KEGG   Rattus norvegicus (rat): 25116Help
Entry
25116             CDS       T01003                                 

Gene name
Hsd11b1, LRRGT00065
Definition
(RefSeq) hydroxysteroid 11-beta dehydrogenase 1
  KO
K15680  corticosteroid 11-beta-dehydrogenase isozyme 1 [EC:1.1.1.146]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00140  Steroid hormone biosynthesis
rno00980  Metabolism of xenobiotics by cytochrome P450
rno01100  Metabolic pathways
rno05204  Chemical carcinogenesis
Module
rno_M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    25116 (Hsd11b1)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    25116 (Hsd11b1)
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis
    25116 (Hsd11b1)
Enzymes [BR:rno01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.146  11beta-hydroxysteroid dehydrogenase
     25116 (Hsd11b1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: adh_short adh_short_C2 KR THF_DHG_CYH_C FMO-like Pyr_redox_2 2-Hacid_dh_C AdoHcyase_NAD Shikimate_DH Pyr_redox_3
Motif
Other DBs
NCBI-GeneID: 25116
NCBI-ProteinID: NP_058776
RGD: 2834
Ensembl: ENSRNOG00000005861
UniProt: P16232
Position
13q27
AA seq 288 aa AA seqDB search
MKKYLLPVLVLCLGYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLT
ARSEEGLQKVVSRCLELGAASAHYIAGTMEDMAFAERFVVEAGKLLGGLDMLILNHITQT
TMSLFHDDIHSVRRSMEVNFLSYVVLSTAALPMLKQSNGSIAIISSMAGKMTQPLIASYS
ASKFALDGFFSTIRKEHLMTKVNVSITLCVLGFIDTETALKETSGIILSQAAPKEECALE
IIKGTVLRKDEVYYDKSSWTPLLLGNPGRRIMEFLSLRSYNRDLFVSN
NT seq 867 nt NT seq  +upstreamnt  +downstreamnt
atgaaaaaatacctcctccccgtcctggtgctctgcctgggttactactattctacaaat
gaagagttcagaccagaaatgctccaggggaagaaagtgattgtcactggggccagcaaa
gggatcggaagagaaatggcatatcatctgtcaaaaatgggagcccatgtggtattgact
gcaaggtcggaggaagggctccagaaggtggtgtctcgctgccttgaactcggagcagcc
tctgctcactatattgccggcactatggaagacatggcttttgcagagcgatttgttgtt
gaggcaggaaagctcttgggtggactggacatgctcattctcaatcacatcacacagacc
actatgtctctcttccacgatgatatccactctgtgcgaagaagcatggaggtcaacttc
ctcagctatgtggtcctgagcacagcagccttgcccatgctgaaacagagcaatggcagc
attgccatcatctcctccatggctgggaaaatgacccaacctctgattgcttcctactct
gcaagcaagtttgctctggatgggttcttttccaccattagaaaagaacacttgatgacc
aaggtcaacgtgtccatcactctctgtgtcctcggcttcatagacacagaaacagctttg
aaagaaacctctgggataatcttgagtcaagctgctcccaaggaggaatgcgccctggag
atcatcaaaggcacagttctgcgcaaagatgaggtatactatgacaaatcatcttggact
ccacttctgcttgggaatccaggaaggaggatcatggaatttctttcattacggtcatat
aacagggacctatttgtaagcaactag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (13)   
   KEGG COMPOUND (13)   
Chemical reaction (6)   
   KEGG ENZYME (1)   
   KEGG REACTION (5)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (53)   
   RefSeq(nuc) (3)   
   GenBank (25)   
   EMBL (25)   
Protein domain (10)   
   Pfam (10)   
All databases (101)   

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