KEGG   Rattus norvegicus (rat): 308457
Entry
308457            CDS       T01003                                 

Gene name
Egln2
Definition
(RefSeq) prolyl hydroxylase EGLN2
  KO
K09592  hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04066  HIF-1 signaling pathway
rno05200  Pathways in cancer
rno05211  Renal cell carcinoma
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    308457 (Egln2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    308457 (Egln2)
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    308457 (Egln2)
Enzymes [BR:rno01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.29  hypoxia-inducible factor-proline dioxygenase
     308457 (Egln2)
SSDB
Motif
Pfam: 2OG-FeII_Oxy_3 2OG-FeII_Oxy_4
Other DBs
NCBI-GeneID: 308457
NCBI-ProteinID: NP_001004083
RGD: 631376
Ensembl: ENSRNOG00000020947
UniProt: Q6AYU4
Position
1
AA seq 415 aa
MDSPCQPQALNQALPQLPGSVSESLEPSRARMGVESYLPCPLLPSYHRSGASGEASAGNG
TPRTTATATTTTASPLREGFGGQDGGELWPLQSEGAAALVTKECQRLAAQGARPEAPKRK
WAKDGGDAPSPSKRPWARQENQEAKGESGVGCDSGGGSSNSTTHSSGEASSRLREEAQPS
APERLALDYIVPCMRYYGICVKDNFLGAVLGGRVLAEVEALKWGGRLRDGQLVSQRAIPP
RSIRGDQIAWVEGHEPGCRSIGALMAHVDAVIRHCAGRLGNYVINGRTKAMVACYPGNGL
GYVRHVDNPHGDGRCITCIYYLNQNWDVKVHGGLLQIFPEGRPVVANIEPLFDRLLIFWS
DRRNPHEVKPAYATRYAITVWYFDAKERAAARDKYQLASGQKGVQVPVSQPATPT
NT seq 1248 nt   +upstreamnt  +downstreamnt
atggacagcccgtgccagccgcaggccctgaatcaagctctccctcagttgccagggtct
gtgtcagagtccttggagcctagccgagccaggatgggggtggagagttacctgccctgt
cctctgctcccctcctaccaccgttcaggagcatctggggaggcctcggctggcaacggg
acccccagaaccacagccactgctactactaccactgccagtcccctgcgggagggcttt
ggtgggcaggatggtggtgagctgtggccactgcagagtgaaggtgctgctgcgttggtt
accaaggagtgccagcgactggcggcccagggtgcccgacctgaggcccccaaacggaag
tgggccaaggatggtggggatgccccttcacccagcaagcgaccgtgggccaggcaagag
aaccaggaggccaagggggaaagtggtgtgggctgtgacagcggtggcggcagcagcaac
agcactacccatagcagtggcgaggcaagttctaggctgagggaggaagcccagccctct
gcacctgagcgcctggccttggactatattgtgccttgcatgcggtactatggtatctgc
gtcaaggacaacttcttgggggcagtactgggtggccgtgtgctggctgaggtggaagcc
ctgaagtggggcgggcgtctacgtgatgggcaactagtgagccagcgggcgatcccaccg
cgcagcattcgtggggaccagattgcctgggtagaaggccacgagccaggctgccggagc
attggtgccctcatggctcatgtggacgcagtaatccgccactgtgcagggcggctgggc
aactacgtcatcaatgggcgcaccaaggccatggtggcgtgttacccaggcaatgggctc
gggtacgtgaggcatgttgacaatccccacggcgatgggcgctgcatcacctgtatctat
tacctgaatcagaactgggatgttaaggtgcatggcggcctgctgcagatcttccctgag
ggtcggccagtggtagccaacatcgagccactctttgaccggttgctcattttctggtct
gaccgacggaatccacatgaggtgaagccagcctatgccaccaggtacgccatcactgtc
tggtattttgatgccaaggagcgggcagcagccagagacaagtatcagctagcatcggga
cagaaaggtgttcaagtacccgtgtcacagccagctacacctacctaa

