KEGG   Rattus norvegicus (rat): 363633
Entry
363633            CDS       T01003                                 

Gene name
Polr2a
Definition
(RefSeq) DNA-directed RNA polymerase II subunit RPB1 isoform X1
  KO
K03006  DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno03020  RNA polymerase
rno05016  Huntington disease
Brite
KEGG Orthology (KO) [BR:rno00001]
 09120 Genetic Information Processing
  09121 Transcription
   03020 RNA polymerase
    363633 (Polr2a)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05016 Huntington disease
    363633 (Polr2a)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03021 Transcription machinery [BR:rno03021]
    363633 (Polr2a)
   03400 DNA repair and recombination proteins [BR:rno03400]
    363633 (Polr2a)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.6  DNA-directed RNA polymerase
     363633 (Polr2a)
Transcription machinery [BR:rno03021]
 Eukaryotic type
  RNA polymerase II system
   RNA polymerase II
    Core subunits
     363633 (Polr2a)
DNA repair and recombination proteins [BR:rno03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   NER (nucleotide excision repair)
    TCR (transcription coupled repair) factors
     DNA-directed RNA polymerase II complex
      363633 (Polr2a)
SSDB
Motif
Pfam: RNA_pol_Rpb1_1 RNA_pol_Rpb1_5 RNA_pol_Rpb1_2 RNA_pol_Rpb1_6 RNA_pol_Rpb1_7 RNA_pol_Rpb1_3 RNA_pol_Rpb1_4 RNA_pol_Rpb1_R
Other DBs
NCBI-GeneID: 363633
NCBI-ProteinID: XP_343923
RGD: 1587326
Ensembl: ENSRNOG00000028834
UniProt: D4A5A6
Position
10
AA seq 1970 aa
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVD
SNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKG
HGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEP
RYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVD
FSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII
RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWS
TFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQD
TLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEM
GHDVTRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKA
HNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKIN
ISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA
MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMR
EDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKL
VIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAI
AHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLT
VFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMP
DFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR
IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLM
EAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTG
MFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPG
YSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP
TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
YSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPT
SPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSPEYTPTSPKY
SPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTS
PKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPEDSDEEN
NT seq 5913 nt   +upstreamnt  +downstreamnt
atgcacgggggtggccctccctccggggacagcgcatgcccgctgcgcaccatcaagaga
gtgcagttcggcgtcctgagtccggatgagttgaagcggatgtctgtgacagagggtggt
atcaaatacccagagacaacagagggtggtcgccccaaacttgggggactaatggatcca
cgacagggggtgattgagcggactggccgttgtcaaacatgtgcaggaaacatgaccgag
tgtcctggccactttggccacattgaactggccaagcctgtgtttcatgtgggcttcctg
gtgaagacaatgaaggttttgcgctgtgtctgcttcttttgctccaaacttcttgtagat
tctaacaacccgaagattaaggacatcctggccaaatctaaggggcagcccaagaaacgg
cttacacatgtctatgacctttgcaagggcaaaaacatctgtgaaggtggagaggagatg
gacaacaagtttggtgtggagcagcctgagggggatgaggatctgaccaaagaaaagggc
catggtggctgtgggcgttatcagccccggatccggcgctctggcctggagttgtatgct
gaatggaaacatgttaatgaggactctcaggagaagaagatcttgctgagtccagaacga
gtgcatgaaatcttcaaacgcatctcagatgaggagtgttttgtgctgggcatggagcct
cgctatgcccggcctgagtggatgattgtcacggtgttgcctgtgcctcctctctctgtg
cgacctgctgtggtgatgcaaggttctgctcgaaaccaggatgatctgactcacaaactg
gctgacattgtgaagatcaacaatcagctgcggcggaacgaacagaatggtgcagctgcc
catgtcatcgcagaagatgtgaaacttctccagttccatgtggccaccatggtggacaac
gaactgcccggcttaccccgtgccatgcagaagtctggccgtcccctcaagtccctgaag
caacggttgaagggcaaggaaggacgggttcgagggaatctaatgggcaagcgagtggac
ttctcagcccgcactgtcatcacccctgaccctaacctatccattgaccaagttggtgtg
ccccgctccattgctgccaacatgacctttgcagagattgtcacacctttcaacattgac
agacttcaggaattagtacgcaggggaaacagccagtatccaggagccaagtacatcatc
cgagacaacggtgatcgaattgacttacggttccatcctaagcccagtgaccttcaccta
cagactggctataaggtggaacggcacatgtgtgatggggacattgttatcttcaatcgt
cagccaactttgcacaaaatgtccatgatggggcatcgggtccgcatcctcccctggtct
acatttcgcttgaatcttagtgtgacaactccatacaatgcagactttgatggagatgag
atgaatttgcacctgcctcagtctctggagacacgggcagagatccaagagttggccatg
gtacctcgaatgattgtcactccccagagcaatcgacctgtcatgggtattgtgcaagac
acactcacagcggtccgcaaattcactaagagagatgtcttcctggagcggggtgaagtg
atgaacctcttaatgttcctgtccacgtgggatgggaaggtcccacagccagccatcctc
aagccccggcccctgtggacaggcaagcaaatcttctccctcatcatacctggtcacatc
aattgtatccgtactcacagcacccatcctgatgatgaagatagtggcccttacaagcac
atctctcctggggacaccaaagtggtggtggagaatggggagcttatcatgggcatcctt
tgtaagaagtctctgggcacatcagcaggctctctggtccacatctcctacttagagatg
ggtcatgacgttacccgcctcttctactccaacattcagactgtcattaacaactggctt
ctcatcgagggtcataccattggcattggggactccattgcagattccaagacttaccag
gacattcagaacactattaagaaagctaaacaggatgtaatagaggtcattgagaaggct
cataacaatgagctagaacccaccccaggaaacacattgcgccagacatttgagaatcaa
gtgaatcgcattctcaatgatgctcgagacaaaactggctcctctgcacagaaatccctc
tctgaatataacaacttcaagtctatggtggtgtctggagctaaagggtccaagatcaac
atctcccaggtcattgccgttgtcgggcagcagaacgtggagggcaagcggatcccattt
ggatttaagcatcggactcttcctcactttatcaaggatgattatggtcccgagagccga
ggctttgtagaaaactcctacttggctggcctcactcccactgagttcttcttccatgcc
atgggaggacgagaaggtctcattgacacagctgttaagactgctgagactgggtatatt
cagcgaaggctgataaaatccatggagtcggtgatggtgaaatatgatgcaactgtgagg
aactccatcaaccaggtggtacagctacgctatggagaggacggcctagcaggcgagagc
gttgagttccagaatctggctacacttaagccttctaataaagcttttgagaagaagttc
cgttttgattataccaatgagagggccctgcggcggactcttcaggaggatctggtaaag
gatgtgctgagcaatgcccacatacagaatgagctagaacgggaatttgaacggatgcgg
gaagatcgggaagtgctcagggtcatcttcccaactggtgacagcaaggtggtcctccct
