KEGG   Rattus norvegicus (rat): 25262
Entry
25262             CDS       T01003                                 

Gene name
Itpr1
Definition
(RefSeq) inositol 1,4,5-trisphosphate receptor type 1 isoform 3
  KO
K04958  inositol 1,4,5-triphosphate receptor type 1
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04020  Calcium signaling pathway
rno04022  cGMP-PKG signaling pathway
rno04070  Phosphatidylinositol signaling system
rno04114  Oocyte meiosis
rno04140  Autophagy - animal
rno04210  Apoptosis
rno04218  Cellular senescence
rno04270  Vascular smooth muscle contraction
rno04371  Apelin signaling pathway
rno04540  Gap junction
rno04611  Platelet activation
rno04621  NOD-like receptor signaling pathway
rno04625  C-type lectin receptor signaling pathway
rno04713  Circadian entrainment
rno04720  Long-term potentiation
rno04723  Retrograde endocannabinoid signaling
rno04724  Glutamatergic synapse
rno04725  Cholinergic synapse
rno04726  Serotonergic synapse
rno04728  Dopaminergic synapse
rno04730  Long-term depression
rno04750  Inflammatory mediator regulation of TRP channels
rno04912  GnRH signaling pathway
rno04915  Estrogen signaling pathway
rno04918  Thyroid hormone synthesis
rno04921  Oxytocin signaling pathway
rno04922  Glucagon signaling pathway
rno04924  Renin secretion
rno04925  Aldosterone synthesis and secretion
rno04927  Cortisol synthesis and secretion
rno04928  Parathyroid hormone synthesis, secretion and action
rno04929  GnRH secretion
rno04934  Cushing syndrome
rno04935  Growth hormone synthesis, secretion and action
rno04970  Salivary secretion
rno04971  Gastric acid secretion
rno04972  Pancreatic secretion
rno05010  Alzheimer disease
rno05012  Parkinson disease
rno05016  Huntington disease
rno05017  Spinocerebellar ataxia
rno05020  Prion disease
rno05022  Pathways of neurodegeneration - multiple diseases
rno05163  Human cytomegalovirus infection
rno05167  Kaposi sarcoma-associated herpesvirus infection
rno05170  Human immunodeficiency virus 1 infection
rno05205  Proteoglycans in cancer
rno05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    25262 (Itpr1)
   04020 Calcium signaling pathway
    25262 (Itpr1)
   04070 Phosphatidylinositol signaling system
    25262 (Itpr1)
   04022 cGMP-PKG signaling pathway
    25262 (Itpr1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    25262 (Itpr1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    25262 (Itpr1)
   04210 Apoptosis
    25262 (Itpr1)
   04218 Cellular senescence
    25262 (Itpr1)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    25262 (Itpr1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    25262 (Itpr1)
   04621 NOD-like receptor signaling pathway
    25262 (Itpr1)
   04625 C-type lectin receptor signaling pathway
    25262 (Itpr1)
  09152 Endocrine system
   04922 Glucagon signaling pathway
    25262 (Itpr1)
   04929 GnRH secretion
    25262 (Itpr1)
   04912 GnRH signaling pathway
    25262 (Itpr1)
   04915 Estrogen signaling pathway
    25262 (Itpr1)
   04921 Oxytocin signaling pathway
    25262 (Itpr1)
   04935 Growth hormone synthesis, secretion and action
    25262 (Itpr1)
   04918 Thyroid hormone synthesis
    25262 (Itpr1)
   04928 Parathyroid hormone synthesis, secretion and action
    25262 (Itpr1)
   04924 Renin secretion
    25262 (Itpr1)
   04925 Aldosterone synthesis and secretion
    25262 (Itpr1)
   04927 Cortisol synthesis and secretion
    25262 (Itpr1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    25262 (Itpr1)
  09154 Digestive system
   04970 Salivary secretion
    25262 (Itpr1)
   04971 Gastric acid secretion
    25262 (Itpr1)
   04972 Pancreatic secretion
    25262 (Itpr1)
  09156 Nervous system
   04724 Glutamatergic synapse
    25262 (Itpr1)
   04725 Cholinergic synapse
    25262 (Itpr1)
   04728 Dopaminergic synapse
    25262 (Itpr1)
   04726 Serotonergic synapse
    25262 (Itpr1)
   04720 Long-term potentiation
    25262 (Itpr1)
   04730 Long-term depression
    25262 (Itpr1)
   04723 Retrograde endocannabinoid signaling
    25262 (Itpr1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    25262 (Itpr1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    25262 (Itpr1)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    25262 (Itpr1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    25262 (Itpr1)
   05163 Human cytomegalovirus infection
    25262 (Itpr1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    25262 (Itpr1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    25262 (Itpr1)
   05012 Parkinson disease
    25262 (Itpr1)
   05016 Huntington disease
    25262 (Itpr1)
   05017 Spinocerebellar ataxia
    25262 (Itpr1)
   05020 Prion disease
    25262 (Itpr1)
   05022 Pathways of neurodegeneration - multiple diseases
    25262 (Itpr1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    25262 (Itpr1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    25262 (Itpr1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:rno01009]
    25262 (Itpr1)
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:rno04040]
    25262 (Itpr1)
Protein phosphatases and associated proteins [BR:rno01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     25262 (Itpr1)
Ion channels [BR:rno04040]
 Ligand-gated channels
  IP3 receptor
   25262 (Itpr1)
SSDB
Motif
Pfam: Ins145_P3_rec RYDR_ITPR MIR RIH_assoc Ion_trans
Other DBs
NCBI-GeneID: 25262
NCBI-ProteinID: NP_001257526
RGD: 2933
Ensembl: ENSRNOG00000007104
UniProt: P29994 C7E1V2 A0A0A0MY31 Q5BJS8
Structure
PDB: 

Position
4
AA seq 2709 aa
MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPEAGDLNNPPKKFRDCLFKL
CPMNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNV
IQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGD
KVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVV
RLFHAEQEKFLTCDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWN
SLFRFKHLATGHYLAAEVDPDFEEECLEFQPSVDPDQDASRSRLRNAQEKMVYSLVSVPE
GNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGT
SPLKEDKEAFAIVPVSPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDL
VYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQAPFTDCGDGPMLRLEE
LGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLH
NNRKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPT
NADILIETKLVLSRFEFEGVSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDAK
EGQKEDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRAS
FCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDSSGASKDEIKERFAQTMEFV
EEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVHV
TTIFPISKMTKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAEP
EKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQSSETSSGNSSQEG
PSNVPGALDFEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGAL
QLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGPD
EPMDGASGENEHKKTEEGTSKPLKHESTSSYNYRVVKEILIRLSKLCVQESASVRKSRKQ
QQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHIN
LFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEG
KFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRMDENSPLMYHIHLVEL
LAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVEMKEI
YTSNHMWKLFENFLVDICRACNNTSDRKHADSVLEKYVTEIVMSIVTTFFSSPFSDQSTT
LQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAIPVDLDSQVNN
LFLKSHNIVQKTAMNWRLSARNAARRDSVLAASRDYRNIIERLQDIVSALEDRLRPLVQA
ELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLRE
MMTKDRGYGEKGEALRQILVNRYYGNIRPSGRRESLTSFGNGPLSPGGPSKPGGGGGGPG
SGSTSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQH
SFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKA
KEPTTQITEEVRDQLLEASAATRKAFTTFRREADPDDHYQSGEGTQATTDKAKDDLEMSA
VITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGLL
GLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALILNDINPLGKKR
MDLVLELKNNASKLLLAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEFEDGEN
GEDGAASPRNVGHNIYILAHQLARHNKELQTMLKPGGQVDGDEALEFYAKHTAQIEIVRL
DRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKLR
AQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFKGVRGGTLEPHWSGLLWTAMLISL
AIVIALPKPHGIRALIASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFTR
GYRAMVLDVEFLYHLLYLLICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSI
ILTAVLALILVYLFSIVGYLFFKDDFILEVDRLPNETAGPETGESLANDFLYSDVCRVET
GENCTSPAPKEELLPVEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEP
LFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKF
DNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIRERNLDWFPRMRAM
SLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQLSELKDQMTEQRKQKQRIGLLGHPPH
MNVNPQQPA
NT seq 8130 nt   +upstreamnt  +downstreamnt
atgtctgacaaaatgtctagtttcctacatatcggagacatttgttctctgtatgcagag
ggatctacgaatggatttatcagcaccttgggcttggttgatgaccgttgcgttgtacag
ccagaagctggggaccttaacaatccacccaagaaattcagagactgcctctttaagcta
tgtcctatgaatcgatattctgcacagaagcagttctggaaagctgctaagcccggggcc
aacagtacaacagatgcggtgctgctcaacaaattgcatcatgctgcagacttggaaaag
aagcagaatgagacagaaaacaggaaattgctggggacggtcatccagtatggcaacgtg
atccagctcctacatttgaaaagcaataaatacttaactgtgaataagaggcttcctgcc
ctgctggagaagaacgccatgagagtgacgttggatgaggctggaaatgaagggtcttgg
ttttacattcagccgttctacaagctccgctccatcggagacagtgtggtcataggtgac
aaggtagttttgaaccctgtcaatgctgggcagccgctacatgccagcagccatcagctg
gtggataacccgggctgcaatgaggtcaactccgtcaactgtaacacaagctggaaaata
gtgcttttcatgaaatggagtgataacaaagatgacattctaaaaggaggtgatgtggta
agactcttccatgctgagcaagagaagtttctcacgtgcgatgagcacaggaagaagcag
cacgtcttcctgaggacaaccggcagacagtcagccacgtcggccaccagctccaaagcc
ctgtgggaagtggaggtagtccagcatgacccatgtcggggtggagctgggtactggaat
agcctcttccggttcaagcacctggctacagggcattacttggcagcagaggtagaccct
gactttgaggaagaatgcctggagtttcagccctcagtggaccctgatcaggacgcatct
cggagcaggttgagaaatgcccaagaaaaaatggtgtactctctggtctctgtgcctgag
ggcaacgacatctcctccatctttgagctagaccccacaactctacgtggaggtgacagc
cttgtcccaaggaactcctatgtccggctcagacacctgtgtacaaacacctgggttcac
agcacaaacatccccattgacaaggaagaggaaaaacctgtcatgctgaagattggtacc
tctcccctgaaggaggacaaggaagcttttgccatagtccccgtttctcctgctgaggtt
cgggacctggactttgccaatgatgccagcaaggtgctgggctccatcgctgggaagttg
gaaaagggcaccatcacccagaatgagagaaggtctgtcaccaagctgctggaagacttg
gtttactttgtcacgggtggaacgaactctggccaagacgtgcttgaagtagtcttctct
aagcccaaccgagagcggcagaagctgatgagggaacagaatattctcaagcagatcttc
aagcttttgcaggcccccttcacggactgcggggatggcccaatgcttcggctggaggag
ctgggggaccagcggcacgctcctttcagacacatttgccgactctgctacagggtcctg
agacactcacagcaagactacaggaagaaccaggagtacatagccaagcagtttggcttc
atgcagaagcagattggctatgatgtgctggccgaagacaccatcactgccctgctccac
aacaaccgaaagctcctggaaaagcacatcaccgcagcagagattgacacgtttgtcagc
ctggtgcgaaagaacagggagcccaggttcttggattacctctctgacctctgtgtatcc
atgaataagtcaatccctgtgacccaggagctcatttgtaaagctgtgctgaatcccacc
aatgctgacatcctgattgagaccaagttggttctttctcgttttgagtttgaaggcgtt
tccaccggagagaatgctctggaagctggggaagatgaggaagaggtgtggctgttctgg
agggacagcaacaaagagatccgtagcaagagtgttagggaattggcacaagatgctaaa
gagggacagaaggaagacagggatgtcctcagctactacaggtatcagctgaacctcttt
gcaaggatgtgtctggaccgccagtacctggccatcaatgaaatatccgggcagctggat
gttgacctcatcctccgctgcatgtccgatgagaacctcccctatgacctcagagcatcc
ttttgccgcctcatgcttcacatgcatgtggaccgagatccccaggagcaggtgacccct
gtgaaatacgcccgtctgtggtcagaaattccctccgagatcgccattgacgactatgac
agcagtggagcatcgaaggatgaaatcaaggagaggtttgctcagacgatggagtttgtg
gaggagtacctgagagatgtggtttgtcaaagattccccttttctgataaggagaaaaat
aagctcacatttgaggttgtgaacttagccaggaacctcatatactttggcttctacaac
ttttctgaccttctccgattaaccaagatcctcttggcaatcttagactgtgttcatgtg
acaaccatcttccccattagcaagatgacgaaaggcgaagagaataaaggcagcaacgtg
atgagatctatccatggagttggggagctcatgacccaggtggtgcttcggggaggaggc
tttttgcccatgactcctatggctgctgcccctgaaggaaatgtgaagcaggcagagcca
gagaaagaggatatcatggtcatggacaccaagttaaagatcattgaaatactccagttt
attttgaatgtgagattggattataggatctcctgcctcctgtgtatatttaagcgggag
tttgatgaaagcaattcccagtcatcagaaacatcctccggaaacagcagccaagaaggg
ccaagtaatgtaccaggtgctcttgactttgaacacattgaagagcaagcagaaggcatc
tttgggggaagtgaggagaacacacctctggacttggatgatcatggtggcagaaccttc
ctcagggtcctgctccacttgacaatgcatgattacccacccctggtgtctggggccctg
cagctcctcttccggcatttcagccagaggcaggaggtccttcaggccttcaaacaggtt
caactgctggttactagccaagatgtggacaactacaaacagatcaagcaagacttggac
cagctaagatccatcgtggagaagtctgagctctgggtatacaaaggccagggtcccgat
gagcctatggacggagcctctggtgaaaacgaacataagaaaactgaggaggggaccagt
aagccactgaagcacgaaagcaccagcagctacaactaccgagtggtgaaagagattctg
attcgacttagcaagctctgtgttcaagagagcgcgtcggtgaggaagagcaggaagcag
cagcagcgactgctgaggaacatgggtgcccatgctgtggtgctggagctgctgcagatc
ccctatgagaaggccgaagataccaagatgcaggagatcatgaggctggctcacgaattt
ctgcagaatttctgcgcaggcaaccagcagaaccaagctttgctacataaacacataaac
