KEGG   Rattus norvegicus (rat): 29153
Entry
29153             CDS       T01003                                 

Gene name
Capn1
Definition
(RefSeq) calpain-1 catalytic subunit
  KO
K01367  calpain-1 [EC:3.4.22.52]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04141  Protein processing in endoplasmic reticulum
rno04210  Apoptosis
rno04217  Necroptosis
rno04218  Cellular senescence
rno05010  Alzheimer disease
rno05022  Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:rno00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    29153 (Capn1)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    29153 (Capn1)
   04217 Necroptosis
    29153 (Capn1)
   04218 Cellular senescence
    29153 (Capn1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    29153 (Capn1)
   05022 Pathways of neurodegeneration - multiple diseases
    29153 (Capn1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:rno01002]
    29153 (Capn1)
Enzymes [BR:rno01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.52  calpain-1
     29153 (Capn1)
Peptidases and inhibitors [BR:rno01002]
 Cysteine peptidases
  Family C2: calpain family
   29153 (Capn1)
SSDB
Motif
Pfam: Peptidase_C2 Calpain_III EF-hand_6 EF-hand_1 EF-hand_8 EF-hand_7
Other DBs
NCBI-GeneID: 29153
NCBI-ProteinID: NP_062025
RGD: 2267
Ensembl: ENSRNOG00000020935
UniProt: P97571
Structure
PDB: 

Position
1
AA seq 713 aa
MAEELITPVYCTGVSAQVQKQRDKELGLGRHENAIKYLGQDYENLRARCLQNGVLFQDDA
FPPVSHSLGFKELGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAA
IASLTLNETILHRVVPYGQSFQEGYAGIFHFQLWQFGEWVDVVVDDLLPTKDGKLVFVHS
AQGNEFWSALLEKAYAKVNGSYEALSGGCTSEAFEDFTGGVTEWYDLQKAPSDLYQIILK
ALERGSLLGCSINISDIRDLEAITFKNLVRGHAYSVTDAKQVTYQGQRVNLIRMRNPWGE
VEWKGPWSDNSYEWNKVDPYEREQLRVKMEDGEFWMSFRDFIREFTKLEICNLTPDALKS
RTLRNWNTTFYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLEEVDDADDYDSRESGCSFL
LALMQKHRRRERRFGRDMETIGFAVYQVPRELAGQPVHLKRDFFLANASRAQSEHFINLR
EVSNRIRLPPGEYIVVPSTFEPNKEGDFLLRFFSEKKAGTQELDDQIQANLPDEKVLSEE
EIDDNFKTLFSKLAGDDMEISVKELQTILNRIISKHKDLRTNGFSLESCRSMVNLMDRDG
NGKLGLVEFNILWNRIRNYLTIFRKFDLDKSGSMSAYEMRMAIEAAGFKLNKKLHELIIT
RYSEPDLAVDFDNFVCCLVRLETMFRFFKILDTDLDGVVTFDLFKWLQLTMFA
NT seq 2142 nt   +upstreamnt  +downstreamnt
atggcagaggagttaatcacacctgtgtactgcaccggggtgtcagcccaagtgcagaag
caacgggacaaggagttgggcttgggccgccatgaaaatgccatcaagtacctgggccag
gattatgaaaatcttcgtgcaagatgcctgcagaacggggtcctcttccaagacgatgcc
ttccctccagtttctcatagcttgggcttcaaggaactgggtcccaattcctctaaaacc
tatggcatcaagtggaagcgtcctacggaactgctgtcaaacccccagttcatcgtggat
ggagccacccgaacggacatctgccagggagcactgggggactgttggctcctggctgcc
attgcctcgctcactctcaacgagactatcctccaccgagtggttccctacggccagagc
ttccaggagggctatgctggcatctttcatttccagctgtggcagtttggggagtgggta
gatgtggttgtggatgatttgctacccaccaaggatggaaagctggtgttcgtgcactct
gcccagggcaacgagttctggagcgctctcctggagaaagcctatgcaaaagtgaatggc
agctatgaggccctttcgggaggctgcacctcagaggccttcgaggactttaccggtggg
gtcactgagtggtacgatctgcagaaggcacccagcgacctctaccagatcattctgaag
gccctggaacgaggctccttgctgggctgctccattaatatctccgatatccgtgatttg
gaggctattacttttaagaacctggtgaggggccatgcatactctgtgacggatgccaag
caggtcacttaccagggccagcgggtgaacctaatccggatgcggaacccctggggtgaa
gtggagtggaaaggaccctggagtgacaactcctatgagtggaacaaagtggacccctat
gaacgtgagcagctgagggtcaagatggaggacggggagttctggatgtccttccgggac
ttcatacgtgagttcaccaaactggaaatctgcaaccttacacctgacgcccttaagagc
agaaccctccggaactggaataccacattttacgagggcacctggcgccggggaagcact
gctggaggctgcaggaactacccagctaccttctgggtaaacccccagttcaagatccgg
ctggaggaggtggatgacgcagacgactatgacagtcgagagtccggctgcagcttcttg
ttggccctcatgcagaagcatcgccgcagggagcgtcgctttggccgggacatggagacc
attggttttgcagtgtaccaggtccctcgggagttggcgggtcagcctgtgcacttgaag
cgtgacttcttcctggccaatgcttctcgggcacaatcagagcactttatcaaccttcga
gaggtcagtaaccgcatccgcctgccgccgggggagtatatagtggtgccctccaccttc
gagcccaacaaagagggtgactttctgctgcgcttcttttcagagaagaaggctgggacc
caggaactagatgaccagatccaggccaacctccccgatgagaaagtgctctctgaagag
gagatcgatgacaacttcaaaaccctgttcagcaagttggcaggggatgacatggagatc
agtgtcaaggagttacagaccatcttgaacagaatcattagcaaacacaaagacctgcgc
actaacggcttcagcctggagtcgtgccgcagcatggtgaacctcatggatcgagacggt
aatgggaaactgggcctggtggagttcaacatcctgtggaaccgcatccgaaattacctg
accatcttccgaaagtttgacctggacaagtctggcagcatgagtgcttatgagatgagg
atggccatcgaggctgcaggcttcaagcttaacaagaagctgcatgagctcatcatcacc
cgctactcagagcccgacctggccgtggactttgacaactttgtgtgctgccttgtgcgc
ctggagaccatgttccggtttttcaaaattctggacacagacctggatggtgttgtgacc
tttgatctatttaagtggttacagctgactatgtttgcatga

