KEGG   Rattus norvegicus (rat): 25021
Entry
25021             CDS       T01003                                 

Gene name
Itgam
Definition
(RefSeq) integrin alpha-M precursor
  KO
K06461  integrin alpha M
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04015  Rap1 signaling pathway
rno04145  Phagosome
rno04514  Cell adhesion molecules
rno04610  Complement and coagulation cascades
rno04613  Neutrophil extracellular trap formation
rno04640  Hematopoietic cell lineage
rno04670  Leukocyte transendothelial migration
rno04810  Regulation of actin cytoskeleton
rno05133  Pertussis
rno05134  Legionellosis
rno05140  Leishmaniasis
rno05146  Amoebiasis
rno05150  Staphylococcus aureus infection
rno05152  Tuberculosis
rno05202  Transcriptional misregulation in cancer
rno05221  Acute myeloid leukemia
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    25021 (Itgam)
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    25021 (Itgam)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    25021 (Itgam)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    25021 (Itgam)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    25021 (Itgam)
   04610 Complement and coagulation cascades
    25021 (Itgam)
   04613 Neutrophil extracellular trap formation
    25021 (Itgam)
   04670 Leukocyte transendothelial migration
    25021 (Itgam)
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    25021 (Itgam)
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    25021 (Itgam)
  09171 Infectious disease: bacterial
   05133 Pertussis
    25021 (Itgam)
   05134 Legionellosis
    25021 (Itgam)
   05150 Staphylococcus aureus infection
    25021 (Itgam)
   05152 Tuberculosis
    25021 (Itgam)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    25021 (Itgam)
   05140 Leishmaniasis
    25021 (Itgam)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:rno04131]
    25021 (Itgam)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:rno04147]
    25021 (Itgam)
   04515 Cell adhesion molecules [BR:rno04515]
    25021 (Itgam)
   04090 CD molecules [BR:rno04090]
    25021 (Itgam)
   00536 Glycosaminoglycan binding proteins [BR:rno00536]
    25021 (Itgam)
Membrane trafficking [BR:rno04131]
 Endocytosis
  Phagocytosis
   Integrins (complement receptors)
    25021 (Itgam)
Exosome [BR:rno04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   25021 (Itgam)
Cell adhesion molecules [BR:rno04515]
 Integrins
  Integrin alpha subunits
   25021 (Itgam)
CD molecules [BR:rno04090]
 Proteins
  25021 (Itgam)
Glycosaminoglycan binding proteins [BR:rno00536]
 Heparan sulfate / Heparin
  Adhesion molecules of cell surface
   25021 (Itgam)
SSDB
Motif
Pfam: VWA Integrin_alpha2 FG-GAP VWA_2 Integrin_alpha FG-GAP_3 FG-GAP_2 DUF3660
Other DBs