ctgtttctcaacccagggatcctggaagcagtgaccatgcagcacatcttcatgaacaac
ttccagctgtgcagtgagatcaacgagagagtggtccagcatttcgttcactgcatagag
acccacggtcgaaatgtccagtatatcaagtttctccagactattgtcaaggccgaaggg
aaattcattaaaaagtgccaagacatggtcatggctgagcttgtcaattctggagaggac
gtcctcgtgttctacaatgacagagcctctttccagactctgatccagatgatgcggtcc
gagcgtgaccggatggatgagaacagccctctcatgtaccacatccatctggtggagctc
ttggctgtgtgcacagagggcaagaatgtgtacacagagatcaagtgcaactccctgctc
ccgctcgatgacatcgttcgtgtggtcactcatgaagactgtatccccgaggttaagatt
gcttacatcaacttcctgaatcactgctatgtggacactgaggtggagatgaaggagatt
tacacaagtaatcacatgtggaagttgtttgagaatttcctcgtggacatctgcagggcc
tgtaacaacacaagtgacaggaagcatgcagactcggttctggagaagtacgtcactgaa
atcgtgatgagcattgtcaccaccttcttcagctctcccttctcagaccagagtaccact
ctgcagactcgccagcctgtctttgtgcagctcctgcaaggcgtgttccgagtttaccac
tgcaactggttgatgccgagccagaaagcctcggtggagagctgtatccgcgtgctctct
gacgtagccaagagccgggccatagccattcctgttgacctagacagccaagtcaacaac
ctcttcctgaagtcccacaacattgtgcagaaaacagccatgaactggcggttatcagcc
cgcaacgctgctcgtagagactctgtcctggcagcttccagagactaccgaaatattatt
gagaggttacaggacatcgtgtctgccctggaggaccgactcaggcccctggtccaggcc
gagctgtctgtgctcgtggatgttctacacagaccggaactgcttttccctgagaacacg
gatgccaggaggaaatgcgaaagtggaggtttcatctgcaagctcataaaacacaccaag
cagctgctagaggagaatgaagagaaactgtgcattaaagtcttacagaccctcagggaa
atgatgaccaaagatagaggctatggagaaaagggtgaggcactccggcaaattttggtc
aaccgttactatggaaacatcagaccttcaggaagaagagagagccttaccagctttggc
aatggtccactatcaccaggaggacccagcaagcctgggggaggagggggaggtcctggg
tccggctccacaagccggggtgagatgagcctggctgaggttcaatgtcatctcgacaag
gaaggcgcctccaatctggtcatcgacctcataatgaatgcatccagcgaccgagtattc
cacgaaagcattctcctggccatcgcacttctggaaggaggcaacaccactatccagcac
tcatttttctgccggctgacggaagataagaaatcagagaagttcttcaaggtcttttac
gatcgaatgaaggtggcccagcaggaaatcaaggcgacagtgaccgtgaacaccagcgat
ttgggaaacaaaaagaaagatgatgaagtggaccgggatgccccatcccggaagaaagcc
aaagagcccacaacacagataacagaagaggtccgggatcagctcttggaagcatctgct
gccaccagaaaagcctttaccaccttccggagggaggccgaccctgatgaccattaccaa
tctggggagggcacccaggctacaacggacaaagccaaggatgacctagagatgagtgca
gtcatcaccatcatgcagcctatcctgcgcttcctgcagctcctgtgtgaaaaccacaac
cgcgatctgcagaatttccttcgttgccaaaataataagaccaactacaacttggtgtgt
gagacactgcagtttctggactgtatctgtgggagcacaactggaggccttggtcttctc
ggactgtacataaatgaaaagaatgtagctcttatcaaccaaaccctggagagtctgact
gagtactgtcaagggccttgccatgaaaaccagaactgcatcgccacccacgagtccaat
ggcatcgatatcatcacagccctcatccttaacgatatcaaccctctggggaagaaacgg
atggacctggtgttagaactgaagaacaatgcttcaaagctactcctggccatcatggaa
agcagacacgatagtgaaaatgcagagaggatcctgtacaacatgaggcccaaggagctg
gtggaagtgatcaagaaggcctacatgcaaggcgaagtggagtttgaggatggggagaac
ggtgaggatggagcagcctcccccaggaacgtgggccataacatctacatcctcgctcac
cagttggctcggcataacaaagaacttcaaaccatgctgaaacctggaggccaggtggat
ggcgatgaagctctggagttctatgcgaagcacacagcacaaattgagattgtcagactg
gaccgaactatggaacagattgtcttccctgtgcccagcatctgtgaatttctgactaag
gaatcgaaacttcgaatatattacaccacagagagggatgagcaaggcagcaagatcaat
gacttcttcctgcgctccgaggacctctttaatgagatgaactggcagaagaaacttcga
gcccagcctgtcttgtactggtgcgcccgaaacatgtctttctggagcagcatctccttc
aacctggccgtcctgatgaacctgctggtggcgtttttctacccatttaaaggagtgaga
ggaggaacactagagccgcactggtccggcctcctgtggacagccatgctcatctctctg
gcaattgtcattgcgctgcccaagccccatggcatccgggccttaattgcttctacaatc
ctacgactgatattttcagttggattacagcccacactgtttctgctgggagctttcaat
gtctgcaataaaatcatcttcctgatgagctttgtgggcaactgtgggaccttcaccaga
ggctaccgagccatggttctggacgttgagttcctctatcatttgctgtatctactgatc
tgtgccatgggcctcttcgtacatgagtttttctatagtttgctgctttttgatttagtg
tacagagaggagactttgcttaatgtcattaaaagtgtcacccgcaatggacggtccatc
atcttgacagcggtcctggctctgattctggtttacctgttctcaattgtgggctacctg
ttcttcaaggatgactttatcttggaagtagacaggttgcccaatgagacagctggtcca
gaaactggtgagagtttggccaacgatttcctgtactctgatgtgtgccgggtagagacg
ggggagaactgcacctctccggcacccaaagaagagctgctccctgtggaagaaacggaa
caggataaggagcacacgtgtgagacactgctcatgtgcatcgtcaccgttctgagtcac
gggctgcggagtgggggcggagtaggagatgtgctcaggaagccatccaaagaggagcct
ctgtttgctgcaagggtgatctatgacctcctcttcttcttcatggtcatcatcattgtc
ctgaacctcatttttggggtcatcatcgacacctttgctgacctgaggagtgagaagcag
aagaaggaagagatcttaaaaaccacgtgcttcatttgtggcttggaaagggacaagttt
gacaataagaccgtcacctttgaagagcacattaaggaagaacacaacatgtggcactat
ctgtgcttcatcgtgctggtgaaagtgaaggactccaccgagtacaccgggcccgagagc
tacgtggcagagatgatcagggaaagaaaccttgattggttccccaggatgagagccatg
tccctggtcagcagtgactctgaaggggaacagaacgagctgaggaacctgcaggagaag
ctggagtccaccatgaagctggtcaccaatctttctggccagctgtcagaactaaaggac
cagatgacagaacaaaggaagcagaaacaaagaattggccttctaggacatcctcctcac
atgaatgtcaacccacagcagccagcctaa

KEGG   Rattus norvegicus (rat): 25679
Entry
25679             CDS       T01003                                 

Gene name
Itpr3
Definition
(RefSeq) inositol 1,4,5-trisphosphate receptor type 3
  KO
K04960  inositol 1,4,5-triphosphate receptor type 3
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04020  Calcium signaling pathway
rno04022  cGMP-PKG signaling pathway
rno04070  Phosphatidylinositol signaling system
rno04114  Oocyte meiosis
rno04210  Apoptosis
rno04218  Cellular senescence
rno04270  Vascular smooth muscle contraction
rno04371  Apelin signaling pathway
rno04540  Gap junction
rno04611  Platelet activation
rno04621  NOD-like receptor signaling pathway
rno04625  C-type lectin receptor signaling pathway
rno04713  Circadian entrainment
rno04720  Long-term potentiation
rno04723  Retrograde endocannabinoid signaling
rno04724  Glutamatergic synapse
rno04725  Cholinergic synapse
rno04726  Serotonergic synapse
rno04728  Dopaminergic synapse
rno04730  Long-term depression
rno04742  Taste transduction
rno04750  Inflammatory mediator regulation of TRP channels
rno04911  Insulin secretion
rno04912  GnRH signaling pathway
rno04915  Estrogen signaling pathway
rno04918  Thyroid hormone synthesis
rno04921  Oxytocin signaling pathway
rno04922  Glucagon signaling pathway
rno04924  Renin secretion
rno04925  Aldosterone synthesis and secretion
rno04927  Cortisol synthesis and secretion
rno04928  Parathyroid hormone synthesis, secretion and action
rno04929  GnRH secretion
rno04934  Cushing syndrome
rno04935  Growth hormone synthesis, secretion and action
rno04970  Salivary secretion
rno04971  Gastric acid secretion
rno04972  Pancreatic secretion
rno05010  Alzheimer disease
rno05012  Parkinson disease