KEGG   Rattus norvegicus (rat): 29154
Entry
29154             CDS       T01003                                 

Gene name
Capn2
Definition
(RefSeq) calpain-2 catalytic subunit
  KO
K03853  calpain-2 [EC:3.4.22.53]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04141  Protein processing in endoplasmic reticulum
rno04210  Apoptosis
rno04217  Necroptosis
rno04218  Cellular senescence
rno04510  Focal adhesion
rno05010  Alzheimer disease
rno05022  Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:rno00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    29154 (Capn2)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    29154 (Capn2)
   04217 Necroptosis
    29154 (Capn2)
   04218 Cellular senescence
    29154 (Capn2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    29154 (Capn2)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    29154 (Capn2)
   05022 Pathways of neurodegeneration - multiple diseases
    29154 (Capn2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:rno01002]
    29154 (Capn2)
Enzymes [BR:rno01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.53  calpain-2
     29154 (Capn2)
Peptidases and inhibitors [BR:rno01002]
 Cysteine peptidases
  Family C2: calpain family
   29154 (Capn2)
SSDB
Motif
Pfam: Peptidase_C2 Calpain_III EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_7
Other DBs
NCBI-GeneID: 29154
NCBI-ProteinID: NP_058812
RGD: 2268
Ensembl: ENSRNOG00000034015
UniProt: Q07009
Structure
PDB: 
1MDW 3BOW 1DF0 1U5I 3DF0

