KEGG   Rattus norvegicus (rat): 29192
Entry
29192             CDS       T01003                                 

Gene name
Psen1
Definition
(RefSeq) presenilin 1
  KO
K04505  presenilin 1 [EC:3.4.23.-]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04310  Wnt signaling pathway
rno04330  Notch signaling pathway
rno04722  Neurotrophin signaling pathway
rno05010  Alzheimer disease
rno05022  Pathways of neurodegeneration - multiple diseases
rno05165  Human papillomavirus infection
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    29192 (Psen1)
   04330 Notch signaling pathway
    29192 (Psen1)
 09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    29192 (Psen1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    29192 (Psen1)
   05022 Pathways of neurodegeneration - multiple diseases
    29192 (Psen1)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    29192 (Psen1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:rno01002]
    29192 (Psen1)
Enzymes [BR:rno01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.23  Aspartic endopeptidases
    3.4.23.-  
     29192 (Psen1)
Peptidases and inhibitors [BR:rno01002]
 Aspartic peptidases
  Family A22: presenilin family
   29192 (Psen1)
SSDB
Motif
Pfam: Presenilin
Other DBs
NCBI-GeneID: 29192
NCBI-ProteinID: NP_062036
RGD: 3425
Ensembl: ENSRNOG00000009110
UniProt: P97887
Position
6q24
AA seq 468 aa
MTEIPAPLSYFQNAQMSEDSHSSSVRSQNDNQERQQHHDRQRLDNPESISNGRPQSNFTR
QVIEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIVSSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMIAIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVPKNPKYSTQGTEREETQDTGTGSDDGGFSEEWEAQRDSHLGPHRSTPESRA
AVQELSGSILTSEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLC
LTLLLLAIFKKALPALPISITFGLIFYFATDYLVQPFMDQLAFHQFYI
NT seq 1407 nt   +upstreamnt  +downstreamnt
atgacagagatacctgcacctttgtcctacttccagaatgcacagatgtctgaggacagc
cactccagcagcgtccgtagccagaatgacaatcaagaacggcagcagcatcatgacaga
cagagacttgacaaccctgagtcgatatctaatggccgaccccagagtaactttaccagg
caggtgatagagcaagatgaggaggaagacgaagagctgacattgaaatatggagccaag
cacgtcatcatgctctttgttcctgtgaccctctgcatggtcgttgtggtggccaccatc
aagtcagtcagcttctacacccggaaggatgggcagctaatctataccccattcacagaa
gacaccgagactgtaggccagagagccctgcactcgatcttgaatgccgccatcatgatc
agtgtcatcgtcgttatgaccatcctcctggtggtcctgtataagtacaggtgctacaag
gtcatccatgcctggcttattgtttcatctctgttgttgctgttctttttttcattcatt
tacttaggggaagtattcaagacctacaatgtcgccgtggactatattacggttgcactc
ctgatctggaattttggtgtggtcgggatgattgccattcactggaaaggcccactccga
ctgcagcaggcgtatctcattatgatcagtgccctcatggccctggtatttatcaagtac
ctccctgaatggaccgcatggctcatcttggctgtgatttcagtatatgatttggtggct
gttctgtgccccaaaggtccacttcgtatgctggtcgaaacagctcaggaaagaaatgag
actctctttccagctcttatctattcctcaaccatggtgtggttggtgaatatggctgaa
ggagacccagaagcccaaaggagggtacccaaaaaccccaagtatagcacacaaggaaca
gagagggaagagacacaggacactggcactgggagcgatgatggtggcttcagtgaggag
tgggaggcccaaagagacagtcacctggggcctcatcgctccactcctgagtcaagagct
gctgtccaggaactttctgggagcatcctcactagtgaagacccggaggaaagaggagta
aagcttgggctgggagatttcattttctacagtgttctggttggtaaggcctcagcgacc
gccagtggggactggaacacaaccatagcctgctttgtagccatattgatcggcctgtgc
cttacgttactcctgctcgccattttcaagaaagcgttgccggcccttcccatctccatc
accttcgggctcattttctactttgccacggattatctcgtgcagcccttcatggaccaa
cttgcattccatcaattttatatctag

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