rno05014  Amyotrophic lateral sclerosis
rno05017  Spinocerebellar ataxia
rno05020  Prion disease
rno05022  Pathways of neurodegeneration - multiple diseases
rno05163  Human cytomegalovirus infection
rno05167  Kaposi sarcoma-associated herpesvirus infection
rno05170  Human immunodeficiency virus 1 infection
rno05205  Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    25679 (Itpr3)
   04020 Calcium signaling pathway
    25679 (Itpr3)
   04070 Phosphatidylinositol signaling system
    25679 (Itpr3)
   04022 cGMP-PKG signaling pathway
    25679 (Itpr3)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    25679 (Itpr3)
   04210 Apoptosis
    25679 (Itpr3)
   04218 Cellular senescence
    25679 (Itpr3)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    25679 (Itpr3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    25679 (Itpr3)
   04621 NOD-like receptor signaling pathway
    25679 (Itpr3)
   04625 C-type lectin receptor signaling pathway
    25679 (Itpr3)
  09152 Endocrine system
   04911 Insulin secretion
    25679 (Itpr3)
   04922 Glucagon signaling pathway
    25679 (Itpr3)
   04929 GnRH secretion
    25679 (Itpr3)
   04912 GnRH signaling pathway
    25679 (Itpr3)
   04915 Estrogen signaling pathway
    25679 (Itpr3)
   04921 Oxytocin signaling pathway
    25679 (Itpr3)
   04935 Growth hormone synthesis, secretion and action
    25679 (Itpr3)
   04918 Thyroid hormone synthesis
    25679 (Itpr3)
   04928 Parathyroid hormone synthesis, secretion and action
    25679 (Itpr3)
   04924 Renin secretion
    25679 (Itpr3)
   04925 Aldosterone synthesis and secretion
    25679 (Itpr3)
   04927 Cortisol synthesis and secretion
    25679 (Itpr3)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    25679 (Itpr3)
  09154 Digestive system
   04970 Salivary secretion
    25679 (Itpr3)
   04971 Gastric acid secretion
    25679 (Itpr3)
   04972 Pancreatic secretion
    25679 (Itpr3)
  09156 Nervous system
   04724 Glutamatergic synapse
    25679 (Itpr3)
   04725 Cholinergic synapse
    25679 (Itpr3)
   04728 Dopaminergic synapse
    25679 (Itpr3)
   04726 Serotonergic synapse
    25679 (Itpr3)
   04720 Long-term potentiation
    25679 (Itpr3)
   04730 Long-term depression
    25679 (Itpr3)
   04723 Retrograde endocannabinoid signaling
    25679 (Itpr3)
  09157 Sensory system
   04742 Taste transduction
    25679 (Itpr3)
   04750 Inflammatory mediator regulation of TRP channels
    25679 (Itpr3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    25679 (Itpr3)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    25679 (Itpr3)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    25679 (Itpr3)
   05163 Human cytomegalovirus infection
    25679 (Itpr3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    25679 (Itpr3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    25679 (Itpr3)
   05012 Parkinson disease
    25679 (Itpr3)
   05014 Amyotrophic lateral sclerosis
    25679 (Itpr3)
   05017 Spinocerebellar ataxia
    25679 (Itpr3)
   05020 Prion disease
    25679 (Itpr3)
   05022 Pathways of neurodegeneration - multiple diseases
    25679 (Itpr3)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    25679 (Itpr3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:rno01009]
    25679 (Itpr3)
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:rno04040]
    25679 (Itpr3)
Protein phosphatases and associated proteins [BR:rno01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     25679 (Itpr3)
Ion channels [BR:rno04040]
 Ligand-gated channels
  IP3 receptor
   25679 (Itpr3)
SSDB
Motif
Pfam: Ins145_P3_rec RYDR_ITPR MIR RIH_assoc Ion_trans
Other DBs
NCBI-GeneID: 25679
NCBI-ProteinID: NP_037270
RGD: 2934
Ensembl: ENSRNOG00000052795
Vega: OTTRNOG00000001959
UniProt: Q63269 C7E1V1
Position
20
AA seq 2670 aa
MNEMSSFLHIGDIVSLYAEGSVNGFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVC
PMNRYSAQKQYWKAKQTKQDKEKIADVVLLQKLQHAAQMEQKQNDTENKKVHGDVVKYGS
VIQLLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGSWLFIQPFWKLRSNGDNVVVG
DKVILNPVNAGQPLHASNYELSDNVGCKEVNSVNCNTSWKINLFMQFRDHLEEVLKGGDV
VRLFHAEQEKFLTCDEYRGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHW
NGLYRFKHLATGNYLAAEENPSYKGDVSDPKAAGPGAQSRTGRRNAGEKIKYRLVAVPHG
NDIASLFELDPTTLQKTDSFVPRNSYVRLRHLCTNTWIQSTNAPIDVEEERPIRLMLGTC
PTKEDKEAFAIVSVPVSEIRDLDFANDASSMLASAVEKLNEGFISQNDRRFVIQLLEDLV
FFVSDVPNNGQNVLDIMVTKPNRERQKLMREQNILKQIFGILKAPFRDKGGEGPLVRLEE
LSDQKNAPYQYMFRLCYRVLRHSQEDYRKNQEHIAKQFGMMQSQIGYDILAEDTITALLH
NNRKLLEKHITKTEVETFVSLVRKNREPRFLDYLSDLCVSNRIAIPVTQELICKCVLDPK
NSDILIQTELRPVKEMAQSHEYLSIEYSEEEVWLTWTDRNNEHHEKSVRQLAQEARAGNA
HDENVLSYYRYQLKLFARMCLDRQYLAIDEISKQLGVELLFLCMADEMLPFDLRASFCHL
MLHVHVDRDPQELVTPVKFARLWTEIPTAITIKDYDSNLNASRDDKKNKFASTMEFVEDY
LNNVVGEAVPFANDEKNILTFEVVSLAHNLIYFGFYSFSELLRLTRTLLGIIDCIQAPAA
VLQAYEEPGGKNVRRSIQGVGHMMSTMVLSRKQSVFGASSLPTGVGVPEQLDRSKFEDNE
HTVVMETKLKILEILQFILNVRLDYRISYLLSVFKKEFVEVFPMQDSGADGTAPAFDSST
ANMNLDRIGEQAEAMFGVGKTSSMLEVDDEGGRMFLRVLLHLTMHDYPPLVSGALQLLFK
HFSQRQEAMHTFKQVQLLISAQDVENYKVIKSELDRLRTMVEKSELWVDKKGSVKGEEGE
AGASKDKKERPSDEEGFLQPHGEKSSENYQIVKGILERLNKMCGVGEQMRKKQQRLLKNM
DAHKVMLDLLQIPYDKNDNKMMEILRYTHQFLQKFCAGNPGNQALLHKHLQLFLTPGLLE
AETMQHIFLNNYQLCSEISEPVLQHFVHLLATHGRHVQYLDFLHTVIKAEGKYVKKCQDM
IMTELTNAGDDVVVFYNDKASLAHLLDMMKAARDGVEDHSPLMYHISLVDLLAACAEGKN
VYTEIKCTSLLPLEDVVSVVTHEDCITEVKMAYVNFVNHCYVDTEVEMKEIYTSNHIWTL
FENFTLDMALVCNKREKRLSDPTLEKYVLTVVLDTISAFFSSPFSENSTSLQTHQTIVVQ
LLQSTTRLLECPWLQQQHKGSVEACVRTLAMVAKSRAILLPMDLDAHMSALLSSGGSCSA
AAQRSAANYKTATRTFPRVIPTANQWDYKNIIEKLQDIITALEERLKPLVQAELSVLVDM
LHWPELLFLEGSEAYQRCESGGFLSKLIRHTKGLMESEEKLCVKVLRTLQQMLQKKSKYG
DRGNQLRKMLLQNYLQNRKSGPRGELTDPTGSGVDQDWSAIAATQCRLDKEGATKLVCDL
ITSTKNEKIFQESIGLAIRLLDGGNTEIQKSFYNLMTSDKKSERFFKVLHDRMKRAQQET
KSTVAVNMSDLGSQPREDREPADPTTKGRVSSFSMPSSSRYSLGPGLHRGHDVSERAQNN
EMGTSVLIMRPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDIMCGSTTGG
LGLLGLYINEDNVGLVIQTLETLTEYCQGPCHENQTCIVTHESNGIDIITALILNDISPL
CKYRMDLVLQLKDNASKLLLALMESRHDSENAERILISLRPQELVDVIKKAYLQEEEREN
SEVSPREVGHNIYILALQLSRHNKQLQHLLKPVKRIQEEEAEGISSMLSLNNKQLSQMLK
SSAPAQEEEEDPLAYYENHTSQIEIVRQDRSMEQIVFPVPAICQFLTEETKHRLFTTTEQ
DEQGSKVSDFFDQSSFLHNEMEWQRRLRSMPLIYWFSRRMTLWGSISFNLAVFINIIIAF
FYPYVEGASTGVLGSPLISLLFWILICFSIAALFTKHYSVRPLIVALVLRSIYYLGIGPT
