KEGG   Rattus norvegicus (rat): 29554Help
Entry
29554             CDS       T01003                                 

Gene name
Pdha1
Definition
(RefSeq) pyruvate dehydrogenase (lipoamide) alpha 1
  KO
K00161  pyruvate dehydrogenase E1 component alpha subunit [EC:1.2.4.1]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00010  Glycolysis / Gluconeogenesis
rno00020  Citrate cycle (TCA cycle)
rno00620  Pyruvate metabolism
rno01100  Metabolic pathways
rno01200  Carbon metabolism
rno04066  HIF-1 signaling pathway
rno04922  Glucagon signaling pathway
rno05230  Central carbon metabolism in cancer
Module
rno_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    29554 (Pdha1)
   00020 Citrate cycle (TCA cycle)
    29554 (Pdha1)
   00620 Pyruvate metabolism
    29554 (Pdha1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    29554 (Pdha1)
 09150 Organismal Systems
  09152 Endocrine system
   04922 Glucagon signaling pathway
    29554 (Pdha1)
 09160 Human Diseases
  09161 Cancer: overview
   05230 Central carbon metabolism in cancer
    29554 (Pdha1)
Enzymes [BR:rno01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.1  pyruvate dehydrogenase (acetyl-transferring)
     29554 (Pdha1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: E1_dh DXP_synthase_N TPP_enzyme_C
Motif
Other DBs
NCBI-GeneID: 29554
NCBI-ProteinID: NP_001004072
RGD: 3286
Ensembl: ENSRNOG00000025383
UniProt: Q4FZZ4
Position
Xq14
AA seq 390 aa AA seqDB search
MRKMLAAVSRVLAGAAQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTRED
GLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRA
HGFTFTRGLPVRAILAELTGRRGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALA
CKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAAST
DYYKRGDFIPGLRVDGMDILCVREATKFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVS
YRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPP
LEELGYHIYSSDPPFEVRGANQWIKFKSVS
NT seq 1173 nt NT seq  +upstreamnt  +downstreamnt
atgaggaagatgcttgccgctgtgtcccgcgtgttggcaggcgctgcgcagaagccggca
agcagagtgctggtagcttcccgtaatttcgcaaatgatgctacatttgagattaagaaa
tgtgaccttcatcgtctagaagagggccctccagtcaccacagtgctcaccagagaggat
gggctcaagtactacaggatgatgcagaccgtgcgccggatggagctcaaggcggatcag
ctgtataagcagaaaattattcgtggtttctgtcacttgtgtgatggtcaggaagcctgc
tgtgtgggcctggaggctggcataaaccccacggaccatctcatcactgcctatcgagcc
catggcttcaccttcactcggggcctgcctgtccgagcaattcttgcagaattaacagga
cgaagaggaggctgtgctaaggggaaaggcggatcaatgcacatgtacgccaagaacttc
tatggcggcaacggtatcgttggagctcaggtgcccctgggtgcaggaattgctctggcc
tgcaagtataatggcaaagatgaggtctgtttgacattatatggtgatggtgctgctaac
cagggtcagatatttgaagcttacaatatggcagcattgtggaaattaccttgtattttc
atctgtgagaataaccgctatggcatgggcacatctgttgagagagcagcagccagcacg
gattactacaaaagaggagatttcattcctggactgagggtagatggaatggatatcttg
tgtgtccgagaggcaacaaagtttgcagctgcctactgcaggtctggtaaggggcctatc
ctgatggagctacagacttaccgctaccatggacatagtatgagtgaccctggagtcagt
tatcgcactcgagaagaaatccaggaagtaagaagtaagagtgaccctattatgcttctc
aaggatagaatggtgaacagcaatcttgcaagtgttgaagaattaaaggagattgatgtg
gaagtgaggaaagaaatcgaggatgctgcccagtttgccacggctgatccggagccgcca
ttggaggagctaggctatcatatctacagcagtgacccacccttcgaagtgcgtggtgcc
aaccagtggatcaagtttaagtcagtcagttaa

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