KEGG   Rattus norvegicus (rat): 29241
Entry
29241             CDS       T01003                                 

Gene name
Adcy8, Ac8
Definition
(RefSeq) adenylate cyclase 8
  KO
K08048  adenylate cyclase 8 [EC:4.6.1.1]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00230  Purine metabolism
rno01100  Metabolic pathways
rno01522  Endocrine resistance
rno04015  Rap1 signaling pathway
rno04020  Calcium signaling pathway
rno04022  cGMP-PKG signaling pathway
rno04024  cAMP signaling pathway
rno04062  Chemokine signaling pathway
rno04072  Phospholipase D signaling pathway
rno04114  Oocyte meiosis
rno04211  Longevity regulating pathway
rno04213  Longevity regulating pathway - multiple species
rno04261  Adrenergic signaling in cardiomyocytes
rno04270  Vascular smooth muscle contraction
rno04371  Apelin signaling pathway
rno04540  Gap junction
rno04611  Platelet activation
rno04713  Circadian entrainment
rno04714  Thermogenesis
rno04720  Long-term potentiation
rno04723  Retrograde endocannabinoid signaling
rno04724  Glutamatergic synapse
rno04725  Cholinergic synapse
rno04727  GABAergic synapse
rno04742  Taste transduction
rno04750  Inflammatory mediator regulation of TRP channels
rno04911  Insulin secretion
rno04912  GnRH signaling pathway
rno04913  Ovarian steroidogenesis
rno04914  Progesterone-mediated oocyte maturation
rno04915  Estrogen signaling pathway
rno04916  Melanogenesis
rno04918  Thyroid hormone synthesis
rno04921  Oxytocin signaling pathway
rno04923  Regulation of lipolysis in adipocytes
rno04925  Aldosterone synthesis and secretion
rno04926  Relaxin signaling pathway
rno04927  Cortisol synthesis and secretion
rno04928  Parathyroid hormone synthesis, secretion and action
rno04934  Cushing syndrome
rno04935  Growth hormone synthesis, secretion and action
rno04970  Salivary secretion
rno04971  Gastric acid secretion
rno04972  Pancreatic secretion
rno04976  Bile secretion
rno05032  Morphine addiction
rno05163  Human cytomegalovirus infection
rno05166  Human T-cell leukemia virus 1 infection
rno05200  Pathways in cancer
rno05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    29241 (Adcy8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    29241 (Adcy8)
   04371 Apelin signaling pathway
    29241 (Adcy8)
   04020 Calcium signaling pathway
    29241 (Adcy8)
   04072 Phospholipase D signaling pathway
    29241 (Adcy8)
   04024 cAMP signaling pathway
    29241 (Adcy8)
   04022 cGMP-PKG signaling pathway
    29241 (Adcy8)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    29241 (Adcy8)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    29241 (Adcy8)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    29241 (Adcy8)
   04062 Chemokine signaling pathway
    29241 (Adcy8)
  09152 Endocrine system
   04911 Insulin secretion
    29241 (Adcy8)
   04923 Regulation of lipolysis in adipocytes
    29241 (Adcy8)
   04912 GnRH signaling pathway
    29241 (Adcy8)
   04913 Ovarian steroidogenesis
    29241 (Adcy8)
   04915 Estrogen signaling pathway
    29241 (Adcy8)
   04914 Progesterone-mediated oocyte maturation
    29241 (Adcy8)
   04921 Oxytocin signaling pathway
    29241 (Adcy8)
   04926 Relaxin signaling pathway
    29241 (Adcy8)
   04935 Growth hormone synthesis, secretion and action
    29241 (Adcy8)
   04918 Thyroid hormone synthesis
    29241 (Adcy8)
   04928 Parathyroid hormone synthesis, secretion and action
    29241 (Adcy8)
   04916 Melanogenesis
    29241 (Adcy8)
   04925 Aldosterone synthesis and secretion
    29241 (Adcy8)
