KEGG   Rattus norvegicus (rat): 293621Help
Entry
293621            CDS       T01003                                 

Gene name
Hras, HRAS1, c-H-ras
Definition
(RefSeq) Harvey rat sarcoma virus oncogene
  KO
K02833  GTPase HRas
Organism
rno  Rattus norvegicus (rat)
Pathway
rno01521  EGFR tyrosine kinase inhibitor resistance
rno01522  Endocrine resistance
rno04010  MAPK signaling pathway
rno04012  ErbB signaling pathway
rno04014  Ras signaling pathway
rno04015  Rap1 signaling pathway
rno04062  Chemokine signaling pathway
rno04068  FoxO signaling pathway
rno04071  Sphingolipid signaling pathway
rno04072  Phospholipase D signaling pathway
rno04137  Mitophagy - animal
rno04140  Autophagy - animal
rno04144  Endocytosis
rno04150  mTOR signaling pathway
rno04151  PI3K-Akt signaling pathway
rno04210  Apoptosis
rno04211  Longevity regulating pathway
rno04213  Longevity regulating pathway - multiple species
rno04218  Cellular senescence
rno04360  Axon guidance
rno04370  VEGF signaling pathway
rno04371  Apelin signaling pathway
rno04510  Focal adhesion
rno04540  Gap junction
rno04550  Signaling pathways regulating pluripotency of stem cells
rno04625  C-type lectin receptor signaling pathway
rno04630  Jak-STAT signaling pathway
rno04650  Natural killer cell mediated cytotoxicity
rno04660  T cell receptor signaling pathway
rno04662  B cell receptor signaling pathway
rno04664  Fc epsilon RI signaling pathway
rno04714  Thermogenesis
rno04720  Long-term potentiation
rno04722  Neurotrophin signaling pathway
rno04725  Cholinergic synapse
rno04726  Serotonergic synapse
rno04730  Long-term depression
rno04810  Regulation of actin cytoskeleton
rno04910  Insulin signaling pathway
rno04912  GnRH signaling pathway
rno04915  Estrogen signaling pathway
rno04916  Melanogenesis
rno04917  Prolactin signaling pathway
rno04919  Thyroid hormone signaling pathway
rno04921  Oxytocin signaling pathway
rno04926  Relaxin signaling pathway
rno04933  AGE-RAGE signaling pathway in diabetic complications
rno05034  Alcoholism
rno05160  Hepatitis C
rno05161  Hepatitis B
rno05165  Human papillomavirus infection
rno05166  HTLV-I infection
rno05167  Kaposi's sarcoma-associated herpesvirus infection
rno05200  Pathways in cancer
rno05203  Viral carcinogenesis
rno05205  Proteoglycans in cancer
rno05206  MicroRNAs in cancer
rno05210  Colorectal cancer
rno05211  Renal cell carcinoma
rno05213  Endometrial cancer
rno05214  Glioma
rno05215  Prostate cancer
rno05216  Thyroid cancer
rno05218  Melanoma
rno05219  Bladder cancer
rno05220  Chronic myeloid leukemia
rno05221  Acute myeloid leukemia
rno05223  Non-small cell lung cancer
rno05224  Breast cancer
rno05225  Hepatocellular carcinoma
rno05226  Gastric cancer
rno05230  Central carbon metabolism in cancer
rno05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:rno00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    293621 (Hras)
   04015 Rap1 signaling pathway
    293621 (Hras)
   04010 MAPK signaling pathway
    293621 (Hras)
   04012 ErbB signaling pathway
    293621 (Hras)
   04370 VEGF signaling pathway
    293621 (Hras)
   04371 Apelin signaling pathway
    293621 (Hras)
   04630 Jak-STAT signaling pathway
    293621 (Hras)
   04068 FoxO signaling pathway
    293621 (Hras)
   04072 Phospholipase D signaling pathway
    293621 (Hras)
   04071 Sphingolipid signaling pathway
    293621 (Hras)
   04151 PI3K-Akt signaling pathway
    293621 (Hras)
   04150 mTOR signaling pathway
    293621 (Hras)
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    293621 (Hras)
   04140 Autophagy - animal
    293621 (Hras)
   04137 Mitophagy - animal
    293621 (Hras)
  Cell growth and death
   04210 Apoptosis
    293621 (Hras)
   04218 Cellular senescence
    293621 (Hras)
  Cellular community - eukaryotes
   04510 Focal adhesion
    293621 (Hras)
   04540 Gap junction
    293621 (Hras)
   04550 Signaling pathways regulating pluripotency of stem cells
    293621 (Hras)
  Cell motility
   04810 Regulation of actin cytoskeleton
    293621 (Hras)
 Organismal Systems
  Immune system
   04625 C-type lectin receptor signaling pathway
    293621 (Hras)
   04650 Natural killer cell mediated cytotoxicity
    293621 (Hras)