LNILGALNLTNKIVFVVSFVGNRGTFIRGYKAMVMDMEFLYHVGYILTSVLGLFAHELFY
SILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVYLFSIVGFLFLKDDFILEVDR
LPGNHSRASTLGMPHGAATFMGTCSGDKMDCVSEVSVPEILEEDEELDSTERACDTLLMC
IVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVYDLLFFFIVIIIVLNLIFGVIIDTFA
DLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKLEHNMWNYLYFIVLVRVKNKT
DYTGPESYVAQMIKNKNLDWFPRMRAMSLVSGEGEGEQNEIRILQEKLGSTMKLVSHLTA
QLNELKEQMTEQRKRRQRLGFVDVQNCMSR
NT seq 8013 nt   +upstreamnt  +downstreamnt
atgaatgaaatgtccagctttcttcacatcggggacattgtgtccctgtacgccgagggc
tctgtcaacggcttcatcagcactttggggctggtggatgaccgttgtgtggtggagcct
gcagctggggacctggacaacccccccaagaagttccgagattgcctcttcaaagtgtgc
cccatgaaccgctactccgcacagaagcagtactggaaagccaagcagactaagcaggac
aaagagaagatcgccgatgtggtgttgctgcagaagctgcagcatgcagcccagatggag
cagaagcaaaacgacacagagaacaagaaggtgcacggggacgtggtgaagtacggcagc
gtgattcagcttctgcacatgaagagcaacaaatacttaacggtgaacaagcggctgccg
gccctgctggagaagaacgccatgcgggtgacgctggacgcgacaggcaacgagggctcc
tggctcttcatccagcccttctggaagcttcggagcaatggggataacgtggttgtgggg
gacaaggtgatcctgaaccctgtcaacgcagggcagcctctacacgccagcaactatgag
cttagtgataacgttggctgcaaggaggtcaactctgtcaactgcaacaccagctggaag
atcaacttattcatgcagttccgggaccatctggaggaggtgttgaaggggggagacgtg
gtgcggctgttccatgcagagcaggagaagttcctgacctgtgacgagtaccggggcaag
cttcaggtgttcctgaggaccacgctgcgtcagtccgccacctcggccaccagctccaac
gcgctctgggaggtggaggtggtccaccatgacccctgccgcggcggagcgggacactgg
aatggtctgtacaggttcaagcacctggccacgggcaactatctggcggctgaagaaaac
cccagctacaagggtgatgtctcagatcctaaggcagcaggaccaggggcccagagccgc
acaggccgcagaaacgccggcgagaagatcaagtaccgtctggtggctgtgccacatggc
aacgacatcgcgtctctcttcgagctggaccccaccacgctgcagaaaaccgactccttc
gtgccccggaactcctacgtgcggctgcggcacctctgtaccaacacctggatccagagc
acgaacgcgcccatcgacgtggaggaggaacggcctatccggctcatgttgggcacgtgc
cccaccaaggaggacaaggaggcctttgccattgtgtcggttcccgtgtctgagatccgc
gacctggactttgccaacgatgcaagctccatgctggccagcgctgtggagaaactcaac
gagggcttcatcagccagaacgaccgcaggtttgtcatccagctgttggaggacttggtg
ttttttgtcagcgatgttcccaacaatgggcagaatgtcctggacatcatggtcaccaaa
cccaaccgagagcggcagaagctgatgcgggagcagaacatacttaagcagatctttggc
atcctgaaggctccattccgtgacaaggggggtgaagggccattggtgcgtctggaggaa
ctgtctgaccagaagaacgccccctaccagtacatgttccgcctgtgttaccgggtgctg
cggcactcccaggaggactaccgtaagaaccaggagcacatagccaagcagttcgggatg
atgcagtcacagattggctatgacatcctggccgaagacaccatcacggccctgctgcac
aacaaccggaagctgctggagaagcacatcaccaagaccgaggtggaaaccttcgtgagc
ctcgtgcgcaagaacagggagcccaggttcctggactacctctccgacctgtgcgtgtcc
aaccgcattgccatccccgtcacccaggagctgatttgcaagtgtgtgctggaccccaag
aacagtgacatccttatccagactgagcttcggcccgtgaaggagatggctcagtctcac
gagtacctcagcatcgagtactcggaggaggaggtgtggctcacatggacggacaggaac
aacgagcatcacgagaagagtgtgaggcagctggcccaggaggcaagggccggcaacgca
cacgacgagaacgtgctcagctactacaggtaccagttgaagctgtttgcccgcatgtgc
ctagaccgccagtacctggccatcgacgagatctccaagcaactgggtgtggagctgctt
ttcctatgcatggcggacgagatgctgccctttgacctccgcgcctcattctgccacctg
atgctacatgtgcacgtggaccgtgacccccaggagctggtgacccctgtcaagtttgcc
cgcctctggacagagatccccacggccatcaccatcaaagactatgattccaatctcaac
gcctcccgagatgacaagaaaaacaagtttgccagcaccatggagttcgtggaggattac
cttaacaacgtggtcggcgaggccgtgccctttgccaacgatgagaagaacatactgacc
tttgaggtggtcagcctggcacacaacctcatctacttcgggttctacagcttcagcgag
ctgctgcgactcacacgcacgttgctgggcatcatcgactgcattcaggcaccagccgct
gtgctgcaggcctatgaggagcctggcggcaagaacgtgcggaggtccatccagggggtg
ggacacatgatgtccaccatggtgctaagccgcaagcagtctgtatttggtgcctccagc
ctgcctactggagtgggtgtccccgagcagctggacagaagcaaatttgaggacaatgaa
cacaccgtggtgatggagaccaagctgaagatcctggagatcctgcagttcatcctcaac
gtgcgcctagactaccgcatctcctacctgctgtcggtcttcaagaaggagtttgtggag
gtctttcccatgcaggacagcggggcagacggcacagcccccgccttcgattcctctact
gccaacatgaatctggaccgcatcggggagcaggcagaggccatgtttggagtagggaag
accagcagcatgctagaggtggatgacgaagggggtcgcatgttcctgcgagtgctgctg
cacctcaccatgcacgactacccacctctggtctccggcgccctgcagctgctcttcaaa
catttcagccagcgccaggaggccatgcacaccttcaagcaggtgcagctgctcatctca
gcccaggatgtggagaactacaaagtgatcaagtcggaactggatcgactgcggacgatg
gtggagaagtcggagctgtgggtggacaagaaaggcagcgtcaagggcgaggagggggag
gcgggcgccagcaaggataagaaggagcggccctcggatgaggagggatttctgcagcca
cacggggagaagagcagtgagaactaccagattgtcaaaggcatcctggagaggctgaac
aagatgtgtggggtcggggagcagatgcgaaagaagcaacagagactgctgaagaacatg
gacgcccacaaggtcatgctggacctgctgcagatcccttatgacaagaacgacaacaag
atgatggagatcctgcgctacacacaccagttcctacagaagttctgtgccgggaaccct
ggcaaccaggcccttctgcacaagcacttgcagctcttcctcacgcccgggctcctggag
gctgagaccatgcagcacattttcctcaacaactatcagctgtgctctgagatcagcgag
ccggtgctgcaacacttcgtgcacctgctggccacacacgggcgccacgtgcagtacctg
gacttcctgcatactgtcatcaaggccgagggcaagtacgtgaagaagtgtcaggacatg
atcatgaccgagctgaccaacgcaggcgacgacgtggtggtgttctacaatgacaaggcc
tctctggcccatctgctggacatgatgaaggcagcccgagatggcgtggaggaccacagc
cccctcatgtaccacatctccctggtggacttgctggctgcctgtgcagaaggcaaaaat
gtctacacagagatcaagtgcacttccctgctgcctctagaggacgtggtgtcggtggtg
acccacgaggactgcatcacggaggttaaaatggcgtatgtgaacttcgtgaaccactgc
tatgtagacacggaggtggagatgaaggagatctataccagcaaccacatctggacgctc
ttcgagaacttcaccctggacatggctctggtctgtaacaagcgggagaagcgcctgtca
gaccccacccttgagaagtacgtgctcaccgtggtgctggacaccatcagcgccttcttc
agttccccattttcagagaacagcacatccctacagacgcatcagacaattgtggttcag
ctgctgcagtccaccacccggctgctcgagtgtccttggctgcagcagcagcacaagggc
tcggtggaggcctgtgtccgcaccctcgccatggtggccaagagtagagccatcttgctg
ccgatggatctggatgcccacatgagcgctctgctcagcagtgggggcagctgctcagcc
gcggcccaacgcagcgctgccaactacaagacggccacgaggaccttccctcgggtcatc
cccaccgccaaccagtgggactacaagaacatcattgagaagttacaggacatcatcacg
gccctagaagagcggctgaagcctctggtgcaggccgagctctcggtgctggtggacatg
ctgcactggcccgagctgctctttctagagggcagtgaggcctaccagcgctgcgagagt
ggcggcttcctgtccaagctcatccgtcacaccaagggtctcatggagtcggaggagaag
ctgtgcgtgaaggtgctgcggacgctgcagcagatgctgcagaagaagagcaagtatggg
gaccggggcaaccagctaaggaagatgctgctgcagaattacctccagaaccggaagtcc
ggtccccggggcgagctcactgaccccacaggctctggcgtggatcaggactggtccgcc
atcgcagccacccagtgccggctggacaaggagggggccaccaagttggtgtgtgatctc
atcaccagcaccaagaacgagaagatcttccaggagagcatcggcctggccatccgcctg
ctggacgggggcaacactgagatccagaagtctttctacaacctgatgacaagtgacaag
aagtcagagcgcttcttcaaagtgctgcatgaccgcatgaagcgtgcccagcaggagacc
aagtccacagttgccgtcaacatgagtgacctgggcagccagcctcgtgaggaccgtgag
ccagcagaccctaccaccaaaggtcgcgtgtcctccttctccatgcccagctcctcccga
tattcgctgggccctggcttgcaccgggggcacgacgtgagcgagcgtgcgcagaacaac
gagatggggacctcggtgctcatcatgcggcccatcctgcgcttcctgcagctgctgtgt