   04927 Cortisol synthesis and secretion
    29241 (Adcy8)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    29241 (Adcy8)
   04270 Vascular smooth muscle contraction
    29241 (Adcy8)
  09154 Digestive system
   04970 Salivary secretion
    29241 (Adcy8)
   04971 Gastric acid secretion
    29241 (Adcy8)
   04972 Pancreatic secretion
    29241 (Adcy8)
   04976 Bile secretion
    29241 (Adcy8)
  09156 Nervous system
   04724 Glutamatergic synapse
    29241 (Adcy8)
   04727 GABAergic synapse
    29241 (Adcy8)
   04725 Cholinergic synapse
    29241 (Adcy8)
   04720 Long-term potentiation
    29241 (Adcy8)
   04723 Retrograde endocannabinoid signaling
    29241 (Adcy8)
  09157 Sensory system
   04742 Taste transduction
    29241 (Adcy8)
   04750 Inflammatory mediator regulation of TRP channels
    29241 (Adcy8)
  09149 Aging
   04211 Longevity regulating pathway
    29241 (Adcy8)
   04213 Longevity regulating pathway - multiple species
    29241 (Adcy8)
  09159 Environmental adaptation
   04713 Circadian entrainment
    29241 (Adcy8)
   04714 Thermogenesis
    29241 (Adcy8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    29241 (Adcy8)
  09165 Substance dependence
   05032 Morphine addiction
    29241 (Adcy8)
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    29241 (Adcy8)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    29241 (Adcy8)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    29241 (Adcy8)
   05163 Human cytomegalovirus infection
    29241 (Adcy8)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    29241 (Adcy8)
Enzymes [BR:rno01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     29241 (Adcy8)
SSDB
Motif
Pfam: Guanylate_cyc AC_N DUF1053 TBK1_ULD
Other DBs
NCBI-GeneID: 29241
NCBI-ProteinID: NP_058838
RGD: 2036
Ensembl: ENSRNOG00000004890
UniProt: P40146
Position
7q33
AA seq 1248 aa
MELSDVHCLSGSEELYTIHPTPPAADGGSGSRPQRLLWQTAVRHITEQRFIHGHRGGGGG
GSRKASNPAGSGPNHHAPQLSSDSVLPLYSLGSGERAHNTGGTKVFPERSGSGSASGSGG
GGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEV
VMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHTYLQ
YSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGTSLLQ
VTLQVLIPRLAVFSINQVLAQVVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRL
ETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGF
TNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCV
EMGLSMIKTIRFVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESG
GIPGRIHISKATLDCLSGDYNVEEGHGKERNEFLRKHNIETYLIKQPEESLLSLPEDIVK
ESVSCSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSG
PEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVL
LFITAIQSLLPSSRLMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINETYL
ARNVIIFASILINFLGAVINILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTGVLA
MVTCAVFLRLNSVLKLAVLLIMIAIYALLTETIYAGLFLSYDNLNHSGEDFLGTKEASLL
LMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKDLREHNENMLRNILPGHVARHF
LEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLG
EDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFN
NFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQ
GFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSL
NRQRQKQLLNENSNSGIIKSHYNRRTLLTPSGPEPGAQAEGTDKSDLP
NT seq 3747 nt   +upstreamnt  +downstreamnt
atggaactctcggatgtgcactgccttagcggcagcgaggaactctataccattcacccg
acgcccccggccgcggacggcgggagcggctctcggccgcagcggctgctgtggcagacg
gcggtgcggcacatcaccgagcagcgcttcatccacggccaccgaggcggcggcggcggg
ggctcccgcaaagcctcgaaccctgcgggcagcggaccaaaccaccacgcgccgcagctg
tctagcgactcggtgctgcctctctattctctgggctccggagagcgagcgcacaacacc