   04660 T cell receptor signaling pathway
    293621 (Hras)
   04662 B cell receptor signaling pathway
    293621 (Hras)
   04664 Fc epsilon RI signaling pathway
    293621 (Hras)
   04062 Chemokine signaling pathway
    293621 (Hras)
  Endocrine system
   04910 Insulin signaling pathway
    293621 (Hras)
   04912 GnRH signaling pathway
    293621 (Hras)
   04915 Estrogen signaling pathway
    293621 (Hras)
   04917 Prolactin signaling pathway
    293621 (Hras)
   04921 Oxytocin signaling pathway
    293621 (Hras)
   04926 Relaxin signaling pathway
    293621 (Hras)
   04919 Thyroid hormone signaling pathway
    293621 (Hras)
   04916 Melanogenesis
    293621 (Hras)
  Nervous system
   04725 Cholinergic synapse
    293621 (Hras)
   04726 Serotonergic synapse
    293621 (Hras)
   04720 Long-term potentiation
    293621 (Hras)
   04730 Long-term depression
    293621 (Hras)
   04722 Neurotrophin signaling pathway
    293621 (Hras)
  Development
   04360 Axon guidance
    293621 (Hras)
  Aging
   04211 Longevity regulating pathway - mammal
    293621 (Hras)
   04213 Longevity regulating pathway - multiple species
    293621 (Hras)
  Environmental adaptation
   04714 Thermogenesis
    293621 (Hras)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    293621 (Hras)
   05230 Central carbon metabolism in cancer
    293621 (Hras)
   05231 Choline metabolism in cancer
    293621 (Hras)
   05206 MicroRNAs in cancer
    293621 (Hras)
   05205 Proteoglycans in cancer
    293621 (Hras)
   05203 Viral carcinogenesis
    293621 (Hras)
   05210 Colorectal cancer
    293621 (Hras)
   05225 Hepatocellular carcinoma
    293621 (Hras)
   05226 Gastric cancer
    293621 (Hras)
   05214 Glioma
    293621 (Hras)
   05216 Thyroid cancer
    293621 (Hras)
   05221 Acute myeloid leukemia
    293621 (Hras)
   05220 Chronic myeloid leukemia
    293621 (Hras)
   05218 Melanoma
    293621 (Hras)
   05211 Renal cell carcinoma
    293621 (Hras)
   05219 Bladder cancer
    293621 (Hras)
   05215 Prostate cancer
    293621 (Hras)
   05213 Endometrial cancer
    293621 (Hras)
   05224 Breast cancer
    293621 (Hras)
   05223 Non-small cell lung cancer
    293621 (Hras)
  Substance dependence
   05034 Alcoholism
    293621 (Hras)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    293621 (Hras)
  Infectious diseases
   05166 HTLV-I infection
    293621 (Hras)
   05161 Hepatitis B
    293621 (Hras)
   05160 Hepatitis C
    293621 (Hras)
   05167 Kaposi's sarcoma-associated herpesvirus infection
    293621 (Hras)
   05165 Human papillomavirus infection
    293621 (Hras)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    293621 (Hras)
   01522 Endocrine resistance
    293621 (Hras)
Membrane trafficking [BR:rno04131]
 Endocytosis
  Macropinocytosis
   Ras GTPases
    293621 (Hras)
Exosome [BR:rno04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   293621 (Hras)
  Exosomal proteins of colorectal cancer cells
   293621 (Hras)
GTP-binding proteins [BR:rno04031]
 Small (Monomeric) G-proteins
  Ras Family
   Ras [OT]
    293621 (Hras)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Ras Roc Arf GTP_EFTU RsgA_GTPase MMR_HSR1 FeoB_N Gtr1_RagA G-alpha ATP_bind_1 Septin Ldh_1_N AAA_25 AAA_16
Motif
Other DBs
NCBI-GeneID: 293621
NCBI-ProteinID: NP_001091711
RGD: 2827
Ensembl: ENSRNOG00000016611
UniProt: P20171
Structure
PDB: 

Position
1q41
AA seq 189 aa AA seqDB search
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL
AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPG
CMSCKCVLS
NT seq 570 nt NT seq  +upstreamnt  +downstreamnt
atgacagaatacaagcttgtggtggtgggcgctggaggcgtgggaaagagtgccctgacc
atccagctgatccagaaccattttgtggacgagtatgatcccactatagaggactcctac
cggaaacaggtagtcattgatggggagacgtgtttactggacatcttagacacagcaggt
caagaagagtatagtgccatgcgggaccagtacatgcgcacaggggagggcttcctctgt
gtatttgccatcaacaacaccaagtcctttgaagacatccatcagtacagggagcagatc
aagcgggtgaaagattcagatgatgtgccaatggtgctggtgggcaacaagtgtgacctg
gccgctcgcactgttgagtctcggcaggcccaggaccttgctcgcagctatggcatcccc
tacattgaaacatcagccaagacccggcagggtgtggaggatgccttctacacactagta
cgtgagattcggcagcataaactgcggaaactgaacccgcctgatgagagtggccctggc
tgcatgagctgcaagtgtgtgctgtcctga

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