KEGG   Rattus norvegicus (rat): 445442
Entry
445442            CDS       T01003                                 

Gene name
Thbs1
Definition
(RefSeq) thrombospondin-1 precursor
  KO
K16857  thrombospondin 1
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04015  Rap1 signaling pathway
rno04115  p53 signaling pathway
rno04145  Phagosome
rno04151  PI3K-Akt signaling pathway
rno04350  TGF-beta signaling pathway
rno04510  Focal adhesion
rno04512  ECM-receptor interaction
rno05144  Malaria
rno05165  Human papillomavirus infection
rno05205  Proteoglycans in cancer
rno05206  MicroRNAs in cancer
rno05219  Bladder cancer
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    445442 (Thbs1)
   04350 TGF-beta signaling pathway
    445442 (Thbs1)
   04151 PI3K-Akt signaling pathway
    445442 (Thbs1)
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    445442 (Thbs1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    445442 (Thbs1)
  09143 Cell growth and death
   04115 p53 signaling pathway
    445442 (Thbs1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    445442 (Thbs1)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    445442 (Thbs1)
   05205 Proteoglycans in cancer
    445442 (Thbs1)
  09162 Cancer: specific types
   05219 Bladder cancer
    445442 (Thbs1)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    445442 (Thbs1)
  09174 Infectious disease: parasitic
   05144 Malaria
    445442 (Thbs1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:rno04131]
    445442 (Thbs1)
  09183 Protein families: signaling and cellular processes
   00536 Glycosaminoglycan binding proteins [BR:rno00536]
    445442 (Thbs1)
   04990 Domain-containing proteins not elsewhere classified [BR:rno04990]
    445442 (Thbs1)
Membrane trafficking [BR:rno04131]
 Endocytosis
  Phagocytosis
   Opsonins
    445442 (Thbs1)
Glycosaminoglycan binding proteins [BR:rno00536]
 Heparan sulfate / Heparin
  Extracellular matrix molecules
   445442 (Thbs1)
Domain-containing proteins not elsewhere classified [BR:rno04990]
 Thrombospondin domain-containing proteins
  Thrombospondins
   445442 (Thbs1)
SSDB
Motif
Pfam: TSP_C TSP_3 TSP_1 TSP1_spondin VWC cEGF EGF_3 EGF_CA TSP1_ADAMTS Laminin_G_3 Laminin_G_2 TSP1_CCN EGF Laminin_G_1
Other DBs
NCBI-GeneID: 445442
NCBI-ProteinID: NP_001013080
RGD: 1588455
UniProt: Q71SA3
Position
3
AA seq 1170 aa
MELLRGLGVLFLLHVCGSNRIPESGGDNGVFDIFELIGGARKVPGRRLVKGQDLSSPAFR
IENANLIPPVPDDKFQDLLDAVWADKGFIFLASLRQMKKTRGTLLAVERKDNSGQIFSVV
SNGKAGTLDLSLSLPGKQQVVSVEEALLATGQWKSITLFVQEDRAQLYIDCDKMESAELD
VPIQSIFTRDLANVARLRVAKGDVNDNFQGVLQNVRFVFGTTPEDILRNKGCSSSTNVLL
TLDNNVVNGSSPAIRTNYIGHKTKDLQAICGLSCDELSSMVLELRGLRTIVTTLQDSIRK
VTEENRELASELRRPPLCFHNGVQYRNNEEWTVDSCTECHCQNSVTICKKVSCPIMPCSN
ATVPDGECCPRCWPSDSADDGWSPWSEWTSCSATCGNGIQQRGRSCDSLNNRCEGSSVQT
RTCHIQECDKRFKQDGGWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARE
TKACKKDACPINGGWSPWSLWDICSVTCGGGVQRRSRLCNNPTPQFGGKDCVGDVTENQV
CNKQDCPIDGCLSNPCFAGAKCTSYPDGSWKCGACPPGYSGNGIQCKDVDECKEVPDACF
NHNGEHRCKNTDPGYNCLPCPPRFTGSQPFGRGVEHAMANKQVCKPRNPCTDGTHDCNKN
AKCNYLGHYSDPMYRCECKPGYAGNGIICGEDTDLDGWPNENLVCVANATYHCKKDNCPN
LPNSGQEDYDKDGIGDACDDDDDNDKIPDDRDNCPFHYNPAQYDYDRDDVGDRCDNCPYN
HNPDQADTDNNGEGDACAVDIDGDGILNERDNCQYVYNVDQRDTDMDGVGDQCDNCPLEH
NPDQLDSDSDRIGDTCDNNQDIDEDGHQNNLDNCPYVPNANQADHDKDGKGDACDHDDDN
DGIPDDRDNCRLVPNPDQKDSDGDGRGDACKDDFDHDNVPDIDDICPENVDISETDFRRF
QMIPLDPKGTSQNDPNWVVRHQGKELVQTVNCDPGLAVGYDEFNAVDFSGTFFINTERDD
DYAGFVFGYQSSSRFYVVMWKQVTQSYWDTNPTRAQGYSGLSVKVVNSTTGPGEHLRNAL
WHTGNTPGQVRTLWHDPRHIGWKDFTAYRWRLSHRPKTGFIRVVMYEGKKIMADSGPIYD
KTYAGGRLGLFVFSQEMVFFSDMKYECRDS
NT seq 3513 nt   +upstreamnt  +downstreamnt