ggtggcaccaaagtctttccggaacgcagcgggagcggcagtgccagtggcagcgggggt
gggggcgacttgggcttcctgcaccttgactgtgccccaagtaactcggatttcttcctc
aatgggggatacagctaccgtggggtcattttcccaaccctacgcaactccttcaagtct
cgggatctggagcgcctctatcaacgctatttcctgggccagaggcgcaaatcggaggta
gtgatgaacgtgctggatgtactaaccaaactcacccttctagtccttcacttgagccta
gcctcggctcccatggaccctctcaagggcatcctgctaggctttttcactggcatcgag
gtggtgatctgcgccctcgtggtggtcaggaaggacaccacctcccacacttacctgcaa
tacagcggcgtggtcacttgggtggctatgaccacccagattctggcagcaggcctgggc
tatgggcttctgggcgacggcataggctacgtgctttttacactcttcgccacctacagc
atgcttccgctgcctctcacctgggccatcttggccggcctgggcacatccttgctgcaa
gtcacacttcaagtgctcatacccagactagcggtcttttccatcaaccaggtcctggcc
caggtggtgctcttcatgtgcatgaatacagcaggcatcttcatcagttacctttcagac
cgcgcccagcggcaggccttcctggagacccggaggtgtgtggaggccaggctccgcctg
gagacagagaaccaaagacaggagcggcttgtgctctctgtgctccccaggtttgtcgtc
ctagaaatgatcaatgacatgaccaatgtggaggacgagcacctgcagcatcagttccac
cgcatctacatccatcgctacgagaacgtcagtattctttttgcagatgtcaaaggattt
accaacctctctacgaccttgtctgctcaggagcttgtcaggatgctcaacgagctcttt
gccagatttgatcggctggcccatgagcatcactgtcttcgcattaaaatcctgggggac
tgctactactgtgtgtcaggactgcctgagccccgccaggaccatgctcattgctgtgtt
gaaatgggcctcagcatgatcaaaactatcaggtttgtgaggtccagaacgaagcatgat
gttgacatgcgaattggaatccattcaggctctgtgctgtgtggtgtgttgggcctgaga
aaatggcagtttgatgtctggtcttgggatgtggacatcgcaaacaaacttgaatctgga
ggaatccctgggagaattcacatttccaaagccacactggattgcctcagtggtgactat
aatgtggaagagggccacggtaaggagaggaatgaattcttgaggaagcataatatagag
acctatttgattaagcagcccgaggagagtttgctatccttgcctgaagatatagttaag
gagtcggtgagctgctcggacaggagaaacagtggggcaacgttcacagaaggatcctgg
agcccagaactgccattcgacaacatcgtgggcaaacagaatactctggctgccctaaca
agaaattcaataaatctgcttccaaaccatctcgcacaagctttgcatgtccagtctggg
cctgaggaaattaacaagagaatagagcataccatcgacttgcggagtggcgataagttg
agaagagagcatatcaagccattctcactgatgtttaaagactccagcctggagcacaag
tattctcaaatgcgggatgaagtattcaagtcaaacttggtctgtgcatttatcgttctt
ctgtttatcactgcgattcaaagtttgcttccttcttcgaggctgatgcctatgaccatc
cagttctccatcctgatcatgctgcactccgccctggtcctcatcaccacggcagaagac
tataagtgtctgcctctcattctccgcaaaacctgttgttggattaacgagacctatttg
gcccgcaacgtcatcatctttgcttccatcttgattaatttcctgggagccgtcataaat
attctgtggtgtgattttgacaagtcgatacccttgaagaacctgactttcaattcctca
gctgtgtttacagatatctgctcctacccagagtactttgtcttcactggggtgttggcc
atggtgacgtgtgcagtatttctccggcttaactctgtcctgaagctggctgtgctgctc
attatgatcgccatctacgccctgctgacagagaccatctatgcaggtctctttctgagt
tatgacaacctgaaccacagtggagaagattttctggggaccaaggaggcatcactgcta
ctgatggccatgttccttcttgctgtattctaccatggacagcagctggagtacacagcc
cgcctagatttcctgtggcgagtacaggccaaagaggagatcaacgagatgaaggacttg
agggaacacaatgagaacatgcttcgcaatatcttacccggccacgtggcccgccacttc
ctggagaaagacagagacaatgaggagctgtattctcaatcctatgatgccgttggggta
atgtttgcctccattcctggatttgcagacttttactctcagacagaaatgaacaaccag
ggagtggaatgtctgcgcttgctgaatgagatcattgctgactttgatgagttacttgga
gaggaccgctttcaggacatagagaagattaagaccattggtagtacatacatggctgtc
tcaggactgtcaccagagaaacagcaatgtgaagataaatggggacatttgtgtgccctg
gctgacttctctcttgccctgactgaaagcatacaagagatcaacaagcattcgttcaac
aattttgaactccgtattggcatcagccatggctcagtggtagcaggtgtaattggcgct
aagaaaccacagtatgacatttggggtaaaactgtgaacttggcaagccgaatggacagc
acaggagtgagtggccggatccaagttcctgaggagacctatctcatcctgaaggatcag
ggctttgccttcgactaccggggagagatatatgtgaagggcatcagcgaacaagaaggg
aaaatcaaaacatattttctcctgggacgagtccaacccaacccattcatcttaccccca
agaagacttcctgggcagtactctctggctgcagttgtccttgggcttgtccagtctctc
aacaggcaaaggcagaagcaactactcaatgagaacagcaactctggcatcatcaagagc
cattacaaccggcggactttgctaacgccaagtgggccagagcctggagcacaggctgaa
ggcactgacaaatccgatttgccataa

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