NCBI-GeneID: 25021
NCBI-ProteinID: NP_036843
RGD: 2926
Ensembl: ENSRNOG00000019728
UniProt: Q9JI30
Position
1
AA seq 1151 aa
MTLKVLLATVLTLCHGFNLDTENPMTFQENASGFGQSVIQLGETRVVVAAPQEVKAVNQT
GALYQCDYSTNRCDPIPLQVPPEAVNMSLGLSLAATTVPPQLLACGPTVHQNCKENTYVN
GLCYLFGSNLLRKPQQFPEALRGCPQQESNIAFLIDGSGSINTIDFQKMKEFVSTVMDQF
QKSKTLFSLMQYSDEFRTHFTFNDFKRNPDPKSHVRPIRQLNGRTKTASGIRKVVRELFQ
KINGARDNAAKILVVITDGEKFGDPLNYEDVIPEAEEAGIIRYVIGVGNAFHKPQSRREL
DTIASKPAGDHVFQVDNFEALNTIRNQLQEKIFAIEGTQTGSTSSFEHEMSQEGFSAAIT
SNGPLLGSVGSFDWAGGAFLYPSKDKASFINTTRIDSDMNDAYLGYASAVISRNRVQSLV
LGAPRYQHIGLVVMFKQNFGAWEPHTDIKGSQIGSYFGASLCSVDMDADGNTNLILIGAP
HHYEKTRGGQVSVCPLPRGRARWQCEAILHGDQGHPWGRFGAALTVLGDVNGDKLTDVAI
GAPGEQENQGAVYIFHGASVASISTPHSQRIAGARFSPGLQYFGQSLSGGKDLTMDGLMD
LAVGAQGRLLLIRAQPVLRLEATMEFSPKNLARSVFACQEEVVKNKDAGEVRVCLQVRKN
TKDRLREGDIQSTVTYDLALDPGRSVVRAFFDETKNGILRRIRVFGLTQKCETLKLILPD
CVDNSVSPIILRLNYTLVGEPLRSSRDLRPVLAMEAQRIFTAMFPFEKNCGNDTICQDDL
SITVSSTRVNTLVVGDSRDFDVSVTLRNDGEDSYGTKVTCYYPSGLSYRKVSASQNQFSK
KPWRVIAEPSSSEGQGVLKSTIWDINHPIFPANSEVTFNVTFDVDSDASLGNKLLLKVVV
TSENNVSRTDKTESQLELPVKYAIYMVVTSGESSIKYLNFTASEMTSKVIQHQYQFNNLG
QRSFPVSVVFWIPVQINKVTIWDPPQVTFSQNLSSVCRTEQKSPSHSKFQDELERTPVLN
CSVAVCKRIQCDIPSFNSKEIFNVTLQGNLLFDWYIETSHDHLLLVSTAEILFNDSAFAL
LPGQETFVKAQTETKVEPYTVHNPVPLIVGSSVGGLVLLALITAGLYKLGFFKRQYKDMM
NEAGGQDGPPQ
NT seq 3456 nt   +upstreamnt  +downstreamnt
atgactcttaaagttcttctggcgacagtcctaaccttgtgtcatggcttcaatttggac
actgaaaatcccatgaccttccaagagaatgcaagtggcttcgggcagagtgtgatccag
cttggtgaaacccgagtggttgttgcagccccccaggaggtaaaggcggttaaccagaca
ggtgccctctaccagtgtgactacagcacaaaccggtgcgaccccattcccctgcaagta
cctccagaggctgtgaatatgtccttgggcctgtccctggctgctactaccgtccctcca
cagctgctggcttgtggccccacagtacaccagaactgcaaggagaacacttacgtcaat
ggattgtgctacctattcggctccaacctgctgaggaagccccagcagttcccagaggct
ctcagaggatgtcctcagcaggagagcaacattgccttcttgattgacggctccggtagc
atcaacacgatcgactttcagaagatgaaggaatttgtctcaactgtgatggaccagttc
caaaagtctaaaaccttgttctctttgatgcagtactctgatgaattccggactcacttc
accttcaatgatttcaagagaaaccctgacccaaaatcacatgtgagacccataaggcag
ctgaatggaaggacaaaaactgcctcagggatccgtaaagtagtgagagaactgtttcag
aaaatcaatggggcccgggacaatgccgcgaagatcctagttgtcatcacagacggagaa
aagtttggtgaccccctaaattatgaggatgtcattcctgaggcagaggaagcagggatc
attcgctacgttattggggtgggaaacgccttccacaaaccacagtcccgcagagagctt
gacaccatcgcgtctaagccagctggtgatcacgtgttccaagtggacaactttgaagct
ctgaataccattcggaaccagctccaggaaaagatctttgcaattgagggcacccagaca
ggaagtaccagctcctttgagcatgagatgtctcaagaaggctttagcgctgccattacc
tccaacggtcccttgctgggctccgtggggagctttgactgggcaggtggagccttcctg
tatccatcaaaggataaagccagtttcatcaacacaaccagaatagattcagacatgaac
gatgcttacttgggttatgcttctgcagtcatctcgaggaaccgcgtccaaagcttggtt
ttaggggcacctcgatatcagcatatcggcctggtggtgatgttcaagcagaatttcggt
gcctgggagccccacactgatatcaagggcagccagatcggctcttattttggggcctcc
