KEGG   Rattus norvegicus (rat): 29513
Entry
29513             CDS       T01003                                 

Gene name
Mapk13, Prkm13
Definition
(RefSeq) mitogen activated protein kinase 13
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno01522  Endocrine resistance
rno04010  MAPK signaling pathway
rno04015  Rap1 signaling pathway
rno04068  FoxO signaling pathway
rno04071  Sphingolipid signaling pathway
rno04114  Oocyte meiosis
rno04218  Cellular senescence
rno04261  Adrenergic signaling in cardiomyocytes
rno04370  VEGF signaling pathway
rno04380  Osteoclast differentiation
rno04550  Signaling pathways regulating pluripotency of stem cells
rno04611  Platelet activation
rno04613  Neutrophil extracellular trap formation
rno04620  Toll-like receptor signaling pathway
rno04621  NOD-like receptor signaling pathway
rno04622  RIG-I-like receptor signaling pathway
rno04625  C-type lectin receptor signaling pathway
rno04657  IL-17 signaling pathway
rno04658  Th1 and Th2 cell differentiation
rno04659  Th17 cell differentiation
rno04660  T cell receptor signaling pathway
rno04664  Fc epsilon RI signaling pathway
rno04668  TNF signaling pathway
rno04670  Leukocyte transendothelial migration
rno04714  Thermogenesis
rno04722  Neurotrophin signaling pathway
rno04723  Retrograde endocannabinoid signaling
rno04728  Dopaminergic synapse
rno04750  Inflammatory mediator regulation of TRP channels
rno04912  GnRH signaling pathway
rno04914  Progesterone-mediated oocyte maturation
rno04917  Prolactin signaling pathway
rno04926  Relaxin signaling pathway
rno04933  AGE-RAGE signaling pathway in diabetic complications
rno04935  Growth hormone synthesis, secretion and action
rno05014  Amyotrophic lateral sclerosis
rno05020  Prion disease
rno05022  Pathways of neurodegeneration - multiple diseases
rno05132  Salmonella infection
rno05133  Pertussis
rno05135  Yersinia infection
rno05140  Leishmaniasis
rno05142  Chagas disease
rno05145  Toxoplasmosis
rno05152  Tuberculosis
rno05161  Hepatitis B
rno05163  Human cytomegalovirus infection
rno05167  Kaposi sarcoma-associated herpesvirus infection
rno05169  Epstein-Barr virus infection
rno05170  Human immunodeficiency virus 1 infection
rno05171  Coronavirus disease - COVID-19
rno05205  Proteoglycans in cancer
rno05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
rno05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    29513 (Mapk13)
   04015 Rap1 signaling pathway
    29513 (Mapk13)
   04370 VEGF signaling pathway
    29513 (Mapk13)
   04668 TNF signaling pathway
    29513 (Mapk13)
   04068 FoxO signaling pathway
    29513 (Mapk13)
   04071 Sphingolipid signaling pathway
    29513 (Mapk13)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    29513 (Mapk13)
   04218 Cellular senescence
    29513 (Mapk13)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    29513 (Mapk13)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    29513 (Mapk13)
   04613 Neutrophil extracellular trap formation
    29513 (Mapk13)
   04620 Toll-like receptor signaling pathway
    29513 (Mapk13)
   04621 NOD-like receptor signaling pathway
    29513 (Mapk13)
   04622 RIG-I-like receptor signaling pathway
    29513 (Mapk13)
   04625 C-type lectin receptor signaling pathway
    29513 (Mapk13)
   04660 T cell receptor signaling pathway
    29513 (Mapk13)
   04658 Th1 and Th2 cell differentiation
    29513 (Mapk13)
   04659 Th17 cell differentiation
    29513 (Mapk13)
   04657 IL-17 signaling pathway
    29513 (Mapk13)
   04664 Fc epsilon RI signaling pathway
    29513 (Mapk13)
   04670 Leukocyte transendothelial migration
    29513 (Mapk13)
  09152 Endocrine system
   04912 GnRH signaling pathway
    29513 (Mapk13)
   04914 Progesterone-mediated oocyte maturation
    29513 (Mapk13)
   04917 Prolactin signaling pathway
    29513 (Mapk13)
   04926 Relaxin signaling pathway
    29513 (Mapk13)