gagaaccataaccgggacctgcagaacttcctgcgctgtcagaacaacaagaccaactac
aacctcgtgtgtgagaccctgcagttcctggacatcatgtgtggcagcaccacagggggc
ctggggctgctggggctctacatcaacgaggacaatgtgggcctggtcatccagaccttg
gagaccctcacagagtactgccagggcccgtgccatgagaaccagacctgcatcgtgact
cacgagtccaacggcattgacatcatcacggcgctgatcctcaatgacatcagcccgctc
tgcaagtaccgcatggacctggtgctgcagctcaaggacaatgcctccaagctgctcctg
gctctgatggagagtcgacatgacagcgagaatgcagaacgcatcctcatcagccttcgg
cctcaggagctggtggacgtgatcaagaaggcctacctgcaggaggaggagcgggaaaat
tccgaagtgagcccacgtgaagtgggccacaacatctacatcctggcactgcagctttcc
aggcacaacaagcagctacagcacctgctgaagccggtgaagcgcatccaggaggaggag
gccgagggcatctcttccatgctcagcctcaacaacaagcagctctctcagatgctcaag
tcctcagcccctgcccaagaggaggaggaagacccgctggcctactatgagaaccacacc
tcgcagattgagattgtgcggcaagaccgaagcatggagcagatcgtgttcccggtacct
gccatctgccagttcctgacagaggagaccaagcaccggctcttcaccaccacggagcag
gacgagcagggcagcaaagtgagcgacttcttcgaccagtcctccttcctgcacaacgag
atggagtggcagcgccggcttcgcagcatgccgctcatctactggttctcccgccgcatg
acgctgtggggtagcatctccttcaacctggcagtgttcatcaacatcatcattgccttc
ttctacccctacgtggaaggcgcgtccacgggcgtgctgggctccccactcatctcgctc
ctcttctggatcctcatctgcttctccattgccgcgctgttcaccaagcactacagcgtc
cgtcccctcattgtggcactggtccttcgctccatctactacctgggcattgggcccacg
ctcaacatcctgggtgctctcaatctgaccaacaagatcgtgtttgtggtgagcttcgtg
ggcaaccgcggcaccttcatccgtggctataaagcaatggtcatggacatggagttcctg
tatcacgtgggctacatcctgacgagtgtcctgggcctctttgctcatgagctcttctac
agtatcctgctctttgacctcatctaccgagaggagacgctgtttaatgtcatcaagagc
gtgacccgcaatggccgctccatcctgctaactgccctgctggccctcatccttgtctac
ctcttctccatcgtgggcttcctcttcctcaaggatgacttcatcctggaggtggaccgg
ctgcctgggaaccactccagagccagcaccctggggatgccacacggagctgccacattt
atgggcacatgtagtggggacaagatggactgtgtctctgaggtctcggtgcctgagatc
ctagaagaggacgaggagctggacagcacagagcgggcctgtgatactctgcttatgtgt
attgtcaccgtcatgaaccacggactgaggaacggtggcggcgtgggcgacatcctccgc
aagccctccaaagacgagtcgctcttcccagccagggtggtgtacgacctcctgttcttc
ttcattgtcatcattattgtcctgaacctcatctttggggtgatcatcgacaccttcgcc
gacctgcgcagcgagaagcagaagaaagaggaaatcctcaagaccacgtgcttcatctgt
ggtctggagagggacaagtttgacaacaagacagtgtcctttgaagagcacatcaaactg
gagcacaacatgtggaactacctgtacttcattgtgctggtccgtgtcaagaacaagaca
gactacacgggccccgagagctacgtggctcagatgatcaagaacaagaacctggactgg
ttcccacggatgcgcgccatgtccttggtgagcggcgagggcgagggcgagcagaacgag
atccgcatcctgcaggagaagcttggctccaccatgaagctggtctcgcacctcaccgcc
cagctcaatgagctcaaggaacagatgacggagcagcggaagcggaggcaacgtctgggc
ttcgtggacgtgcagaactgcatgagccgctga

KEGG   Rattus norvegicus (rat): 81678
Entry
81678             CDS       T01003                                 

Gene name
Itpr2
Definition
(RefSeq) inositol 1,4,5-trisphosphate receptor type 2
  KO
K04959  inositol 1,4,5-triphosphate receptor type 2
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04020  Calcium signaling pathway
rno04022  cGMP-PKG signaling pathway
rno04070  Phosphatidylinositol signaling system
rno04114  Oocyte meiosis
rno04210  Apoptosis
rno04218  Cellular senescence
rno04270  Vascular smooth muscle contraction
rno04371  Apelin signaling pathway
rno04540  Gap junction
rno04611  Platelet activation
rno04621  NOD-like receptor signaling pathway
rno04625  C-type lectin receptor signaling pathway
rno04720  Long-term potentiation
rno04723  Retrograde endocannabinoid signaling
rno04724  Glutamatergic synapse
rno04725  Cholinergic synapse
rno04726  Serotonergic synapse
rno04728  Dopaminergic synapse
rno04730  Long-term depression
rno04750  Inflammatory mediator regulation of TRP channels
rno04912  GnRH signaling pathway
rno04915  Estrogen signaling pathway
rno04918  Thyroid hormone synthesis
rno04921  Oxytocin signaling pathway
rno04922  Glucagon signaling pathway
rno04924  Renin secretion
rno04925  Aldosterone synthesis and secretion
rno04927  Cortisol synthesis and secretion
rno04928  Parathyroid hormone synthesis, secretion and action
rno04929  GnRH secretion
rno04934  Cushing syndrome
rno04935  Growth hormone synthesis, secretion and action
rno04970  Salivary secretion
rno04971  Gastric acid secretion
rno04972  Pancreatic secretion
rno05010  Alzheimer disease
rno05012  Parkinson disease
rno05017  Spinocerebellar ataxia
rno05020  Prion disease
rno05022  Pathways of neurodegeneration - multiple diseases
rno05163  Human cytomegalovirus infection
rno05167  Kaposi sarcoma-associated herpesvirus infection
rno05170  Human immunodeficiency virus 1 infection
rno05205  Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    81678 (Itpr2)
   04020 Calcium signaling pathway
    81678 (Itpr2)
   04070 Phosphatidylinositol signaling system
    81678 (Itpr2)
   04022 cGMP-PKG signaling pathway
    81678 (Itpr2)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    81678 (Itpr2)
   04210 Apoptosis
    81678 (Itpr2)
   04218 Cellular senescence
    81678 (Itpr2)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    81678 (Itpr2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    81678 (Itpr2)
   04621 NOD-like receptor signaling pathway
    81678 (Itpr2)
   04625 C-type lectin receptor signaling pathway
    81678 (Itpr2)
  09152 Endocrine system
   04922 Glucagon signaling pathway
    81678 (Itpr2)
   04929 GnRH secretion
    81678 (Itpr2)
   04912 GnRH signaling pathway
    81678 (Itpr2)
   04915 Estrogen signaling pathway
    81678 (Itpr2)
   04921 Oxytocin signaling pathway
    81678 (Itpr2)
   04935 Growth hormone synthesis, secretion and action
    81678 (Itpr2)
   04918 Thyroid hormone synthesis
    81678 (Itpr2)
   04928 Parathyroid hormone synthesis, secretion and action
    81678 (Itpr2)
   04924 Renin secretion
    81678 (Itpr2)
   04925 Aldosterone synthesis and secretion
    81678 (Itpr2)
   04927 Cortisol synthesis and secretion
    81678 (Itpr2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    81678 (Itpr2)
  09154 Digestive system
   04970 Salivary secretion
    81678 (Itpr2)
   04971 Gastric acid secretion
    81678 (Itpr2)
   04972 Pancreatic secretion
    81678 (Itpr2)
  09156 Nervous system
   04724 Glutamatergic synapse
    81678 (Itpr2)
   04725 Cholinergic synapse
    81678 (Itpr2)
   04728 Dopaminergic synapse
    81678 (Itpr2)
   04726 Serotonergic synapse
    81678 (Itpr2)
   04720 Long-term potentiation
    81678 (Itpr2)
