KEGG   Rattus norvegicus (rat): 312299
Entry
312299            CDS       T01003                                 

Gene name
Ezh2
Definition
(RefSeq) enhancer of zeste 2 polycomb repressive complex 2 subunit
  KO
K11430  [histone H3]-lysine27 N-trimethyltransferase EZH2 [EC:2.1.1.356]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00310  Lysine degradation
rno01100  Metabolic pathways
rno05206  MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    312299 (Ezh2)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    312299 (Ezh2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:rno03036]
    312299 (Ezh2)
Enzymes [BR:rno01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.356  [histone H3]-lysine27 N-trimethyltransferase
     312299 (Ezh2)
Chromosome and associated proteins [BR:rno03036]
 Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     312299 (Ezh2)
   Polycomb group proteins
    PRC2-EZH2 complex
     312299 (Ezh2)
SSDB
Motif
Pfam: PRC2_HTH_1 SET EZH2_WD-Binding preSET_CXC
Other DBs
NCBI-GeneID: 312299
NCBI-ProteinID: NP_001128451
RGD: 1595860
Ensembl: ENSRNOG00000006048
UniProt: B5DFE2
Position
4q24
AA seq 746 aa
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKTMFSSNRQKILERTETLNQEW
KQRRIQPVHIMTSVSSLRGTRECSVTSDLDFPAQVIPLKTLNAVASVPIMYSWSPLQQNF
MVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQ
YNDDDDDDDGDDPDEREEKQKDLDDSRDDKETCPPRKFPADKIFEAISSMFPDKGTAEEL
KEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFH
ATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPN
NSSRPSTPTISVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKM
KPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPV
PTEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQ
NFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVS
CKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDK
YMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGE
ELFFDYRYSQADALKYVGIEREMEIP
NT seq 2241 nt   +upstreamnt  +downstreamnt
atgggccagactgggaagaaatctgagaagggaccggtttgttggcggaagcgtgtaaag
tcagagtacatgagactgagacagctcaagaggttcagaagagctgacgaagtaaagact
atgtttagttccaatcgtcagaaaattttggaaagaactgaaaccttaaatcaagaatgg
aagcagcgaaggatacagcctgtgcacatcatgacttctgtgagctcattacgcgggact
agggagtgttcagtgaccagtgacttggattttccagcacaagtcatcccgttaaagacc
ctaaatgctgtcgcatcggtgcccataatgtattcttggtctcccttacaacagaatttt
atggtggaagatgaaactgttttacataacattccttatatgggggatgaagttctggat
caggatggcactttcattgaagaattaataaaaaattatgatggaaaagtgcatggagac
agagaatgtggatttataaatgatgaaatttttgtggagttggtaaatgctcttggtcaa
tataatgatgatgacgatgatgatgatggagacgatcctgatgaaagagaagaaaaacag
aaagatctagacgatagtcgagatgataaagaaacttgcccacctcggaaatttcctgct
gataaaatatttgaagccatttcctcaatgtttccagataagggcacagcagaagaactg
aaagaaaagtataaagaactcacggagcagcagctccccggtgctctacctcctgaatgt
accccaaacatcgatggaccaaatgccaaatctgttcagagggagcaaagtttacattca
tttcatacgctcttttgtcgacgatgttttaagtatgactgcttcctacatccctttcat
gcaacacccaacacatataagaggaagaacacagaaacagctctggacaacaagccttgt
ggaccacagtgttatcagcatctggagggagctaaggagtttgctgctgcccttactgct
gagcggataaagacaccacctaaacgtccagggggccgcagaagaggaagacttccgaat
aacagtagcagacccagcacccccaccatcagtgtgctggagtcaaaggatacagacagt
gacagagaagcagggactgaaaccgggggagagaacaacgataaagaagaagaagagaaa
aaagatgagacttccagttcctctgaagcaaattctcggtgtcaaacaccaataaagatg
aagccaaatattgaacctcctgagaatgtggagtggagtggtgctgaagcctccatgttt
agagtcctcattggtacttactacgataacttttgtgccattgctaggctaattgggacc
aaaacatgtagacaggtgtatgagtttagagtcaaagagtccagtatcatagcacctgtt
cccactgaggatgtggacactcctccaagaaagaagaaaagaaaacatcggttgtgggct
gcacactgcagaaagatccaactgaaaaaggacggctcctctaaccatgtttacaactat
caaccctgtgaccatccacggcagccttgtgacagttcgtgcccttgtgtgatagcacaa
aatttttgtgaaaagttttgtcaatgtagttcagagtgtcaaaaccgctttcctggatgc
cggtgcaaagcacaatgcaacaccaagcagtgtccgtgctacctggctgtccgagagtgt
gatcctgacctctgtctcacttgtggagctgctgaccactgggacagtaaaaatgtgtcc
tgcaagaactgtagcattcagcggggctctaaaaagcacttactgctggcaccgtctgat
gtggcaggctggggcatctttatcaaagatccagtacagaaaaatgaattcatctcagaa
tactgtggagagattatttctcaggatgaagcagacagaagagggaaagtgtatgacaaa
tacatgtgcagctttctgttcaacttgaacaatgattttgtggtggatgcaacccgcaag
ggcaacaaaattcgttttgctaatcattcagtaaatccaaactgctatgcaaaagttatg
atggttaatggtgaccacaggataggcatctttgctaagagagctatccagactggtgaa
gagttgttctttgattacagatacagccaggctgatgccctgaagtatgtgggcatcgaa
cgagaaatggaaatcccttga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (10)   
   UniProt (1)   
   RefSeq(pep) (9)   
DNA sequence (13)   
   RefSeq(nuc) (9)   
   GenBank (2)   
   EMBL (2)   
Protein domain (4)   
   Pfam (4)   
All databases (50)   

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