ctctgttctgtggacatggacgctgatggcaataccaacttgatcctcattggggcccct
catcactatgagaagacccgagggggccaggtgtcagtgtgccccttgcctagggggaga
gcacggtggcagtgtgaagctattctccatggcgatcagggccatccatggggtcgcttt
ggggcagcattgacagtgctgggagatgtgaatggagacaaactgacagatgtggccatt
ggggccccaggagagcaggagaatcagggtgctgtctacatttttcatggagcatcagta
gccagcatcagtacccctcacagccagcggatcgcaggcgcccgcttctcccccgggctc
cagtactttgggcagtctctgagtgggggcaaggatctcacaatggacggcctgatggac
ttggctgtgggggcgcaggggcgtcttctgctgatcagagcccagcctgtgctgagactg
gaggcaaccatggaattcagccccaagaatctagcaaggagtgtgtttgcgtgtcaagaa
gaagtagtcaaaaacaaggatgctggggaggtcagagtctgcctccaagtccgcaagaac
accaaggacaggctgcgagaaggagacatccagagcactgtcacttatgacctggcttta
gaccccggccgctcagttgtccgagccttctttgatgaaacaaagaacggcatactcagg
cgcatccgggtctttggattgacacagaaatgtgaaaccctgaagctaattttaccggac
tgtgtggacaactcagtgagtcccatcatcctgcgccttaattacacactggttggggag
cccttgcggtcctctagggaccttcggccagttctggctatggaggctcagaggatcttc
acagctatgtttccctttgagaagaattgtggcaatgacaccatttgccaggatgatctc
agcatcaccgtgagttccacacgcgtgaacactttggtggtgggagactcccgggacttt
gacgtgagtgtgactctgagaaatgatggcgaggattcctatgggaccaaggttacctgc
tattacccatctggcttgtcttaccggaaggtgtcagcaagccagaaccagttctccaag
aagccttggcgtgtgatagctgagcccagttcttctgaagggcaaggggttctgaagagc
accatctgggacataaaccatcccatctttcccgctaattctgaggtcacgtttaatgtc
acatttgatgtggactctgatgcctcccttgggaacaaactgctcctcaaggtcgttgtg
accagtgagaacaacgtgtccaggaccgacaaaactgagtctcagttggagttgcctgtg
aagtacgccatctacatggtcgtcaccagtggtgagagttctatcaaatatctcaacttc
acagcttcagagatgaccagtaaggtcatacagcatcagtaccagttcaacaacctgggc
cagaggagcttccctgtcagcgtggtcttctggatccctgtccagatcaacaaggtgacc
atatgggatcctccccaggtcaccttctcccagaacctctcaagtgtctgtcgcactgag
cagaaatccccctctcactccaagttccaggatgagcttgaaaggaccccagtgctgaac
tgctctgttgcagtctgcaagagaatccagtgtgacatcccttccttcaacagtaaagaa
atattcaacgtcaccctccagggcaatctgctatttgactggtacatcgagacttctcat
gaccacctcctgcttgtgagcactgccgagatcctctttaacgactccgcatttgcccta
cttccggggcaggagacgtttgtgaaggctcagacagagaccaaagtggagccatataca
gttcacaatcctgtaccactcattgtgggcagctccgtcggaggcctggtgctcttggct
ctcatcactgctggcctatacaagcttggctttttcaaacgacagtacaaggacatgatg
aatgaagccggtggccaagatggcccacctcagtaa

KEGG   Rattus norvegicus (rat): 309684
Entry
309684            CDS       T01003                                 

Gene name
Itgb2
Definition
(RefSeq) integrin beta-2 precursor
  KO
K06464  integrin beta 2
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04015  Rap1 signaling pathway
rno04145  Phagosome
rno04390  Hippo signaling pathway
rno04514  Cell adhesion molecules
rno04610  Complement and coagulation cascades
rno04613  Neutrophil extracellular trap formation
rno04650  Natural killer cell mediated cytotoxicity
rno04670  Leukocyte transendothelial migration
rno04810  Regulation of actin cytoskeleton
rno05133  Pertussis
rno05134  Legionellosis
rno05140  Leishmaniasis
