgaaagataaatcaaaccttcttgtcttcagaacaaatggtgtttctgatgtt
cagctctcaccaacattacagaggcataataatgtgaatcaaatggtgtttcacaaaatc
aggaatgaagatttgatatttaatgaaagccttggccaaggcacttttacaaaaatattt
aaaggtgtaagaagagaagttggagattatggtcagctgcacgaaaccgaagttcttttg
aaagtcctagataaagcacatagaaactattcagagtctttctttgaagcagcaagcatg
atgagtcagctttctcacaagcatttggttttgaattatggagtatgtgtctgtggagag
gagaacattttggttcaagagtttgtaaaatttggatccctggatacatacctgaaaaaa
aacaaaaattccataaatatactatggaaacttggagtggccaaacagttggcatgggcc
atgcacttcctcgaagaaaaatcccttattcatgggaatgtgtgtgccaaaaatatcctg
cttatcagagaagaagacaggaaaacagggaatccacctttcatcaaacttagtgatcct
gggattagcatcacagttctaccaaaggacattcttcaggagagaataccatgggtacca
cctgagtgcattgaaaaccctaaaaatctaactttggcaacagacaagtggagctttggc
accactctgtgggagatctgcagtggaggagacaagcctctgagtgctctggactctcaa
agaaagctgcagttctatgaagataagcaccagctcccagcacccaagtggacagagttg
gcaaaccttataaatacttgcatggattatgagccagacttcaggcctgccttcagagct
gtcatccgtgatctgaacagcctgtttactccagattatgaactgctgacagaaaatgac
atgctacccaacatgagaataggtgccctaggattttctggtgcttttgaagacagggac
cctacacagtttgaagagagacacttgaaatttctacagcaacttggcaagggtaacttt
gggagtgtggagatgtgccgctatgacccgctgcaggacaacactggagaggtggtagct
gttaagaagctccagcacagcacggaagagcatctccgagactttgaaagggaaattgaa
atcctgaaatccttgcagcatgacaacatcgtgaagtacaagggagtgtgctacagtgct
ggtcggcgcaacctaagattaattatggaatatttgccgtatggaagtttacgagactat
ctccaaaaacataaagaacggatagatcacaaaaaacttctgcagtatacatcccagata
tgcaagggcatggagtatcttggtacaaaaaggtatatccaccgggatctggcaacaagg
aatatattggtagaaaatgagaacagagttaaaataggagattttggattaaccaaagtc
ttgccacaggacaaagaatactacaaagtaaaggaaccaggtgaaagtcccatattctgg
tatgctcccgaatccttgacagagagcaagttttctgtggcctcagatgtgtggagcttt
ggtgtggttctgtacgaacttttcacgtatatcgagaagagcaaaagcccacctgtggaa
tttatgcgaatgatcggcaatgataaacaagggcagatgatcgtattccatttgatagag
ctactgaagaacaacggaagactgccgagaccagaagggtgcccagacgagatttatgtg
atcatgacagaatgctggaacaacaatgtcaaccaacgtccctctttcagggacctttcc
cttcgggtggatcaaatccgggacagtatggctgcatga

KEGG   Rattus norvegicus (rat): 25326
Entry
25326             CDS       T01003                                 

Gene name
Jak3
Definition
(RefSeq) tyrosine-protein kinase JAK3
  KO
K11218  Janus kinase 3 [EC:2.7.10.2]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04062  Chemokine signaling pathway
rno04151  PI3K-Akt signaling pathway
rno04217  Necroptosis
rno04550  Signaling pathways regulating pluripotency of stem cells
rno04630  JAK-STAT signaling pathway
rno04658  Th1 and Th2 cell differentiation
rno04659  Th17 cell differentiation
rno05161  Hepatitis B
rno05162  Measles
rno05166  Human T-cell leukemia virus 1 infection
rno05169  Epstein-Barr virus infection
rno05200  Pathways in cancer
rno05203  Viral carcinogenesis
rno05223  Non-small cell lung cancer
rno05340  Primary immunodeficiency
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    25326 (Jak3)
   04151 PI3K-Akt signaling pathway