   04935 Growth hormone synthesis, secretion and action
    29513 (Mapk13)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    29513 (Mapk13)
  09156 Nervous system
   04728 Dopaminergic synapse
    29513 (Mapk13)
   04723 Retrograde endocannabinoid signaling
    29513 (Mapk13)
   04722 Neurotrophin signaling pathway
    29513 (Mapk13)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    29513 (Mapk13)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    29513 (Mapk13)
  09159 Environmental adaptation
   04714 Thermogenesis
    29513 (Mapk13)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    29513 (Mapk13)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    29513 (Mapk13)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    29513 (Mapk13)
   05020 Prion disease
    29513 (Mapk13)
   05022 Pathways of neurodegeneration - multiple diseases
    29513 (Mapk13)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    29513 (Mapk13)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    29513 (Mapk13)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    29513 (Mapk13)
   05135 Yersinia infection
    29513 (Mapk13)
   05133 Pertussis
    29513 (Mapk13)
   05152 Tuberculosis
    29513 (Mapk13)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    29513 (Mapk13)
   05161 Hepatitis B
    29513 (Mapk13)
   05171 Coronavirus disease - COVID-19
    29513 (Mapk13)
   05163 Human cytomegalovirus infection
    29513 (Mapk13)
   05167 Kaposi sarcoma-associated herpesvirus infection
    29513 (Mapk13)
   05169 Epstein-Barr virus infection
    29513 (Mapk13)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    29513 (Mapk13)
   05140 Leishmaniasis
    29513 (Mapk13)
   05142 Chagas disease
    29513 (Mapk13)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    29513 (Mapk13)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:rno01001]
    29513 (Mapk13)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     29513 (Mapk13)
Protein kinases [BR:rno01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   29513 (Mapk13)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr RIO1 APH Kdo Kinase-like FTA2
Other DBs
NCBI-GeneID: 29513
NCBI-ProteinID: NP_062104
RGD: 3045
Ensembl: ENSRNOG00000000515
Vega: OTTRNOG00000001972
UniProt: Q32Q45
Position
20p12
AA seq 366 aa
MSLIRKRGFYKQDINKTAWELPKTYLAPAHVGSGAYGAVCSAIDKRTGEKVAIKKLSRPF
QSEIFAKRAYRELLLLKHMHHENVIGLLDVYTPATSVQNFQDFYLVMPFMQTDLQKIMGM
EFSEEKVQYLVYQMLKGLKYIHSAGIVHRDLKPGNLAVNEDCELKILDFGLARHTDAEMT
GYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTG
VPGAEFVQKLKDKAAKSYIQSLPQSPKKDFTQLFPRASPQAVDLLDKMLELDVDKRLTAA
QALAHPFFEPFRDPEEETEAQQPFDDALEREKLSVDEWKQHIYKEIANFSPIARKDSRRR
SGMKLQ
NT seq 1101 nt   +upstreamnt  +downstreamnt
atgagcctcattcggaaaaggggcttctacaagcaggacatcaacaagactgcctgggag
ctgcccaagacctacctggcgcccgcgcacgtcggcagcggggcctatggcgcggtgtgc
tcggccatcgacaagcggacaggggagaaggtggccatcaagaagctgagccggcccttc
cagtcggagatctttgccaagcgcgcttaccgcgaactcctgctgttgaagcacatgcac
catgagaacgtcattgggcttctggatgtctacacacctgccacttccgttcaaaacttc
caagatttctacctggtgatgcctttcatgcagaccgacctgcagaagataatggggatg
gagttcagtgaggagaaggtccagtatttggtgtaccagatgctcaaaggtctaaagtac
atccactcagctggtatcgttcacagggacctgaagccaggcaacctggccgtgaatgaa
gactgtgagctgaagatcctggactttgggctggcacgccacacggacgcggagatgact
ggctatgtggtgacccgctggtaccgggctcctgaggtgatcctcagctggatgcattac
aaccagacggtggatatctggtctgttggctgcatcatggccgagatgctaaccggaaag
acactcttcaagggtaaggactacctggaccagctgacccagatcctgaaagtgactggg
gtgccaggtgccgagttcgtgcagaagctgaaagacaaggcggccaaatcctacattcag
tccctgccccagagccccaagaaggatttcacacagcttttcccacgcgccagcccgcaa
gctgtagacctgctggacaagatgctggagctggacgtggacaagcgtctgaccgctgct
caggcactcgctcaccccttctttgaacccttccgggaccctgaggaggagacagaggcc
cagcagccatttgatgatgccttagagcgggagaaactcagcgtggacgaatggaaacaa
cacatctacaaagagatcgccaacttcagtcccatagcccggaaggactcgcggcgacga
agtgggatgaagctgcagtga

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