   04730 Long-term depression
    81678 (Itpr2)
   04723 Retrograde endocannabinoid signaling
    81678 (Itpr2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    81678 (Itpr2)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    81678 (Itpr2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    81678 (Itpr2)
   05163 Human cytomegalovirus infection
    81678 (Itpr2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    81678 (Itpr2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    81678 (Itpr2)
   05012 Parkinson disease
    81678 (Itpr2)
   05017 Spinocerebellar ataxia
    81678 (Itpr2)
   05020 Prion disease
    81678 (Itpr2)
   05022 Pathways of neurodegeneration - multiple diseases
    81678 (Itpr2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    81678 (Itpr2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:rno04040]
    81678 (Itpr2)
Ion channels [BR:rno04040]
 Ligand-gated channels
  IP3 receptor
   81678 (Itpr2)
SSDB
Motif
Pfam: Ins145_P3_rec RYDR_ITPR MIR RIH_assoc Ion_trans DUF2207
Other DBs
NCBI-GeneID: 81678
NCBI-ProteinID: NP_112308
RGD: 69649
UniProt: P29995
Position
4
AA seq 2701 aa
MSDKMSSFLYIGDIVSLYAEGSVNGFISTLGLVDDRCVVHPEAGDLTNPPKKFRDCLFKV
CPMNRYSAQKQYWKAKQAKQGNHTEAALLKKLQHAAELEQKQNESENRKLLGEIVKYSNV
IQLLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGD
KVVLMPVNAGQPLHASNVELLDNPGCKEVNAVNCNTSWKITLFMKFSSYREDVLKGGDVV
RLFHAEQEKFLTCDDYEKKQHIFLRTTLRQSATSATSSKALWEIEVVHHDPCRGGAGQWN
SLFRFKHLATGNYLAAELNPDYRDAQNEGKTVRDGELPTSKKKRQAGEKIMYTLVSVPHG
NDIASLFELDATTLQRADCLVPRNSYVRLRHLCTNTWVTSTSIPIDTEEERPVMLKIGTC
QTKEDKEAFAIVCVPLSEVRDLDFANDANKVLATTVKKLENGSITQNERRFVTKLLEDLI
FFVADVTNNGQDVLDVVITKPNRERQKLMREQNILAQVFGILKAPFKEKAGEGSMLRLED
LGDQRYAPYKYVLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLH
NNRKLLEKHITAKEIETFVSLLRRNREPRFLDYLSDLCVSNSTAIPVTQELICKFMLSPG
NADILIQTKLVSMQVENPMESSILPDDIDDEEVWLYWIDSNKEPHGKAIRHLAQEAREGT
KADLEVLTYYRYQLNLFARMCLDRQYLAINQISTQLSVDLILRCVSDESLPFDLRASFCR
LMLHMHVDRDPQESVVPVRYARLWTEIPTKITIHEYDSITDSSRNDMKRKFALTMEFVEE
YLKEVVNQPFPFGDKEKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDIVQAPM
SSYFERLSKFQDGSNNVMRTIHGVGEMMTQMVLSRGSIFPVSVPDAQPSVHPSKQASPGE
QEDVTVMDTKLKVIEILQFILSVRLDYRISYMLSIYKKEFGENDGNGDPSASGTPETLLP
SALVPDIDEIAAQAETMFAGRKEKTPVQLDDEGGRTFLRVLIHLIMHDYAPLLSGALQLL
FKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEKSSSYENGD
MGEGQAKGGEEANEESNLLSPVQDGAKTPQIDSNKGNNYRIVKEILIRLSKLCVQNKKCR
NQHQRLLKNMGAHSVVLDLLQIPYEKTDEKMNEVMDLAHTFLQNFCRGNPQNQVLLHKHL
NLFLTPGLLEAETMRHIFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIVKAD
GKYVKKCQDMVMTELINGGEDVLIFYNDRASFPILLNMMCSERARGDESGPLAYHITLVE
LLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAYVNFVNHCYVDTEVEMKE
IYTSNHIWKLFENFLVDMARVCNTTTDRKHADTFLERCVTESVMNIVSGFFNSPFSDNST
SLQTHQPVFIQLLQSAFRIYNCTWPNPAQKASVESCIRALAEVAKNRGIAIPVDLDSQVN
TLFMKNHSSTVQRAAMGWRLSARSGPRFKEALGGPAWDYRNIIEKLQDVVASLEQQFSPM
MQAEFSVLVDVLYSPELLFPEGSDARIRCGAFMSKLINHTKKLMEKEEKLCIKILQTLRE
MLEKKDSFMEEGSTLRKILLNRYFKGDHSVGVNGPLSGAYAKTAQVGGGFTGQDADKTGI
SMSDIQCLLDKEGASELVIDVIVNTKNDRIFSEGILLGIALLEGGNTQTQNSFYQQLHEQ
KKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDLGSKKREEDSDLMALGPRMRVRDSSLHLK
EGMKGQLTEASSATSKAYCVYRREMDPDIDTMCPGQEAGSAEEKSAEEVTMSPAITIMRP
ILRFLQLLCENHNRELQNFLRNQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEK
NVALVNQTLESLTEYCQGPCHENQTCIATHESNGIDIIIALILSDINPLGKYRMDLVLQL
KNNASKLLLAIMESRHDSENAERILFNMRPKELVDVMKNAYNQGLECNHGDEEGGDDGVS
PKDVGHNIYILAHQLARHNKLLQQMLKPGSDPEEGDEALKYYANHTAQIEIVRHDRTMEQ
IVFPVPNICEFLTRESKYRVFNTTERDEQGSKVNDFFQQTEDLYNEMKWQKKIRNNPALF
WFSRHISLWGSISFNLAVFINLAVALFYPFGDDGDEGTLSPLFSALLWVAVAICTSMLFF
FSKPVGIRPFLVSIMLRSIYTIGLGPTLILLGAANLCNKIVFLVSFVGNRGTFTRGYRAV
ILDMAFLYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVIKSVTRNGRSIILTAV
LALILVYLFSIIGFLFLKDDFTMEVDRLKNRTPVTGNDGVPTMTLTSMLGTCPKENCSPT
IPSSNAAGEGGEDGIERTCDTLLMCIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVVY
DLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFE
EHIKSEHNMWHYLYFIVLVKVKDPTEYTGPESYVAQMITEKNLDWFPRMRAMSLVSNEGD
SEQNEIRNLQEKLESTMSLVKQLSGQLAELKEQMTEQRKNKQRLGFLGSNTPHVNHHMPP
H
NT seq 8106 nt   +upstreamnt  +downstreamnt
atgtctgacaaaatgtccagcttcctctacattggggacatcgtgtccctgtacgcggag
ggctcggtcaatggcttcatcagcaccctggggttggtggatgaccgttgtgtggtgcat
ccggaggcgggggatcttaccaacccacccaagaagttcagagactgcctcttcaaggtg
tgccccatgaatcgatactctgcccagaagcagtactggaaagccaagcaggcgaagcag
ggaaaccacacggaggctgccctgctgaagaagctccagcacgccgcagagctggaacaa
aaacagaatgagtcagagaacaggaaacttttgggagaaattgtgaaatacagcaacgtt
atacaactactgcacataaaaagcaacaagtacctcaccgtgaacaagaggttacctgcc
ttactggagaagaatgccatgcgtgtgtccctggatgctgcagggaacgaagggtcctgg
ttctacatccatcccttctggaagctgagaagcgagggtgataatatcgtcgtgggagat
aaagtcgttctgatgcctgtaaatgctgggcagcccctgcatgccagcaacgtggagctc
ctggacaaccccggctgcaaagaggtgaatgctgttaattgcaacactagctggaaaatc
actttattcatgaagttcagctcctaccgagaggatgtattaaaagggggtgacgttgtg
agactgtttcatgcggaacaagagaagtttctgacctgtgatgactatgagaaaaaacag
cacattttcctgcggacgaccttgcgtcaatcagcaacgtcggccactagctctaaagca
ctctgggagatagaggtggttcaccatgatccatgccgcggaggtgcaggacagtggaac
agcctgttcaggtttaagcatcttgcaactgggaactacttagctgcagagcttaaccct
gactatcgagatgctcaaaatgaaggaaaaactgtgagagacggggagcttccaacctca
aagaaaaaacgccaggcaggggagaagatcatgtacacgctggtctcggtcccgcacgga
aatgacatcgcgtccctttttgaacttgacgccacaactctgcagagagctgactgcctg
gttccgaggaactcctacgtgcggttgaggcacctgtgtaccaacacgtgggtaacaagc
accagcatccccatagacacagaggaagagaggcctgtcatgctgaaaattgggacctgc
cagaccaaggaagacaaagaagcctttgccatcgtgtgcgtcccgctgtctgaggtccga
gacctggactttgccaacgatgccaacaaagtattggccaccacggtgaagaagctggag
aatggcagcatcacccagaatgagaggaggtttgtgactaagttgttggaagacctcatt
ttctttgtggctgatgtgaccaacaacggacaggatgttctggatgtggtcatcaccaag
cccaaccgggaacggcaaaaactaatgagggaacagaatattctggcacaggtgtttggg
atccttaaagcccctttcaaggagaaggctggggaaggctcgatgctgaggctggaggac
ctgggcgaccagcgctatgccccgtacaagtacgtgctgcgtctctgctaccgcgtgctg
cggcattcgcagcaggactacaggaagaaccaggagtacatcgctaagaacttctgcgtc
atgcagtctcagatcggctatgatattttggcagaagatacgatcacagccttgctacac
aacaaccgcaaactcctggagaaacacatcacggccaaagaaatcgagaccttcgtcagc
ctgctcaggaggaaccgggagccgaggtttctggactatctgtctgacctctgcgtgtcc
aatagcaccgccatccctgtgactcaggagctcatctgcaaattcatgctgagccccggc
aatgcggacatcctcattcagacgaagctggtgtccatgcaagtggaaaaccccatggag
agttccatccttcccgatgacatcgacgacgaggaggtttggctttactggattgacagc