atggagctcctcaggggactaggcgtcctgttcctgttgcatgtgtgtggaagcaaccgc
attccagagtctgggggagacaatggtgtgttcgacatttttgaactcattggaggtgcc
cgcaaggttccgggtcgccgactggtgaagggccaagatctatccagccccgccttccgg
atcgagaatgccaacctgatcccccctgtgccagatgacaagttccaagacctactggac
gctgtgtgggccgacaaaggcttcatcttcctggcttccttgaggcagatgaagaagact
cggggcacactcctggccgtggaacggaaagacaattctggccagatcttcagtgtggtc
tccaatggcaaagccggcaccctcgatctgagtctgagcctgcccgggaagcagcaagtg
gtgtcagtggaggaagctctcctggccactggccagtggaagagcatcacgctgtttgtc
caagaagacagggcccagctctacattgactgtgacaagatggagagcgcagagctggat
gttcccatccagagcatcttcaccagggatttggccaatgtcgccaggctccgagtcgca
aagggagatgtcaatgacaattttcagggggtgctgcagaatgtgaggtttgtctttgga
accaccccagaagacattctcaggaacaaaggctgctccagttctaccaacgtccttctc
acccttgacaacaacgtggtgaacggttccagccctgccatccgcaccaactacatcggc
cacaaaacaaaggacctccaagccatctgtggcctctcctgtgacgaactatccagcatg
gtcctggaactgaggggcctgcgtaccatcgtgaccacgctacaggacagcattcgaaaa
gtgacggaagagaacagagagctggctagcgagctgaggcggcctcccctctgcttccac
aatggagtccaatacaggaacaacgaggagtggactgtagatagttgcacagagtgtcac
tgccagaactcagttaccatctgcaaaaaggtgtcctgtcccatcatgccctgctccaat
gccacagttcctgatggtgaatgctgcccacggtgctggcccagtgactctgctgacgat
ggctggtctccctggtctgagtggacctcttgctctgccacctgtggcaatgggattcag
caacgtggtcgctcctgtgacagcctcaacaacagatgtgagggctcttcagtacagacg
aggacctgccacattcaggagtgcgacaaaagatttaaacaggatggtggttggagtcac
tggtccccgtggtcgtcctgttctgtgacctgtggtgacggtgtgatcacgaggatccga
ctctgcaactcccccagcccccagatgaacgggaagccctgtgaaggtgaagctcgggag
accaaagcctgcaagaaggacgcctgcccaatcaatggaggctggagtccctggtcacta
tgggacatctgctctgtcacctgtggaggaggagtacagagacgtagccgactctgcaac
aaccccacaccccagtttggaggcaaagactgtgttggtgatgtgacggaaaatcaagtt
tgcaacaagcaggactgtccgattgatggatgcctgtccaatccctgctttgctggtgcc
aagtgtacgagctatcctgatggtagctggaaatgtggtgcgtgtcctcctggctacagt
ggaaatggtatccagtgcaaagacgtcgacgagtgcaaagaagtgcctgatgcttgcttc
aatcacaacggagaacatcggtgcaagaacacagatcctggctacaactgcctgccctgc
ccaccacgattcaccggctcacagcccttcggcagaggtgtcgaacacgctatggccaac
aaacaggtgtgcaaaccccgaaacccctgcaccgacgggacacacgactgcaacaagaac
gccaagtgcaactacctgggtcactacagcgaccccatgtaccgctgtgagtgcaagcct
ggctacgcaggcaatggcatcatttgcggagaggacacagaccttgacggctggcctaat
gaaaacctggtgtgtgtggccaacgcaacttaccactgcaaaaaggacaactgccccaat
cttcccaattcggggcaggaagactatgacaaggatgggattggcgatgcctgtgatgac
gatgatgacaacgacaagattcctgatgacagggacaactgtccattccattacaaccca
gcccagtatgactatgacagagatgatgtgggagaccgctgtgacaattgcccctacaac
cacaaccctgaccaggcagacacagacaacaatggggagggagatgcctgcgctgtggac
atcgatggggatggaatcctcaatgaacgagacaactgccagtatgtttacaacgtggat
cagagggacacggacatggatggggttggagaccagtgtgacaactgccccctggaacac
aatccagaccagctggactctgactcggaccgcataggggacacctgtgacaacaatcag
gacatcgatgaggatggccatcagaacaacctggacaactgtccctatgtgcccaatgcc
aaccaggccgaccacgataaagatggtaaaggagacgcctgtgaccatgacgatgacaac
gacggcatccctgatgacagagacaactgcaggctggtgcccaatcctgaccagaaggac
tctgatggtgatggccgaggcgatgcctgcaaagacgactttgaccatgacaatgtgcca
gacattgatgacatctgtcctgagaatgttgacatcagtgaaaccgatttccgccgattc
cagatgattcctctagatcccaaaggaacctcccaaaatgaccctaactgggttgtccgc
catcagggcaaagaacttgtccagactgtaaactgtgaccctggacttgctgtaggttat
gatgagtttaatgccgtggacttcagtggtaccttcttcatcaacactgagagggatgac
gactatgctggctttgttttcggctaccagtccagcagccgcttctacgttgtgatgtgg
aaacaagtcacccagtcctactgggacaccaaccccacaagggctcagggatactcaggc
ctgtctgtaaaggttgtaaactccaccactggccccggcgagcacctgcggaatgcactg
tggcacacaggaaacacccctggccaggtgcgcaccctgtggcatgaccctcgtcacatt
ggctggaaagatttcactgcatacagatggcgtctcagccacaggccaaagaccggtttt
atcagagtggtgatgtatgaaggaaagaaaatcatggctgactcaggacccatctatgac
aaaacctacgctggcggtagactaggcctgttcgtcttctctcaagaaatggtgttcttc
tcggacatgaaatacgagtgccgagactcctaa

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