tgtaaccttctgcggatgatctggaatgcacagaaaatcttccatatcaaccctcgcctt
ccctctgacctgcaccccatcaaagtggtagagggagtcaaagaattgagcaagaagttg
gtaattgtgaatggagatgacccactaagtcggcaggcacaggagaatgccactttgctc
ttcaacatccacctaagatccacactttgctctcgccgaatggctgaggagtttcggctc
agtggagaggcctttgactggctgctcggggagatagagtccaagttcaaccaagccatt
gcccatcctggagaaatggtgggagctttggctgctcagtctcttggagaacctgccact
cagatgaccctgaacactttccactatgctggtgtatctgccaagaatgtgacgctgggt
gtacctcggcttaaggagctcatcaacatctctaagaagccaaagaccccttcactcact
gtcttcctgttaggccaatctgcccgagacgctgagcgggccaaggacattctttgccgc
ttggaacatacaacattgaggaaggtgactgccaacacagccatctactatgaccccaac
cctcagagcacagtggtggcagaagatcaggagtgggtgaatgtgtactatgagatgcct
gactttgatgtagcccgaatatccccctggctgctgcgtgtggaactggaccgaaagcac
atgactgaccggaagcttaccatggaacagattgctgaaaaaatcaatgcaggctttggc
gatgatttgaattgtatcttcaatgatgataatgcagagaagctggtccttcgtatccgc
atcatgaacagtgatgaaaacaagatgcaggaggaggaagaggtggtggataagatggat
gatgatgttttcctgcggtgcattgagtccaacatgctgacagatatgaccctgcagggt
attgagcagatcagcaaggtatacatgcacttacctcagacagacaacaagaagaagatc
atcatcacagaagatggggagttcaaggccctgcaagaatggatcttggagacagatggt
gtgagcctgatgcgggtgctgagcgagaaggatgtagaccctgtgcgcactacgtccaat
gacatcgtggagatcttcacggtactgggcattgaggctgtgcggaaggccctggagcga
gaactgtaccatgtcatctcctttgatggttcctacgtcaattatcggcatttggctctt
ctgtgtgacacaatgacatgccgtggccacttgatggccatcactcgtcatggagtcaac
cgccaggacactggaccactcatgaaatgctcctttgaggaaacggtggatgtccttatg
gaagcagctgcacatggggagagtgaccccatgaagggagtctctgagaatattatgctg
ggccagctcgctccagctggtactggctgttttgacctcctgcttgatgctgagaaatgc
aaatacggcatggaaatccccaccaatatccccggactgggggccgctggacctactggc
atgttctttggctctgcacccagtccgatgggaggaatctctcctgcaatgacaccctgg
aaccagggtgcaactccagcctatggtgcctggtccccaagtgttgggagtgggatgacc
ccaggagcagctggcttctctcccagtgctgcatctgatgccagtggcttcagcccaggt
tactcgcctgcatggtctcccacaccaggctctccaggctcccctggaccctcaagccca
tatatcccctcaccaggtggtgctatgtctcccagctactcaccaacatcaccagcatat
gagccgcgctcccctgggggctatacaccgcagagcccctcatactcccctacttctcct
tcctactccccaacgtctccgtcttattctccaaccagtcccaactatagtcctacctca
cctagctactccccaacctctcctagctattccccaacctctccatcctactcaccaacc
tctccatcctactcaccaacctctcccagctactccccaacctctcccagctactcccca
acatcacccagctattctccaacttctcccagctactcaccaacatctcctagctattcc
ccaacatctcccagctactcaccaacctctccaagctattctcccacctcccccagttac
tcaccgacatctccaagctactcaccaacttctccaagttactcaccaacttccccaagt
tactcacccactagccctaactattccccaactagtcccaactataccccaacctcaccc
agctacagcccaacctcacccagctactcacctactagtccaaactatacacctaccagc
cctaactacagcccaacctctccaagctattccccaacctcacccagttactctcccacc
tcacccagctactctccctcgagcccacggtatacacctcagtctccaacctacacaccg
agttcaccaagctacagccctagctcgccaagctacagccctacttcccccaagtatacc
ccaactagtccttcctacagtcctagctcaccagagtataccccaacttctcccaaatac
tcacctacaagccccaaatattcacccacttctcccaagtattctcctaccagccccact
tactcacccaccaccccaaaatactcgccaacctctcctacatattcaccaacctctcca
gtctacaccccgacctctcccaagtactcccctactagtcctacctactccccaacttct
cccaagtactcgcccaccagtcccacctactcacccacctctcccaagggctccacctac
tctcccacttctcctggctactcccccaccagccccacctacagcctcaccagtccagcc
atcagcccagaagacagcgatgaggagaactga

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