rno05144  Malaria
rno05146  Amoebiasis
rno05150  Staphylococcus aureus infection
rno05152  Tuberculosis
rno05166  Human T-cell leukemia virus 1 infection
rno05323  Rheumatoid arthritis
rno05416  Viral myocarditis
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    309684 (Itgb2)
   04390 Hippo signaling pathway
    309684 (Itgb2)
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    309684 (Itgb2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    309684 (Itgb2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    309684 (Itgb2)
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    309684 (Itgb2)
   04613 Neutrophil extracellular trap formation
    309684 (Itgb2)
   04650 Natural killer cell mediated cytotoxicity
    309684 (Itgb2)
   04670 Leukocyte transendothelial migration
    309684 (Itgb2)
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    309684 (Itgb2)
  09171 Infectious disease: bacterial
   05133 Pertussis
    309684 (Itgb2)
   05134 Legionellosis
    309684 (Itgb2)
   05150 Staphylococcus aureus infection
    309684 (Itgb2)
   05152 Tuberculosis
    309684 (Itgb2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    309684 (Itgb2)
   05144 Malaria
    309684 (Itgb2)
   05140 Leishmaniasis
    309684 (Itgb2)
  09163 Immune disease
   05323 Rheumatoid arthritis
    309684 (Itgb2)
  09166 Cardiovascular disease
   05416 Viral myocarditis
    309684 (Itgb2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:rno04131]
    309684 (Itgb2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:rno04147]
    309684 (Itgb2)
   04515 Cell adhesion molecules [BR:rno04515]
    309684 (Itgb2)
   04090 CD molecules [BR:rno04090]
    309684 (Itgb2)
Membrane trafficking [BR:rno04131]
 Endocytosis
  Phagocytosis
   Integrins (complement receptors)
    309684 (Itgb2)
Exosome [BR:rno04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   309684 (Itgb2)
Cell adhesion molecules [BR:rno04515]
 Integrins
  Integrin beta subunits
   309684 (Itgb2)
CD molecules [BR:rno04090]
 Proteins
  309684 (Itgb2)
SSDB
Motif
Pfam: Integrin_beta Integrin_b_cyt Integrin_B_tail PSI_integrin EGF_2
Other DBs
NCBI-GeneID: 309684
NCBI-ProteinID: NP_001032869
RGD: 1305581
Ensembl: ENSRNOG00000001224
UniProt: B2RYB8
Position
20
AA seq 768 aa
MLGPHTLLLILAGLLFLGSALSEECTKYKVSNCRDCIQSGPGCSWCQKLNFTGPGEPDSL
RCDTRAQLLLKGCPADDIMDPKSFADLHPQYQVQRSQLSPQKVTLNLRPGQAAAFNVTFR
RAKGYPIDLYYLMDLSYSMLDDLNNVKKLGGDLLQALNEITESGRIGFGSFVDKTVLPFV
NTHPEKLRNPCPNKEKACQPPFAFRHVLKLTDNSNQFQTEVGKQLISGNLDAPEGGLDAI
MQVAACPEEIGWRNVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNMYKRSNEFD
YPSVGQLAHKLSESNIQPIFAVTKKMVKTYEKLTEIIPKSAVGELSDDSSNVVQLIKKAY
YKLSSRVFLDHTTIPDTLKVTYDSFCNNRVSSIGKSRGDCDGVQINNPVTFQVKVTASEC
IQEQSFVIRALGFTDTVTVQVHPQCECQCRDQSRMRNLCGGKGVMECGICRCESGYIGKN