    25326 (Jak3)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    25326 (Jak3)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    25326 (Jak3)
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    25326 (Jak3)
   04659 Th17 cell differentiation
    25326 (Jak3)
   04062 Chemokine signaling pathway
    25326 (Jak3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    25326 (Jak3)
   05203 Viral carcinogenesis
    25326 (Jak3)
  09162 Cancer: specific types
   05223 Non-small cell lung cancer
    25326 (Jak3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    25326 (Jak3)
   05161 Hepatitis B
    25326 (Jak3)
   05162 Measles
    25326 (Jak3)
   05169 Epstein-Barr virus infection
    25326 (Jak3)
  09163 Immune disease
   05340 Primary immunodeficiency
    25326 (Jak3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:rno01001]
    25326 (Jak3)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     25326 (Jak3)
Protein kinases [BR:rno01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   25326 (Jak3)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 Jak1_Phl APH ABC1 pKID Kdo Haspin_kinase
Other DBs
NCBI-GeneID: 25326
NCBI-ProteinID: NP_036987
RGD: 2940
Ensembl: ENSRNOG00000018669
UniProt: Q63272
Position
16
AA seq 1100 aa
MAPPSEETPLISQRSCSLSSSEAGALHVLLPPRGPGPPQRLSFSFGDYLAEDLCVRAAKA
CGILPVYHSLFALATEDLSCWFPPSHIFSIEDVDTQVLVYRLRFYFPGWFGLETCHRFGL
HKDLTSAILDVHVLEHLFAQHRSDLVSGRLPVGLSLKDQGEFLSLAVLDLAQMARKQAQR
PGELLKSVSYKACLPPSLRDLIQGQSFVTRRRIRRTVVQALRRVVACQADRYALMAKYIL
DLERLHPAATTESFLVGLPGAQEEPGCLRVTGDNGIAWSSKDQELFQTFCDFPEIVDVSI
KQAPRVGPAGEHRLVTITRMDGHILEAEFPGLPEALSFVALVDGYFRLICDSRHFFCKEV
APPRLLEEEAELCHGPITLDFAIHKLKAAGSLPGSYILRRSPQDYDSFLLTACVQTPLGP
DYKGCLIRQDPSGAFSLVGLSQLHRSLQELLTACWHSGLQVDGTALNLTSCCVPRPKEKS
NLIVVRRGRNPTPAPGHSPSCCALTKLSFHTIPADSLEWHENLGHGSFTKIFHGHRREVV
DGETHDTEVLLKVMDSRHQNCMESFLEAASLMSQVSYPHLVLLHGVCMAGDSIMVQEFVY
LGAIDTYLRKRGHLVPASWKLQVTKQLAYALNYLEDKGLPHGNVSARKVLLAREGVDGNP
PFIKLSDPGVSPTVLSLEMLTDRIPWVAPECLQEAGTLNLEADKWGFGATTWEVFSGAPM
HITSLEPAKKLKFYEDRGQLPALKWTELEGLIAQCMAYDPGRRPSFRAILRDLNGLITSD
YELLSDPTPGIPNPRDELCGGAQLYACQDPAIFEERHLKYISLLGKGNFGSVELCRYDPL
GDNTGPLVAVKQLQHSGPEQQRDFQREIQILKALHCDFIVKYRGVSYGPGRQSLRLVMEY
LPSGCLRDFLQRHRARLHNDRLLLFAWQICKGMEYLGARRCVHRDLAARNILVESEAHVK
IADFGLAKLLPLGKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYS
DKSCSPSTEFLRMMGPEREGSPLCHLLELLAEGRRLPPPSTCPTEVQELMQLCWSPNPQD
RPAFDTLSPQLDALWRGSPG
NT seq 3303 nt   +upstreamnt  +downstreamnt
atggcacctccaagcgaggagacacctctcatctctcagcgctcttgtagcctctcatcc
tcagaagcaggagccctgcatgtgctccttcctccccggggacctgggcctccccagcga
ctgtcattctcttttggggactacttggctgaggacctgtgtgtgcgggctgccaaggcc
tgtggcatcctgcccgtttatcattcgctcttcgctctggccaccgaggacttgtcttgc
tggttccccccaagccacatcttctccatagaggacgtggacactcaagtcttggtctac
aggctacgcttttattttcctggttggtttggactggagacctgtcaccgctttgggtta
cacaaagatttgaccagtgccatccttgacgtacatgttttagaacacctctttgcccag
caccgcagtgacctggtgagtgggcgtctcccagtaggccttagcctgaaggaccaggga
