KEGG   Rattus norvegicus (rat): 25630
Entry
25630             CDS       T01003                                 

Gene name
Pkm, PK, PKM12, Pk3, Pkm2
Definition
(RefSeq) pyruvate kinase, muscle
  KO
K00873  pyruvate kinase [EC:2.7.1.40]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00010  Glycolysis / Gluconeogenesis
rno00230  Purine metabolism
rno00620  Pyruvate metabolism
rno01100  Metabolic pathways
rno01200  Carbon metabolism
rno01230  Biosynthesis of amino acids
rno01240  Biosynthesis of cofactors
rno04922  Glucagon signaling pathway
rno04930  Type II diabetes mellitus
rno05165  Human papillomavirus infection
rno05203  Viral carcinogenesis
rno05230  Central carbon metabolism in cancer
Module
rno_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
rno_M00002  Glycolysis, core module involving three-carbon compounds
rno_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP
rno_M00050  Guanine ribonucleotide biosynthesis IMP => GDP,GTP
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    25630 (Pkm)
   00620 Pyruvate metabolism
    25630 (Pkm)
  09104 Nucleotide metabolism
   00230 Purine metabolism
    25630 (Pkm)
 09150 Organismal Systems
  09152 Endocrine system
   04922 Glucagon signaling pathway
    25630 (Pkm)
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    25630 (Pkm)
   05230 Central carbon metabolism in cancer
    25630 (Pkm)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    25630 (Pkm)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    25630 (Pkm)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.40  pyruvate kinase
     25630 (Pkm)
Membrane trafficking [BR:rno04131]
 Autophagy
  Chaperone mediated autophagy (CMA)
   Selective cargos
    25630 (Pkm)
Exosome [BR:rno04147]
 Exosomal proteins
  Proteins found in most exosomes
   25630 (Pkm)
SSDB
Motif
Pfam: PK PK_C HpcH_HpaI
Other DBs
NCBI-GeneID: 25630
NCBI-ProteinID: NP_445749
RGD: 3337
Ensembl: ENSRNOG00000011329
UniProt: P11980
Position
8q24
AA seq 531 aa
MPKPDSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSAPITARNTGIICTIGPASRSVEM
LKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESFASDPILYRPVAVALDTKGPEIR
TGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGL
ISLQVKEKGADYLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMV
FASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIE
IPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM
LSGETAKGDYPLEAVRMQHLIAREAEAAVFHRLLFEELARASSQSTDPLEAMAMGSVEAS
YKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDAVLD
AWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
NT seq 1596 nt   +upstreamnt  +downstreamnt
atgcccaagccagacagcgaagcagggactgccttcattcagacccagcagctccatgca
gccatggctgacaccttcctggaacacatgtgccgcctggacattgactccgcacccatc
acggcccgcaacactgggatcatctgtaccattggccctgcttcccgatctgtggagatg
ctgaaggagatgattaagtctgggatgaatgtggctcggctgaatttctctcatggaacc
catgagtaccatgcagagactatcaagaatgtccgtgcagccacagaaagctttgcatct
gatcccattctctaccgacctgttgcggtggctctggatacaaagggacctgagatccgg
actggactcatcaagggcagcggcaccgcagaggtggagctgaagaagggagccacactg
aagatcaccctggacaacgcctacatggagaagtgcgatgagaacatcctgtggctggac
tataagaacatctgcaaggtggtggaggtgggcagcaagatctacgtggacgatgggctc
atctccctgcaggtgaaggagaaaggtgctgactacctggtgacagaagtggaaaatggt
ggctccttgggcagcaagaagggcgtgaacctgcctggtgctgctgtggacctccctgct
gtgtcagaaaaggacatccaggacctgaagtttggggtggagcaggacgtggacatggtg
tttgcgtctttcatccgcaaggcggctgacgtgcatgaggttaggaaggtcctgggagag
aagggcaagaacatcaagatcatcagcaaaatcgagaaccatgaaggtgtccgcaggttt
gatgagattttggaggccagcgatggaatcatggtagctcgtggtgacctgggcattgag
attccggcagagaaggtcttcctagctcagaagatgatgattggacgatgcaaccgagct
gggaagccagtcatctgcgccacccagatgctggagagcatgatcaagaagccacgcccc
acccgtgctgaaggcagtgacgtggccaatgcagtcctagatggagctgactgcatcatg
ctgtccggagaaacagccaaaggggactaccctctggaggctgttcgcatgcagcacctg
atagctcgagaggctgaggcagccgtgttccaccgcctgctgtttgaagagcttgcgcga
gcctccagtcaatccacagaccccctggaggccatggccatgggcagcgtggaggcctct
tataaatgtttagcagcagctttgatagttctgacggagtccggcaggagtgctcaccaa
gtggcccggtaccgcccaagggctcctatcattgctgtgacacgcaatccccagacagcc
cgccaggcccatctgtaccgtggcatcttccctgtgctgtgtaaggatgccgtactggat
gcctgggctgaggacgttgatcttcgtgtgaacttggccatgaatgttggcaaggcccga
ggcttcttcaagaagggagatgtggtcattgtgctgactggatggcgccctggctctggc
ttcaccaacaccatgcgtgtagtgcctgtaccatga

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (16)   
   KEGG PATHWAY (12)   
   KEGG MODULE (4)   
Chemical substance (12)   
   KEGG COMPOUND (12)   
Chemical reaction (6)   
   KEGG ENZYME (1)   
   KEGG REACTION (5)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (18)   
   RefSeq(nuc) (4)   
   GenBank (7)   
   EMBL (7)   
Protein domain (3)   
   Pfam (3)   
All databases (72)   

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