KEGG   Rattus norvegicus (rat): 308913
Entry
308913            CDS       T01003                                 

Gene name
Egln1
Definition
(RefSeq) egl nine homolog 1
  KO
K09592  hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04066  HIF-1 signaling pathway
rno05200  Pathways in cancer
rno05211  Renal cell carcinoma
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    308913 (Egln1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    308913 (Egln1)
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    308913 (Egln1)
Enzymes [BR:rno01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.29  hypoxia-inducible factor-proline dioxygenase
     308913 (Egln1)
SSDB
Motif
Pfam: 2OG-FeII_Oxy_3 zf-MYND 2OG-FeII_Oxy_4 zf-Mss51
Other DBs
NCBI-GeneID: 308913
NCBI-ProteinID: XP_038954143
RGD: 631375
Position
19
AA seq 401 aa
MASDSGGPGVLSASERDRQYCELCGKMENLLRCGRCRSSFYCCKEHQRQDWKKHKLVCQG
GEAPRAQPAPAQPRVAPPPGGAPGAARAGGAARRGDSSTAASRVPGPEDATQAGSGPGPA
EPSSEDPPPSRSPGPERASLCPAGGGPGEALSPSGGLRPNGQTKPLPALKLALEYIVPCM
NKHGICVVDDFLGRETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGK
EPGCETIGLLMSSMDDLIRHCSGKLGNYRINGRTKAMVACYPGNGTGYVRHVDNPNGDGR
CVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYAT
RYAITVWYFDADERARAKVKYLTGEKGVRVELKPNSVSKDV
NT seq 1206 nt   +upstreamnt  +downstreamnt
atggccagtgacagcggcgggcccggcgtgctgagcgccagcgagcgcgaccggcagtac
tgcgagctgtgcgggaagatggagaacctgctgcgctgcggccgctgccgcagctccttc
tactgctgcaaggagcaccagcgccaggactggaagaagcacaagctggtgtgccagggc
ggcgaggccccccgcgcgcagcccgcgccagcgcagccccgcgtcgcgcccccgcccggt
ggggcccccggagccgcgcgcgccggcggggcggcccggcgaggggacagcagcacggcg
gcctcgcgcgtaccgggcccggaggacgcgacgcaggccgggagcggccccggcccggca
gagcccagctccgaggatcctccgcctagcaggtctccgggccccgagcgcgctagcttg
tgcccagcgggcggcggccccggggaggcgctgagtcccagcggagggctgcggcccaac
gggcagaccaagccgctgcccgcgctgaagctggcgctggagtacatcgtgccgtgcatg
aacaagcacggcatctgcgtggtggacgacttcctgggcagggagaccgggcagcagatc
ggcgacgaggtgcgcgccctgcacgacaccggcaagttcacggacgggcaactggtcagc
cagaagagtgactcttccaaggacatccggggggacaagatcacctggatcgagggcaaa
gagcccggctgcgagaccatcggcctgctcatgagcagcatggacgacctgatccgccac
tgcagcgggaagctgggcaactacaggataaacggccgaacgaaagccatggtcgcctgt
tacccaggcaacgggacaggctacgtccgtcacgtcgataacccaaatggagacggaaga
tgtgtgacatgtatatattatctaaataaagactgggacgccaaggtgagcggaggtatt
cttcgaattttcccagaaggcaaagcccagtttgctgacattgaacccaagtttgataga
ttgctgtttttctggtctgaccggcgtaaccctcatgaagtacagcctgcatacgccaca
aggtacgcaataaccgtttggtatttcgatgcagacgagcgagcaagagctaaagtaaaa
tatctcacaggtgagaaaggtgtgagggttgaactcaagcccaattcagtcagcaaagat
gtctag

KEGG   Rattus norvegicus (rat): 54702
Entry
54702             CDS       T01003                                 

Gene name
Egln3
Definition
(RefSeq) prolyl hydroxylase EGLN3
  KO
K09592  hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04066  HIF-1 signaling pathway
rno05200  Pathways in cancer
rno05211  Renal cell carcinoma
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    54702 (Egln3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    54702 (Egln3)
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    54702 (Egln3)
Enzymes [BR:rno01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.29  hypoxia-inducible factor-proline dioxygenase
     54702 (Egln3)
SSDB
Motif
Pfam: 2OG-FeII_Oxy_3 2OG-FeII_Oxy_4
Other DBs
NCBI-GeneID: 54702
NCBI-ProteinID: NP_062244
RGD: 71019
Ensembl: ENSRNOG00000005053
UniProt: Q62630
Position
6
AA seq 355 aa
MTLRSRRGFLSFLPGLRPPRRWLRISKRGPPTSHWASPALGGRTLHYSCRSQSGTPFSSE
FQATFPAFAAKVARGPWLPQVVEPPARLSASPLCVRSGQALGACTLGVPRLGSVSEMPLG
HIMRLDLEKIALEYIVPCLHEVGFCYLDNFLGEVVGDCVLERVKQLHYNGALRDGQLAGP
RAGVSKRHLRGDQITWIGGNEEGCEAINFLLSLIDRLVLYCGSRLGKYYVKERSKAMVAC
YPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKLHGGVLRIFPEGKSFVADVEPIFDR
LLFFWSDRRNPHEVQPSYATRYAMTVWYFDAEERAEAKKKFRNLTRKTESALAKD
NT seq 1068 nt   +upstreamnt  +downstreamnt
atgacgttgaggtcaaggcggggcttcctctcgttcctccccgggctgcggccgccgcgg
cggtggctccgcatctccaaaaggggccctccgacttctcactgggccagtccggcgctg
ggtggcagaactctacactactcctgccggtctcagagcgggactcccttctcttcagag
tttcaagcaactttccccgcctttgcagctaaagtggctcggggaccgtggctgccgcag
gtggtagagcccccggcccggctctctgcatctccgctgtgcgttcgctctgggcaagcc
ctcggtgcgtgcaccctgggggtcccccgcctcggctctgtgagcgagatgcctctggga
cacatcatgaggctggatctggagaagatcgccctggagtacatcgtgccctgtctgcac
gaggtcggcttctgctacctggacaacttcctaggcgaggtggtgggcgactgcgtactg
gagcgagtcaagcagctgcattacaacggggccctgcgtgacggccagctggcggggccc
cgcgccggcgtctccaagcggcacctgcgaggcgaccagatcacgtggatcgggggcaac
gaggagggctgcgaggccatcaacttcctcctgtccctcatcgacaggctggtcctgtac
tgcgggagccgcctgggcaaatactatgtcaaggagcggtccaaggcgatggtggcttgc
tatccaggaaatggaacaggttatgttcgtcatgtggacaaccccaatggtgatggccgc
tgtatcacctgtatctactacctgaataagaattgggacgccaagttacatggaggggtc
ctgcggatatttccagaaggaaaatcatttgtagcagacgtggagcccatttttgataga
ctcctgttcttctggtcagaccgcaggaatccacatgaagttcagccctcctatgccacc
aggtacgccatgactgtctggtacttcgatgctgaagaaagggcagaagccaaaaagaaa
ttcaggaatctaactagaaaaactgaatctgctcttgctaaagactga

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