Position
13
AA seq 700 aa
MAGIAMKLAKDREAAEGLGSHERAIKYLNQDYETLRNECLEAGALFQDPSFPALPSSLGF
KELGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEI
LARVVPLDQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSAL
LEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELRKPPPNLFKIIQKALEKGSLLGC
SIDITSAADSEAVTYQKLVKGHAYSVTGAEEVESSGSLQKLIRIRNPWGQVEWTGKWNDN
CPSWNTVDPEVRANLTERQEDGEFWMSFSDFLRHYSRLEICNLTPDTLTCDSYKKWKLTK
MDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDDEDGERGCTFLVGLIQKHRRRQR
KMGEDMHTIGFGIYEVPEELTGQTNIHLSKNFFLTTRARERSDTFINLREVLNRFKLPPG
EYVLVPSTFEPHKNGDFCIRVFSEKKADYQTVDDEIEANIEEIEANEEDIGDGFRRLFAQ
LAGEDAEISAFELQTILRRVLAKREDIKSDGFSIETCKIMVDMLDEDGSGKLGLKEFYIL
WTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKLPCQLHQVIVARFADDELIIDFD
NFVRCLVRLEILFKIFKQLDPENTGTIQLDLISWLSFSVL
NT seq 2103 nt   +upstreamnt  +downstreamnt
atggcgggcatcgcgatgaaactggccaaagaccgcgaggcggccgaggggctggggtct
cacgagagagccatcaagtacctcaaccaggactacgagacactgcggaacgagtgcctg
gaggccggggcgctcttccaggatccttccttccccgccctgccgtcgtccctgggcttc
aaggagttggggccctactccagcaaaactcggggcatcgaatggaagcggcccacggag
atctgcgcagacccccagttcattattggaggtgctacccgcacagacatctgccaagga
gcccttggggactgctggcttctggctgccatcgcctccctcaccttgaatgaagaaatc
ctggctcgagttgtgcctctagaccagagcttccaggaaaactatgcaggcatcttccat
ttccagttctggcaatatggcgaatgggtggaggtggtggtggacgacagactgcccact
aaggacggggagctgctctttgttcattcagctgaggggagcgagttctggagtgccctt
ctggagaaggcctatgccaagatcaatgggtgctatgaagcactctcagggggtgccacc
actgagggctttgaagacttcacaggaggcattgccgagtggtatgagctgaggaagcct
cctcccaatttgttcaagatcatccagaaggctttggagaaaggttctctgcttggctgc
tctatcgatatcaccagcgctgcggattctgaggccgttacgtaccagaagttggtgaaa
ggacatgcgtactccgtcactggagccgaggaggttgaaagctcaggaagcctgcagaaa
ttgatacgtatcaggaacccctggggacaagtggagtggaccgggaagtggaatgacaac
tgccccagctggaacacggttgacccagaagtaagggcaaatctaacagaacggcaggag
gacggagaattctggatgtccttcagtgacttcctgaggcactactctcgtctagaaatc
tgcaacctgaccccggacaccctcacctgtgactcctacaagaagtggaaactcaccaag
atggatgggaactggaggcgaggctccactgcagggggctgcaggaattacccaaatacc
ttctggatgaaccctcagtacctaatcaagctggaggaagaagatgaagatgatgaggat
ggggagaggggctgtaccttcctggtgggcctcatccagaagcatcggcggcggcagagg
aagatgggtgaggacatgcacaccattggcttcggcatctatgaggtcccagaggagcta
acagggcagaccaacatccacctcagcaaaaactttttcctgacaacccgagccagggag
cggtcagataccttcatcaacctccgggaggtcctcaaccgcttcaagctgcccccggga
gaatatgtccttgttccttccaccttcgagccccacaagaatggcgatttctgcatccga
gtcttctcagagaagaaggctgactaccaaactgtcgatgatgaaatcgaggccaacatt
gaagagattgaagccaatgaggaggacattggagatggattcagaaggctgtttgctcag
ctggctggagaggatgcggagatctctgcctttgagctgcagaccatcttgagaagagtt
ctagccaagcgcgaagacatcaagtcagatggcttcagcatcgagacctgtaagatcatg
gtggacatgctggatgaagatgggagcggcaagctggggctgaaggagttctacatcctc
tggacgaagattcagaaataccaaaaaatttaccgagagatcgacgtggacaggtcggga
accatgaattcctatgagatgcggaaggctttggaagaagcaggtttcaagctgccctgt
caacttcatcaagtcatcgttgcccggtttgcagatgacgaactcatcatcgactttgac
aactttgtgcggtgtttggttcggctggaaatactattcaagatattcaagcagctggac
cctgagaacactggaacgatacagctcgaccttatctcgtggctgagtttttcagtactc
tga

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