CECQTQGRSSQELEGNCRKDNSSIVCSGLGDCICGQCVCHTSDIPNKVIFGQYCECDNFN
CERYDGQVCGGLKRGSCSCGQCNCKEGFEGSACQCQRSTTGCLNARLVECSGRGRCQCNR
CICEKGYQPPLCEECPGCPLPCSTYVFCAECLKFDKGPFQKNCSVQCANVTLQTVPFKKK
PCKERDSEGCWITYTLQQKDGNAYNIHVDDDRECVKGPNVAAIIGGTVAGVVLIGVLLLV
IWKALTHLTDLNEYRRFEKEKLKSQWNNDNPLFKSATTTVMNPKFAES
NT seq 2307 nt   +upstreamnt  +downstreamnt
atgctgggcccacacacactgctactcatcctagctggactactcttcctgggatctgcc
ctgtccgaggaatgcaccaagtacaaagtcagcaactgccgggactgtatccagtcgggg
cctggctgctcgtggtgccagaagctgaacttcaccggaccaggggagcctgactccttg
cgctgtgacacgcgggcacagctgctcctcaagggttgcccagccgatgatataatggac
cccaagagctttgctgatctccacccccaatatcaggtgcaacggagtcaactgtctcca
caaaaagtgacccttaacttgcgaccagggcaggctgctgcattcaatgtgactttccga
cgggccaagggctaccccattgatctgtactacctcatggacctctcctactctatgctc
gatgacctgaacaatgtcaagaagttgggtggtgatttgctgcaggccctcaacgagatc
acagagtccggccgcatcggcttcgggtccttcgtggacaagacggtgctgccttttgtc
aacacccatcccgagaagctgaggaacccatgccccaacaaggagaaagcctgccagcct
ccgtttgcctttcgccacgtgctcaagctaaccgacaactccaaccagtttcagacagag
gtcggcaagcaactgatttccggaaacctggacgcccctgagggcgggctggatgccata
atgcaagtggctgcctgtccggaggaaattggctggcgcaatgtcacgaggctgctggtg
tttgccacagacgacggcttccactttgccggtgatgggaaactgggtgccatcctgacc
cccaacgatggccgctgccacctggaggataacatgtacaagaggagcaatgagttcgac
tacccgtcagtgggccagctggcccacaaactttccgagagcaacatccagcccatcttt
gcagtgacaaagaagatggtgaaaacctatgagaaactgacagagattatccccaagtca
gcggtgggcgagctgtctgacgattccagtaacgtagtccagcttatcaagaaagcctac
tacaaactctcctctagagtcttcctggaccacaccaccatcccggacaccctgaaagtc
acctatgactccttctgtaataacagagtatcgagtataggcaaatcccgaggggactgt
gacggtgtgcagatcaacaacccggtcaccttccaggtaaaggtcacggcttcggagtgt
atccaggagcagtcctttgtcatccgggcgctgggcttcaccgacacagtgacggtacag
gtccatccccagtgcgagtgccagtgccgggaccagagtcggatgaggaatctctgtgga
ggcaagggagtcatggagtgtggcatctgcaggtgtgagtctggctacattgggaaaaac
tgtgagtgtcagacgcagggccggagcagccaggagctggaggggaactgccggaaggac
aatagttccattgtgtgctcggggctgggggactgcatctgcgggcagtgcgtgtgccac
acgagtgacatccccaacaaagtgatctttgggcaatactgcgagtgtgacaacttcaac
tgtgagagatatgatggccaagtctgcggtggcctaaagagaggctcctgctcctgtggc
cagtgtaattgcaaggagggtttcgagggttctgcttgccagtgtcagaggtctaccacg
ggctgtctgaacgcacggctggtggagtgcagtggccgtggccggtgccaatgcaacaga
tgcatctgtgagaaaggttaccagccacctctgtgtgaagagtgtcccggctgccccttg
ccctgcagcacctacgtcttctgtgccgagtgcctgaaatttgataagggcccctttcag
aagaattgtagtgttcagtgtgccaatgtgacgctgcagactgtccctttcaagaaaaag
ccctgcaaggagagggactcggagggctgctggataacctacactttgcagcagaaggac
ggaaacgcttacaacatccatgtggacgacgatcgagagtgtgtgaaaggccccaacgtg
gctgccatcatagggggcactgtggccggcgttgtactgattggtgtcctcctcctggtc
atctggaaggctcttacccacctgactgacctcaatgaatacagacgctttgagaaggag
aaactcaagtcccagtggaacaacgacaaccccctcttcaagagcgccacgacaacggtc
atgaaccctaagtttgctgagagctag

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