KEGG   Rattus norvegicus (rat): 25366
Entry
25366             CDS       T01003                                 

Gene name
Acvr2b
Definition
(RefSeq) activin receptor type-2B precursor
  KO
K13596  activin receptor type-2B [EC:2.7.11.30]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04060  Cytokine-cytokine receptor interaction
rno04350  TGF-beta signaling pathway
rno04550  Signaling pathways regulating pluripotency of stem cells
rno05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    25366 (Acvr2b)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    25366 (Acvr2b)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    25366 (Acvr2b)
 09160 Human Diseases
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    25366 (Acvr2b)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:rno01001]
    25366 (Acvr2b)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.30  receptor protein serine/threonine kinase
     25366 (Acvr2b)
Protein kinases [BR:rno01001]
 Receptor serine/threonine kinases (RSTK): TKL group
  TGFBR2 family [OT]
   25366 (Acvr2b)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Activin_recp Pkinase_fungal
Other DBs
NCBI-GeneID: 25366
NCBI-ProteinID: NP_113742
RGD: 2028
Ensembl: ENSRNOG00000014477
UniProt: P38445 A0A0G2JSN4
Structure
PDB: 
6MAC 1NYS 1NYU

Position
8
AA seq 512 aa
MTAPWAALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCY
ASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEPG
GPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHEDPGPPP
PSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMK
HENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSY
LHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVG
TRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQ
HPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSL
IRRSVNSSTSDCLVSLVTSVTNVDLLPKESSI
NT seq 1539 nt   +upstreamnt  +downstreamnt
atgacggcgccctgggcggccctcgcccttctctggggatcgctgtgcgccggttccggg
cgaggggaagctgagactcgggagtgcatctactacaacgccaactgggagctggagcgc
accaaccagagcggcctggagcgctgcgagggggaacaggacaagcggctgcactgctat
gcctcgtggcgcaacagctcgggcaccatcgagctggtgaagaagggctgctggctagat
gacttcaattgctacgacaggcaggagtgtgtggccactgaggagaacccccaggtgtat
ttctgctgctgtgaaggcaatttctgcaacgagcgcttcacccatttgccggagcctggg
ggcccagaagtcacgtacgagccacccccgacagcccccaccctgctcacggtgctggcc
tattcgctgctgcccattggaggcctctctctcatcgtcctgctggccttctggatgtac
cgacatcgaaagcctccctacggccacgtggacatccatgaggaccctgggcctcctccc
ccatcgcctctggtgggcctgaagccgctacagttgctggagatcaaggctcgaggtcgc
tttggctgcgtctggaaggctcagctcatgaacgactttgtggctgtgaagatcttccca
cttcaggacaagcagtcgtggcagagtgagcgggagatcttcagcacaccgggcatgaag
cacgaaaacctcctgcagttcattgctgcagagaaacgaggctccaacctggaggtggag
ctgtggctcatcacagccttccacgacaagggctccctcacggattacctcaaggggaac
atcatcacgtggaacgagctgtgtcatgtggcagagacgatgtcacgaggcctctcgtac
ctgcatgaggatgtgccgtggtgtcgtggcgagggccacaagccttctattgcccacagg
gacttcaaaagcaagaatgttctgctgaagagcgacctcaccgcggtgctggctgacttt
ggcctggctgttcggtttgagccggggaagcctccaggggatacccatgggcaggttggc
accagacggtacatggcccccgaggtgctggagggggccatcaacttccagagagacgcc
ttcctgcgtatcgacatgtacgccatgggcctggtgctgtgggagctcgtttctcgttgc
aaggccgcagatgggcctgtcgatgagtacatgctgcctttcgaggaagagattggccaa
cacccttcactggaggagcttcaggaggtggttgtccacaagaagatgaggcccaccatt
aaggatcactggctgaaacatccgggcctggcccagctctgcgtgaccatcgaggagtgc
tgggaccatgatgcagaggctcgtctgtctgcaggctgtgtggaagagcgggtatccctg
atcaggaggtcggtcaacagctctacctcggactgtctcgtctctctggtgacctccgtc
accaatgtggacctgctccctaaagagtccagcatctaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (8)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (12)   
   RefSeq(nuc) (6)   
   GenBank (3)   
   EMBL (3)   
Protein domain (4)   
   Pfam (4)   
All databases (39)   

