KEGG   Rattus norvegicus (rat): 25290
Entry
25290             CDS       T01003                                 

Gene name
Alox5
Definition
(RefSeq) polyunsaturated fatty acid 5-lipoxygenase
  KO
K00461  arachidonate 5-lipoxygenase [EC:1.13.11.34]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00590  Arachidonic acid metabolism
rno01100  Metabolic pathways
rno04664  Fc epsilon RI signaling pathway
rno04726  Serotonergic synapse
rno04913  Ovarian steroidogenesis
rno05145  Toxoplasmosis
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    25290 (Alox5)
 09150 Organismal Systems
  09151 Immune system
   04664 Fc epsilon RI signaling pathway
    25290 (Alox5)
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    25290 (Alox5)
  09156 Nervous system
   04726 Serotonergic synapse
    25290 (Alox5)
 09160 Human Diseases
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    25290 (Alox5)
Enzymes [BR:rno01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.34  arachidonate 5-lipoxygenase
     25290 (Alox5)
SSDB
Motif
Pfam: Lipoxygenase PLAT
Other DBs
NCBI-GeneID: 25290
NCBI-ProteinID: NP_036954
RGD: 2096
Ensembl: ENSRNOG00000012972
UniProt: P12527
Position
4
AA seq 674 aa
MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYNDFERGAVDSYDVTVDE
ELGEIYLVKIEKRKYWLHDDWYLKYITLKTPHGDYIEFPCYRWITGEGEIVLRDGCAKLA
RDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVL
NYSKAMENLFINRFMHMFQSSWHDFADFEKIFVKISNTISERVKNHWQEDLMFGYQFLNG
CNPVLIKRCTELPKKLPVTTEMVECSLERQLSLEQEVQEGNIFIVDYELLDGIDANKTDP
CTHQFLAAPICLLYKNLANKIVPIAIQLNQTPGEKNPIFLPTDSKYDWLLAKIWVRSSDF
HIHQTITHLLRTHLVSEVFGIAMYRQLPAVHPLFKLLVAHVRFTIAINTKAREQLICEYG
LFDKANATGGGGHVQMVQRAVQDLTYSSLCFPEAIKARGMDNTEDIPYYFYRDDGLLVWE
AIQSFTTEVVSIYYEDDQVVEEDQELQDFVKDVYVYGMRGRKASGFPKSIKSREKLSEYL
TVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCW
HLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMIRFRKNLEAIVSVIAERNKNKKLPY
YYLSPDRIPNSVAI
NT seq 2025 nt   +upstreamnt  +downstreamnt
atgccttcctacactgtcaccgtagccaccggtagccagtggttcgcgggcaccgacgac
tacatttacctcagcctcattggctctgcgggctgcagtgagaagcatcttcttgacaaa
gctttctacaatgacttcgagcgcggcgcggtggactcctatgacgtcactgtggatgaa
gaactgggtgagatctacctagtcaaaatcgagaagcgcaaatactggctccatgatgac
tggtacttgaaatacatcacactgaagacaccccacggggactacatagagttcccttgt
tatcgttggatcacaggcgagggcgagattgtcctgagggatggatgtgcaaaattggcc
cgagatgaccaaatccacatcctcaagcagcacaggcggaaagaactggaaacacgtcag
aaacagtatcgatggatggagtggaaccccggcttccctttgagtattgatgctaaatgc
cacaaggatctgccccgagatatccagtttgatagtgaaaagggagtggactttgttctg
aactactcaaaagcgatggagaacctgttcatcaatcgcttcatgcacatgttccagtct
tcctggcatgactttgctgactttgagaaaatcttcgtcaaaatcagcaacactatttct
gagagagtcaagaaccactggcaagaggacctcatgtttggctaccagttcctgaatggc
tgcaacccagtactcatcaagcgctgcacagagttgcctaagaagctcccagtgaccaca
gaaatggtggagtgcagcctagagcggcagctcagtttagaacaggaagtacaggaaggg
aacattttcatcgttgattacgaactactggatggcattgatgctaacaaaactgacccc
tgtacacaccagttcctggccgcccccatctgcctgctgtataagaacctagccaacaag
attgttcccatcgccatccagctcaaccaaacccctggagagaagaacccaattttcctc
cctacggactcaaaatacgactggcttttggccaaaatctgggtgcgttcaagtgacttc
catatccatcaaacaatcacccatcttctccgcacacatctggtgtctgaggtgttcggt
attgccatgtaccgccagctgcctgctgtgcacccccttttcaagctgctggtagcccat
gtgaggttcaccattgccatcaacactaaggcccgggaacagcttatctgtgagtacggc
ctttttgacaaggccaatgccaccggaggtggtgggcacgtgcagatggtgcagagagct
gtccaggacctgacctattcctccctgtgcttcccggaggccatcaaggcccggggcatg
gacaacaccgaggacatcccctactacttctatcgtgatgatggactgctcgtgtgggaa
gctatccagtcgttcacaactgaggtggtaagcatctactatgaggatgaccaggtggtg
gaggaggaccaggaactgcaggacttcgtgaaggatgtttacgtttatggcatgcggggc
agaaaggcctcaggtttccccaagtccatcaagagcagggagaaattgtctgagtacctg
acggtggtgatcttcacagcctcggcccagcatgcagctgtaaactttggccagtatgac
tggtgctcctggatccccaacgctcctccaactatgcgggccccaccacccacggccaag
ggtgtggtcaccatcgagcagattgtggatactctaccagaccgtggccgctcatgttgg
catctaggtgcagtgtgggccttgagccagtttcaagagaatgagctgtttctgggcatg
tacccagaggagcatttcatcgagaagccagtgaaagaagccatgattcgattccgcaag
aacctggaggccatcgtcagcgtgattgccgagcgcaataagaacaaaaagctcccctac
tactacctgtcaccagacaggattccaaacagtgtagccatctaa

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