aacaaggagcctcacggcaaggccatcaggcacctggcccaggaggccagggaaggcacc
aaggctgacctagaagtcctgacctattacaggtaccagctaaacctctttgcaaggatg
tgcttggaccgccagtacctggccatcaaccagatttcaacacagctgtctgtagacctg
atcctgcggtgcgtgtctgacgagagcctgccctttgacctccgagcctctttctgccga
ctcatgctccacatgcacgtggaccgggacccccaggagtctgtggtgcctgtccgctac
gcccggctctggactgagatccccaccaagatcacgatccatgagtatgactccatcaca
gactcttccagaaatgacatgaagaggaagtttgccctgacaatggaatttgtcgaagaa
tatttgaaagaagttgtgaatcaaccgtttccttttggagacaaagagaaaaataaactg
acatttgaggtggtccacctggcccggaacctcatctacttcggattctacagcttcagc
gagttgctgcggctgacgagaactctgctggcgatcctggacatcgtccaggcccccatg
tcgtcgtattttgaaagattaagcaagtttcaagatggaagcaacaatgtcatgaggacc
atccacggggtgggagagatgatgacacagatggtgctcagcagaggctccattttccca
gtgagcgtgcccgacgcacagcccagcgtccaccccagcaagcaggcgagccccggcgag
caggaggatgtgacggttatggataccaagctaaaggttatcgagattttacagttcatc
ctgagtgtcaggctggactaccgtatctcttacatgctgtccatatacaagaaggaattt
ggggagaatgatggcaacggtgacccctctgccagcggcaccccggaaacattgctacca
tcagctcttgtccctgacattgatgagattgcggctcaggcagaaacgatgtttgctgga
agaaaagaaaaaactccagttcagcttgatgatgagggaggcagaaccttcttaagagtc
ctcatccacctgatcatgcatgactatgctccactgctgtccggggccctgcagctgctg
ttcaaacacttcagccagagagcagaagtgcttcaggccttcaaacaggtgcagttacta
gtgtcgaaccaagatgtcgataactacaagcaaatcaaggcagacctggaccaacttcgg
ctgacggtggagaagtccgagctatgggtggaaaagagcagcagctatgagaatggagac
atgggcgagggccaggccaaaggaggcgaagaggcaaatgaggagtccaacctcttgagc
ccggtgcaggacggcgcgaagacacctcagatcgacagcaacaagggcaacaactaccgg
atcgtcaaggagatcttgattaggctgagtaagctctgtgtgcagaacaagaaatgtcgt
aatcaacaccaacggttgctgaaaaatatgggggctcactccgtggtactggaccttctg
cagatcccctatgagaagaccgacgagaagatgaacgaggtgatggacttagcccacacc
ttcctgcagaacttctgccgcgggaatccacagaaccaagttctccttcacaagcatctc
aacctgttcctaacccctggactcctggaggcggaaaccatgcggcacatcttcatgaac
aattaccatctgtgcaatgagatcagcgagagggtggtccagcactttgtgcactgcatt
gagacacacggccgccacgtggagtacctgaggttcctgcagaccatcgtgaaagcagac
ggcaaatacgtgaagaaatgccaggacatggtgatgaccgagctgatcaatgggggtgaa
gacgtactgatattctacaacgaccgagcctcatttcccatccttctcaacatgatgtgc
tccgagagagcccgtggggatgagagcggccccctggcctaccatatcacccttgtggag
ttgctggcagcgtgcactgaggggaagaacgtctacacggagatcaagtgcaattctctc
ttgcctctggacgacatagtgagggtggtgacccacgacgactgcattcctgaggtaaaa
attgcatacgtgaactttgtcaaccattgttacgttgacacagaagtggagatgaaggaa
atctatacaagtaaccacatttggaagttatttgagaacttcttggtggatatggcaagg
gtctgcaacaccaccacggaccggaaacacgcagacacctttctggagaggtgtgtgaca
gagtcagtcatgaacatcgtgagcggcttcttcaactcgccgttttcggataacagtacc
agcctccagacccatcagccggtctttatccagctgctgcagtccgccttcagaatttac
aactgcacctggcccaacccagcccagaaagcctccgtggaatcctgcatcagagccctg
gctgaagtggccaaaaaccgtgggattgcgattccggtggatttggacagccaggtcaac
acactcttcatgaagaatcactcaagtacagtgcagagggcggccatgggctggaggctc
tctgctcgctccggacctcgcttcaaggaagctcttggagggccagcatgggactacagg
aatattattgaaaagttacaggatgtcgtggcctctctggaacagcagttcagccccatg
atgcaggctgagttctctgtgcttgtggatgtgctgtacagcccggagctactgttccca
gaaggaagcgatgccaggatacgatgtggtgccttcatgtccaagctgattaatcacaca
aagaaactgatggaaaaagaagaaaaactgtgcattaaaatcctccagacgttacgggag
atgctggagaagaaagacagcttcatggaagagggtagcacattacggaaaatcctcctg
aatcggtacttcaagggtgaccacagcgttggtgtgaacggacctctgtcaggagcctac
gccaagacagcacaagtgggagggggcttcactggacaggatgccgataagacggggatt
tccatgtccgatatccagtgtttgctggacaaggaaggggcctccgaacttgtcatcgat
gtcattgtgaacaccaaaaacgacaggatcttttccgagggcatcttgcttggcattgcc
ctgctggaaggaggaaacacacaaacccagaattctttctaccagcagttgcatgaacaa
aaaaagtcagagaaattcttcaaagtcctttacgatcggatgaaggctgctcagaaagag
atcagatccacggtgactgtcaacaccatagacttagggagcaagaagagagaggaggac
agtgacctcatggccttgggccctcggatgagagtgagagactcatcgctgcatttgaaa
gagggaatgaaagggcagttgactgaggcgtcttcagccacgtccaaagcatactgtgtg
tacagaagggaaatggacccagacattgacacaatgtgcccgggacaggaagcaggaagt
gcggaggaaaagtctgcagaggaagttaccatgagcccagccatcactatcatgcggccc
atcctcaggttcctgcagttactgtgtgagaatcacaaccgggagcttcagaacttcttg
aggaaccagaacaacaaaacaaactacaaccttgtctgtgaaacacttcagtttctggac
tgcatctgtggaagcaccacagggggcctaggcctgctggggctctacatcaatgagaag
aacgtagctctggtcaaccagaccctggagagcttgaccgagtactgccagggcccgtgt
catgagaaccagacctgtatcgccactcacgaatccaatgggattgacatcatcatcgcc
ttgattctgagtgacatcaaccctctgggcaagtacagaatggacctggtgctacagctg
aagaacaacgcctccaagcttctgctggccattatggagagcagacacgacagtgagaat
gcagagagaattctcttcaacatgagacccaaggaactggtggatgtcatgaagaatgcc
tataaccaaggcctggaatgtaaccatggggacgaggagggaggagatgatggtgtttct
ccaaaagacgttggacacaacatctacatcctggcccatcagttggcccgccacaataaa
ctcctacagcagatgctcaagcctggatccgatccagaggaaggggatgaagccttgaag
tactatgccaaccacaccgcacagatcgagattgtgcggcacgaccggactatggagcag
attgttttccccgtccccaatatctgcgaattcctcactcgggaatccaaataccgggtg
ttcaacacaacggagagggatgagcaaggaagcaaggtgaacgacttcttccagcaaacg
gaagatctctacaacgagatgaaatggcaaaagaagatcaggaacaaccccgccctgttc
tggttctccaggcacatctccctgtgggggagcatctccttcaacctggctgtgttcatc
aacctggccgtggctctcttctacccattcggggatgacggcgatgaaggtacgctctcc
ccgctgttctcagccctcctttgggtagcagtggcgatctgcacgtctatgctgttcttc
ttctccaagcctgtgggcatccggccattccttgtgtctatcatgctcagatcaatatac
accatcggtctggggccaacgctaatacttcttggtgctgccaatctatgcaataaaatc
gtgttcctggtgagttttgtgggaaaccgaggcacattcacccgagggtaccgagcagtc
attctggacatggcctttctttaccacgtggcctatgtcttggtttgcatgcttggcctc
ttcgtccacgagttcttctacagcttcctgctttttgacttggtgtacagagaagagacc
ctgctgaacgtcatcaaaagcgtcacacggaatggccgctccatcatcctgactgcggtc
ttggctcttatcctggtctacctgttctccatcatcggcttccttttcttaaaggatgac
ttcaccatggaggtggacagattgaaaaacagaactccagtcacaggtaacgacggggtt
cccactatgaccttaacttccatgctgggaacctgccctaaggaaaactgctcacccacg
atcccctcttcgaatgcagccggtgagggaggtgaggacggcatcgagaggacctgtgac
accctgctcatgtgcattgtcaccgtgctgaaccagggcctcaggaatggtggcggagtt
ggtgacgtgctgagacgaccctcgaaggatgagcctttgtttgctgcccgggtggtctac
gacctccttttcttcttcatcgtcatcatcatcgtccttaacctgatttttggtgtaatc
attgacactttcgctgacctcaggagtgagaagcagaagaaagaagaaattctcaagaca
acctgcttcatctgtggcttggagagggacaagtttgataacaagacggtgtcctttgag
gagcacatcaagtcagagcacaacatgtggcattacttgtacttcatcgtcctggtgaag
gtgaaggacccaacagaatacacagggcctgagagctacgtggctcagatgatcacagag
aagaatttagactggtttcctcggatgcgagccatgtcacttgtcagcaatgaaggtgac
agtgagcaaaatgagatccggaacctgcaggagaagctggagtccactatgagtctggtg
aaacagttgtcggggcagctggcagagctgaaggagcagatgacagaacaaaggaaaaac
aagcaaaggctgggcttccttggatcaaacacaccccatgtgaaccatcacatgccaccg
cactga

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