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KEGG   Rattus norvegicus (rat): 29263
Entry
29263             CDS       T01003                                 

Gene name
Acvr2a
Definition
(RefSeq) activin receptor type-2A precursor
  KO
K04670  activin receptor type-2A [EC:2.7.11.30]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04060  Cytokine-cytokine receptor interaction
rno04350  TGF-beta signaling pathway
rno04550  Signaling pathways regulating pluripotency of stem cells
rno05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    29263 (Acvr2a)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    29263 (Acvr2a)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    29263 (Acvr2a)
 09160 Human Diseases
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    29263 (Acvr2a)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:rno01001]
    29263 (Acvr2a)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.30  receptor protein serine/threonine kinase
     29263 (Acvr2a)
Protein kinases [BR:rno01001]
 Receptor serine/threonine kinases (RSTK): TKL group
  TGFBR2 family [OT]
   29263 (Acvr2a)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Activin_recp Pkinase_fungal APH Dynein_IC2
Other DBs
NCBI-GeneID: 29263
NCBI-ProteinID: NP_113759
RGD: 70911
Ensembl: ENSRNOG00000005334
Vega: OTTRNOG00000002257
UniProt: P38444
Position
3
AA seq 513 aa
MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWERDRTNQTGVEPCYGDKDKRRHC
FATWKNISGSIEIVKQGCWLDDINCYDRTDCIEKKDSPEVYFCCCEGNMCNEKFSYFPEM
EVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGP
PPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPG
MKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGL
AYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQV
GTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIG
QHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERIT
QMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
NT seq 1542 nt   +upstreamnt  +downstreamnt
atgggagctgctgcaaagttggcgttcgccgtctttcttatctcttgctcttcaggtgct
atacttggcagatcggaaactcaggagtgtcttttctttaatgctaattgggaaagagac
agaaccaatcagactggtgttgagccttgctatggtgataaagacaaacgacgacattgt
tttgctacctggaagaatatttctggttccattgaaatagtaaagcaaggttgttggctg
gatgatatcaactgctatgacaggactgattgtatagaaaaaaaagacagccctgaagtg
tacttttgttgctgtgagggcaatatgtgtaatgaaaagttctcttattttccggagatg
gaagtcacacagcccacatcaaatcctgttaccccgaaaccaccctactacaacatcctg
ctgtattccttggtaccacttatgttaattgcggggattgtcatttgtgcgttttgggtg
tacagacatcacaagatggcctaccctcctgtacttgttcctactcaggaccctggacca
cctccaccttccccattactagggttgaagccattgcagctattggaagtgaaagcaagg
ggaagatttggttgtgtctggaaagcccagttgctcaatgagtatgtggctgtcaaaata
tttccgatacaggacaaacagtcctggcagaatgaatatgaagtctatagtttacctggt
atgaagcatgaaaacatactacagttcattggtgcagagaaaagaggcaccagtgttgat
gtggacctgtggctaatcacggcttttcatgaaaagggctcactgtcagactttcttaag
gctaatgtggtctcttggaatgaactttgtcatattgcagaaaccatggctagaggattg
gcatatttacatgaggatatacctggcttaaaagatggccacaagcctgcaatatctcac
agggacataaaaagtaaaaatgtgctgttgaaaaacaatctgacagcttgcattgctgac
tttgggttggccttaaagtttgaggctggcaagtctgcaggtgacacccatggccaggtt
ggtacccggaggtatatggctccagaggtgttagagggtgctataaacttccaaagggac
gcatttctgaggatagatatgtacgccatgggattagtcctgtgggaactggcttctcgt
tgtactgctgcagatggacctgtagatgagtacatgttgccatttgaggaggaaattggc
cagcatccatctcttgaagatatgcaggaagttgttgtgcataaaaaaaagaggcccgtt
ttaagagattattggcagaaacacgcaggaatggcaatgctctgtgaaacgatagaagaa
tgctgggatcatgatgcagaagccaggttatcagctggatgtgtaggtgaaagaattact
cagatgcaaagactaacaaatataattactacagaggacattgtaacagtggtcacaatg
gtgacaaatgttgactttcctcccaaagaatctagtctatga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (8)   
   RefSeq(nuc) (2)   
   GenBank (3)   
   EMBL (3)   
Protein domain (6)   
   Pfam (6)   
All databases (40)   

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