KEGG   Rattus norvegicus (rat): 24674Help
Entry
24674             CDS       T01003                                 

Gene name
Ppp3ca, Calna1
Definition
(RefSeq) protein phosphatase 3 catalytic subunit alpha
  KO
K04348  serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04010  MAPK signaling pathway
rno04020  Calcium signaling pathway
rno04022  cGMP-PKG signaling pathway
rno04114  Oocyte meiosis
rno04218  Cellular senescence
rno04310  Wnt signaling pathway
rno04360  Axon guidance
rno04370  VEGF signaling pathway
rno04380  Osteoclast differentiation
rno04625  C-type lectin receptor signaling pathway
rno04650  Natural killer cell mediated cytotoxicity
rno04658  Th1 and Th2 cell differentiation
rno04659  Th17 cell differentiation
rno04660  T cell receptor signaling pathway
rno04662  B cell receptor signaling pathway
rno04720  Long-term potentiation
rno04724  Glutamatergic synapse
rno04728  Dopaminergic synapse
rno04921  Oxytocin signaling pathway
rno04922  Glucagon signaling pathway
rno04924  Renin secretion
rno05010  Alzheimer disease
rno05014  Amyotrophic lateral sclerosis (ALS)
rno05031  Amphetamine addiction
rno05152  Tuberculosis
rno05163  Human cytomegalovirus infection
rno05166  Human T-cell leukemia virus 1 infection
rno05167  Kaposi sarcoma-associated herpesvirus infection
rno05170  Human immunodeficiency virus 1 infection
rno05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    24674 (Ppp3ca)
   04310 Wnt signaling pathway
    24674 (Ppp3ca)
   04370 VEGF signaling pathway
    24674 (Ppp3ca)
   04020 Calcium signaling pathway
    24674 (Ppp3ca)
   04022 cGMP-PKG signaling pathway
    24674 (Ppp3ca)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    24674 (Ppp3ca)
   04218 Cellular senescence
    24674 (Ppp3ca)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    24674 (Ppp3ca)
   04650 Natural killer cell mediated cytotoxicity
    24674 (Ppp3ca)
   04660 T cell receptor signaling pathway
    24674 (Ppp3ca)
   04658 Th1 and Th2 cell differentiation
    24674 (Ppp3ca)
   04659 Th17 cell differentiation
    24674 (Ppp3ca)
   04662 B cell receptor signaling pathway
    24674 (Ppp3ca)
  09152 Endocrine system
   04922 Glucagon signaling pathway
    24674 (Ppp3ca)
   04921 Oxytocin signaling pathway
    24674 (Ppp3ca)
   04924 Renin secretion
    24674 (Ppp3ca)
  09156 Nervous system
   04724 Glutamatergic synapse
    24674 (Ppp3ca)
   04728 Dopaminergic synapse
    24674 (Ppp3ca)
   04720 Long-term potentiation
    24674 (Ppp3ca)
  09158 Development and regeneration
   04360 Axon guidance
    24674 (Ppp3ca)
   04380 Osteoclast differentiation
    24674 (Ppp3ca)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    24674 (Ppp3ca)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    24674 (Ppp3ca)
   05014 Amyotrophic lateral sclerosis (ALS)
    24674 (Ppp3ca)
  09165 Substance dependence
   05031 Amphetamine addiction
    24674 (Ppp3ca)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    24674 (Ppp3ca)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    24674 (Ppp3ca)
   05170 Human immunodeficiency virus 1 infection
    24674 (Ppp3ca)
   05163 Human cytomegalovirus infection
    24674 (Ppp3ca)
   05167 Kaposi sarcoma-associated herpesvirus infection
    24674 (Ppp3ca)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:rno01009]
    24674 (Ppp3ca)
Enzymes [BR:rno01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     24674 (Ppp3ca)
Protein phosphatases and associated proteins [BR:rno01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Calcineurin (PPP3/ PP2B)
    Catalytic subunits
     24674 (Ppp3ca)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Metallophos DUF5378
Motif
Other DBs
NCBI-GeneID: 24674
NCBI-ProteinID: NP_058737
RGD: 3382
Ensembl: ENSRNOG00000009882
UniProt: P63329
Structure
PDB: 

Position
2q43
AA seq 521 aa AA seqDB search
MSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESV
ALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYV
DRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMD
AFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFG
NEKTQEHFTHNTVRGCSYFYSYPAVCDFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFP
SLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEK
VTEMLVNVLNICSDDELGSEEDGFDGATAAARKEVIRNKIRAIGKMARVFSVLREESESV
LTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEADEAIKGFSPQHKITSFEEAKGLDRIN
ERMPPRRDAMPSDANLNSINKALASETNGTDSNGSNSSNIQ
NT seq 1566 nt NT seq  +upstreamnt  +downstreamnt
atgtccgagcccaaggcgattgatcccaagttgtcgactacggacagggtggtgaaagcc
gttccatttccgccaagtcaccggctgacagcaaaggaagtgtttgataacgatgggaag
cctcgtgtggatatcttaaaagcacatctcatgaaggaaggcaggctggaagaaagtgtc
gcgttgagaataataacagagggtgcttcgattctccgacaggaaaaaaacttgctggat
attgatgccccagtcacagtttgcggggacatccatggacaattctttgacttgatgaag
ctctttgaagtgggaggatctcctgccaacactcgctacctcttcttaggggactatgtt
gacagagggtacttcagtatcgaatgtgtgctgtatttgtgggccttgaaaattctttac
cccaaaacactgtttttacttcgtggaaaccatgaatgtaggcacctaacagagtatttc
acgtttaaacaagaatgtaaaataaagtattcagaacgcgtttatgacgcctgtatggat
gccttcgactgccttcccctggctgcgctgatgaaccaacaattcctgtgtgtacacggt
ggtttgtctccagagattaacactctagatgacatcagaaaattagaccgattcaaagaa
ccacctgcttatgggcctatgtgtgacatcttgtggtcagaccccctggaggactttgga
aatgagaagactcaggaacatttcactcacaacacagtcaggggttgttcgtacttctac
agttacccggctgtatgtgacttcctgcagcacaataatttgttgtccatactccgagcc
cacgaagcccaggacgcagggtaccgcatgtacaggaaaagccaaacaactggcttcccg
tctctaattacgatcttctcggcaccaaattacttagatgtgtacaataataaagctgca
gtgttgaagtacgagaacaacgtgatgaacatcaggcagttcaactgctccccccatccg
tactggctcccaaatttcatggatgttttcacctggtcgctgccatttgttggggagaaa
gtgactgagatgctggtaaacgtcctgaacatctgctcagatgatgaactggggtcagaa
gaagatggatttgacggagccacggctgcagcccggaaggaggtcatcaggaacaagatc
cgagcaataggcaaaatggccagagtattctcagttctcagagaagagagtgagagcgtt
ctaactctgaagggcctgaccccgactggcatgctccccagcggagtgctctctggcggg
aaacaaactctgcaaagcgctactgttgaggccattgaggctgatgaagccatcaaagga
ttctcaccacaacataagattaccagcttcgaggaggccaagggcttagaccgaattaac
gagaggatgccgcctcgcagagacgccatgccttccgacgccaaccttaactccatcaac
aaggctctcgcctcagagactaacggcacagacagcaacggcagtaatagcagcaatatt
cagtga

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