gagttcctgagcctagctgtgctggacctggcccagatggctcgtaagcaggcccagcgg
ccaggagagctgctgaagtccgtcagttacaaagcctgtctgccgcccagcctgcgcgac
ctgatccagggccagagcttcgtgacgcgcaggcgcatccgcaggaccgtggtccaggcg
ctgcgccgtgtagtagcctgccaagccgaccgctacgcactcatggccaagtacatccta
gaccttgagcggctgcatccagcggccaccactgagtccttcctcgtgggactcccgggc
gcccaggaggagccgggttgcctgcgtgtgacaggggataatggcatcgcctggagctcc
aaggaccaggagcttttccagaccttctgtgactttccagaaatcgtggatgtcagcatc
aagcaggctccacgcgtgggtccggcaggggagcaccggctagtcaccatcaccaggatg
gacggtcacatcctggaagcggagttcccggggctgcctgaggcgctgtctttcgtggcg
ctcgtggatgggtactttcgcctgatctgcgactccaggcatttcttctgcaaggaggtg
gcaccgccacggctgctggaggaagaggcggagctgtgccatggacccatcacgttagac
tttgccatccacaagctgaaggctgctggctccctcccgggctcctacattctccgacgc
agcccgcaggactatgacagctttcttcttactgcctgtgtccagactcctcttggcccc
gactacaagggctgcctcatccgccaagaccccagtggggctttctccctggttggtctc
agccagctgcacagaagcctacaggagctgctcacagcctgctggcattctggactgcaa
gtagacggcactgccctgaacctcacatcttgctgcgtccccagacccaaggaaaagtcc
aatttgatcgtggtgcgtaggggccgcaaccccacgcctgcccccgggcactccccatcc
tgctgtgcgctgactaagttgagcttccacacaatcccagcagacagcctggagtggcac
gagaatcttggtcacggctcttttaccaagatcttccatggccataggcgggaggttgtg
gatggtgagacacatgacacagaagtcctcctgaaggttatggactccagacaccagaac
tgcatggagtcctttctggaagccgcaagcttgatgagccaagtatcctacccgcacctg
gtgttgctgcatggagtctgcatggctggagacagcatcatggtgcaggaatttgtgtac
cttggagcaattgacacgtacctgcgcaagcgtggtcacctggtgccggccagctggaaa
ctgcaggtgaccaagcagctggcctatgcccttaactacttggaggacaaaggcctccct
catggcaacgtctcagcgaggaaggtgctgctagctcgtgagggggttgatgggaatcca
cctttcatcaagctgagtgatcctggtgtcagcccaactgttttgagcctggaaatgctc
actgacaggattccctgggtggccccggagtgtctccaggaagctggaacgctcaacttg
gaggctgacaagtggggctttggcgccaccacgtgggaggtgttcagcggggcacccatg
cacattacctcgctggagcccgccaagaagctgaagttctatgaggaccggggacagctg
ccggccctcaaatggacagagctggaggggctcatcgcacagtgcatggcgtatgatcct
ggccggcgcccctccttccgagccatcctcagagacctcaacggcctcattacatcagat
tacgagctcctctcagaccccacacctggcatcccgaatccccgagatgagctgtgtggt
ggtgcccagctctatgcctgccaggaccccgccatcttcgaggagagacaccttaagtac
atctccctgctgggcaaggggaacttcggcagcgtggagctgtgccgctacgaccctctg
ggagacaatacgggacccctggtagcagtgaagcagttacagcacagcgggccagaacag
cagagggacttccagcgagagattcagatcctcaaggctctacactgtgacttcatcgtc
aagtaccggggagtcagctatgggcctggtcgccagagcctgcggttagtgatggagtac
ctgcccagcggctgcctgcgggacttcctgcagcgccaccgcgcgcgcctgcacaacgac
cgcctactgctgttcgcctggcagatctgcaagggcatggagtacctgggcgcacgccgc
tgcgtgcatcgtgacctggctgcgcgcaacatcctggtggagagtgaggcgcatgtgaag
attgctgacttcggcctcgctaagctgctgcctctcggaaaagactactacgtggtccgc
gagccgggccaaagtcccatcttctggtacgcccctgagtccctatctgacaacatcttc
tcccgccaatctgacgtgtggagcttcggcgtggtgctgtatgagctcttcacctacagc
gacaagagctgcagcccatccactgagttcctgcgcatgatggggcctgagcgtgaggga
tccccgctctgccacctcttggagctgctggcagagggccgccgtctcccaccaccctcc
acctgccctactgaggttcaagagctcatgcagctgtgctggtcgcccaacccacaagac
cggccagcatttgacaccctgagcccccagctggatgcgctgtggcgcggaagccccgga
tag

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